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Tytuł:
In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression.
Autorzy:
Guet-McCreight A; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada. .
Chameh HM; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Mazza F; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Prevot TD; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Valiante TA; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.; Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada.; Center for Advancing Neurotechnological Innovation to Application, Toronto, ON, Canada.; Max Planck-University of Toronto Center for Neural Science and Technology, Toronto, ON, Canada.
Sibille E; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Hay E; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada. .; Department of Physiology, University of Toronto, Toronto, ON, Canada. .; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. .
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Źródło:
Communications biology [Commun Biol] 2024 Feb 23; Vol. 7 (1), pp. 225. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Depression*/drug therapy
Receptors, GABA-A*/metabolism
Humans ; Neurons/metabolism ; Interneurons/metabolism ; Brain/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation.
Autorzy:
Tsai YC; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.; Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Hleihil M; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.; Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Otomo K; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Abegg A; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Cavaccini A; Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Panzanelli P; Department of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy.
Cramer T; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.; Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Ferrari KD; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.; Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Barrett MJP; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.; Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Bosshard G; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Karayannis T; Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Weber B; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.; Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Tyagarajan SK; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.; Center for Neuroscience Zurich (ZNZ), Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Stobart JL; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. .; College of Pharmacy, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 20; Vol. 14 (1), pp. 4169. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, GABA-A*/metabolism
Vibrissae*/metabolism
Membrane Proteins*
Animals ; Carrier Proteins/metabolism ; Pyramidal Cells/metabolism ; Synapses/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GABAergic regulation of striatal spiny projection neurons depends upon their activity state.
Autorzy:
Day M; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Belal M; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Surmeier WC; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Melendez A; Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America.
Wokosin D; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Tkatch T; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America.
Clarke VRJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America.
Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2024 Jan 31; Vol. 22 (1), pp. e3002483. Date of Electronic Publication: 2024 Jan 31 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, GABA-A*
Interneurons*
Mice ; Animals ; Corpus Striatum/physiology ; Neostriatum ; Synaptic Transmission/physiology ; GABAergic Neurons/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epileptic Encephalopathy GABRB Structural Variants Share Common Gating and Trafficking Defects.
Autorzy:
Hernandez CC; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Hu N; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Shen W; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Macdonald RL; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Dec 14; Vol. 13 (12). Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Receptors, GABA-A*/metabolism
Brain Diseases*
Humans ; Mutation, Missense ; Mutation ; Seizures
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development of QSAR model based on Monte Carlo optimization for predicting GABAA receptor binding of newly emerging benzodiazepines.
Autorzy:
Antović A; .
Karadžić R; .
Živković J; .
Veselinovic A; Faculty of Medicine, University of Nis, Serbia. .
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Źródło:
Acta chimica Slovenica [Acta Chim Slov] 2023 Nov 23; Vol. 70 (4), pp. 634-641. Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Benzodiazepines*/pharmacology
Receptors, GABA-A*
Quantitative Structure-Activity Relationship ; Protein Binding ; Monte Carlo Method
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors.
Autorzy:
Li S; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China.
Wei X; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China.
Huang H; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China.
Ye L; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China.
Ma M; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China.
Sun L; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China.
Lu Y; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China.
Wu Y; Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Shuangyong Road No.6, Nanning, Guangxi, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Oct 09; Vol. 21 (1), pp. 707. Date of Electronic Publication: 2023 Oct 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anticonvulsants*/pharmacology
Anticonvulsants*/therapeutic use
Anticonvulsants*/metabolism
Receptors, GABA-A*/metabolism
Humans ; Carrier Proteins/metabolism ; gamma-Aminobutyric Acid/metabolism ; Neurons ; Seizures/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extra-Synaptic GABA A Receptor Potentiation and Neurosteroid-Induced Learning Deficits Are Inhibited by GR3027, a GABA A Modulating Steroid Antagonist.
Autorzy:
Bengtsson SKS; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, SE-901 85 Umeå, Sweden.
Sjöstedt J; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, SE-901 85 Umeå, Sweden.
Malinina E; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, SE-901 85 Umeå, Sweden.; Department of Integrative Medical Biology, Umeå University, SE-901 87 Umeå, Sweden.
Das R; Department of Integrative Medical Biology, Umeå University, SE-901 87 Umeå, Sweden.; Umecrine Cognition AB, SE-171 65 Solna, Sweden.
Doverskog M; Umecrine Cognition AB, SE-171 65 Solna, Sweden.
Johansson M; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, SE-901 85 Umeå, Sweden.; Umecrine Cognition AB, SE-171 65 Solna, Sweden.
Haage D; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, SE-901 85 Umeå, Sweden.; Department of Nursing Sciences, Mid Sweden University, AE-851 70 Sundsvall, Sweden.
Bäckström T; Umeå Neurosteroid Research Center, Department of Clinical Sciences, Umeå University, SE-901 85 Umeå, Sweden.; Umecrine Cognition AB, SE-171 65 Solna, Sweden.
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Źródło:
Biomolecules [Biomolecules] 2023 Oct 09; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, GABA-A*
Neurosteroids*
Male ; Rats ; Humans ; Animals ; GABA Antagonists ; Rats, Wistar ; Pregnanolone/pharmacology ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of Developmental Changes of GABA A Receptors on Interneuron-NG2 Glia Transmission in the Hippocampus.
Autorzy:
Patt L; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Tascio D; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Domingos C; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Timmermann A; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Jabs R; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Henneberger C; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.
Steinhäuser C; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Seifert G; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 30; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 30.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, GABA-A*
Animals ; Mice ; gamma-Aminobutyric Acid ; Hippocampus ; Interneurons ; Neuroglia
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interleukin 6 (IL-6) Regulates GABAA Receptors in the Dorsomedial Hypothalamus Nucleus (DMH) through Activation of the JAK/STAT Pathway to Affect Heart Rate Variability in Stressed Rats.
Autorzy:
Zhang L; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Shi W; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Liu J; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Chen K; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Zhang G; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Zhang S; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Cong B; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Li Y; Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 19; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 19.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, GABA-A*
Interleukin-6*/genetics
Animals ; Rats ; Heart Rate ; Janus Kinases ; STAT Transcription Factors ; Signal Transduction ; Hypothalamus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Isoallopregnanolone Inhibits Estrus Cycle-Dependent Aggressive Behavior.
Autorzy:
Bäckström T; Umeå Neurosteroid Research Center, Department of Clinical Science, Umeå University, SE-901 85 Umea, Sweden.
Bengtsson SKS; Umeå Neurosteroid Research Center, Department of Clinical Science, Umeå University, SE-901 85 Umea, Sweden.
Sjöstedt J; Umeå Neurosteroid Research Center, Department of Clinical Science, Umeå University, SE-901 85 Umea, Sweden.
Malinina E; Umeå Neurosteroid Research Center, Department of Clinical Science, Umeå University, SE-901 85 Umea, Sweden.
Johansson M; Umeå Neurosteroid Research Center, Department of Clinical Science, Umeå University, SE-901 85 Umea, Sweden.
Ragagnin G; Umeå Neurosteroid Research Center, Department of Clinical Science, Umeå University, SE-901 85 Umea, Sweden.
Ekberg K; Asarina Pharma AB, Fogdevreten 2, SE-171 65 Solna, Sweden.
Lundgren P; Umeå Neurosteroid Research Center, Department of Clinical Science, Umeå University, SE-901 85 Umea, Sweden.
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Źródło:
Biomolecules [Biomolecules] 2023 Jun 20; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 20.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, GABA-A*
Aggression*/physiology
Rats ; Female ; Animals ; Rats, Wistar ; Estrus ; Pregnanolone/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Receptor Binding Studies of α5 GABA A R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders.
Autorzy:
Sharmin D; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA.
Mian MY; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA.
Marcotte M; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON M5S 2S1, Canada.
Prevot TD; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON M5S 2S1, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.
Sibille E; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON M5S 2S1, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5T 1R8, Canada.
Witkin JM; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA.; Laboratory of Antiepileptic Drug Discovery, Ascension, St. Vincent, Indianapolis, IN 46260, USA.
Cook JM; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin Milwaukee, Milwaukee, WI 53201, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jun 14; Vol. 28 (12). Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, GABA-A*/metabolism
Cognitive Dysfunction*/drug therapy
Animals ; Humans ; Ligands ; GABA-A Receptor Agonists/pharmacology ; Benzodiazepines/pharmacology ; Benzodiazepines/metabolism ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacological Analysis of GABA A Receptor and Sigma1R Chaperone Interaction: Research Report I-Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABA A Receptors' Ligands.
Autorzy:
Voronin MV; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
Shangin SV; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
Litvinova SA; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
Abramova EV; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
Kurbanov RD; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
Rybina IV; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
Vakhitova YV; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
Seredenin SB; Department of Pharmacogenetics, Federal State Budgetary Institution 'Research Zakusov Institute of Pharmacology', Baltiyskaya Street 8, 125315 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 31; Vol. 24 (11). Date of Electronic Publication: 2023 May 31.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Anxiety Agents*/pharmacology
Receptors, GABA-A*/metabolism
Animals ; Mice ; Anticonvulsants/pharmacology ; Benzodiazepines/pharmacology ; Diazepam/pharmacology ; Hypnotics and Sedatives/pharmacology ; Ligands ; Mice, Inbred ICR ; Research Report ; Sigma-1 Receptor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations.
Autorzy:
Sui J; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Zhan L; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Ji S; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Wu W; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Chen Y; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Yun F; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Liang W; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Wang J; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Cao M; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Shen D; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
Zhang Q; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Department of Neurology, Affiliated Hospital of Nantong University, Medical School, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14583.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Zebrafish*
Epilepsy*/genetics
Animals ; Humans ; Receptors, GABA-A/genetics ; Receptors, GABA-A/metabolism ; Mutation/genetics ; Valproic Acid/pharmacology ; Valproic Acid/therapeutic use ; Phenotype ; Inflammation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA A Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor.
Autorzy:
Pierce SR; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Germann AL; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xu SQ; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Menon SL; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ortells MO; Facultad de Medicina, Universidad de Morón, CONICET, Morón 1708, Argentina.
Arias HR; Department of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, OK 74464, USA.
Akk G; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Apr 20; Vol. 13 (4). Date of Electronic Publication: 2023 Apr 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Anesthetics*
Receptors, GABA-A*/genetics
Receptors, GABA-A*/metabolism
Allosteric Regulation ; alpha7 Nicotinic Acetylcholine Receptor/genetics ; alpha7 Nicotinic Acetylcholine Receptor/metabolism ; Binding Sites ; Humans ; Animals
Czasopismo naukowe
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Tytuł:
Alfaxalone is an effective anesthetic for the electrophysiological study of anoxia-tolerance mechanisms in western painted turtle pyramidal neurons.
Autorzy:
Suganthan H; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Stefano DD; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Buck LT; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.
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Źródło:
PloS one [PLoS One] 2024 Apr 16; Vol. 19 (4), pp. e0298065. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Turtles*/physiology
Hypoxia, Brain*
Anesthetics*/pharmacology
Pregnanediones*
Animals ; Receptors, GABA-A/metabolism ; Pyramidal Cells/metabolism ; Hypoxia/metabolism ; Mammals
Czasopismo naukowe
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Tytuł:
AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.
Autorzy:
Simmons SC; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Flerlage WJ; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Langlois LD; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Shepard RD; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Bouslog C; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Thomas EH; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Gouty KM; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Sanderson JL; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA.
Gouty S; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Cox BM; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA.
Dell'Acqua ML; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA. .
Nugent FS; Uniformed Services University of the Health Sciences, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD, 20814, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Mar 20; Vol. 7 (1), pp. 345. Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Corticotropin-Releasing Hormone*/metabolism
Habenula*/metabolism
Animals ; Male ; Mice ; A Kinase Anchor Proteins/genetics ; A Kinase Anchor Proteins/metabolism ; Endocannabinoids ; Neuronal Plasticity/physiology ; Neurons/physiology ; Receptors, AMPA/genetics ; Receptors, AMPA/metabolism ; Receptors, GABA-A/metabolism ; Synaptic Transmission/physiology
Czasopismo naukowe
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Tytuł:
Local effect of allopregnanolone in rat ovarian steroidogenesis, follicular and corpora lutea development.
Autorzy:
Cáceres ARR; Laboratorio de Fisiopatología Ovárica, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU - CONICET Mendoza), Av. Ruiz Leal s/n Parque General San Martín, CP 5500, Mendoza, Argentina.; Facultad de Ingeniería y Facultad de Ciencias Médicas, Universidad de Mendoza, Mendoza, Argentina.
Cardone DA; Laboratorio de Fisiopatología Ovárica, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU - CONICET Mendoza), Av. Ruiz Leal s/n Parque General San Martín, CP 5500, Mendoza, Argentina.
Sanhueza MLÁ; Laboratorio de Fisiopatología Ovárica, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU - CONICET Mendoza), Av. Ruiz Leal s/n Parque General San Martín, CP 5500, Mendoza, Argentina.
Bosch IM; C&S Argentina, I+D+I, Buenos Aires, Argentina.
Cuello-Carrión FD; Laboratorio de Oncología, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU - CONICET Mendoza), Mendoza, Argentina.
Rodriguez GB; Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.
Scotti L; Ovarian Pathophysiology Studies Laboratory, Institute of Experimental Biology and Medicine (IByME) - CONICET, Buenos Aires, Argentina.
Parborell F; Ovarian Pathophysiology Studies Laboratory, Institute of Experimental Biology and Medicine (IByME) - CONICET, Buenos Aires, Argentina.
Halperin J; Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Ciudad Autónoma de Buenos Aires, Argentina.
Laconi MR; Laboratorio de Fisiopatología Ovárica, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU - CONICET Mendoza), Av. Ruiz Leal s/n Parque General San Martín, CP 5500, Mendoza, Argentina. .; Facultad de Ingeniería y Facultad de Ciencias Médicas, Universidad de Mendoza, Mendoza, Argentina. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 16; Vol. 14 (1), pp. 6402. Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
Pregnanolone*/pharmacology
Progesterone*/pharmacology
Pregnancy ; Female ; Rats ; Animals ; Proliferating Cell Nuclear Antigen ; Bicuculline/pharmacology ; Receptors, GABA-A ; Corpus Luteum
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice.
Autorzy:
Plasil SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Farris SP; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
Blednov Y; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
Mayfield RD; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Mangieri RA; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA.
Nwokeji UJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Aziz HC; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA.
Lambeth PS; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.; Department of Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Harris RA; The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, USA.
Homanics GE; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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Źródło:
Genes, brain, and behavior [Genes Brain Behav] 2024 Feb; Vol. 23 (1), pp. e12886.
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Long Noncoding*/genetics
Alcoholism*/genetics
Humans ; Female ; Mice ; Male ; Animals ; Ethanol/toxicity ; Alcohol Drinking/genetics ; Receptors, GABA-A/genetics ; Mutation ; Mice, Inbred C57BL
Czasopismo naukowe
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Tytuł:
Blue Native PAGE-Antibody Shift in Conjunction with Mass Spectrometry to Reveal Protein Subcomplexes: Detection of a Cerebellar α1/α6-Subunits Containing γ-Aminobutyric Acid Type A Receptor Subtype.
Autorzy:
Chen M; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Koopmans F; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Paliukhovich I; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
van der Spek SJF; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Dong J; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Smit AB; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Li KW; Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 21; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 21.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, GABA*/metabolism
Receptors, GABA-A*/metabolism
Mice ; Animals ; Native Polyacrylamide Gel Electrophoresis ; Cerebellum/metabolism ; Antibodies/metabolism ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABA A Receptor Subtype.
Autorzy:
Crocetti L; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Italy.
Guerrini G; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Italy.
Melani F; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Italy.
Vergelli C; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Italy.
Giovannoni MP; Neurofarba, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Mar 29; Vol. 28 (7). Date of Electronic Publication: 2023 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, GABA-A*/metabolism
Thiophenes*
Structure-Activity Relationship ; Molecular Docking Simulation ; Pyrimidines/pharmacology ; Pyrimidines/chemistry ; gamma-Aminobutyric Acid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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