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Wyszukujesz frazę ""Receptors, Interleukin-6"" wg kryterium: Temat


Tytuł :
Antibody to Interleukin-6 Receptor Inhibits In Vivo Growth of Human Colorectal Carcinoma Cell Xenografts.
Autorzy :
Chung YC; Department of Surgery, Cheng-Ching General Hospital, Chung-Kang Branch, Taichung, Taiwan, R.O.C.; Department of Surgery, Kuang Tien General Hospital, Taichung, Taiwan, R.O.C.
Ku YL; Department of Surgery, Cheng-Ching General Hospital, Chung-Kang Branch, Taichung, Taiwan, R.O.C.
Chiang HC; Department of Colorectal Surgery, Asia University Hospital, Taichung, Taiwan, R.O.C.
Liu WC; Department of Pathology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan, R.O.C.
Kao TY; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu, Taiwan, R.O.C.
Yang CH; Department of Business Administration, Yuanpei University of Medical Technology, Hsinchu, Taiwan, R.O.C.
Huang CC; Department of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan, R.O.C.
Hsu CP; Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu, Taiwan, R.O.C.; .; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan, R.O.C.
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Źródło :
Anticancer research [Anticancer Res] 2021 Oct; Vol. 41 (10), pp. 4907-4916.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*pharmacology
Colorectal Neoplasms/*prevention & control
Neovascularization, Pathologic/*prevention & control
Receptors, Interleukin-6/*antagonists & inhibitors
Animals ; Apoptosis ; Cell Proliferation ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans ; Male ; Mice ; Mice, Nude ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Receptors, Interleukin-6/immunology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms.
Autorzy :
Kang S; Laborabory of Immune Regulation, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan. .
Kishimoto T; Laborabory of Immune Regulation, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan. .
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Źródło :
Experimental & molecular medicine [Exp Mol Med] 2021 Jul; Vol. 53 (7), pp. 1116-1123. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibodies, Monoclonal, Humanized/*therapeutic use
COVID-19/*prevention & control
Interleukin-6/*genetics
Receptors, Interleukin-6/*genetics
Antibodies, Monoclonal, Humanized/immunology ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/pathology ; Cytokine Release Syndrome/genetics ; Cytokine Release Syndrome/immunology ; Cytokines/genetics ; Cytokines/metabolism ; Endothelium, Vascular/immunology ; Humans ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/immunology ; Receptors, Interleukin-6/antagonists & inhibitors ; Receptors, Interleukin-6/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Sepsis/genetics ; Sepsis/immunology ; Sepsis/pathology ; Sepsis/prevention & control
Czasopismo naukowe
Tytuł :
Depression and interleukin-6 signaling: A Mendelian Randomization study.
Autorzy :
Kelly KM; Department of Epidemiology, School of Public Health, University of Michigan, United States; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands. Electronic address: .
Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, United States; Institute for Social Research, University of Michigan, United States.
Mezuk B; Department of Epidemiology, School of Public Health, University of Michigan, United States; Institute for Social Research, University of Michigan, United States.
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Jul; Vol. 95, pp. 106-114. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Interleukin-6*/genetics
Receptors, Interleukin-6*/genetics
Animals ; Cytokine Receptor gp130 ; Depression/genetics ; Mendelian Randomization Analysis
Czasopismo naukowe
Tytuł :
Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R.
Autorzy :
Xu Y; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Li X; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Li H; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zhong L; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Lin Y; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Xie J; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
Zheng D; Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Jun; Vol. 25 (11), pp. 4912-4921. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*pathology
Hypoxia/*physiopathology
Kidney Tubules, Proximal/*pathology
MicroRNAs/*genetics
Oxygen/*metabolism
RNA, Circular/*genetics
Receptors, Interleukin-6/*metabolism
Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Apoptosis ; Cell Proliferation ; Cells, Cultured ; Gene Expression Regulation ; Humans ; Kidney Tubules, Proximal/metabolism ; Receptors, Interleukin-6/genetics
Czasopismo naukowe
Tytuł :
Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context.
Autorzy :
Angriman F; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Ferreyro BL; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Respirology, Sinai Health System and University Health Network, Toronto, ON, Canada. Electronic address: .
Burry L; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; Department of Pharmacy and Medicine, Sinai Health System, Toronto, ON, Canada.
Fan E; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Respirology, Sinai Health System and University Health Network, Toronto, ON, Canada; Toronto General Hospital Research Institute, Toronto, ON, Canada.
Ferguson ND; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Respirology, Sinai Health System and University Health Network, Toronto, ON, Canada; Toronto General Hospital Research Institute, Toronto, ON, Canada.
Husain S; Transplant Infectious Diseases, Ajmera Transplant Center, University Health Network, University of Toronto, Toronto, ON, Canada.
Keshavjee SH; Toronto Lung Transplant Program and Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON, Canada.
Lupia E; Department of Medical Sciences, University of Turin, Turin, Italy.
Munshi L; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Respirology, Sinai Health System and University Health Network, Toronto, ON, Canada.
Renzi S; The Hospital for Sick Children, Division of Haematology/Oncology, Toronto, ON, Canada.
Ubaldo OGV; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Respirology, Sinai Health System and University Health Network, Toronto, ON, Canada.
Rochwerg B; Department of Medicine, Division of Critical Care, and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Del Sorbo L; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Department of Medicine, Division of Respirology, Sinai Health System and University Health Network, Toronto, ON, Canada.
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Źródło :
The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Jun; Vol. 9 (6), pp. 655-664. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19*/immunology
COVID-19*/therapy
Clinical Trials as Topic*/methods
Clinical Trials as Topic*/statistics & numerical data
Antibodies, Monoclonal, Humanized/*pharmacology
Receptors, Interleukin-6/*antagonists & inhibitors
Antibodies, Monoclonal, Humanized/immunology ; Humans ; Patient Selection ; Receptors, Interleukin-6/immunology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
The role of IL-6 and IL-6 blockade in COVID-19.
Autorzy :
Potere N; Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.
Batticciotto A; Rheumatology Unit, Internal Medicine Department, ASST Sette Laghi, Ospedale Di Circolo - Fondazione Macchi, Varese, Italy.
Vecchié A; Department of Internal Medicine, ASST Sette Laghi, Varese, Italy.
Porreca E; Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.
Cappelli A; Rheumatology Unit, Internal Medicine Department, ASST Sette Laghi, Ospedale Di Circolo - Fondazione Macchi, Varese, Italy.
Abbate A; Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Dentali F; Department of Medicine and Surgery, Insubria University, Varese, Italy.
Bonaventura A; Department of Internal Medicine, ASST Sette Laghi, Varese, Italy.; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy.
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Źródło :
Expert review of clinical immunology [Expert Rev Clin Immunol] 2021 Jun; Vol. 17 (6), pp. 601-618. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
COVID-19/*drug therapy
Interleukin-6/*antagonists & inhibitors
Receptors, Interleukin-6/*antagonists & inhibitors
SARS-CoV-2/*pathogenicity
Animals ; Anti-Inflammatory Agents/adverse effects ; COVID-19/immunology ; COVID-19/virology ; Host-Pathogen Interactions ; Humans ; Interleukin-6/metabolism ; Receptors, Interleukin-6/metabolism ; SARS-CoV-2/immunology ; Signal Transduction ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Practical management of patients on anti-IL6R therapy - the CRI guidelines.
Autorzy :
Morel J; Service de Rhumatologie, CHU Montpellier, Montpellier, France.
Tournadre A; Service de Rhumatologie, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Sellam J; Service de Rhumatologie, CHU Saint-Antoine, Paris, France.
Pham T; Service de Rhumatologie, CHU Sainte-Marguerite, Marseille, France.
Richez C; Service de Rhumatologie, CHU Pellegrin, Bordeaux, France. Electronic address: .
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Corporate Authors :
CRI and all the expert contributors
Źródło :
Joint bone spine [Joint Bone Spine] 2021 Jun; Vol. 88 (4 Suppl 1), pp. 105220.
Typ publikacji :
Editorial
MeSH Terms :
Interleukin-6*
Receptors, Interleukin-6*
Humans
Opinia redakcyjna
Tytuł :
In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor.
Autorzy :
Ando T; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
Yamamoto M; Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
Takamori Y; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
Tsukamoto K; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
Fuji D; Department of Biotechnology, Faculty of Life and Environmental Sciences, University of Yamanashi, Kofu, Yamanashi, Japan.
Kawakami T; Faculty of Life and Environmental Sciences, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Kofu, Yamanashi, Japan.; JST, PRESTO, Kawaguchi, Saitama, Japan.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2021 Apr 24; Vol. 85 (5), pp. 1170-1174.
Typ publikacji :
Journal Article
MeSH Terms :
Aptamers, Nucleotide/*therapeutic use
COVID-19/*drug therapy
Cytokine Release Syndrome/*drug therapy
Interleukin-6/*antagonists & inhibitors
Receptors, Interleukin-6/*antagonists & inhibitors
Aptamers, Nucleotide/chemistry ; Base Sequence ; COVID-19/complications ; Cytokine Release Syndrome/etiology ; DNA, Viral/drug effects ; Humans ; Interleukin-6/metabolism ; Receptors, Interleukin-6/metabolism ; SELEX Aptamer Technique
Czasopismo naukowe
Tytuł :
Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells.
Autorzy :
Montgomery A; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Tam F; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Gursche C; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Cheneval C; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Besler K; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Enns W; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Manku S; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Rey K; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Hanson PJ; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Rose-John S; Institute of Biochemistry, Christian-Albrechts University Kiel, Kiel, Germany.
McManus BM; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Choy JC; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Apr 01; Vol. 320 (4), pp. C554-C565. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aorta, Abdominal/*drug effects
Cytokine Receptor gp130/*agonists
Endothelial Cells/*drug effects
Graft Rejection/*prevention & control
Interleukin-6/*pharmacology
Receptors, Interleukin-6/*agonists
Adult ; Aged ; Animals ; Aorta, Abdominal/metabolism ; Aorta, Abdominal/pathology ; Aorta, Abdominal/transplantation ; Cells, Cultured ; Cytokine Receptor gp130/metabolism ; Disease Models, Animal ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Endothelial Cells/transplantation ; Female ; Graft Rejection/metabolism ; Graft Rejection/pathology ; Humans ; Inflammation Mediators/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Middle Aged ; Receptors, Interleukin-6/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients.
Autorzy :
Yang P; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Zhao Y; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Li J; BGI-Shenzhen, Shenzhen, China.; BGI Education Center, University of Chinese Academic of Sciences, Shenzhen, China.
Liu C; BGI-Shenzhen, Shenzhen, China.; Shenzhen Bay Laboratory, Shenzhen, China.
Zhu L; BGI-Shenzhen, Shenzhen, China.; Shenzhen Bay Laboratory, Shenzhen, China.
Zhang J; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yu Y; BGI-Shenzhen, Shenzhen, China.; BGI College, Zhengzhou University, Zhengzhou, China.
Wang WJ; BGI-Shenzhen, Shenzhen, China.
Lei G; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Yan J; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Sun F; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Bian C; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Meng F; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Xu Z; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Bai C; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China.
Ye B; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Guo Y; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
Shu L; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yuan X; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Zhang N; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Bi Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Shi Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Wu G; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Zhang S; Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China. .
Gao GF; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. .; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China. .
Liu L; BGI-Shenzhen, Shenzhen, China. .; Shenzhen Bay Laboratory, Shenzhen, China. .
Liu WJ; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. .
Sun HX; BGI-Shenzhen, Shenzhen, China. .
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Źródło :
Cellular & molecular immunology [Cell Mol Immunol] 2021 Apr; Vol. 18 (4), pp. 1064-1066. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Letter
MeSH Terms :
COVID-19/*immunology
COVID-19/*metabolism
Cell-Free Nucleic Acids/*blood
Cytokine Release Syndrome/*immunology
Interleukin-6/*metabolism
MicroRNAs/*blood
Receptors, Interleukin-6/*metabolism
COVID-19/blood ; COVID-19/genetics ; Cytokine Release Syndrome/blood ; Down-Regulation ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA/blood ; Receptors, Interleukin-6/genetics ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
Expression of Interleukin 6 signaling receptors in carotid atherosclerosis.
Autorzy :
Ziegler L; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.; Department of Medicine, Danderyd Hospital, Stockholm, Sweden.
Lundqvist J; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Dreij K; Unit of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Wallén H; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.; Department of Cardiology, Danderyd Hospital, Stockholm, Sweden.
de Faire U; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Paulsson-Berne G; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Hedin U; Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Matic L; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Gigante B; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Cardiology, Danderyd Hospital, Stockholm, Sweden.
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Źródło :
Vascular medicine (London, England) [Vasc Med] 2021 Feb; Vol. 26 (1), pp. 3-10. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Plaque, Atherosclerotic*
Carotid Arteries/*metabolism
Carotid Stenosis/*metabolism
Cytokine Receptor gp130/*metabolism
Interleukin-6/*metabolism
Receptors, Interleukin-6/*metabolism
Aged ; Biomarkers/metabolism ; Carotid Arteries/surgery ; Carotid Stenosis/blood ; Carotid Stenosis/genetics ; Carotid Stenosis/therapy ; Cross-Sectional Studies ; Cytokine Receptor gp130/blood ; Cytokine Receptor gp130/genetics ; Endarterectomy, Carotid ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Interleukin-6/blood ; Interleukin-6/genetics ; Male ; Receptors, Interleukin-6/blood ; Receptors, Interleukin-6/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Systemic lupus erythematosus is associated with impaired autophagic degradation via interleukin-6 in macrophages.
Autorzy :
Hsu HC; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen YH; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Lin TS; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan; Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Shen CY; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Hsieh SC; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2021 Feb 01; Vol. 1867 (2), pp. 166027. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*immunology
Interleukin-6/*metabolism
Lupus Erythematosus, Systemic/*immunology
Macrophages/*metabolism
Receptors, Interleukin-6/*metabolism
Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Autophagy/drug effects ; Case-Control Studies ; Cells, Cultured ; Healthy Volunteers ; Humans ; Interleukin-6/blood ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Macrophages/immunology ; Microtubule-Associated Proteins/analysis ; Microtubule-Associated Proteins/metabolism ; Paracrine Communication/drug effects ; Paracrine Communication/immunology ; Primary Cell Culture ; RNA-Binding Proteins/analysis ; RNA-Binding Proteins/metabolism ; Receptors, Interleukin-6/analysis ; Receptors, Interleukin-6/antagonists & inhibitors ; Recombinant Proteins/metabolism ; Severity of Illness Index ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Interleukin-6 controls recycling and degradation, but not internalization of its receptors.
Autorzy :
Flynn CM; Institute of Biochemistry, Kiel University, Kiel, Germany.
Kespohl B; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Daunke T; Institute of Biochemistry, Kiel University, Kiel, Germany.
Garbers Y; Institute of Psychology, Kiel University, Kiel, Germany.
Düsterhöft S; Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany.
Rose-John S; Institute of Biochemistry, Kiel University, Kiel, Germany.
Haybaeck J; Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria; Diagnostic & Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, Graz, Austria.
Lokau J; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany.
Aparicio-Siegmund S; Institute of Biochemistry, Kiel University, Kiel, Germany.
Garbers C; Department of Pathology, Otto-von-Guericke-University Magdeburg, Medical Faculty, Magdeburg, Germany. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100434. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokine Receptor gp130/*metabolism
Receptors, Interleukin-6/*metabolism
Cytokine Receptor gp130/genetics ; Cytokines/metabolism ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Interleukin-6/physiology ; Receptors, Interleukin ; Receptors, Interleukin-6/genetics ; Receptors, Interleukin-6/physiology ; Signal Transduction ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.
Autorzy :
Bin S; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China. Electronic address: .
Xin L; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Lin Z; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Jinhua Z; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Rui G; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
Xiang Z; Department of Orthopaedic, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), NO.61, Jiefang West Road, Changsha city, Hunan Province 410000, China.
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2021 Feb; Vol. 118, pp. 104570. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chondrocytes/*pathology
Gene Expression Regulation/*drug effects
MicroRNAs/*genetics
Receptors, Interleukin-6/*metabolism
Scoliosis/*pathology
Apoptosis ; Case-Control Studies ; Cell Proliferation ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Ferroptosis ; Humans ; Interleukin-6/pharmacology ; Receptors, Interleukin-6/genetics ; Scoliosis/drug therapy ; Scoliosis/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Molecular dynamics analysis of the binding of human interleukin-6 with interleukin-6 α-receptor.
Autorzy :
Gupta M; UT/ORNL Center for Molecular Biophysics, Oak Ridge National Lab, Oak Ridge, Tennessee, USA.
Ha K; Tickle College of Engineering, University of Tennessee, Knoxville, Tennessee, USA.
Agarwal R; UT/ORNL Center for Molecular Biophysics, Oak Ridge National Lab, Oak Ridge, Tennessee, USA.
Quarles LD; Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Smith JC; UT/ORNL Center for Molecular Biophysics, Oak Ridge National Lab, Oak Ridge, Tennessee, USA.
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Źródło :
Proteins [Proteins] 2021 Feb; Vol. 89 (2), pp. 163-173. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Molecular Dynamics Simulation*
Apoproteins/*chemistry
Interleukin-6/*chemistry
Receptors, Interleukin-6/*chemistry
Apoproteins/metabolism ; Binding Sites ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Interleukin-6/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Receptors, Interleukin-6/metabolism ; Static Electricity ; Structural Homology, Protein ; Thermodynamics
Czasopismo naukowe
Tytuł :
Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia.
Autorzy :
Larsson SC; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden susanna.larsson@ki.; Dept of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Burgess S; Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Gill D; Dept of Epidemiology and Biostatistics, School of Public Health, St Mary's Hospital, Imperial College London, London, UK.; Clinical Pharmacology and Therapeutics Section, Institute of Medical and Biomedical Education and Institute for Infection and Immunity, St George's, University of London, London, UK.; Clinical Pharmacology Group, Pharmacy and Medicines Directorate, St George's University Hospitals NHS Foundation Trust, London, UK.; Novo Nordisk Research Centre Oxford, Old Road Campus, Oxford, UK.
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Źródło :
The European respiratory journal [Eur Respir J] 2021 Jan 14; Vol. 57 (1). Date of Electronic Publication: 2021 Jan 14 (Print Publication: 2021).
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Hospitalization*
COVID-19/*epidemiology
Pneumonia/*epidemiology
Receptors, Interleukin-6/*antagonists & inhibitors
C-Reactive Protein/immunology ; COVID-19/drug therapy ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/physiopathology ; European Continental Ancestry Group/genetics ; Genetic Predisposition to Disease ; Humans ; Mendelian Randomization Analysis ; Pneumonia/genetics ; Polymorphism, Single Nucleotide ; Receptors, Interleukin-6/genetics ; Respiratory Insufficiency/physiopathology ; SARS-CoV-2 ; Severity of Illness Index
SCR Protocol :
COVID-19 drug treatment
Raport

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