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Tytuł :
rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA in a Southern Chinese male population.
Autorzy :
Qi N; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
Chen Y; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Department of Urology Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Zeng Y; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
Bao M; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
Long X; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
Guo Y; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
Tan A; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Department of Chemotherapy, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Gao Y; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Zhang H; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
Yang X; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
Hu Y; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China.
Mo Z; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Department of Urology Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: .
Jiang Y; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China; Guangxi Key Laboratory of Genomic and Personalized Medicine, Nanning, Guangxi 530021, China; Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning, Guangxi 530021, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Dec 30; Vol. 763, pp. 145067. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Single Nucleotide*
12E7 Antigen/*blood
Prostate-Specific Antigen/*blood
Receptors, G-Protein-Coupled/*genetics
Adult ; Cell Proliferation ; HEK293 Cells ; Humans ; MAP Kinase Signaling System ; Male ; Middle Aged ; PC-3 Cells ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
ADGRF4 Regulates Non-small Cell Lung Cancer Cell Invasiveness.
Autorzy :
Yoon JH; Major in Biotechnology, Division of Food Science and Biotechnology, College of Health and Life Sciences, Korea National University of Transportation, Chungbuk, Republic of Korea.
Cho SG; Major in Biotechnology, Division of Food Science and Biotechnology, College of Health and Life Sciences, Korea National University of Transportation, Chungbuk, Republic of Korea .
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Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6835-6844.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*pathology
Lung Neoplasms/*genetics
Lung Neoplasms/*pathology
Receptors, G-Protein-Coupled/*genetics
Biomarkers, Tumor ; Carcinoma, Non-Small-Cell Lung/mortality ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Lung Neoplasms/mortality ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
Autorzy :
Li D; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Zhang L; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Fu J; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Huang H; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Sun S; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Zhang D; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Zhao L; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Ucheojor Onwuka J; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Zhao Y; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
Cui B; Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, China.
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Źródło :
Cancer science [Cancer Sci] 2020 Dec; Vol. 111 (12), pp. 4558-4566. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Receptors, Gastrointestinal Hormone/*metabolism
Biomarkers, Tumor/genetics ; Cell-Free Nucleic Acids ; Colorectal Neoplasms/diagnosis ; CpG Islands ; Gene Expression ; Humans ; Leukocytes/metabolism ; Methylation ; Protein Array Analysis ; Receptors, G-Protein-Coupled/genetics ; Receptors, Gastrointestinal Hormone/genetics ; Reproducibility of Results ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force.
Autorzy :
Yeung J; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.
Adili R; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.
Stringham EN; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.
Luo R; Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115.
Vizurraga A; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.
Rosselli-Murai LK; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.
Stoveken HM; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.
Yu M; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.
Piao X; Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115.; Newborn Brain Research Institute, Department of Pediatrics, Weill Institute for Neuroscience, University of California, San Francisco, CA 94158.
Holinstat M; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109.; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109.
Tall GG; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28275-28286. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Hemostasis*
Blood Platelets/*metabolism
Collagen/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Animals ; Humans ; Integrins/metabolism ; Mice ; Mice, Knockout ; Platelet Adhesiveness ; Platelet Aggregation ; Pseudopodia/metabolism ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction ; Thrombosis/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer.
Autorzy :
Lee S; Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.
Jun J; Division of Medical Genetics, University of California, San Diego, CA, U.S.A.
Kim WJ; Division of Medical Genetics, University of California, San Diego, CA, U.S.A.
Tamayo P; Division of Medical Genetics, University of California, San Diego, CA, U.S.A.
Howell SB; Division of Hematology, Department of Medicine, University of California, San Diego, CA, U.S.A. .
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Źródło :
Anticancer research [Anticancer Res] 2020 Nov; Vol. 40 (11), pp. 6017-6028.
Typ publikacji :
Journal Article
MeSH Terms :
Wnt Signaling Pathway*/genetics
Cystadenocarcinoma, Serous/*metabolism
Cystadenocarcinoma, Serous/*pathology
Ovarian Neoplasms/*metabolism
Ovarian Neoplasms/*pathology
Receptors, G-Protein-Coupled/*metabolism
Thrombospondins/*metabolism
Cystadenocarcinoma, Serous/genetics ; Fallopian Tubes/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Neoplasm Grading ; Ovarian Neoplasms/genetics ; Ovary/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, G-Protein-Coupled/genetics ; Thrombospondins/genetics
Czasopismo naukowe
Tytuł :
GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain.
Autorzy :
Braden; INRAe, UMR 1280, Physiopathologie des Adaptations Nutritionnelles, CHU Hôtel-Dieu, Nantes, France (F.K.-C., M.T., K.O.) and Physiogenex SAS, Prologue Biotech, Rue Pierre et Marie Curie, Laboratoryège-Innopole, France (F.B., T.S.).
Giancotti LA; INRAe, UMR 1280, Physiopathologie des Adaptations Nutritionnelles, CHU Hôtel-Dieu, Nantes, France (F.K.-C., M.T., K.O.) and Physiogenex SAS, Prologue Biotech, Rue Pierre et Marie Curie, Laboratoryège-Innopole, France (F.B., T.S.).
Chen Z; INRAe, UMR 1280, Physiopathologie des Adaptations Nutritionnelles, CHU Hôtel-Dieu, Nantes, France (F.K.-C., M.T., K.O.) and Physiogenex SAS, Prologue Biotech, Rue Pierre et Marie Curie, Laboratoryège-Innopole, France (F.B., T.S.).
DeLeon C; INRAe, UMR 1280, Physiopathologie des Adaptations Nutritionnelles, CHU Hôtel-Dieu, Nantes, France (F.K.-C., M.T., K.O.) and Physiogenex SAS, Prologue Biotech, Rue Pierre et Marie Curie, Laboratoryège-Innopole, France (F.B., T.S.).
Latzo N; INRAe, UMR 1280, Physiopathologie des Adaptations Nutritionnelles, CHU Hôtel-Dieu, Nantes, France (F.K.-C., M.T., K.O.) and Physiogenex SAS, Prologue Biotech, Rue Pierre et Marie Curie, Laboratoryège-Innopole, France (F.B., T.S.) .
Boehn T
D'Cunha N
Thompson BM
Doyle TM
McDonald JG
Walker JK
Kolar GR
Arnatt CK
Salvemini D
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Nov; Vol. 375 (2), pp. 367-375. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuralgia/*metabolism
Oxysterols/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Spinal Cord/*metabolism
Animals ; Female ; HL-60 Cells ; Humans ; Male ; Mice ; Neuralgia/drug therapy ; Neuralgia/pathology ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Signal Transduction ; Spinal Cord/pathology
Czasopismo naukowe
Tytuł :
A hypertension patient-derived iPSC model demonstrates a role for G protein-coupled estrogen receptor in hypertension risk and development.
Autorzy :
Fredette NC; Department of Pathology, Immunology and Experimental Medicine, University of Florida College of Medicine, Gainesville, Florida.
Malik E; Department of Pathology, Immunology and Experimental Medicine, University of Florida College of Medicine, Gainesville, Florida.
Mukhtar ML; Department of Mechanical & Aerospace Engineering, University of Florida Herbert Wertheim College of Engineering, Gainesville, Florida.
Prossnitz ER; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Terada N; Department of Pathology, Immunology and Experimental Medicine, University of Florida College of Medicine, Gainesville, Florida.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Nov 01; Vol. 319 (5), pp. C825-C838. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
Endothelial Cells/*metabolism
Hypertension/*genetics
Induced Pluripotent Stem Cells/*metabolism
Receptors, Estrogen/*genetics
Receptors, G-Protein-Coupled/*genetics
Adult ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Base Sequence ; CRISPR-Cas Systems ; Cadherins/genetics ; Cadherins/metabolism ; Cell Adhesion ; Cell Differentiation ; Cell Engineering/methods ; Endothelial Cells/pathology ; Female ; Gene Editing/methods ; Gene Expression Regulation ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Induced Pluripotent Stem Cells/pathology ; Models, Biological ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Primary Cell Culture ; Receptors, Estrogen/deficiency ; Receptors, G-Protein-Coupled/deficiency ; Risk Factors ; THP-1 Cells ; von Willebrand Factor/genetics ; von Willebrand Factor/metabolism
Czasopismo naukowe
Tytuł :
Targeting FFA1 and FFA4 receptors in cancer-induced cachexia.
Autorzy :
Freitas RDS; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.; Centro de Pesquisas em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Muradás TC; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.; Centro de Pesquisas em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Dagnino APA; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.; Centro de Pesquisas em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Rost FL; Centro de Pesquisas em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Costa KM; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Venturin GT; Centro de Pesquisa Pré-Clínica, Instituto do Cérebro do Rio Grande do Sul (Brain Institute of Rio Grande do Sul - BraIns), Porto Alegre, Brazil.
Greggio S; Centro de Pesquisa Pré-Clínica, Instituto do Cérebro do Rio Grande do Sul (Brain Institute of Rio Grande do Sul - BraIns), Porto Alegre, Brazil.
da Costa JC; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.; Centro de Pesquisa Pré-Clínica, Instituto do Cérebro do Rio Grande do Sul (Brain Institute of Rio Grande do Sul - BraIns), Porto Alegre, Brazil.
Campos MM; Programa de Pós-graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.; Centro de Pesquisas em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.; Programa de Pós-graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Nov 01; Vol. 319 (5), pp. E877-E892. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Body Weight/*drug effects
Cachexia/*drug therapy
Carcinoma, Lewis Lung/*metabolism
Docosahexaenoic Acids/*therapeutic use
Receptors, G-Protein-Coupled/*metabolism
alpha-Linolenic Acid/*therapeutic use
Animals ; Benzoates/pharmacology ; Biphenyl Compounds/pharmacology ; Cachexia/etiology ; Cachexia/metabolism ; Carcinoma, Lewis Lung/complications ; Disease Models, Animal ; Docosahexaenoic Acids/pharmacology ; Methylamines/pharmacology ; Mice ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Neoplasm Transplantation ; Phenylpropionates/pharmacology ; Propionates/pharmacology ; Pyrimidines/pharmacology ; Receptors, G-Protein-Coupled/agonists ; Sulfonamides/pharmacology ; Xanthenes/pharmacology ; alpha-Linolenic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Niacin inhibits the synthesis of milk fat in BMECs through the GPR109A-mediated downstream signalling pathway.
Autorzy :
Wang J; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Cao Y; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Fu S; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Li W; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Ge Y; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Cheng J; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Liu J; College of Veterinary Medicine, Jilin University, Changchun 130062, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118415. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Dietary Fats/*metabolism
Epithelial Cells/*metabolism
Mammary Glands, Animal/*metabolism
Milk/*metabolism
Niacin/*pharmacology
Receptors, G-Protein-Coupled/*metabolism
Animals ; Cattle ; Epithelial Cells/drug effects ; Female ; Hypolipidemic Agents/pharmacology ; Mammary Glands, Animal/drug effects ; Milk/drug effects ; Receptors, G-Protein-Coupled/genetics
Czasopismo naukowe
Tytuł :
Umami-enhancing effect of typical kokumi-active γ-glutamyl peptides evaluated via sensory analysis and molecular modeling approaches.
Autorzy :
Yang J; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Huang Y; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Cui C; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Dong H; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zeng X; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China. Electronic address: .
Bai W; College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; Academy of Contemporary Agricultural Engineering Innovations, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Feb 15; Vol. 338, pp. 128018. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Taste*/drug effects
Dipeptides/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Sodium Glutamate/*metabolism
Adult ; Amino Acids/chemistry ; Amino Acids/metabolism ; Dipeptides/chemistry ; Female ; Flavoring Agents/chemistry ; Flavoring Agents/pharmacology ; Humans ; Hydrogen Bonding ; Male ; Middle Aged ; Models, Molecular ; Molecular Docking Simulation ; Receptors, G-Protein-Coupled/chemistry ; Sodium Glutamate/chemistry ; Sodium Glutamate/pharmacology
Czasopismo naukowe
Tytuł :
Acetic acid stimulates G-protein-coupled receptor GPR43 and induces intracellular calcium influx in L6 myotube cells.
Autorzy :
Maruta H; Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan.
Yamashita H; Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan.; Graduate School of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan.
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Źródło :
PloS one [PLoS One] 2020 Sep 30; Vol. 15 (9), pp. e0239428. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetic Acid/*pharmacology
Calcium/*metabolism
Intracellular Space/*drug effects
Intracellular Space/*metabolism
Muscle Fibers, Skeletal/*cytology
Receptors, G-Protein-Coupled/*metabolism
Active Transport, Cell Nucleus/drug effects ; Animals ; Cell Line ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Gene Expression Regulation/drug effects ; Gene Silencing ; MEF2 Transcription Factors/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Muscle, Skeletal/cytology ; NFATC Transcription Factors/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; RNA, Messenger/genetics ; Rats ; Receptors, G-Protein-Coupled/deficiency ; Receptors, G-Protein-Coupled/genetics
Czasopismo naukowe
Tytuł :
Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice.
Autorzy :
Wei LL; From the Core Research Laboratory (L.-L.W., N.M., K.-Y.W., J.-X.W., T.-Y.D., S.-J.Z., K.L.), Xi'an Jiaotong University, China.
Ma N; From the Core Research Laboratory (L.-L.W., N.M., K.-Y.W., J.-X.W., T.-Y.D., S.-J.Z., K.L.), Xi'an Jiaotong University, China.
Wu KY; From the Core Research Laboratory (L.-L.W., N.M., K.-Y.W., J.-X.W., T.-Y.D., S.-J.Z., K.L.), Xi'an Jiaotong University, China.
Wang JX; From the Core Research Laboratory (L.-L.W., N.M., K.-Y.W., J.-X.W., T.-Y.D., S.-J.Z., K.L.), Xi'an Jiaotong University, China.
Diao TY; From the Core Research Laboratory (L.-L.W., N.M., K.-Y.W., J.-X.W., T.-Y.D., S.-J.Z., K.L.), Xi'an Jiaotong University, China.
Zhao SJ; From the Core Research Laboratory (L.-L.W., N.M., K.-Y.W., J.-X.W., T.-Y.D., S.-J.Z., K.L.), Xi'an Jiaotong University, China.
Bai L; The Second Affiliated Hospital and Cardiovascular Research Center, School of Basic Medical Sciences, Health Science Center (L.B., E.L.), Xi'an Jiaotong University, China.
Liu E; The Second Affiliated Hospital and Cardiovascular Research Center, School of Basic Medical Sciences, Health Science Center (L.B., E.L.), Xi'an Jiaotong University, China.
Li ZF; National Local Joint Engineering Research Centre of Biodiagnostics and Biotherapy (Z.-F.L.), Xi'an Jiaotong University, China.
Zhou W; Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, Faculty of Life Sciences & Medicine (W.Z.), King's College London, United Kingdom.
Chen D; Department of Inflammation Biology, School of Immunology & Microbial Sciences (D.C.), King's College London, United Kingdom.
Li K; From the Core Research Laboratory (L.-L.W., N.M., K.-Y.W., J.-X.W., T.-Y.D., S.-J.Z., K.L.), Xi'an Jiaotong University, China.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Sep; Vol. 40 (9), pp. 2070-2083. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aorta/*metabolism
Aortic Diseases/*prevention & control
Atherosclerosis/*prevention & control
Inflammation/*prevention & control
Macrophages, Peritoneal/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Animals ; Aorta/immunology ; Aorta/pathology ; Aortic Diseases/immunology ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Atherosclerosis/immunology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Cells, Cultured ; Chemokine CCL2/metabolism ; Chemotaxis ; Disease Models, Animal ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; NF-kappa B/metabolism ; Phenotype ; Plaque, Atherosclerotic ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, G-Protein-Coupled/deficiency ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
G protein-coupled receptor-associated sorting proteins: function and relevant disorders.
Autorzy :
Zhang M; Department of Medical Genetics, Nanjing Medical University, Nanjing 211166, China.
Liang LH; Department of Medical Genetics, Nanjing Medical University, Nanjing 211166, China.
Lu YJ; Department of Medical Genetics, Nanjing Medical University, Nanjing 211166, China.
Cao X; Department of Medical Genetics, Nanjing Medical University, Nanjing 211166, China.
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Źródło :
Yi chuan = Hereditas [Yi Chuan] 2020 Aug 20; Vol. 42 (8), pp. 713-724.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Deafness*/genetics
Neoplasms*/genetics
Nervous System Diseases*/genetics
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Humans ; Ligands ; Protein Transport/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Structure and dynamics of the active Gs-coupled human secretin receptor.
Autorzy :
Dong M; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Deganutti G; School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, UK.; Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Alison Gingell Building, Coventry University, CV1 2DS, Coventry, UK.
Piper SJ; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Liang YL; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Khoshouei M; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.; Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4002, Basel, Switzerland.
Belousoff MJ; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Harikumar KG; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Reynolds CA; School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, UK.
Glukhova A; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Furness SGB; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Christopoulos A; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
Danev R; Graduate School of Medicine, University of Tokyo, N415, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.
Wootten D; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. .
Sexton PM; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. .
Miller LJ; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 18; Vol. 11 (1), pp. 4137. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
GTP-Binding Protein alpha Subunits, Gs/*chemistry
Receptors, G-Protein-Coupled/*chemistry
Receptors, Gastrointestinal Hormone/*chemistry
Secretin/*chemistry
Amino Acid Sequence ; Animals ; Binding Sites/genetics ; Cell Line ; Cricetinae ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Cysteine/chemistry ; Cysteine/metabolism ; GTP-Binding Protein alpha Subunits, Gs/ultrastructure ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Insecta ; Models, Molecular ; Protein Binding ; Protein Domains/genetics ; Protein Structure, Secondary ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/ultrastructure ; Receptors, Gastrointestinal Hormone/metabolism ; Receptors, Gastrointestinal Hormone/ultrastructure ; Secretin/metabolism
Czasopismo naukowe
Tytuł :
GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis.
Autorzy :
She L; Department of Medical College, Hunan Polytechnic of Environment and Biology, Hengyang 421001, China.
Yao H; Department of Medical College, Hunan Polytechnic of Environment and Biology, Hengyang 421001, China.
He L; Department of Medical College, Hunan Polytechnic of Environment and Biology, Hengyang 421001, China.
Li Y; Department of Medical College, Hunan Polytechnic of Environment and Biology, Hengyang 421001, China.
Cao J; Department of Medical College, Hunan Polytechnic of Environment and Biology, Hengyang 421001, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Aug 05; Vol. 52 (8), pp. 914-915.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Atherosclerosis*/metabolism
Atherosclerosis*/pathology
Drug Delivery Systems*
Hypercholesterolemia*/drug therapy
Hypercholesterolemia*/genetics
Hypercholesterolemia*/metabolism
Hypercholesterolemia*/pathology
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/metabolism
Signal Transduction*/drug effects
Signal Transduction*/genetics
Humans
Czasopismo naukowe
Tytuł :
Jana Selent.
Autorzy :
Marx V; Nature Methods, . .
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Źródło :
Nature methods [Nat Methods] 2020 Aug; Vol. 17 (8), pp. 753.
Typ publikacji :
Biography; Historical Article; Journal Article; Portrait
MeSH Terms :
Drug Discovery*/history
Receptors, G-Protein-Coupled*/agonists
Receptors, G-Protein-Coupled*/antagonists & inhibitors
Receptors, G-Protein-Coupled*/chemistry
Receptors, G-Protein-Coupled*/history
Biotechnology/history ; Germany ; History of Pharmacy ; History, 21st Century ; Interdisciplinary Research/history ; Spain
Personal Name as Subject :
Selent J
Czasopismo naukowe
Tytuł :
Genetically encoded biosensors based on innovative scaffolds.
Autorzy :
Moeyaert B; Laboratory for Nanobiology, Department of Chemistry, KU Leuven, Celestijnenlaan 200G, 3001 Heverlee, Belgium.
Dedecker P; Laboratory for Nanobiology, Department of Chemistry, KU Leuven, Celestijnenlaan 200G, 3001 Heverlee, Belgium. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2020 Aug; Vol. 125, pp. 105761. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biosensing Techniques/*methods
Fluorescence Resonance Energy Transfer/*methods
Protein Engineering/*methods
Receptors, G-Protein-Coupled/*genetics
Signal Transduction/*drug effects
Antibodies ; Calcium/chemistry ; Calcium/metabolism ; Luminescent Proteins/chemistry ; Neurotransmitter Agents/pharmacology ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/drug effects
Czasopismo naukowe
Tytuł :
Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture.
Autorzy :
Yeliseev A; National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, 20892, USA. .
van den Berg A; ThermoFisher Scientific, 7335 Executive Way, Frederick, MD, 21704, USA.
Zoubak L; National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, 20892, USA.
Hines K; National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, 20892, USA.
Stepnowski S; ThermoFisher Scientific, 7335 Executive Way, Frederick, MD, 21704, USA.
Williston K; ThermoFisher Scientific, 7335 Executive Way, Frederick, MD, 21704, USA.
Yan W; ThermoFisher Scientific, 7335 Executive Way, Frederick, MD, 21704, USA.
Gawrisch K; National Institute on Alcoholism and Alcohol Abuse, NIH, Bethesda, MD, 20892, USA.
Zmuda J; ThermoFisher Scientific, 7335 Executive Way, Frederick, MD, 21704, USA.
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 08; Vol. 10 (1), pp. 16805. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Receptors, G-Protein-Coupled/*metabolism
Animals ; Cell Line ; Cells, Cultured ; Escherichia coli/metabolism ; Hot Temperature ; Protein Processing, Post-Translational ; Protein Stability ; Receptor, Cannabinoid, CB2/isolation & purification ; Receptor, Cannabinoid, CB2/metabolism ; Receptors, G-Protein-Coupled/isolation & purification ; Recombinant Proteins
Czasopismo naukowe
Tytuł :
Intrinsic Efficacy of Opioid Ligands and Its Importance for Apparent Bias, Operational Analysis, and Therapeutic Window.
Autorzy :
Gillis A; Discipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia (A.G., M.J.C.) and EMBL Australia Node in Single Molecule Science, University of New South Wales, New South Wales, Australia (V.S.).
Sreenivasan V; Discipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia (A.G., M.J.C.) and EMBL Australia Node in Single Molecule Science, University of New South Wales, New South Wales, Australia (V.S.).
Christie MJ; Discipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia (A.G., M.J.C.) and EMBL Australia Node in Single Molecule Science, University of New South Wales, New South Wales, Australia (V.S.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Oct; Vol. 98 (4), pp. 410-424. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Analgesics, Opioid/*pharmacology
Receptors, G-Protein-Coupled/*metabolism
Receptors, Opioid, mu/*metabolism
Animals ; Humans ; Ligands ; Receptors, G-Protein-Coupled/agonists ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Leucine-rich repeat-containing G-protein-coupled receptor 2 (LGR2) can regulate PO activity and AMP genes expression in Macrobrachium nipponense.
Autorzy :
Cao X; Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China.
Zhang C; Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China.
Zhang R; Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China.
Wang K; Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China.
Dai X; Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China.
Huang X; Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China. Electronic address: .
Ren Q; Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural Technology, College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China; Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province, Lianyungang, Jiangsu, 222005, China. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2020 Oct; Vol. 126, pp. 14-24. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthropod Proteins/*metabolism
Palaemonidae/*physiology
Proteins/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Signal Transduction/*immunology
Animals ; Antimicrobial Cationic Peptides/immunology ; Antimicrobial Cationic Peptides/metabolism ; Arthropod Proteins/genetics ; Arthropod Proteins/immunology ; Gastric Mucosa/metabolism ; Gene Knockdown Techniques ; Gills/metabolism ; Host Microbial Interactions/immunology ; Immunity, Innate ; Molting/physiology ; Monophenol Monooxygenase/metabolism ; Palaemonidae/microbiology ; Proteins/genetics ; Receptors, G-Protein-Coupled/genetics ; Staphylococcus aureus/immunology ; Transcription Factors ; Up-Regulation/immunology ; Vibrio parahaemolyticus/immunology ; White spot syndrome virus 1/immunology
Czasopismo naukowe

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