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Wyszukujesz frazę ""Receptors, Histamine H4"" wg kryterium: Temat


Tytuł :
Evolutionary history of histamine receptors: Early vertebrate origin and expansion of the H 3 -H 4 subtypes.
Autorzy :
Ravhe IS; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.
Krishnan A; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.
Manoj N; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address: .
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Źródło :
Molecular phylogenetics and evolution [Mol Phylogenet Evol] 2021 Jan; Vol. 154, pp. 106989. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Receptors, Histamine H3/*genetics
Receptors, Histamine H4/*genetics
Vertebrates/*genetics
Animals ; Humans ; Molecular Docking Simulation ; Phylogeny ; Receptors, Histamine H3/chemistry ; Receptors, Histamine H4/chemistry ; Receptors, Muscarinic/chemistry ; Receptors, Muscarinic/genetics ; Structural Homology, Protein ; Synteny/genetics
Czasopismo naukowe
Tytuł :
The Novel H 4 R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
Autorzy :
Balbino AM; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo-campus Diadema, Diadema, Brazil.
Lima LJS; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo-campus Diadema, Diadema, Brazil.
Fernandes GAB; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo-campus Diadema, Diadema, Brazil.
Corrêa MF; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo-campus Diadema, Diadema, Brazil.
Gomes E; Department of Immunology, Universidade de São Paulo, São Paulo, Brazil.
Landgraf MA; Universidade Paulista - campus Rangel, Santos, Brazil.
Fernandes JPS; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo-campus Diadema, Diadema, Brazil, .
Landgraf RG; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo-campus Diadema, Diadema, Brazil, .
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2020 Nov 21; Vol. 54 (6), pp. 1163-1176.
Typ publikacji :
Journal Article
MeSH Terms :
Asthma*/drug therapy
Asthma*/metabolism
Asthma*/pathology
Lung*/metabolism
Lung*/pathology
Receptors, Histamine H4*/antagonists & inhibitors
Receptors, Histamine H4*/metabolism
Piperazines/*pharmacology
Animals ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred BALB C ; Piperazines/chemistry ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
The H 4 R is highly expressed on eosinophils from AD patients and IL-4 upregulates expression and function via the JAK/STAT pathway.
Autorzy :
Schaper-Gerhardt K; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Köther B; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Wolff L; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Kabatas A; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Gehring M; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Nikolouli E; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Mommert S; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Werfel T; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Gutzmer R; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
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Źródło :
Allergy [Allergy] 2021 Apr; Vol. 76 (4), pp. 1261-1264. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Eosinophils*
Interleukin-4*/genetics
Humans ; Receptors, G-Protein-Coupled ; Receptors, Histamine ; Receptors, Histamine H4
Raport
Tytuł :
Histamine Induces Microglia Activation and the Release of Proinflammatory Mediators in Rat Brain Via H 1 R or H 4 R.
Autorzy :
Zhang W; Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Zhang X; Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Zhang Y; Department of Anesthesiology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Qu C; Department of Geriatrics, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China.
Zhou X; Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China. .
Zhang S; Clinical Research Center, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, People's Republic of China. .
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Źródło :
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2020 Jun; Vol. 15 (2), pp. 280-291. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Histamine/*pharmacology
Inflammation Mediators/*metabolism
Microglia/*metabolism
Receptors, Histamine H1/*metabolism
Receptors, Histamine H4/*metabolism
Animals ; Brain/drug effects ; Histamine H1 Antagonists/pharmacology ; Inflammation Mediators/agonists ; Male ; Microglia/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, Histamine H4/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Mouse Colonic Epithelial Cells Functionally Express the Histamine H 4 Receptor.
Autorzy :
Schirmer B; Institute of Pharmacology, Hannover Medical School, Hannover, Germany .
Lindemann L; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Bittkau KS; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Isaev R; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Bösche D; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Juchem M; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Seifert R; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Neumann D; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 May; Vol. 373 (2), pp. 167-174. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colon/*physiology
Intestinal Mucosa/*physiology
Receptors, Histamine H4/*physiology
Animals ; Colitis/chemically induced ; Dextran Sulfate ; Electric Impedance ; Male ; Mice ; Mice, Inbred BALB C ; RNA, Messenger/analysis ; Receptors, Histamine H4/genetics
Czasopismo naukowe
Tytuł :
Histamine H 4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway.
Autorzy :
Sanna MD; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, Viale G. Pieraccini 6, University of Florence, 50139, Florence, Italy.
Borgonetti V; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, Viale G. Pieraccini 6, University of Florence, 50139, Florence, Italy.
Masini E; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, Viale G. Pieraccini 6, University of Florence, 50139, Florence, Italy.
Galeotti N; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, Viale G. Pieraccini 6, University of Florence, 50139, Florence, Italy. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Feb 05; Vol. 868, pp. 172859. Date of Electronic Publication: 2019 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Adrenergic Neurons/*drug effects
Guanidines/*administration & dosage
Locus Coeruleus/*drug effects
Neuralgia/*drug therapy
Receptors, Histamine H4/*agonists
Thiourea/*analogs & derivatives
Adrenergic Neurons/metabolism ; Adrenergic alpha-2 Receptor Agonists/administration & dosage ; Animals ; Benzimidazoles/administration & dosage ; Clonidine/administration & dosage ; Disease Models, Animal ; Histamine/metabolism ; Humans ; Injections, Spinal ; Locus Coeruleus/pathology ; Male ; Mice ; Mice, Knockout ; Microinjections ; Neuralgia/pathology ; Norepinephrine/metabolism ; Pain Management/methods ; Receptors, Histamine H4/genetics ; Receptors, Histamine H4/metabolism ; Thiourea/administration & dosage
Czasopismo naukowe
Tytuł :
Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model.
Autorzy :
Nicoud MB; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Táquez Delgado MA; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Sarasola MP; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Vidal A; Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Speisky D; Pathology Department, British Hospital, Buenos Aires, Argentina.
Cremaschi GA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Sterle HA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Medina VA; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Jan; Vol. 70 (1), pp. 233-244. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*immunology
Breast Neoplasms/*metabolism
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Receptors, Histamine H4/*deficiency
Receptors, Histamine H4/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Disease Models, Animal ; Female ; Histamine/immunology ; Interleukin-2 Receptor alpha Subunit/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; T-Lymphocytes, Regulatory/metabolism ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Nothing to sneeze at: Histamine and histamine receptors in oral carcinogenesis.
Autorzy :
Salem A; Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program (TRIMM), Research Program Unit (RPU), University of Helsinki, Helsinki, Finland.
Salo T; Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program (TRIMM), Research Program Unit (RPU), University of Helsinki, Helsinki, Finland.; Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.; Oulu University Hospital, Oulu, Finland.; Helsinki University Hospital (HUS), Helsinki, Finland.
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Źródło :
Oral diseases [Oral Dis] 2021 Jul; Vol. 27 (5), pp. 1090-1096. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinoma, Squamous Cell*
Mouth Neoplasms*
Carcinogenesis ; Histamine ; Humans ; Receptors, G-Protein-Coupled ; Receptors, Histamine ; Receptors, Histamine H4 ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue.
Autorzy :
Zhao YX; Institute of Stem Cell Research and Regenerative Medicine of Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Pan JB; The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Fudan University, Shanghai, China.; Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, China.
Wang YN; The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Fudan University, Shanghai, China.; Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, China.
Zou Y; The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Fudan University, Shanghai, China.; Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, China.
Guo L; The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Fudan University, Shanghai, China.; Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, China.
Tang QQ; Institute of Stem Cell Research and Regenerative Medicine of Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Fudan University, Shanghai, China.; Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, China.
Qian SW; The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, Fudan University, Shanghai, China.; Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai, China.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2019 Dec 01; Vol. 317 (6), pp. E1158-E1171. Date of Electronic Publication: 2019 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cold Temperature*
Adipocytes/*metabolism
Adipose Tissue, Brown/*metabolism
Adipose Tissue, White/*metabolism
Oxygen Consumption/*genetics
Receptors, Histamine H4/*genetics
Subcutaneous Fat/*metabolism
Thermogenesis/*genetics
3T3-L1 Cells ; Adipocytes/drug effects ; Adipose Tissue, White/drug effects ; Animals ; Basal Metabolism/drug effects ; Basal Metabolism/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Knockdown Techniques ; Histamine Agonists/pharmacology ; Lipolysis/drug effects ; Lipolysis/genetics ; MAP Kinase Signaling System ; Methylhistamines/pharmacology ; Mice ; Oxygen Consumption/drug effects ; Receptors, Histamine H4/agonists ; Receptors, Histamine H4/metabolism ; Subcutaneous Fat/drug effects ; Thermogenesis/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Basal Histamine H 4 Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif.
Autorzy :
Wifling D; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
Pfleger C; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.
Kaindl J; Computer Chemistry Center, Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Nägelsbachstr. 25, 91052, Erlangen, Germany.
Ibrahim P; Computer Chemistry Center, Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Nägelsbachstr. 25, 91052, Erlangen, Germany.
Kling RC; Computer Chemistry Center, Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Nägelsbachstr. 25, 91052, Erlangen, Germany.
Buschauer A; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.; John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC) &, Institute for Complex Systems-Structural Biochemistry (ICS 6), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str., 52425, Jülich, Germany.
Clark T; Computer Chemistry Center, Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Nägelsbachstr. 25, 91052, Erlangen, Germany.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2019 Nov 18; Vol. 25 (64), pp. 14613-14624. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Phenylalanine/*analogs & derivatives
Receptors, Histamine H4/*agonists
Animals ; Binding Sites ; Catalytic Domain ; Humans ; Mice ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Phenylalanine/chemistry ; Protein Stability ; Receptors, Histamine H4/genetics ; Receptors, Histamine H4/metabolism
Czasopismo naukowe
Tytuł :
Histamine-4 receptor antagonist ameliorates Parkinson-like pathology in the striatum.
Autorzy :
Fang Q; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Xicoy H; Dept. Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, The Netherlands; Dept. Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Neuroscience, Faculty of Science, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, The Netherlands.
Shen J; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Luchetti S; Dept. Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands; Dept. Neuroimmunology, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands.
Dai D; Technology Centre of Dalian Customs District P.R.China, Dalian, Liaoning 116001, China.
Zhou P; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China; Department of Infectious Diseases, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Qi XR; Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200072, China.
Martens GJM; Dept. Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Neuroscience, Faculty of Science, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, The Netherlands.
Huitinga I; Dept. Neuroimmunology, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Swaab DF; Dept. Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands.
Liu C; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China. Electronic address: .
Shan L; Dept. Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Feb; Vol. 92, pp. 127-138. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Corpus Striatum*/drug effects
Corpus Striatum*/metabolism
Parkinson Disease*/drug therapy
Parkinson Disease*/pathology
Receptors, Histamine H4/*antagonists & inhibitors
Animals ; Disease Models, Animal ; Microglia/metabolism ; Nerve Degeneration/pathology ; Rats ; Substantia Nigra/metabolism ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
Eosinophils adhesion assay as a tool for phenotypic drug screening - The pharmacology of 1,3,5 - Triazine and 1H-indole like derivatives against the human histamine H 4 receptor.
Autorzy :
Grosicki M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Medyczna 9, 30-688, Kraków, Poland; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzyńskiego 14, 30-348, Krakow, Poland.
Adami M; University of Parma, Department of Medicine and Surgery, Via Gramsci 14, 43126, Parma, Italy.
Micheloni C; University of Parma, Department of Medicine and Surgery, Via Gramsci 14, 43126, Parma, Italy.
Głuch-Lutwin M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmacobiology, Medyczna 9, 30-688, Kraków, Poland.
Siwek A; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmacobiology, Medyczna 9, 30-688, Kraków, Poland.
Latacz G; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Medyczna 9, 30-688, Kraków, Poland.
Łażewska D; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Medyczna 9, 30-688, Kraków, Poland.
Więcek M; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Medyczna 9, 30-688, Kraków, Poland.
Reiner-Link D; Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Universitätsstraße 1, 40225, Duesseldorf, Germany.
Stark H; Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Universitätsstraße 1, 40225, Duesseldorf, Germany.
Chlopicki S; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzyńskiego 14, 30-348, Krakow, Poland; Chair of Pharmacology, Jagiellonian University Medical College, Grzegorzecka 16, 31-531, Krakow, Poland.
Kieć-Kononowicz K; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Medyczna 9, 30-688, Kraków, Poland. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Jan 05; Vol. 890, pp. 173611. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Eosinophils/*metabolism
Indoles/*pharmacology
Receptors, Histamine H4/*antagonists & inhibitors
Triazines/*pharmacology
Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/metabolism ; Cell Adhesion/drug effects ; Cell Line, Transformed ; Cell Line, Tumor ; Cell Membrane Permeability/drug effects ; Cell Survival/drug effects ; Computer Simulation ; Croton Oil/toxicity ; Disease Models, Animal ; Drug Discovery ; Drug Evaluation, Preclinical ; Edema/chemically induced ; Edema/drug therapy ; Endothelial Cells/metabolism ; Eosinophils/drug effects ; Humans ; Indoles/administration & dosage ; Indoles/chemistry ; Male ; Mice ; Pruritus/chemically induced ; Pruritus/drug therapy ; Triazines/administration & dosage ; Triazines/chemistry ; Triazines/metabolism
Czasopismo naukowe
Tytuł :
Management of peripheral vertigo with antihistamines: New options on the horizon.
Autorzy :
Dyhrfjeld-Johnsen J; Sensorion SA, Montpellier, France.
Attali P; Sensorion SA, Montpellier, France.
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Źródło :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2019 Oct; Vol. 85 (10), pp. 2255-2263. Date of Electronic Publication: 2019 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Histamine Antagonists/*administration & dosage
Receptors, Histamine H4/*antagonists & inhibitors
Vertigo/*drug therapy
Aged ; Animals ; Azetidines/administration & dosage ; Azetidines/adverse effects ; Azetidines/pharmacology ; Betahistine/administration & dosage ; Betahistine/pharmacology ; Histamine Agonists/administration & dosage ; Histamine Agonists/pharmacology ; Histamine Antagonists/adverse effects ; Histamine Antagonists/pharmacology ; Humans ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Pyrimidines/pharmacology ; Receptors, Histamine H4/metabolism ; Vertigo/physiopathology
Czasopismo naukowe
Tytuł :
Histamine H4 receptor agonists induce epithelial-mesenchymal transition events and enhance mammosphere formation via Src and TGF-β signaling in breast cancer cells.
Autorzy :
Galarza TE; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Laboratorio de Radioisótopos, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
Táquez Delgado MA; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Laboratorio de Radioisótopos, Buenos Aires, Argentina.
Mohamad NA; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Laboratorio de Radioisótopos, Buenos Aires, Argentina.
Martín GA; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Laboratorio de Radioisótopos, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina. Electronic address: .
Cricco GP; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Laboratorio de Radioisótopos, Buenos Aires, Argentina. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114177. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*metabolism
Epithelial-Mesenchymal Transition/*physiology
Oncogene Protein pp60(v-src)/*metabolism
Receptors, Histamine H4/*agonists
Receptors, Histamine H4/*metabolism
Transforming Growth Factor beta1/*metabolism
Epithelial-Mesenchymal Transition/drug effects ; Female ; Humans ; Indoles/pharmacology ; MCF-7 Cells ; Piperazines/pharmacology
Czasopismo naukowe
Tytuł :
[ H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H 4 Receptors.
Autorzy :
Bartole E; Institute of Pharmacy , University of Regensburg , D-93053 Regensburg , Germany.
Littmann T; Institute of Pharmacy , University of Regensburg , D-93053 Regensburg , Germany.
Tanaka M; Department of Chemistry, School of Science , University of Tokyo , 7-3-1 Bunkyo-ku , Hongo , Tokyo 113-0033 , Japan.
Ozawa T; Department of Chemistry, School of Science , University of Tokyo , 7-3-1 Bunkyo-ku , Hongo , Tokyo 113-0033 , Japan.
Buschauer A; Institute of Pharmacy , University of Regensburg , D-93053 Regensburg , Germany.
Bernhardt G; Institute of Pharmacy , University of Regensburg , D-93053 Regensburg , Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2019 Sep 12; Vol. 62 (17), pp. 8338-8356. Date of Electronic Publication: 2019 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pyrimidines/*pharmacology
Receptors, Histamine H4/*agonists
Animals ; Binding Sites/drug effects ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Ligands ; Mice ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Radioligand Assay ; Rats ; Receptors, Histamine H4/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Histamine H4 receptor regulates Th2-cytokine profile through thymic stromal lymphopoietin in allergic rhinitis.
Autorzy :
Wang WW; Schools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Pan YL; Schools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Yu HW; Schools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Zhang B; Schools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China.
Shao SW; Schools of Medicine and Nursing Sciences, Huzhou University, No.759, East Second Ring Road, Huzhou, 313000, Zhejiang, China. .
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Źródło :
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2019 Jun; Vol. 276 (6), pp. 1655-1661. Date of Electronic Publication: 2019 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
OX40 Ligand*/immunology
OX40 Ligand*/metabolism
Receptors, Histamine H4*/agonists
Receptors, Histamine H4*/antagonists & inhibitors
Receptors, Histamine H4*/immunology
Rhinitis, Allergic*/immunology
Rhinitis, Allergic*/metabolism
Th2 Cells*/immunology
Th2 Cells*/metabolism
Cytokines/*immunology
Inflammation/*metabolism
Animals ; Cytokines/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Histamine Agents/pharmacology ; Humans ; Nasal Mucosa/drug effects ; Nasal Mucosa/immunology ; Nasal Mucosa/metabolism ; Rats ; Up-Regulation
Czasopismo naukowe
Tytuł :
Alkyl derivatives of 1,3,5-triazine as histamine H 4 receptor ligands.
Autorzy :
Łażewska D; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Mogilski S; Department of Pharmacodynamic, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Hagenow S; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Kuder K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Głuch-Lutwin M; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Siwek A; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Więcek M; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Kaleta M; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Seibel U; Department of Pharmaceutical/Medicinal Chemistry, University of Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
Buschauer A; Department of Pharmaceutical/Medicinal Chemistry, University of Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
Filipek B; Department of Pharmacodynamic, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Apr 01; Vol. 27 (7), pp. 1254-1262. Date of Electronic Publication: 2019 Feb 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Analgesics/*pharmacology
Inflammation/*drug therapy
Receptors, Histamine H4/*antagonists & inhibitors
Triazines/*pharmacology
Analgesics/chemical synthesis ; Analgesics/chemistry ; Animals ; Carrageenan ; Dose-Response Relationship, Drug ; Formaldehyde ; Humans ; Inflammation/chemically induced ; Inflammation/metabolism ; Ligands ; Mice ; Molecular Structure ; Rats ; Receptors, Histamine H4/metabolism ; Structure-Activity Relationship ; Triazines/chemical synthesis ; Triazines/chemistry
Czasopismo naukowe
Tytuł :
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
Autorzy :
Zhou P; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China; Department of Clinical Laboratory, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, China.
Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Fang Q; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Wang J; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Li W; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Meng X; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Shen J; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Luan Y; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China; Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Liao P; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.
Swaab DF; Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Shan L; Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. Electronic address: .
Liu C; College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2019 Feb; Vol. 76, pp. 61-73. Date of Electronic Publication: 2018 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microglia/*drug effects
Parkinson Disease/*metabolism
Receptors, Histamine H4/*metabolism
Animals ; Behavior, Animal/drug effects ; Brain/metabolism ; Corpus Striatum/metabolism ; Disease Models, Animal ; Disease Progression ; Dopaminergic Neurons/metabolism ; Histamine/metabolism ; Indoles/pharmacology ; Inflammation/metabolism ; Male ; Microglia/metabolism ; Nerve Degeneration/metabolism ; Parkinson Disease/immunology ; Parkinson Disease/pathology ; Parkinsonian Disorders/metabolism ; Piperazines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Histamine H4/agonists ; Rotenone/pharmacology ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
Immunomodulatory role of histamine H4 receptor in breast cancer.
Autorzy :
Sterle HA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Nicoud MB; Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.; Laboratory of Radioisotopes, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Massari NA; Immunology Department, School of Natural Sciences, National University of Patagonia San Juan Bosco, Chubut, Argentina.
Táquez Delgado MA; Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Herrero Ducloux MV; Pathology Department, School of Natural Sciences, National University of Patagonia San Juan Bosco, Chubut, Argentina.
Cremaschi GA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.; Laboratory of Radioisotopes, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Medina VA; Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. .; Laboratory of Radioisotopes, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina. .
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Źródło :
British journal of cancer [Br J Cancer] 2019 Jan; Vol. 120 (1), pp. 128-138. Date of Electronic Publication: 2018 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*genetics
Immunomodulation/*genetics
Receptors, Histamine H4/*genetics
T-Lymphocytes, Regulatory/*immunology
Animals ; Antigens, CD19/immunology ; Breast Neoplasms/immunology ; Breast Neoplasms/therapy ; CD4-Positive T-Lymphocytes/immunology ; Female ; Forkhead Transcription Factors/immunology ; Humans ; Killer Cells, Natural/immunology ; Mice ; Mice, Knockout ; Receptors, Histamine H4/immunology
Czasopismo naukowe
Tytuł :
Histamine H 4 receptor mediates chemotaxis of human lung mast cells.
Autorzy :
Kay LJ; Academic Unit of Respiratory Medicine, University of Sheffield, The Medical School (Floor L), Beech Hill Road, Sheffield S10 2RX, UK.
Suvarna SK; Department of Histopathology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK.
Peachell PT; Academic Unit of Respiratory Medicine, University of Sheffield, The Medical School (Floor L), Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2018 Oct 15; Vol. 837, pp. 38-44. Date of Electronic Publication: 2018 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Chemotaxis*
Lung/*cytology
Mast Cells/*physiology
Receptors, Histamine H4/*physiology
Humans ; Indoles/pharmacology ; Lung/physiology ; Oximes/pharmacology ; Piperazines/pharmacology ; Receptors, Histamine H4/agonists ; Receptors, Histamine H4/analysis
Czasopismo naukowe

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