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Wyszukujesz frazę ""Receptors, Metabotropic Glutamate"" wg kryterium: Temat


Tytuł :
Pathogenic GRM7 Mutations Associated with Neurodevelopmental Disorders Impair Axon Outgrowth and Presynaptic Terminal Development.
Autorzy :
Song JM; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.; Transplantation Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
Kang M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.; Transplantation Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
Park DH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.; Transplantation Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
Park S; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.; Transplantation Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
Lee S; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.; Transplantation Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
Suh YH; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea .; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.; Transplantation Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Mar 17; Vol. 41 (11), pp. 2344-2359. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Presynaptic Terminals*
Axons/*pathology
Neurodevelopmental Disorders/*genetics
Neurodevelopmental Disorders/*pathology
Point Mutation/*genetics
Receptors, Metabotropic Glutamate/*genetics
Animals ; Axons/drug effects ; Cell Count ; Cell Survival ; Cyclic AMP-Dependent Protein Kinases/biosynthesis ; Cyclic AMP-Dependent Protein Kinases/genetics ; Female ; Gene Expression Regulation ; Male ; Neurons/metabolism ; Neurons/pathology ; Pregnancy ; Primary Cell Culture ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/biosynthesis ; Receptors, Metabotropic Glutamate/drug effects ; Signal Transduction/genetics ; Synapses/pathology ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Conformational rearrangement during activation of a metabotropic glutamate receptor.
Autorzy :
Liauw BW; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Afsari HS; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Vafabakhsh R; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Mar; Vol. 17 (3), pp. 291-297. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutamic Acid/*chemistry
Receptors, Metabotropic Glutamate/*chemistry
Allosteric Regulation ; Amino Acids/pharmacology ; Binding Sites ; Biosensing Techniques ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cyclopropanes/pharmacology ; Fluorescence Resonance Energy Transfer ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glutamic Acid/pharmacology ; Glycine/analogs & derivatives ; Glycine/pharmacology ; HEK293 Cells ; Humans ; Ligands ; Models, Molecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization/drug effects ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/genetics ; Receptors, Metabotropic Glutamate/metabolism ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
Autorzy :
Shen Y; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Zhang ZC; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China. Electronic address: .
Cheng S; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Liu A; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Zuo J; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Xia S; Institute of Neuroscience, Soochow University, Suzhou 215000, China.
Liu X; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Liu W; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Jia Z; Neurosciences and Mental Health Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1A1, Canada.
Xie W; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China.
Han J; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China; Department of Neurology, Affiliated ZhongDa Hospital, Institute of Neuropsychiatry, Southeast University, Nanjing, Jiangsu 210009, China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1425-1438.e10. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Synaptic Depression*
Peptide Chain Elongation, Translational*
DNA-Binding Proteins/*metabolism
Hippocampus/*metabolism
Peptide Elongation Factor 2/*metabolism
Receptors, Metabotropic Glutamate/*biosynthesis
Animals ; DNA-Binding Proteins/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Mice ; Mice, Knockout ; Peptide Elongation Factor 2/genetics ; Phosphorylation ; Receptors, Metabotropic Glutamate/genetics
Czasopismo naukowe
Tytuł :
Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains.
Autorzy :
Bratek-Gerej E; Department of Neurochemistry, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland.
Bronisz A; Tumor Microenvironment Laboratory, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland.
Ziembowicz A; Department of Neurochemistry, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland.
Salinska E; Department of Neurochemistry, Mossakowski Medical Research Institute Polish Academy of Sciences, Warsaw, Poland.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Mar 06; Vol. 2021, pp. 8848015. Date of Electronic Publication: 2021 Mar 06 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Hypoxia-Ischemia, Brain/*pathology
Receptors, Metabotropic Glutamate/*agonists
Amino Acids/pharmacology ; Animals ; Animals, Newborn ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Caspase 3/metabolism ; Caspase 9/metabolism ; Dipeptides/pharmacology ; Female ; Hippocampus/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Rats, Wistar ; Receptors, Metabotropic Glutamate/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
GABAergic and glycinergic systems regulate ON-OFF electroretinogram by cooperatively modulating cone pathways in the amphibian retina.
Autorzy :
Hirasawa H; Department of Physiology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Miwa N; Department of Physiology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Watanabe SI; Department of Physiology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2021 Mar; Vol. 53 (5), pp. 1428-1440. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electroretinography*
Receptors, Metabotropic Glutamate*
Amphibians ; Animals ; Retina ; Retinal Cone Photoreceptor Cells
Czasopismo naukowe
Tytuł :
Metabotropic Glutamate Receptors at the Aged Mossy Fiber - CA3 Synapse of the Hippocampus.
Autorzy :
Griego E; Departamento de Farmacobiología, Cinvestav Sede Sur, México City, Mexico.
Galván EJ; Departamento de Farmacobiología, Cinvestav Sede Sur, México City, Mexico. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2021 Feb 21; Vol. 456, pp. 95-105. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mossy Fibers, Hippocampal*
Receptors, Metabotropic Glutamate*/metabolism
CA3 Region, Hippocampal/*cytology
Humans ; Synapses/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.
Autorzy :
Cachope R; CHDI Foundation, USA; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.
Pereda AE; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: .
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Źródło :
Neuroscience [Neuroscience] 2021 Feb 21; Vol. 456, pp. 85-94. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Receptors, Metabotropic Glutamate*
Electrical Synapses ; Gap Junctions ; Neuronal Plasticity ; Synapses ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the developing somatosensory cortex.
Autorzy :
Mascio G; IRCCS Neuromed, Pozzilli, Italy.
Bucci D; IRCCS Neuromed, Pozzilli, Italy.
Notartomaso S; IRCCS Neuromed, Pozzilli, Italy.
Liberatore F; IRCCS Neuromed, Pozzilli, Italy.
Antenucci N; Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
Scarselli P; IRCCS Neuromed, Pozzilli, Italy.
Imbriglio T; IRCCS Neuromed, Pozzilli, Italy.
Caruso S; Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
Gradini R; Department of Experimental Medicine, Sapienza University, Rome, Italy.
Cannella M; IRCCS Neuromed, Pozzilli, Italy.
Di Menna L; IRCCS Neuromed, Pozzilli, Italy.
Bruno V; IRCCS Neuromed, Pozzilli, Italy.; Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
Battaglia G; IRCCS Neuromed, Pozzilli, Italy.; Department of Physiology and Pharmacology, Sapienza University, Rome, Italy.
Nicoletti F; IRCCS Neuromed, Pozzilli, Italy. .; Department of Physiology and Pharmacology, Sapienza University, Rome, Italy. .
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Źródło :
Translational psychiatry [Transl Psychiatry] 2021 Feb 18; Vol. 11 (1), pp. 109. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Metabotropic Glutamate*
Somatosensory Cortex*
Animals ; Extracellular Matrix/metabolism ; Interneurons/metabolism ; Mice ; Parvalbumins/metabolism
Czasopismo naukowe
Tytuł :
Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression.
Autorzy :
Zhang Z; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Zheng X; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Liu Y; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Luan Y; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Wang L; Department of Obstetrics and Gynecology, Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, China.
Zhao L; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Zhang J; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Tian Y; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Lu H; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Chen X; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Liu Y; Institute of Neurobiology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 Feb; Vol. 156 (4), pp. 465-480. Date of Electronic Publication: 2020 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*physiology
Lateral Ventricles/*metabolism
Neural Stem Cells/*metabolism
PTEN Phosphohydrolase/*biosynthesis
Receptors, Metabotropic Glutamate/*metabolism
Anilides/pharmacology ; Animals ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Cells, Cultured ; Cyclohexanecarboxylic Acids/pharmacology ; Dose-Response Relationship, Drug ; Gene Expression ; Lateral Ventricles/cytology ; Lateral Ventricles/drug effects ; Male ; Neural Stem Cells/drug effects ; Neurogenesis/drug effects ; Neurogenesis/physiology ; PTEN Phosphohydrolase/genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/agonists
Czasopismo naukowe
Tytuł :
Regulation of the parental gene GRM4 by circGrm4 RNA transcript and glutamate-mediated neurovascular toxicity in eyes.
Autorzy :
Eyob W; College of Arts and Sciences, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
George AK; Eye and Vision Science Laboratory, Department of Physiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Homme RP; Eye and Vision Science Laboratory, Department of Physiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Stanisic D; Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Sandhu H; Department of Ophthalmology and Visual Sciences and Kentucky Lions Eye Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Tyagi SC; Department of Physiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Singh M; Eye and Vision Science Laboratory, Department of Physiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Feb; Vol. 476 (2), pp. 663-673. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cystathionine beta-Synthase/*genetics
Eye/*blood supply
Eye/*metabolism
Glutamic Acid/*metabolism
MicroRNAs/*metabolism
RNA, Circular/*metabolism
Receptors, Metabotropic Glutamate/*metabolism
Animals ; Cystathionine beta-Synthase/metabolism ; Endothelial Cells/metabolism ; Epigenesis, Genetic ; Eye Diseases/chemically induced ; Eye Diseases/genetics ; Eye Diseases/metabolism ; Eye Diseases/pathology ; Homocysteine/metabolism ; Humans ; Hyperhomocysteinemia/genetics ; MicroRNAs/genetics ; RNA, Circular/genetics ; Receptors, Metabotropic Glutamate/genetics ; Vascular Diseases/chemically induced ; Vascular Diseases/genetics ; Vascular Diseases/metabolism ; Vascular Diseases/pathology
Czasopismo naukowe
Tytuł :
N-linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1.
Autorzy :
Park DH; Department of Biomedical Sciences, Neuroscience Research Institute, Transplantation Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Park S; Department of Biomedical Sciences, Neuroscience Research Institute, Transplantation Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Song JM; Department of Biomedical Sciences, Neuroscience Research Institute, Transplantation Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Kang M; Department of Biomedical Sciences, Neuroscience Research Institute, Transplantation Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Lee S; Department of Biomedical Sciences, Neuroscience Research Institute, Transplantation Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Horak M; Institute of Physiology of the Czech Academy of Sciences, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague 4, Czech Republic.
Suh YH; Department of Biomedical Sciences, Neuroscience Research Institute, Transplantation Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Nov; Vol. 34 (11), pp. 14977-14996. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Synaptic Transmission*
Cell Membrane/*metabolism
Nerve Tissue Proteins/*metabolism
Neurons/*metabolism
Polysaccharides/*metabolism
Receptors, Metabotropic Glutamate/*metabolism
Animals ; Autophagy ; Cell Movement ; Female ; Glycosylation ; Nerve Tissue Proteins/genetics ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/chemistry ; Receptors, Metabotropic Glutamate/genetics
Czasopismo naukowe
Tytuł :
Group II Metabotropic Glutamate Receptors Modulate Sound Evoked and Spontaneous Activity in the Mouse Inferior Colliculus.
Autorzy :
Kristaponyte I; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272 .; School of Biomedical Sciences, Kent State University, Kent, OH 44240.
Beebe NL; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272.
Young JW; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272.
Shanbhag SJ; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272.
Schofield BR; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272.
Galazyuk AV; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272.
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Źródło :
ENeuro [eNeuro] 2021 Jan 15; Vol. 8 (1). Date of Electronic Publication: 2021 Jan 15 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Inferior Colliculi*
Receptors, Metabotropic Glutamate*/genetics
Animals ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Sound
Czasopismo naukowe
Tytuł :
Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats.
Autorzy :
Wang J; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Jiang C; Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Shenzhen Nanshan People's Hospital and the 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, People's Republic of China.
Ba X; Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Shenzhen Nanshan People's Hospital and the 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, People's Republic of China.
Yang S; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Wu J; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Huang Z; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Jin G; School of Pharmaceutical Sciences, Nation-regional Engineering Lab for Synthetic Biology of Medicine, International Cancer Center, Shenzhen University Health Science Center, Shenzhen, People's Republic of China.
Hao Y; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2021 Jan; Vol. 238 (1), pp. 107-119. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Pain/*prevention & control
Benzhydryl Compounds/*pharmacology
Excitatory Amino Acid Agonists/*pharmacology
Neuralgia/*prevention & control
Paclitaxel/*adverse effects
Receptors, Metabotropic Glutamate/*agonists
Acute Pain/metabolism ; Allosteric Regulation/drug effects ; Animals ; Glutamic Acid/metabolism ; Male ; Neuralgia/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Metabotropic Glutamate/metabolism ; Spinal Cord/drug effects ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.
Autorzy :
Zhang Q; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hangkong Road, Wuhan, 430030, People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Chen X; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hangkong Road, Wuhan, 430030, People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Li S; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hangkong Road, Wuhan, 430030, People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Yao T; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hangkong Road, Wuhan, 430030, People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Wu J; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hangkong Road, Wuhan, 430030, People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address: .
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Źródło :
Journal of psychiatric research [J Psychiatr Res] 2021 Jan; Vol. 132, pp. 65-71. Date of Electronic Publication: 2020 Oct 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Attention Deficit Disorder with Hyperactivity*/genetics
Receptors, Metabotropic Glutamate*/genetics
Case-Control Studies ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
Autorzy :
Masugi-Tokita M; Department of Urology, Shiga University of Medical Science, Otsu, Japan. .; World Premier International Research Center Initiative-Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, Japan. .; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan. .
Tomita K; Department of Urology, Shiga University of Medical Science, Otsu, Japan.
Kobayashi K; Department of Urology, Shiga University of Medical Science, Otsu, Japan.
Yoshida T; Department of Urology, Shiga University of Medical Science, Otsu, Japan.
Kageyama S; Department of Urology, Shiga University of Medical Science, Otsu, Japan.
Sakamoto H; Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University, Setouchi, Japan.
Kawauchi A; Department of Urology, Shiga University of Medical Science, Otsu, Japan.
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2020 Dec; Vol. 57 (12), pp. 5208-5218. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Ejaculation/*physiology
Receptors, Metabotropic Glutamate/*metabolism
Animals ; Axons/metabolism ; Ejaculation/drug effects ; Female ; Galanin/metabolism ; Lumbar Vertebrae/drug effects ; Lumbar Vertebrae/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Biological ; Nitric Oxide Synthase Type I/metabolism ; Parasympathetic Nervous System/drug effects ; Parasympathetic Nervous System/physiology ; Pyridones/pharmacology ; Receptors, Metabotropic Glutamate/antagonists & inhibitors ; Sexual Behavior, Animal/drug effects ; Spinal Cord/drug effects ; Spinal Cord/physiology ; Synapses/drug effects ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Regulation of Glutamatergic Activity via Bidirectional Activation of Two Select Receptors as a Novel Approach in Antipsychotic Drug Discovery.
Autorzy :
Cieślik P; Department of Neurobiology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smętna Street, 31-343 Krakow, Poland.
Wierońska JM; Department of Neurobiology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smętna Street, 31-343 Krakow, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 20; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antipsychotic Agents/*therapeutic use
Muscarinic Antagonists/*therapeutic use
Receptors, Metabotropic Glutamate/*antagonists & inhibitors
Receptors, Muscarinic/*metabolism
Schizophrenia/*drug therapy
Animals ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Drug Combinations ; Drug Discovery ; Humans ; Receptors, Metabotropic Glutamate/metabolism
Czasopismo naukowe
Tytuł :
Synthesis and SAR of a series of mGlu 7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core.
Autorzy :
Kalbfleisch JJ; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA.
Reed CW; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Park C; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Spearing PK; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Quitalig MC; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Jenkins MT; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Rodriguez AL; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Blobaum AL; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Conn PJ; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.
Niswender CM; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: .
Lindsley CW; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Nov 15; Vol. 30 (22), pp. 127529. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Receptors, Metabotropic Glutamate/*antagonists & inhibitors
Allosteric Regulation/drug effects ; Dose-Response Relationship, Drug ; High-Throughput Screening Assays ; Humans ; Molecular Structure ; Receptors, Metabotropic Glutamate/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The mGluR2/3 agonist pomaglumetad methionil normalizes aberrant dopamine neuron activity via action in the ventral hippocampus.
Autorzy :
Sonnenschein SF; Departments of Neuroscience, Psychiatry and Psychology, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA. .
Grace AA; Departments of Neuroscience, Psychiatry and Psychology, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
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Źródło :
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2020 Nov; Vol. 45 (12), pp. 2106-2113. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dopaminergic Neurons*
Receptors, Metabotropic Glutamate*
Action Potentials ; Amino Acids ; Animals ; Female ; Hippocampus ; Humans ; Rats ; Rats, Sprague-Dawley ; Ventral Tegmental Area
Czasopismo naukowe
Tytuł :
Cholesterol Localization around the Metabotropic Glutamate Receptor 2.
Autorzy :
Kurth M; Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Lolicato F; Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Sandoval-Perez A; Max Planck Tandem Group in Computational Biophysics, University of Los Andes, Bogotá, Colombia.
Amaya-Espinosa H; Max Planck Tandem Group in Computational Biophysics, University of Los Andes, Bogotá, Colombia.
Teslenko A; Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Sinning I; Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Beck R; Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Brügger B; Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Aponte-Santamaría C; Max Planck Tandem Group in Computational Biophysics, University of Los Andes, Bogotá, Colombia.; Interdisciplinary Center for Scientific Computing, University of Heidelberg, Heidelberg, Germany.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2020 Oct 15; Vol. 124 (41), pp. 9061-9078. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Metabotropic Glutamate*
Amino Acids ; Cholesterol
Czasopismo naukowe

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