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Wyszukujesz frazę ""Receptors, Histamine H4"" wg kryterium: Temat


Tytuł:
Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.
Autorzy:
Zhang C; Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Guangdong Province, Shenzhen, People's Republic of China.
Xiong Y
Li J
Yang Y
Liu L
Wang W
Wang L
Li M
Fang Z
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (2), pp. e31207. Date of Electronic Publication: 2012 Feb 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Progression*
Gene Deletion*
Gene Expression Regulation, Neoplastic*/drug effects
Down-Regulation/*genetics
Receptors, G-Protein-Coupled/*genetics
Receptors, Histamine/*genetics
Stomach Neoplasms/*genetics
Stomach Neoplasms/*pathology
Case-Control Studies ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Copy Number Variations/genetics ; Down-Regulation/drug effects ; Gene Dosage/genetics ; Genes, Neoplasm/genetics ; Histamine/pharmacology ; Humans ; In Situ Hybridization, Fluorescence ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Histamine H4
Czasopismo naukowe
Tytuł:
A QSAR study on 2-(4-methylpiperazin-1-yl)quinoxalines as human histamine H4 receptor ligands.
Autorzy:
Sharma BK; Department of Chemistry, S K Government College, Sikar, Rajasthan, India. bksharma_ />Pilania P
Singh P
Prabhakar YS
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2011 Jun; Vol. 26 (3), pp. 412-21. Date of Electronic Publication: 2010 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Quantitative Structure-Activity Relationship*
Piperazines/*pharmacology
Quinoxalines/*pharmacology
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Humans ; Ligands ; Piperazines/chemical synthesis ; Piperazines/chemistry ; Quinoxalines/chemical synthesis ; Quinoxalines/chemistry ; Receptors, G-Protein-Coupled/chemistry ; Receptors, Histamine/chemistry ; Receptors, Histamine H4
Czasopismo naukowe
Tytuł:
Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression.
Autorzy:
Fang Z; Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Guangdong Province, Shenzhen, China.
Yao W
Xiong Y
Li J
Liu L
Shi L
Zhang W
Zhang C
Nie L
Wan J
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Źródło:
BMC cancer [BMC Cancer] 2011 May 24; Vol. 11, pp. 195:1-11. Date of Electronic Publication: 2011 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms/*physiopathology
Receptors, G-Protein-Coupled/*metabolism
Receptors, Histamine/*metabolism
Antimetabolites, Antineoplastic/pharmacology ; Apoptosis/drug effects ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Fluorouracil/pharmacology ; Gene Expression/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Histamine H3 Antagonists/pharmacology ; Humans ; Imidazoles/pharmacology ; RNA, Messenger/metabolism ; Receptors, G-Protein-Coupled/agonists ; Receptors, Histamine H4 ; Signal Transduction ; Thiourea/analogs & derivatives ; Thiourea/pharmacology
Czasopismo naukowe
Tytuł:
Histamine H(4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity.
Autorzy:
Gschwandtner M; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany. />Schäkel K
Werfel T
Gutzmer R
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Źródło:
Immunology [Immunology] 2011 Jan; Vol. 132 (1), pp. 49-56. Date of Electronic Publication: 2010 Aug 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Sugars/*metabolism
Dendritic Cells/*immunology
Dendritic Cells/*metabolism
Inflammation/*immunology
Receptors, G-Protein-Coupled/*metabolism
Receptors, Histamine/*metabolism
Cytokines/biosynthesis ; Dendritic Cells/drug effects ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/immunology ; Flow Cytometry ; Histamine/immunology ; Humans ; Indoles/pharmacology ; Interferon-gamma/immunology ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Methylhistamines/pharmacology ; Piperazines/pharmacology ; Psoriasis/drug therapy ; Psoriasis/immunology ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/genetics ; Receptors, Histamine/genetics ; Receptors, Histamine H4 ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł:
Histamine receptors and cancer pharmacology.
Autorzy:
Medina VA; Laboratory of Radioisotopes, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Rivera ES
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2010 Oct; Vol. 161 (4), pp. 755-67.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Delivery Systems*
Neoplasms/*physiopathology
Receptors, Histamine/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Cell Proliferation ; Drug Design ; Histamine/metabolism ; Humans ; Neoplasms/drug therapy ; Receptors, G-Protein-Coupled/drug effects ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Histamine/drug effects ; Receptors, Histamine H4
Czasopismo naukowe
Tytuł:
H4 histamine receptors mediate cell cycle arrest in growth factor-induced murine and human hematopoietic progenitor cells.
Autorzy:
Petit-Bertron AF; Université Paris Descartes, Faculté de Médecine, CNRS UMR8147, Hôpital Necker, Paris, France.
Machavoine F
Defresne MP
Gillard M
Chatelain P
Mistry P
Schneider E
Dy M
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Źródło:
PloS one [PLoS One] 2009 Aug 07; Vol. 4 (8), pp. e6504. Date of Electronic Publication: 2009 Aug 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle/*physiology
Hematopoietic Stem Cells/*drug effects
Intercellular Signaling Peptides and Proteins/*pharmacology
Receptors, G-Protein-Coupled/*physiology
Receptors, Histamine/*physiology
Animals ; Cell Proliferation ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Gene Silencing ; Hematopoietic Stem Cells/cytology ; Humans ; Mice ; Receptors, Histamine H4 ; Signal Transduction
Czasopismo naukowe
Tytuł:
The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
Autorzy:
Connelly WM; Department of Pharmacology & Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Shenton FC
Lethbridge N
Leurs R
Waldvogel HJ
Faull RL
Lees G
Chazot PL
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 May; Vol. 157 (1), pp. 55-63.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*physiology
Neurons/*metabolism
Receptors, G-Protein-Coupled/*physiology
Receptors, Histamine/*physiology
Animals ; Brain/anatomy & histology ; Brain/metabolism ; Excitatory Postsynaptic Potentials ; Humans ; Immunoblotting ; Immunohistochemistry ; Male ; Membrane Potentials ; Mice ; Mice, Inbred C3H ; Patch-Clamp Techniques ; Receptors, G-Protein-Coupled/biosynthesis ; Receptors, Histamine/biosynthesis ; Receptors, Histamine H4
Czasopismo naukowe
Tytuł:
Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.
Autorzy:
Lim HD; Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Adami M
Guaita E
Werfel T
Smits RA
de Esch IJ
Bakker RA
Gutzmer R
Coruzzi G
Leurs R
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 May; Vol. 157 (1), pp. 34-43.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Guanidines/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Thiourea/*analogs & derivatives
Agmatine/pharmacology ; Animals ; Cell Line ; Chemotaxis/drug effects ; Chlorocebus aethiops ; Dendritic Cells/physiology ; Gastric Acid/metabolism ; Histamine Agonists/pharmacology ; Humans ; Male ; Methylhistamines/pharmacology ; Mice ; Radioligand Assay ; Rats ; Rats, Wistar ; Receptors, Histamine ; Receptors, Histamine H2/metabolism ; Receptors, Histamine H3/metabolism ; Receptors, Histamine H4 ; Thiourea/pharmacology
Czasopismo naukowe
Tytuł:
In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.
Autorzy:
Strakhova MI; Neuroscience Research, Global Pharmaceutical Research Division, Abbott Laboratories, Abbott Park, IL 60064, USA. />Cuff CA
Manelli AM
Carr TL
Witte DG
Baranowski JL
Vortherms TA
Miller TR
Rundell L
McPherson MJ
Adair RM
Brito AA
Bettencourt BM
Yao BB
Wetter JM
Marsh KC
Liu H
Cowart MD
Brioni JD
Esbenshade TA
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 May; Vol. 157 (1), pp. 44-54.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Piperazines/*pharmacology
Pyrimidines/*pharmacology
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Binding, Competitive ; Calcium/metabolism ; Cell Shape ; Chemotaxis ; Eosinophils/drug effects ; Eosinophils/physiology ; Female ; Histamine/pharmacology ; Humans ; Male ; Mast Cells/cytology ; Mast Cells/drug effects ; Mice ; Mice, Inbred BALB C ; Peritonitis/chemically induced ; Peritonitis/drug therapy ; Peritonitis/immunology ; Piperazines/pharmacokinetics ; Prostaglandin D2/metabolism ; Pyrimidines/pharmacokinetics ; RNA, Messenger/biosynthesis ; Radioligand Assay ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled/biosynthesis ; Receptors, G-Protein-Coupled/genetics ; Receptors, Histamine/biosynthesis ; Receptors, Histamine/genetics ; Receptors, Histamine H4 ; Recombinant Proteins/antagonists & inhibitors ; Zymosan
Czasopismo naukowe
Tytuł:
Molecular and biochemical pharmacology of the histamine H4 receptor.
Autorzy:
Leurs R; Department of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, VU University Amsterdam, Amsterdam, The Netherlands. />Chazot PL
Shenton FC
Lim HD
de Esch IJ
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 May; Vol. 157 (1), pp. 14-23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Receptors, G-Protein-Coupled*/agonists
Receptors, G-Protein-Coupled*/antagonists & inhibitors
Receptors, G-Protein-Coupled*/genetics
Receptors, G-Protein-Coupled*/physiology
Receptors, Histamine*/genetics
Receptors, Histamine*/physiology
Animals ; Binding Sites ; Humans ; Ligands ; Models, Molecular ; Phylogeny ; Protein Conformation ; Receptors, Histamine H4 ; Species Specificity
Czasopismo naukowe
Tytuł:
The role of histamine H4 receptor in immune and inflammatory disorders.
Autorzy:
Zampeli E; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Tiligada E
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 May; Vol. 157 (1), pp. 24-33. Date of Electronic Publication: 2009 Mar 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Immune System Diseases/*metabolism
Inflammation/*metabolism
Receptors, G-Protein-Coupled/*physiology
Receptors, Histamine/*physiology
Cell Differentiation ; Chemotaxis ; Chronic Disease ; Dendritic Cells/immunology ; Dendritic Cells/physiology ; Eosinophils/physiology ; Histamine/immunology ; Histamine/metabolism ; Humans ; Immune System Diseases/drug therapy ; Immune System Diseases/immunology ; Inflammation/drug therapy ; Inflammation/immunology ; Ligands ; Mast Cells/physiology ; Polymorphism, Genetic ; Receptors, G-Protein-Coupled/genetics ; Receptors, Histamine/genetics ; Receptors, Histamine H4 ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/physiology
Czasopismo naukowe
Tytuł:
Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.
Autorzy:
Rossbach K; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Wendorff S
Sander K
Stark H
Gutzmer R
Werfel T
Kietzmann M
Bäumer W
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Źródło:
Experimental dermatology [Exp Dermatol] 2009 Jan; Vol. 18 (1), pp. 57-63. Date of Electronic Publication: 2008 Jul 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Haptens/*chemistry
Histamine H1 Antagonists/*pharmacology
Indoles/*pharmacology
Piperazines/*pharmacology
Pruritus/*metabolism
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Th2 Cells/*immunology
Animals ; Dermatitis, Atopic ; Dose-Response Relationship, Drug ; Female ; Imidazoles/pharmacology ; Inflammation ; Mice ; Mice, Inbred BALB C ; Receptors, Histamine ; Receptors, Histamine H4 ; Thiourea/analogs & derivatives ; Thiourea/pharmacology ; Time Factors
Czasopismo naukowe
Tytuł:
Suppression of ischaemia-induced cytokine release by dimaprit and amelioration of liver injury in rats.
Autorzy:
Motoki A; Department of Anaesthesiology and Resuscitology, Ehime University Graduate School of Medicine, Shitsukawa, Touon-shi, Ehime, Japan. />Adachi N
Liu K
Takahashi HK
Nishibori M
Yorozuya T
Arai T
Nagaro T
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2008 Apr; Vol. 102 (4), pp. 394-8. Date of Electronic Publication: 2008 Feb 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytokines/*metabolism
Dimaprit/*pharmacology
Histamine Agonists/*pharmacology
Ischemia/*drug therapy
Liver/*drug effects
Reperfusion Injury/*prevention & control
Adenosine Triphosphate/metabolism ; Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Dimaprit/therapeutic use ; Disease Models, Animal ; Down-Regulation ; Hepatic Artery/surgery ; Histamine/blood ; Histamine Agonists/therapeutic use ; Interleukin-12/blood ; Ischemia/complications ; Ischemia/metabolism ; Ischemia/pathology ; Ligation ; Liver/blood supply ; Liver/enzymology ; Liver/pathology ; Male ; Portal Vein/surgery ; Rats ; Rats, Wistar ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Histamine/metabolism ; Receptors, Histamine H2/drug effects ; Receptors, Histamine H2/metabolism ; Receptors, Histamine H4 ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Severity of Illness Index ; Time Factors
Czasopismo naukowe
Tytuł:
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.
Autorzy:
Thurmond RL; Johnson & Johnson Pharmaceutical Research & Development, L.L.C. San Diego, California 92121, USA. />Gelfand EW
Dunford PJ
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Źródło:
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2008 Jan; Vol. 7 (1), pp. 41-53.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Histamine/*physiology
Histamine H1 Antagonists/*therapeutic use
Hypersensitivity/*physiopathology
Inflammation/*drug therapy
Receptors, G-Protein-Coupled/*physiology
Receptors, Histamine/*physiology
Receptors, Histamine H1/*physiology
Arthritis/physiopathology ; Drug Design ; Histamine/blood ; Hypersensitivity/drug therapy ; Ligands ; Receptors, Histamine H4
Czasopismo naukowe
Tytuł:
Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses.
Autorzy:
Sugata Y; Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Okano M
Fujiwara T
Matsumoto R
Hattori H
Yamamoto M
Nishibori M
Nishizaki K
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Źródło:
Immunology [Immunology] 2007 Jun; Vol. 121 (2), pp. 266-75. Date of Electronic Publication: 2007 Mar 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Histamine Agonists/*pharmacology
Receptors, G-Protein-Coupled/*agonists
T-Lymphocytes/*drug effects
Adenylyl Cyclases/physiology ; Allergens/immunology ; Antigens, Plant ; Apoptosis ; Cells, Cultured ; Epitopes, T-Lymphocyte/immunology ; Gene Expression/immunology ; Histamine/pharmacology ; Histamine Antagonists/pharmacology ; Humans ; Interferon-gamma/biosynthesis ; Interleukin-5/biosynthesis ; Oligonucleotide Array Sequence Analysis/methods ; Plant Proteins/immunology ; RNA, Messenger/genetics ; Receptors, G-Protein-Coupled/immunology ; Receptors, Histamine/biosynthesis ; Receptors, Histamine/genetics ; Receptors, Histamine/immunology ; Receptors, Histamine H4 ; T-Lymphocytes/immunology ; Tuberculin/immunology
Czasopismo naukowe
Tytuł:
Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.
Autorzy:
Gbahou F; INSERM, Unité de Neurobiologie et Pharmacologie Moléculaire (U573), Centre Paul Broca, 2 ter rue d'Alésia, 75014 Paris, France.
Vincent L
Humbert-Claude M
Tardivel-Lacombe J
Chabret C
Arrang JM
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2006 Apr; Vol. 147 (7), pp. 744-54.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Histamine/*analogs & derivatives
Histamine/*pharmacology
Receptors, G-Protein-Coupled/*drug effects
Receptors, Histamine/*drug effects
Receptors, Histamine H3/*drug effects
Binding, Competitive/drug effects ; Colforsin/pharmacology ; Cyclic AMP/metabolism ; DNA, Complementary/biosynthesis ; DNA, Complementary/genetics ; Histamine/metabolism ; Histamine H2 Antagonists/metabolism ; Humans ; Imidazoles/metabolism ; In Vitro Techniques ; Kidney/cytology ; Kidney/drug effects ; Kidney/metabolism ; Receptors, Histamine H4 ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Transfection
Czasopismo naukowe

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