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Wyszukujesz frazę ""Receptors, Lysophosphatidic Acid"" wg kryterium: Temat


Tytuł :
Transcriptional regulation of lysophosphatidic acid receptors 2 and 3 regulates myeloid commitment of hematopoietic stem cells.
Autorzy :
Lin KH; Department of Life Science, National Taiwan University, Taipei, Taiwan.; Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Chiang JC; Department of Life Science, National Taiwan University, Taipei, Taiwan.; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
Chen WM; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
Ho YH; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Yao CL; Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, Taiwan.
Lee H; Department of Life Science, National Taiwan University, Taipei, Taiwan.; Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan.; Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan.; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Center for Biotechnology, National Taiwan University, Taipei, Taiwan.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Apr 01; Vol. 320 (4), pp. C509-C519. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Lineage*
Hematopoiesis*
Transcription, Genetic*
Hematopoietic Stem Cells/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Binding Sites ; Erythropoiesis ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; GATA2 Transcription Factor/genetics ; GATA2 Transcription Factor/metabolism ; HEK293 Cells ; Humans ; K562 Cells ; Promoter Regions, Genetic ; Receptors, Lysophosphatidic Acid/genetics ; Signal Transduction ; Thrombopoiesis
Czasopismo naukowe
Tytuł :
Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2.
Autorzy :
Fischer C; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.
Endle H; Institute for Microscopic Anatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.; Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Schumann L; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.
Wilken-Schmitz A; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.
Kaiser J; Institute for Human Genetics, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Gerber S; Institute for Human Genetics, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Vogelaar CF; Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Schmidt MHH; Institute of Anatomy, Medical Faculty Carl Gustav Carus Technische Universität, School of Medicine, Dresden, Germany.
Nitsch R; Institute for Translational Neuroscience, Westfälische Wilhelms Universität, Münster, Germany.
Snodgrass I; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.
Thomas D; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.
Vogt J; Center of Anatomy, University of Cologne, Cologne, Germany.
Tegeder I; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Feb; Vol. 78 (3), pp. 1029-1050. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Maze Learning/*physiology
Memory/*physiology
Neurons/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Aging ; Animals ; Brain/metabolism ; Calcium-Binding Proteins/deficiency ; Calcium-Binding Proteins/genetics ; Chromatography, High Pressure Liquid ; Dentate Gyrus/metabolism ; Discriminant Analysis ; EGF Family of Proteins/deficiency ; EGF Family of Proteins/genetics ; Female ; Liver/metabolism ; Long-Term Potentiation ; Male ; Maze Learning/drug effects ; Memory/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Principal Component Analysis ; Receptors, Lysophosphatidic Acid/antagonists & inhibitors ; Receptors, Lysophosphatidic Acid/deficiency ; Receptors, Lysophosphatidic Acid/genetics ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.
Autorzy :
Chiang JC; Department of Life Science, National Taiwan University, Taipei, Taiwan; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chen WM; Department of Life Science, National Taiwan University, Taipei, Taiwan; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lin KH; Department of Life Science, National Taiwan University, Taipei, Taiwan.
Hsia K; Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan.
Ho YH; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Lin YC; Department of Life Science, National Taiwan University, Taipei, Taiwan.
Shen TL; Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan; Center for Biotechnology, National Taiwan University, Taipei, Taiwan.
Lu JH; Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Surgery, Medicine & Pediatrics, School of Medicine, National Defense Medical Center, Taipei, Taiwan; Department of Pediatrics, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Chen SK; Department of Life Science, National Taiwan University, Taipei, Taiwan; Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
Yao CL; Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, Taiwan.
Chen BPC; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: .
Lee H; Department of Life Science, National Taiwan University, Taipei, Taiwan; Center for Biotechnology, National Taiwan University, Taipei, Taiwan; Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Jan; Vol. 1866 (1), pp. 158818. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Hemolytic/*genetics
Erythroid Cells/*metabolism
Erythropoiesis/*genetics
Myeloid Cells/*metabolism
Receptors, Lysophosphatidic Acid/*genetics
Stem Cells/*metabolism
Anemia, Hemolytic/chemically induced ; Anemia, Hemolytic/drug therapy ; Anemia, Hemolytic/metabolism ; Animals ; Cell Differentiation/drug effects ; Cell Lineage/drug effects ; Cell Lineage/genetics ; Disease Models, Animal ; Erythroid Cells/cytology ; Erythroid Cells/drug effects ; Erythropoiesis/drug effects ; Gene Expression Regulation ; Humans ; Isoquinolines/pharmacology ; K562 Cells ; Lysophospholipids/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Myeloid Cells/cytology ; Myeloid Cells/drug effects ; Organothiophosphates/pharmacology ; Phenylhydrazines/administration & dosage ; Phosphatidic Acids/pharmacology ; Receptors, Lysophosphatidic Acid/agonists ; Receptors, Lysophosphatidic Acid/metabolism ; Stem Cells/cytology ; Stem Cells/drug effects
Czasopismo naukowe
Tytuł :
Cannabinoid CB 1 and CB 2 receptors differentially regulate TNF-α-induced apoptosis and LPA 1 -mediated pro-survival signaling in HT22 hippocampal cells.
Autorzy :
Olianas MC; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Dedoni S; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Onali P; Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 01; Vol. 276, pp. 119407. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cannabinoid Receptor Agonists/*pharmacology
Hippocampus/*pathology
Receptor, Cannabinoid, CB1/*metabolism
Receptor, Cannabinoid, CB2/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Tumor Necrosis Factor-alpha/*pharmacology
Adrenergic Uptake Inhibitors/pharmacology ; Amitriptyline/pharmacology ; Animals ; Cell Survival ; Cells, Cultured ; Hippocampus/drug effects ; Hippocampus/metabolism ; Mice ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphorylation ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB2/agonists ; Receptors, Lysophosphatidic Acid/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
Autorzy :
Geng H; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Lan R; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Liu Y; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Chen W; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Wu M; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Saikumar P; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Weinberg JM; Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Venkatachalam MA; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Mar 01; Vol. 320 (3), pp. F359-F374. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acute Kidney Injury/*metabolism
Cytokines/*metabolism
Kidney Tubules, Proximal/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Reperfusion Injury/*metabolism
Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Animals ; Cell Line ; Connective Tissue Growth Factor/metabolism ; Disease Models, Animal ; ErbB Receptors/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibrosis ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Kidney Tubules, Proximal/pathology ; Lymphokines/metabolism ; Male ; Mice ; Phosphorylation ; Platelet-Derived Growth Factor/metabolism ; Rats, Sprague-Dawley ; Receptors, Lysophosphatidic Acid/genetics ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; Signal Transduction ; Transcription Factor AP-1/metabolism ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA 2 ) and LPA 3 in osteosarcoma cells.
Autorzy :
Minami K; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Ueda N; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Ishimoto K; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Kurisu R; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Takamoto M; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Ikeda H; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Tsujiuchi T; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2021 Feb; Vol. 118, pp. 104596. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Gene Expression Regulation, Neoplastic*
Bone Neoplasms/*pathology
Endothelial Cells/*pathology
Osteosarcoma/*pathology
Receptors, Lysophosphatidic Acid/*metabolism
Apoptosis ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Cell Proliferation ; Endothelial Cells/metabolism ; Humans ; Lysophospholipids/metabolism ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Receptors, Lysophosphatidic Acid/genetics ; Signal Transduction ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA 2 ) signaling enhances cancer cell survival to cisplatin.
Autorzy :
Minami K; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Ueda N; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Ishimoto K; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Kurisu R; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Takamoto M; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Ikeda H; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Tsujiuchi T; Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Nov 12; Vol. 532 (3), pp. 427-432. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Survival/*drug effects
Cisplatin/*pharmacology
Fibrosarcoma/*drug therapy
GTP-Binding Protein alpha Subunits, G12-G13/*metabolism
GTP-Binding Protein alpha Subunits, Gi-Go/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/physiology ; Fibrosarcoma/metabolism ; Fibrosarcoma/pathology ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Humans ; Models, Biological ; Receptors, Lysophosphatidic Acid/antagonists & inhibitors ; Receptors, Lysophosphatidic Acid/genetics ; Signal Transduction/drug effects ; rhoA GTP-Binding Protein/metabolism ; rhoC GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
Downregulated circular RNA zRANB1 mediates Wnt5a/β-Catenin signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models.
Autorzy :
Wei M; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Li L; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhang Y; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Zhang M; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
Su Z; Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Nov 30; Vol. 761, pp. 145038. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs/*genetics
Neuralgia/*genetics
Receptors, Lysophosphatidic Acid/*genetics
Animals ; Constriction, Pathologic/genetics ; Disease Progression ; Gene Expression Regulation/genetics ; HEK293 Cells ; Humans ; Inflammation/genetics ; Male ; MicroRNAs/metabolism ; RNA, Circular/genetics ; RNA, Long Noncoding/genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Lysophosphatidic Acid/metabolism ; Signal Transduction/genetics ; Tumor Necrosis Factor-alpha/genetics ; Ubiquitin Thiolesterase/genetics ; Wnt Signaling Pathway/genetics ; Wnt-5a Protein/genetics ; Wnt-5a Protein/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Differential anatomical and cellular expression of lysophosphatidic acid receptor 1 in adult mouse brain.
Autorzy :
Kajitani N; Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan; Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure, 737-0023, Japan. Electronic address: .
Okada-Tsuchioka M; Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure, 737-0023, Japan.
Kano K; Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Omori W; Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure, 737-0023, Japan.
Boku S; Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Aoki J; Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Takebayashi M; Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan; Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure, 737-0023, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Oct 15; Vol. 531 (2), pp. 89-95. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Aging/*metabolism
Brain/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Animals ; Astrocytes/metabolism ; Biomarkers/metabolism ; Lysophospholipids/metabolism ; Mice, Inbred C57BL ; Receptors, Lysophosphatidic Acid/genetics ; beta-Galactosidase/metabolism
Czasopismo naukowe
Tytuł :
Exosomal circLPAR1 Promoted Osteogenic Differentiation of Homotypic Dental Pulp Stem Cells by Competitively Binding to hsa-miR-31.
Autorzy :
Xie L; Department of Oral Implantology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, China.; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla, Thailand.
Guan Z; Biomedical Research Center, The Affiliated Calmette Hospital of Kunming Medical University (the First Hospital of Kunming), Kunming, China.
Zhang M; Department of Periodontology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, China.
Lyu S; Biomedical Research Center, The Affiliated Calmette Hospital of Kunming Medical University (the First Hospital of Kunming), Kunming, China.
Thuaksuban N; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla, Thailand.
Kamolmattayakul S; Faculty of Dentistry, Bangkok Thonburi University, Bangkok, Thailand.
Nuntanaranont T; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla, Thailand.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Sep 28; Vol. 2020, pp. 6319395. Date of Electronic Publication: 2020 Sep 28 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Dental Pulp*/cytology
Dental Pulp*/metabolism
MicroRNAs*/chemistry
MicroRNAs*/metabolism
RNA, Circular*/chemistry
RNA, Circular*/metabolism
Receptors, Lysophosphatidic Acid*/chemistry
Receptors, Lysophosphatidic Acid*/genetics
Receptors, Lysophosphatidic Acid*/metabolism
Osteogenesis/*physiology
Cell Differentiation/physiology ; Cells, Cultured ; Exosomes/metabolism ; Humans ; Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice.
Autorzy :
Ueda H; Department of Molecular Pharmacology, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Neyama H; RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Matsushita Y; Division of Genome Medicine, Institute of Advanced Medical Sciences, Tokushima University, Tokushim 770-8501, Japan.
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Źródło :
Cells [Cells] 2020 Aug 16; Vol. 9 (8). Date of Electronic Publication: 2020 Aug 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Experimental/*metabolism
Hyperalgesia/*metabolism
Neuralgia/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Signal Transduction/*genetics
Animals ; Blood Glucose/analysis ; Body Weight ; Carbamates/pharmacology ; Carbamates/therapeutic use ; Diabetes Mellitus, Experimental/chemically induced ; Diet, High-Fat/adverse effects ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Isoxazoles/pharmacology ; Isoxazoles/therapeutic use ; Lysophospholipids/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neuralgia/chemically induced ; Neuralgia/drug therapy ; Phenylacetates/pharmacology ; Phenylacetates/therapeutic use ; Propionates/pharmacology ; Propionates/therapeutic use ; Receptors, Lysophosphatidic Acid/antagonists & inhibitors ; Receptors, Lysophosphatidic Acid/genetics ; Streptozocin/adverse effects
Czasopismo naukowe
Tytuł :
Lysophosphatidic Acid Receptor Agonism: Discovery of Potent Nonlipid Benzofuran Ethanolamine Structures.
Autorzy :
Guillot E; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.) .
Le Bail JC; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
Paul P; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
Fourgous V; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
Briand P; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
Partiseti M; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
Cornet B; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
Janiak P; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
Philippo C; Diabetes and Cardiovascular Unit, Sanofi R&D, Chilly-Mazarin, France (E.G., J.C.L.B., P.B., P.J.); Global Research Portfolio and Project Management, Sanofi R&D, Chilly-Mazarin, France (C.P.); Translational Science Unit, Sanofi R&D, Chilly-Mazarin, France (P.P., V.F.); In-silico design, Chilly-Mazarin, France (B.C.); and Integrated Drug Discovery, Sanofi R&D, Vitry-Sur-Seine, France (M.P.).
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Aug; Vol. 374 (2), pp. 283-294. Date of Electronic Publication: 2020 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Benzofurans/*chemistry
Benzofurans/*pharmacology
Ethanolamine/*chemistry
Receptors, Lysophosphatidic Acid/*agonists
Adipocytes/cytology ; Adipocytes/drug effects ; Animals ; Benzofurans/metabolism ; Brain/drug effects ; Brain/metabolism ; CHO Cells ; Cell Differentiation/drug effects ; Cricetulus ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Humans ; Molecular Docking Simulation ; Muscle Contraction/drug effects ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Protein Conformation ; Rabbits ; Rats ; Receptors, Lysophosphatidic Acid/chemistry ; Receptors, Lysophosphatidic Acid/metabolism ; beta-Arrestin 2/metabolism
Czasopismo naukowe
Tytuł :
Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification.
Autorzy :
Alioli CA; Centre de Physiopathologie de Toulouse Purpan INSERM UMR 1043, Toulouse, France.
Demesmay L; Pathophysiology, Diagnosis and treatments of bone diseases, INSERM UMR1033, Lyon, France.
Laurencin-Dalacieux S; Centre de Physiopathologie de Toulouse Purpan INSERM UMR 1043, Toulouse, France.
Beton N; Centre de Physiopathologie de Toulouse Purpan INSERM UMR 1043, Toulouse, France.
Farlay D; Pathophysiology, Diagnosis and treatments of bone diseases, INSERM UMR1033, Lyon, France.
Follet H; Pathophysiology, Diagnosis and treatments of bone diseases, INSERM UMR1033, Lyon, France.
Saber A; Centre de Physiopathologie de Toulouse Purpan INSERM UMR 1043, Toulouse, France.
Duboeuf F; Pathophysiology, Diagnosis and treatments of bone diseases, INSERM UMR1033, Lyon, France.
Chun J; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 90237, USA.
Rivera R; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 90237, USA.
Bouvard D; Institute for Advance Biosciences, Grenoble, France.
Machuca-Gayet I; Pathophysiology, Diagnosis and treatments of bone diseases, INSERM UMR1033, Lyon, France.
Salles JP; Centre de Physiopathologie de Toulouse Purpan INSERM UMR 1043, Toulouse, France.
Gennero I; Centre de Physiopathologie de Toulouse Purpan INSERM UMR 1043, Toulouse, France.
Peyruchaud O; Pathophysiology, Diagnosis and treatments of bone diseases, INSERM UMR1033, Lyon, France. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2020 Aug; Vol. 1865 (8), pp. 158715. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Osteoblasts/*metabolism
Osteocytes/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Animals ; Bone Density ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Osteogenesis ; Receptors, Lysophosphatidic Acid/deficiency ; Receptors, Lysophosphatidic Acid/genetics
Czasopismo naukowe
Tytuł :
Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages.
Autorzy :
Gaire BP; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.
Lee CH; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.
Kim W; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.
Sapkota A; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.
Lee DY; Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute for Agricultural and Life Sciences, Seoul National University, Seoul 08826, Korea.
Choi JW; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea.
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Źródło :
Cells [Cells] 2020 Jul 22; Vol. 9 (8). Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imiquimod/*adverse effects
Inflammasomes/*metabolism
Macrophages/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Psoriasis/*blood
Psoriasis/*chemically induced
Receptors, Lysophosphatidic Acid/*blood
Animals ; Bone Marrow Cells/cytology ; Cells, Cultured ; Disease Models, Animal ; Gene Knockdown Techniques ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred ICR ; Receptors, Lysophosphatidic Acid/antagonists & inhibitors ; Receptors, Lysophosphatidic Acid/genetics ; Signal Transduction/genetics ; Skin/injuries ; Skin/metabolism ; Transfection ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Engineering of siRNA loaded PLGA Nano-Particles for highly efficient silencing of GPR87 gene as a target for pancreatic cancer treatment.
Autorzy :
Ceylan S; Department of Medicinal Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey.
Bahadori F; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey.
Akbas F; Department of Medicinal Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
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Źródło :
Pharmaceutical development and technology [Pharm Dev Technol] 2020 Sep; Vol. 25 (7), pp. 855-864. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Nanoparticles*/administration & dosage
Polylactic Acid-Polyglycolic Acid Copolymer*/administration & dosage
Gene Targeting/*methods
Pancreatic Neoplasms/*genetics
RNA, Small Interfering/*genetics
Receptors, Lysophosphatidic Acid/*genetics
Animals ; Cell Line, Tumor ; Gene Silencing/physiology ; Genetic Engineering/methods ; HEK293 Cells ; Humans ; Pancreatic Neoplasms/therapy ; RNA, Small Interfering/administration & dosage ; Receptors, Lysophosphatidic Acid/antagonists & inhibitors ; Renilla
Czasopismo naukowe
Tytuł :
Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse.
Autorzy :
Ledein L; Cardiovascular & Metabolism Unit, Sanofi, Chilly-Mazarin, France.
Léger B; Cardiovascular & Metabolism Unit, Sanofi, Chilly-Mazarin, France.
Dees C; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
Beyer C; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
Distler A; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
Vettori S; Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy.
Boukaiba R; IDD Department, Sanofi, Vitry-sur-Seine, France.
Bidouard JP; Cardiovascular & Metabolism Unit, Sanofi, Chilly-Mazarin, France.
Schaefer M; R&D Diabetes Division, Sanofi, Frankfurt, Germany.
Pernerstorfer J; R&D Diabetes Division, Sanofi, Frankfurt, Germany.
Ruetten H; R&D Diabetes Division, Sanofi, Frankfurt, Germany.
Jagerschmidt A; Cardiovascular & Metabolism Unit, Sanofi, Chilly-Mazarin, France.
Janiak P; Cardiovascular & Metabolism Unit, Sanofi, Chilly-Mazarin, France.
Distler JHW; Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
Distler O; Department of Rheumatology, University Hospital Zurich, Zürich, Switzerland.
Illiano S; Cardiovascular & Metabolism Unit, Sanofi, Chilly-Mazarin, France.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2020 Sep; Vol. 177 (18), pp. 4296-4309. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Lysophosphatidic Acid*
Scleroderma, Systemic*/drug therapy
Scleroderma, Systemic*/pathology
Animals ; Disease Models, Animal ; Fibroblasts/pathology ; Fibrosis ; Humans ; Mice ; Skin/pathology
Czasopismo naukowe
Tytuł :
LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.
Autorzy :
Shukla PK; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Meena AS; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Gangwar R; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Szabo E; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Balogh A; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Chin Lee S; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Vandewalle A; INSERM U773, Centre de Recherche Biomédicale, Bichat-Beaujon, CRB3, UFR de Médecine, Paris Cedex 18, France.
Tigyi G; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Rao R; Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Sep; Vol. 34 (9), pp. 11641-11657. Date of Electronic Publication: 2020 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Radiation, Ionizing*
Colon/*radiation effects
Intestinal Mucosa/*radiation effects
Receptors, Lysophosphatidic Acid/*genetics
Tight Junctions/*radiation effects
Adherens Junctions/drug effects ; Adherens Junctions/metabolism ; Adherens Junctions/radiation effects ; Animals ; Caco-2 Cells ; Cell Line ; Colon/drug effects ; Colon/metabolism ; Humans ; Intercellular Junctions/drug effects ; Intercellular Junctions/metabolism ; Intercellular Junctions/radiation effects ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Lysophospholipids/pharmacology ; Mice, Knockout ; Permeability/drug effects ; Permeability/radiation effects ; Receptors, Lysophosphatidic Acid/metabolism ; Tight Junction Proteins/genetics ; Tight Junction Proteins/metabolism ; Tight Junctions/drug effects ; Tight Junctions/metabolism
Czasopismo naukowe
Tytuł :
LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.
Autorzy :
Zhang HP; Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. .
Chen QK
Xu JF
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Źródło :
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2020 Sep; Vol. 24 (17), pp. 8902-8910.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
Neoplasm Proteins/*metabolism
Proto-Oncogene Proteins/*metabolism
Receptors, Lysophosphatidic Acid/*metabolism
Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line ; Cell Proliferation ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Nude ; Middle Aged ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Receptors, Lysophosphatidic Acid/genetics
Czasopismo naukowe
Tytuł :
The curly coat phenotype of the Ural Rex feline breed is associated with a mutation in the lipase H gene.
Autorzy :
Manakhov AD; Laboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str., 3, Moscow, 119333, Russia.; Centre for Genetics and Genetic Technologies, Faculty of Biology, Lomonosov Moscow State University, Lomonosovsky prospekt, 27-1, Moscow, 119192, Russia.
Andreeva TV; Laboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str., 3, Moscow, 119333, Russia.; Centre for Genetics and Genetic Technologies, Faculty of Biology, Lomonosov Moscow State University, Lomonosovsky prospekt, 27-1, Moscow, 119192, Russia.
Rogaev EI; Laboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str., 3, Moscow, 119333, Russia.; Centre for Genetics and Genetic Technologies, Faculty of Biology, Lomonosov Moscow State University, Lomonosovsky prospekt, 27-1, Moscow, 119192, Russia.; Department of Psychiatry, University of Massachusetts Medical School, Maple Avenue, 222, Shrewsbury, MA, 01545, USA.
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Źródło :
Animal genetics [Anim Genet] 2020 Aug; Vol. 51 (4), pp. 584-589. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Cats/*genetics
Hair/*anatomy & histology
Keratins, Hair-Specific/*genetics
Lipase/*genetics
Receptors, Lysophosphatidic Acid/*genetics
Animals ; Keratins, Hair-Specific/metabolism ; Lipase/metabolism ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Receptors, Lysophosphatidic Acid/metabolism ; Species Specificity
Czasopismo naukowe

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