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Wyszukujesz frazę ""Receptors, Glucagon"" wg kryterium: Temat


Tytuł :
Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.
Autorzy :
Kaur S; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Chen Y; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Shenoy SK; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 04; Vol. 295 (49), pp. 16630-16642. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deubiquitinating Enzymes/*metabolism
Endosomes/*metabolism
Receptors, Glucagon/*metabolism
rab4 GTP-Binding Proteins/*metabolism
Cell Line ; Down-Regulation ; Endosomal Sorting Complexes Required for Transport/antagonists & inhibitors ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomal Sorting Complexes Required for Transport/metabolism ; Glucagon/pharmacology ; Humans ; Monensin/pharmacology ; Mutagenesis ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptors, Glucagon/agonists ; Receptors, Glucagon/genetics ; Ubiquitin Thiolesterase/antagonists & inhibitors ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/metabolism ; Ubiquitination/drug effects ; rab4 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors.
Autorzy :
Darbalaei S; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yuliantie E; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Dai A; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
Chang R; School of Pharmacy, Fudan University, Shanghai 201203, China.
Zhao P; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.
Yang D; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang MW; The National Center for Drug Screening and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Pharmacy, Fudan University, Shanghai 201203, China; School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. Electronic address: .
Sexton PM; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia. Electronic address: .
Wootten D; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114150. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon-Like Peptide 1/*agonists
Oxyntomodulin/*pharmacology
Peptides/*pharmacology
Receptors, Glucagon/*agonists
Amino Acid Sequence ; Dose-Response Relationship, Drug ; Drug Agonism ; Glucagon-Like Peptide 1/metabolism ; HEK293 Cells ; Humans ; Oxyntomodulin/genetics ; Oxyntomodulin/metabolism ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Peptides/genetics ; Peptides/metabolism ; Protein Binding ; Receptors, Glucagon/metabolism
Czasopismo naukowe
Tytuł :
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide.
Autorzy :
Chang R; School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai, China.
Zhang X; Monash Institute of Pharmaceutical Sciences, Drug Discovery Biology, Monash University, Parkville, Victoria, Australia.
Qiao A; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Dai A; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; The National Center for Drug Screening, Shanghai, China.
Belousoff MJ; Monash Institute of Pharmaceutical Sciences, Drug Discovery Biology, Monash University, Parkville, Victoria, Australia.
Tan Q; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Shao L; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhong L; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Lin G; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Liang YL; Monash Institute of Pharmaceutical Sciences, Drug Discovery Biology, Monash University, Parkville, Victoria, Australia.
Ma L; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Han S; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yang D; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; The National Center for Drug Screening, Shanghai, China.
Danev R; Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Wang MW; School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai, China .; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; The National Center for Drug Screening, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Wootten D; Monash Institute of Pharmaceutical Sciences, Drug Discovery Biology, Monash University, Parkville, Victoria, Australia .
Wu B; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China .; University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Sexton PM; Monash Institute of Pharmaceutical Sciences, Drug Discovery Biology, Monash University, Parkville, Victoria, Australia .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 10; Vol. 295 (28), pp. 9313-9325. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Receptors, Glucagon*/agonists
Receptors, Glucagon*/chemistry
Receptors, Glucagon*/ultrastructure
Peptides/*chemistry
Animals ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/chemistry ; Glucagon-Like Peptide-1 Receptor/ultrastructure ; Humans ; Protein Domains ; Protein Structure, Quaternary
Czasopismo naukowe
Tytuł :
The V369M Gcgr knock-in mice are a precision medicine model of mild Mahvash disease.
Autorzy :
Yu R; Division of Endocrinology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, U.S.A.
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Źródło :
The Biochemical journal [Biochem J] 2020 Aug 14; Vol. 477 (15), pp. 2873-2874.
Typ publikacji :
Letter; Comment
MeSH Terms :
Metabolic Diseases*
Receptors, Glucagon*/genetics
Animals ; Glucagon ; Humans ; Mice ; Mutation ; Precision Medicine
Opinia redakcyjna
Tytuł :
The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor.
Autorzy :
Ansell TB; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Song W; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Sansom MSP; Department of Biochemistry, University of Oxford, Oxford, United Kingdom. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2020 Jul 21; Vol. 119 (2), pp. 300-313. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycosphingolipids*
Receptors, Glucagon*/metabolism
Molecular Dynamics Simulation ; Protein Binding ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
Structural basis of G s and G i recognition by the human glucagon receptor.
Autorzy :
Qiao A; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Han S; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Li X; University of Chinese Academy of Sciences, Beijing 100049, China.; National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Li Z; School of Pharmacy, Fudan University, Shanghai 201203, China.
Zhao P; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Dai A; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Chang R; School of Pharmacy, Fudan University, Shanghai 201203, China.
Tai L; University of Chinese Academy of Sciences, Beijing 100049, China.; National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Tan Q; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Chu X; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Ma L; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Thorsen TS; Novo Nordisk A/S, Måløv 2760, Denmark.
Reedtz-Runge S; Novo Nordisk A/S, Måløv 2760, Denmark.
Yang D; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Wang MW; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Pharmacy, Fudan University, Shanghai 201203, China.; National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Sexton PM; School of Pharmacy, Fudan University, Shanghai 201203, China.; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Wootten D; School of Pharmacy, Fudan University, Shanghai 201203, China. .; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Sun F; University of Chinese Academy of Sciences, Beijing 100049, China. .; National Laboratory of Biomacromolecules, National Center of Protein Science-Beijing, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Zhao Q; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. .; University of Chinese Academy of Sciences, Beijing 100049, China.; CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing 100101, China.
Wu B; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. .; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; CAS Center for Excellence in Biomacromolecules, Chinese Academy of Sciences, Beijing 100101, China.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Mar 20; Vol. 367 (6484), pp. 1346-1352.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GTP-Binding Protein alpha Subunits, Gi-Go/*chemistry
GTP-Binding Protein alpha Subunits, Gs/*chemistry
Glucagon/*chemistry
Receptors, Glucagon/*chemistry
Binding Sites ; Cryoelectron Microscopy ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; GTP-Binding Protein alpha Subunits, Gi-Go/ultrastructure ; GTP-Binding Protein alpha Subunits, Gs/metabolism ; GTP-Binding Protein alpha Subunits, Gs/ultrastructure ; Glucagon/metabolism ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Conformation, alpha-Helical ; Receptors, Glucagon/metabolism ; Receptors, Glucagon/ultrastructure ; Signal Transduction
Czasopismo naukowe
Tytuł :
Glucagon receptor antagonist upregulates circulating GLP-1 level by promoting intestinal L-cell proliferation and GLP-1 production in type 2 diabetes.
Autorzy :
Lang S; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Yang J; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.
Yang K; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.
Gu L; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Cui X; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Wei T; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Liu J; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.
Le Y; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.
Wang H; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.
Wei R; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China .; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
Hong T; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China .; Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China.
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Źródło :
BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2020 Mar; Vol. 8 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*blood
Glucagon-Like Peptide 1/*blood
Ileum/*metabolism
Receptors, Glucagon/*metabolism
Animals ; Antibodies, Monoclonal/administration & dosage ; Cell Proliferation/drug effects ; Diabetes Mellitus, Experimental/blood ; Ileum/drug effects ; L Cells ; Male ; Mice ; Mice, Inbred C57BL ; Proglucagon/metabolism ; Receptors, Glucagon/antagonists & inhibitors ; Receptors, Glucagon/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Rational design and evaluation of GLP-1 derivative for treating hyperglycemia combined with overexercise-induced myocardial injury.
Autorzy :
Wang Y; School of Physical Education, Shandong Normal University, Jinan 250358, Shandong, PR China.
Xia Z; Department of Nephrology, The First Affiliated Hospital of University of South China, Hengyang 421001, Hunan, PR China.
Xie H; School of Athletic Training, Guangzhou Sport University, Guangzhou 510000, Guangdong, PR China. Electronic address: .
Dong J; School of Physical Education, Shandong Normal University, Jinan 250358, Shandong, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 May 01; Vol. 272, pp. 119030. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Glucagon-Like Peptide 1/*analogs & derivatives
Glucagon-Like Peptide 1/*pharmacology
Hyperglycemia/*drug therapy
Animals ; Chromatography, Liquid ; Diabetes Mellitus, Experimental/drug therapy ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucose/metabolism ; Hypoglycemic Agents/pharmacology ; Liraglutide/pharmacology ; Male ; Mice ; Mice, Inbred DBA ; Obesity/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Glucagon/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
S3-2, a novel long-lasting oxyntomodulin derivative, exerts improvement on diabesity and renal injury through activating GLP-1 and glucagon receptors.
Autorzy :
Huang P; Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China.
Meng L; Center for Systemic Inflammation Research, School of Preclinical Medicine, Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China.
Tan J; Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China.
Gu X; Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China.
Huang M; Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China.
Huang F; Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China.
Ma R; Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China.
Wang J; Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, Guangxi, PR China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 119136. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*drug therapy
Obesity/*drug therapy
Oxyntomodulin/*chemistry
Oxyntomodulin/*pharmacology
Albumins/genetics ; Animals ; Blood Glucose/drug effects ; Disease Models, Animal ; Glucagon/metabolism ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucose/metabolism ; Hypoglycemic Agents/pharmacology ; Insulin/metabolism ; Kidney/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Peptides/pharmacology ; Receptors, Glucagon/metabolism
Czasopismo naukowe
Tytuł :
Anti-inflammatory and atheroprotective properties of glucagon.
Autorzy :
Osaka N; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Kushima H; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Mori Y; Anti-glycation Research Section, Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Saito T; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Hiromura M; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Terasaki M; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Yashima H; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Ohara M; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Fukui T; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
Matsui T; Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Hirano T; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.; Diabetes Center, Ebina General Hospital, Ebina, Kanagawa, Japan.
Yamagishi SI; Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan.
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Źródło :
Diabetes & vascular disease research [Diab Vasc Dis Res] 2020 May-Jun; Vol. 17 (5), pp. 1479164120965183.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*administration & dosage
Aorta/*drug effects
Aortic Diseases/*prevention & control
Atherosclerosis/*prevention & control
Glucagon/*administration & dosage
Receptors, Glucagon/*agonists
Animals ; Aorta/metabolism ; Aorta/pathology ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Disease Models, Animal ; Humans ; Inflammation Mediators/metabolism ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Knockout, ApoE ; Receptors, Glucagon/metabolism ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Effect of hydrophobic and hydrogen bonding interactions on the potency of ß-alanine analogs of G-protein coupled glucagon receptor inhibitors.
Autorzy :
Venugopal PP; Biophysical and Computational Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore, India.
Das BK; Biophysical and Computational Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore, India.
Soorya E; Biophysical and Computational Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore, India.
Chakraborty D; Biophysical and Computational Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore, India.
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Źródło :
Proteins [Proteins] 2020 Feb; Vol. 88 (2), pp. 327-344. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Alanine/*chemistry
Receptors, G-Protein-Coupled/*chemistry
Receptors, Glucagon/*chemistry
Alanine/metabolism ; Alanine/pharmacology ; Amino Acids/chemistry ; Amino Acids/metabolism ; Amino Acids/pharmacology ; Binding Sites ; Catalytic Domain ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Protein Binding ; Quantitative Structure-Activity Relationship ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Glucagon/antagonists & inhibitors ; Receptors, Glucagon/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network.
Autorzy :
Kang Q; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China.; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Hu M; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China.
Jia J; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China.
Bai X; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China.
Liu C; The Key Laboratory of Mariculture, Education Ministry of China and College of Fisheries, Ocean University of China, Qingdao 266003, China.
Wu Z; School of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.
Chen W; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Li M; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen 361102, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 22; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Networks and Pathways/*genetics
Receptors, Glucagon/*genetics
Transcriptome/*genetics
Zebrafish/*genetics
Animals ; Gene Expression Profiling/methods ; Glucose/genetics ; Glucose/metabolism ; Liver/metabolism ; Liver/physiology ; Receptors, Glucagon/metabolism ; Signal Transduction/genetics ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
Tumor promoting effects of glucagon receptor: a promising biomarker of papillary thyroid carcinoma via regulating EMT and P38/ERK pathways.
Autorzy :
Jiang HC; Eye 3 Division of Red Flag Hospital of Mudanjiang Medical University, Mudanjiang, 157000, Heilongjiang, People's Republic of China.
Chen XR; Color Doppler Ultrasound Room, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, 157000, Heilongjiang, People's Republic of China.
Sun HF; Department of Endocrinology, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, 157000, Heilongjiang, People's Republic of China.
Nie YW; Hepatobiliary Surgery, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, 157000, Heilongjiang, People's Republic of China. .
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Źródło :
Human cell [Hum Cell] 2020 Jan; Vol. 33 (1), pp. 175-184. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Glucagon*
MAP Kinase Signaling System/*genetics
Organic Cation Transport Proteins/*genetics
Thyroid Cancer, Papillary/*genetics
Thyroid Neoplasms/*genetics
Biomarkers, Tumor ; Humans ; Thyroid Cancer, Papillary/diagnosis ; Thyroid Neoplasms/diagnosis
Czasopismo naukowe
Tytuł :
Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression.
Autorzy :
Nason SR; Comprehensive Diabetes Center and Department of Medicine - Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama.
Kim T; Comprehensive Diabetes Center and Department of Medicine - Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama.
Antipenko JP; Comprehensive Diabetes Center and Department of Medicine - Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama.
Finan B; Novo Nordisk Research Center, Indianapolis, IN.
DiMarchi R; Novo Nordisk Research Center, Indianapolis, IN.; Department of Chemistry, Indiana University, Bloomington, IN.
Hunter CS; Comprehensive Diabetes Center and Department of Medicine - Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama.
Habegger KM; Comprehensive Diabetes Center and Department of Medicine - Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama.
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Źródło :
Endocrinology [Endocrinology] 2020 Jan 01; Vol. 161 (1).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Liver/*drug therapy
Gene Expression Regulation/*drug effects
Lipid Metabolism/*drug effects
Peptides/*pharmacology
Receptors, Glucagon/*metabolism
Receptors, Leptin/*metabolism
Animals ; Area Under Curve ; Diet, High-Fat ; Homeostasis ; Lipid Metabolism/physiology ; Liver/drug effects ; Liver/metabolism ; Mice ; Mice, Knockout ; Obesity/chemically induced ; Receptors, Glucagon/genetics ; Receptors, Leptin/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Design of novel Xenopus GLP-1-based dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists.
Autorzy :
Jiang N; Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
Jing L; Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
Li Q; Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China.
Su S; Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, PR China.
Yang Q; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, PR China.
Zhou F; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, PR China.
Chen X; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, PR China.
Han J; School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, PR China. Electronic address: .
Tang C; Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China. Electronic address: .
Tang W; Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 113118. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Glucagon-Like Peptide 1/*agonists
Peptides/*pharmacology
Receptors, Glucagon/*agonists
Animals ; Dose-Response Relationship, Drug ; Molecular Structure ; Peptides/chemical synthesis ; Peptides/chemistry ; Structure-Activity Relationship ; Xenopus
Czasopismo naukowe
Tytuł :
Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.
Autorzy :
Bozadjieva Kramer N; Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI.; Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI.; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI.
Lubaczeuski C; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL.
Blandino-Rosano M; Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI.; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL.
Barker G; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL.
Gittes GK; UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburg, PA.
Caicedo A; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL.
Bernal-Mizrachi E; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Miller School of Medicine, University of Miami, Miami, FL .; Veterans Affairs Medical Center, Miami, FL.
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Źródło :
Diabetes [Diabetes] 2021 Feb; Vol. 70 (2), pp. 477-491. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Blood Glucose/*metabolism
Glucagon/*blood
Glucagon-Secreting Cells/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Animals ; Body Weight/physiology ; Disease Models, Animal ; Disease Susceptibility ; Eating/physiology ; Glucagon-Like Peptide 1/metabolism ; Glucose Intolerance/metabolism ; Insulin/blood ; Insulin Secretion/physiology ; Mice ; Receptors, Glucagon/metabolism ; Signal Transduction/physiology ; Tuberous Sclerosis Complex 2 Protein/genetics ; Tuberous Sclerosis Complex 2 Protein/metabolism
Czasopismo naukowe
Tytuł :
Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder.
Autorzy :
Cavino K; Regeneron Pharmaceuticals, Tarrytown, New York USA.
Sung B; Regeneron Pharmaceuticals, Tarrytown, New York USA.
Su Q; Regeneron Pharmaceuticals, Tarrytown, New York USA.
Na E; Regeneron Pharmaceuticals, Tarrytown, New York USA.
Kim J; Regeneron Pharmaceuticals, Tarrytown, New York USA.
Cheng X; Regeneron Pharmaceuticals, Tarrytown, New York USA.
Gromada J; Regeneron Pharmaceuticals, Tarrytown, New York USA.
Okamoto H; Regeneron Pharmaceuticals, Tarrytown, New York USA.
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Źródło :
Endocrinology [Endocrinology] 2021 Jan 01; Vol. 162 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Hyperammonemia/*therapy
Ornithine Carbamoyltransferase Deficiency Disease/*therapy
Receptors, Glucagon/*antagonists & inhibitors
Amino Acids/blood ; Ammonia/blood ; Animals ; Body Weight ; Gene Expression Regulation/drug effects ; Glutamate-Ammonia Ligase/genetics ; Glutamate-Ammonia Ligase/metabolism ; Glutaminase/genetics ; Glutaminase/metabolism ; Male ; Mice ; Ornithine Carbamoyltransferase/genetics ; Ornithine Carbamoyltransferase/metabolism ; Ornithine Carbamoyltransferase Deficiency Disease/mortality
Czasopismo naukowe
Tytuł :
Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP.
Autorzy :
Chepurny OG; From the Departments of Medicine.
Matsoukas MT; the Department of Pharmacy, University of Patras, 26500 Patras, Greece.
Liapakis G; the Department of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Crete, Greece, and.
Leech CA; Surgery, and.
Milliken BT; the Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Doyle RP; From the Departments of Medicine, .; the Department of Chemistry, Syracuse University, Syracuse, New York 13244.
Holz GG; From the Departments of Medicine, .; Pharmacology, State University of New York (SUNY), Upstate Medical University, Syracuse, New York 13210.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Mar 08; Vol. 294 (10), pp. 3514-3531. Date of Electronic Publication: 2019 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescence Resonance Energy Transfer*
Cyclic AMP/*metabolism
Glucagon-Like Peptide-1 Receptor/*agonists
Glucagon-Like Peptide-1 Receptor/*antagonists & inhibitors
Receptors, Glucagon/*agonists
Receptors, Glucagon/*antagonists & inhibitors
Amino Acid Sequence ; Drug Discovery ; Glucagon/metabolism ; Glucagon-Like Peptide-1 Receptor/chemistry ; Glucagon-Like Peptide-1 Receptor/metabolism ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; Peptides/chemistry ; Peptides/metabolism ; Peptides/pharmacology ; Protein Conformation ; Receptors, Glucagon/chemistry ; Receptors, Glucagon/metabolism
Czasopismo naukowe
Tytuł :
Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice.
Autorzy :
Motegi M; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Himeno T; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Nakai-Shimoda H; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Inoue R; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Ozeki N; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Hayashi Y; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Sasajima S; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Mohiuddin MS; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Asano-Hayami E; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kato M; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Asano S; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Miura-Yura E; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Morishita Y; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kondo M; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Tsunekawa S; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kato Y; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kato K; Laboratory of Medicine, Aichi Gakuin University School of Pharmacy, 1-100 Kusumotocho, Chikusa-ku, Nagoya, Aichi, 464-8650, Japan.
Naruse K; Department of Internal Medicine, Aichi Gakuin University School of Dentistry, 2-11 Suemoridori, Chikusa-ku, Nagoya, Aichi, 464-8651, Japan.
Seino Y; Department of Endocrinology and Metabolism, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-tyo, Toyoake, Aichi, 470-1192, Japan.
Hayashi Y; Department of Endocrinology, Division of Stress Adaptation and Recognition, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601, Japan.
Nakamura J; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kamiya H; Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Oct 29; Vol. 532 (1), pp. 47-53. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetic Neuropathies/*etiology
Glucagon-Like Peptides/*deficiency
Animals ; Diabetic Neuropathies/genetics ; Diabetic Neuropathies/pathology ; Disease Models, Animal ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Glucagon/deficiency ; Glucagon/genetics ; Glucagon/metabolism ; Glucagon-Like Peptide 1/deficiency ; Glucagon-Like Peptide 1/genetics ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptides/genetics ; Glucagon-Like Peptides/metabolism ; Hyperalgesia/etiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Fibers, Myelinated/pathology ; Neural Conduction ; Neuronal Outgrowth ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Glucagon/genetics ; Receptors, Glucagon/metabolism
Czasopismo naukowe
Tytuł :
A Dual GLP-1/GIP Receptor Agonist Does Not Antagonize Glucagon at Its Receptor but May Act as a Biased Agonist at the GLP-1 Receptor.
Autorzy :
Al-Zamel N; Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, PO Box 24923, 13110 Safat, Kuwait.
Al-Sabah S; Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, PO Box 24923, 13110 Safat, Kuwait. .
Luqmani Y; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, 13110 Safat, Kuwait.
Adi L; Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, PO Box 24923, 13110 Safat, Kuwait.
Chacko S; Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, PO Box 24923, 13110 Safat, Kuwait.
Schneider TD; Institute of Forensic Medicine, Department of Forensic Pharmacology and Toxicology, University of Zurich, 190/52 CH-8057 Zurich, Switzerland.
Krasel C; School of Pharmacy, Institute for Pharmacology and Toxicology, The Philipps University of Marburg, Karl-von-Frisch-Straße, 135033 Marburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 19; Vol. 20 (14). Date of Electronic Publication: 2019 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Glucagon/*metabolism
Glucagon-Like Peptide-1 Receptor/*agonists
Glucagon-Like Peptide-1 Receptor/*metabolism
Receptors, Gastrointestinal Hormone/*agonists
Receptors, Gastrointestinal Hormone/*metabolism
Receptors, Glucagon/*metabolism
Amino Acid Sequence ; Arrestin/metabolism ; Arrestin/pharmacology ; Bioluminescence Resonance Energy Transfer Techniques ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Ligands ; Peptides/chemistry ; Peptides/pharmacology ; Receptors, Glucagon/antagonists & inhibitors
Czasopismo naukowe

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