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Wyszukujesz frazę ""Receptors, N-Methyl-D-Aspartate"" wg kryterium: Temat


Tytuł:
Rabphilin-3A undergoes phase separation to regulate GluN2A mobility and surface clustering.
Autorzy:
Yang L; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Wei M; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Wang Y; School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Zhang J; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Liu S; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Liu M; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Wang S; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Li K; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Dong Z; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China.
Zhang C; School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, China. .; Chinese Institute for Brain Research, Beijing, 102206, China. .; State Key Laboratory of Translational Medicine and Innovative Drug Development, Nanjing, 210000, Jiangsu, China. .; Beijing Laboratory of Oral Health, Capital Medical University, Beijing, 100050, China. .
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Źródło:
Nature communications [Nat Commun] 2023 Jan 24; Vol. 14 (1), pp. 379. Date of Electronic Publication: 2023 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Hippocampus*/metabolism
Receptors, N-Methyl-D-Aspartate*/genetics
Receptors, N-Methyl-D-Aspartate*/metabolism
Synapses*/genetics
Synapses*/metabolism
Neurons*/metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Vesicular Transport Proteins/metabolism
Czasopismo naukowe
Tytuł:
Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus.
Autorzy:
Reyes-Méndez ME; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.
Herrera-Zamora JM; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.
Osuna-Lopez F; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.
Aguilar-Martínez IS; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.
Góngora-Alfaro JL; Departamento de Neurociencias, Centro de Investigaciones Regionales 'Dr. Hideyo, Noguchi', Universidad Autónoma de Yucatán, Mérida, México.
Navarro-Polanco RA; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.
Sánchez-Pastor E; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.
Moreno-Galindo EG; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.
Alamilla J; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México.; Consejo Nacional de Ciencia y Tecnología (CONACYT), Universidad de Colima, Colima, México.
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Źródło:
Synapse (New York, N.Y.) [Synapse] 2023 Jan; Vol. 77 (1), pp. e22250. Date of Electronic Publication: 2022 Sep 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/genetics
Receptors, N-Methyl-D-Aspartate*/metabolism
Suprachiasmatic Nucleus*/metabolism
Vesicular Glutamate Transport Protein 2*/metabolism
Animals ; Rats ; Circadian Rhythm/physiology ; Mammals/metabolism ; Retinal Ganglion Cells/metabolism
Czasopismo naukowe
Tytuł:
Systematic analysis to identify novel disease indications and plausible potential chemical leads of glutamate ionotropic receptor NMDA type subunit 1, GRIN1.
Autorzy:
Bhardwaj T; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Ahmad I; Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Somvanshi P; School of Computational & Integrative Sciences (SC&IS), Jawaharlal Nehru University, New Delhi, India.; Special Centre of Systems Medicine (SCSM), Jawaharlal Nehru University, New Delhi, India.
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Źródło:
Journal of molecular recognition : JMR [J Mol Recognit] 2023 Jan; Vol. 36 (1), pp. e2997. Date of Electronic Publication: 2022 Nov 08.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/genetics
Receptors, N-Methyl-D-Aspartate*/chemistry
Receptors, N-Methyl-D-Aspartate*/metabolism
Schizophrenia*/drug therapy
Schizophrenia*/genetics
Schizophrenia*/metabolism
Humans ; Computer Simulation ; Glutamic Acid/metabolism ; Nerve Tissue Proteins/metabolism ; Rare Diseases
Czasopismo naukowe
Tytuł:
Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Autorzy:
Chou TH; W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Kang H; W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Simorowski N; W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Furukawa H; W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2022 Dec 01; Vol. 82 (23), pp. 4548-4563.e4. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/genetics
Receptors, N-Methyl-D-Aspartate*/chemistry
Receptors, N-Methyl-D-Aspartate*/metabolism
Glutamic Acid*/metabolism
Humans ; Glycine/metabolism ; Synaptic Transmission ; Protein Subunits/metabolism
Czasopismo naukowe
Tytuł:
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.
Autorzy:
Yukawa T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Yamashita T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Imaeda T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Kakei H; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Hashizume S; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Nakamura M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Daini M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Okabe A; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Nakashima K; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Harada A; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Narita N; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Bettini E; Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy.
Ugolini A; Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy.
Corsi M; Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy.
Hasui T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Feb 01; Vol. 79, pp. 117150. Date of Electronic Publication: 2022 Dec 24.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/metabolism
Rats ; Animals ; Hippocampus/metabolism
Czasopismo naukowe
Tytuł:
Endogenous d-serine exists in the mammalian brain independent of synthesis by serine racemase.
Autorzy:
Osaki A; Department of Pharmacology, Keio University School of Medicine, 160-8582, Tokyo, Japan.
Aoyama M; Vita-Salute San Raffaele University, 20132, Milano, Italy.
Mita M; KAGAMI INC., 567-0085, Osaka, Japan.
Hamase K; Graduate School of Pharmaceutical Sciences, Kyushu University, 812-8582, Fukuoka, Japan.
Yasui M; Department of Pharmacology, Keio University School of Medicine, 160-8582, Tokyo, Japan.
Sasabe J; Department of Pharmacology, Keio University School of Medicine, 160-8582, Tokyo, Japan. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Jan 22; Vol. 641, pp. 186-191. Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Serine*/metabolism
Receptors, N-Methyl-D-Aspartate*/metabolism
Mice ; Animals ; Brain/metabolism ; Racemases and Epimerases/genetics ; Racemases and Epimerases/metabolism ; Mice, Knockout ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles.
Autorzy:
Nomoto M; Research Centre for Idling Brain Science, University of Toyama, Toyama, 930-0194, Japan. .; Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan. .; CREST, JST, University of Toyama, Toyama, 930-0194, Japan. .
Ohkawa N; Division for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Dokkyo Medical University, Shimotsuga-Gun, Tochigi, 321-0293, Japan.
Inokuchi K; Research Centre for Idling Brain Science, University of Toyama, Toyama, 930-0194, Japan. .; Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan. .; CREST, JST, University of Toyama, Toyama, 930-0194, Japan. .
Oishi N; Research Centre for Idling Brain Science, University of Toyama, Toyama, 930-0194, Japan.; Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.; CREST, JST, University of Toyama, Toyama, 930-0194, Japan.; Pharmaceutical Division, Pharmaceutical Research Laboratory, Drug Discovery and Pharmacology Group, Ube Corporation, 1978-5, Kogushi, Ube, Yamaguchi, 755-8633, Japan.
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Źródło:
Molecular brain [Mol Brain] 2023 Jan 20; Vol. 16 (1), pp. 12. Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
Hippocampus*/metabolism
Mice ; Animals ; Synaptic Transmission ; Mice, Transgenic ; CA3 Region, Hippocampal/metabolism
Czasopismo naukowe
Tytuł:
Muscarinic and NMDA Receptors in the Substantia Nigra Play a Role in Reward-Related Learning.
Autorzy:
Galaj E; Department of Psychological and Brain Sciences, Colgate University, Hamilton, New York, USA.
Barrera ED; The Graduate Center of the City University of New York, New York, New York, USA.
Lynch OL; Department of Psychological and Brain Sciences, Colgate University, Hamilton, New York, USA.
Diodati R; Department of Psychological and Brain Sciences, Colgate University, Hamilton, New York, USA.
Thomas A; Department of Psychological and Brain Sciences, Colgate University, Hamilton, New York, USA.
Schneider P; Department of Psychological and Brain Sciences, Colgate University, Hamilton, New York, USA.
Lenhard H; Department of Psychological and Brain Sciences, Colgate University, Hamilton, New York, USA.
Vashisht A; The Graduate Center of the City University of New York, New York, New York, USA.
Ranaldi R; The Graduate Center of the City University of New York, New York, New York, USA.; Department of Psychology, Queens College of the City University of New York, Flushing, New York, USA.
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Źródło:
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2023 Jan 19; Vol. 26 (1), pp. 80-90.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
N-Methylaspartate*
Rats ; Animals ; Reward ; Scopolamine/pharmacology ; Cholinergic Agents ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł:
Cortical inhibitory but not excitatory synaptic transmission and circuit refinement are altered after the deletion of NMDA receptors during early development.
Autorzy:
Deng R; Department of Biology, University of Maryland, College Park, MD, 20742, USA.; Biological Sciences Graduate Program, University of Maryland, College Park, MD, 20742, USA.
Chang M; Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 733 N. Broadway Avenue / Miller 379, Baltimore, MD, 21205, USA.
Kao JPY; Center for Biomedical Engineering and Technology, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Kanold PO; Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 733 N. Broadway Avenue / Miller 379, Baltimore, MD, 21205, USA. .; Department of Biology, University of Maryland, College Park, MD, 20742, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 12; Vol. 13 (1), pp. 656. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*
Synaptic Transmission*/physiology
Neurons/physiology ; Cerebral Cortex/physiology ; Receptors, AMPA ; Receptors, GABA-A/genetics
Czasopismo naukowe
Tytuł:
NMDA receptor blockade in the dorsolateral striatum impairs consolidation but not retrieval of habit memory.
Autorzy:
Goodman J; Department of Psychology, Delaware State University, Dover, DE, United States.
Leong KC; Department of Psychology, Trinity University, San Antonio, TX, United States.
Packard MG; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.
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Źródło:
Neurobiology of learning and memory [Neurobiol Learn Mem] 2023 Jan; Vol. 197, pp. 107709. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/physiology
N-Methylaspartate*/pharmacology
Rats ; Male ; Animals ; Rats, Long-Evans ; Memory/physiology ; Habits ; 2-Amino-5-phosphonovalerate/pharmacology
Czasopismo naukowe
Tytuł:
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Autorzy:
Liu WY; Innovation Center for Neurological Disorders and Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Xicheng District, Beijing, People's Republic of China.
Li Y; Innovation Center for Neurological Disorders and Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Xicheng District, Beijing, People's Republic of China.
Li Y; Innovation Center for Neurological Disorders and Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Xicheng District, Beijing, People's Republic of China.; Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, People's Republic of China.; Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, People's Republic of China.; Center of Alzheimer's Disease, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, People's Republic of China.; Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, 100053, People's Republic of China.
Xu LZ; Innovation Center for Neurological Disorders and Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Xicheng District, Beijing, People's Republic of China.; Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, People's Republic of China.; Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, People's Republic of China.; Center of Alzheimer's Disease, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, People's Republic of China.; Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, 100053, People's Republic of China.
Jia JP; Innovation Center for Neurological Disorders and Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Xicheng District, Beijing, People's Republic of China. .; Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, People's Republic of China. .; Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, People's Republic of China. .; Center of Alzheimer's Disease, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, People's Republic of China. .; Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, 100053, People's Republic of China. .
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Źródło:
Molecular neurobiology [Mol Neurobiol] 2023 Jan; Vol. 60 (1), pp. 133-144. Date of Electronic Publication: 2022 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Neuroblastoma*/pathology
Neuroprotective Agents*/pharmacology
Receptors, N-Methyl-D-Aspartate*/metabolism
Abietanes*/pharmacology
Humans ; Amyloid beta-Peptides/metabolism ; Apoptosis
Czasopismo naukowe
Tytuł:
Pharmacological characterization and differential expression of NMDA receptor subunits in the chicken vestibular system during development.
Autorzy:
Ramírez A; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México.; Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Monjaraz E; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Manjarrez E; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Moyaho A; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Cebada J; Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Flores A; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México.
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Źródło:
Synapse (New York, N.Y.) [Synapse] 2023 Jan; Vol. 77 (1), pp. e22252. Date of Electronic Publication: 2022 Sep 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
Chickens*/metabolism
Animals ; N-Methylaspartate ; Vestibular System ; Glycine
Czasopismo naukowe
Tytuł:
α2δ-1 protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens.
Autorzy:
Jin D; Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Chen H; Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Chen SR; Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Pan HL; Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
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Źródło:
Journal of neurochemistry [J Neurochem] 2023 Jan; Vol. 164 (2), pp. 143-157. Date of Electronic Publication: 2022 Oct 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
Analgesics, Opioid*/pharmacology
Mice ; Animals ; Nucleus Accumbens ; Gabapentin/pharmacology ; Morphine/pharmacology
Czasopismo naukowe
Tytuł:
Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators.
Autorzy:
Niu M; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.
Yang X; Department of Pharmaceutical Engineering, Hebei Chemical & Pharmaceutical College, Fangxing Road 88, Shijiazhuang, 050026, Hebei, China.; Hebei Technological Innovation Center of Chiral Medicine, Shijiazhuang, China.
Li Y; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.
Sun Y; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, China.; State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, China.
Wang L; Department of Family and Consumer Sciences, California State University, Long Beach, USA.
Ha J; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.
Xie Y; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.
Gao Z; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China.; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, China.; State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, China.
Tian C; Department of Anesthesiology, The First Hospital of Hebei Medical University, Donggang Road 89, Shijiazhuang, 050000, Hebei, China. .
Wang L; Department of Pharmaceutical Engineering, Hebei Chemical & Pharmaceutical College, Fangxing Road 88, Shijiazhuang, 050026, Hebei, China. .; Hebei Technological Innovation Center of Chiral Medicine, Shijiazhuang, China. .
Sun Y; Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, Hebei, China. .; Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, China. .; State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, China. .
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Źródło:
Cellular and molecular neurobiology [Cell Mol Neurobiol] 2023 Jan; Vol. 43 (1), pp. 139-153. Date of Electronic Publication: 2022 Jan 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
Neuronal Plasticity*
Excitatory Amino Acid Antagonists/pharmacology
Czasopismo naukowe
Tytuł:
Roles of Phosphorylation of N-Methyl-D-Aspartate Receptor in Chronic Pain.
Autorzy:
Pan L; Department of Biochemistry and Molecular Biology and Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.; Hunan Key Laboratory of Animal Models for Human Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Li T; Department of Biochemistry and Molecular Biology and Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.; Hunan Key Laboratory of Animal Models for Human Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Wang R; Department of Biochemistry and Molecular Biology and Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.; Hunan Key Laboratory of Animal Models for Human Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Deng W; Department of Biochemistry and Molecular Biology and Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.; Hunan Key Laboratory of Animal Models for Human Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Pu H; College of Advanced Interdisciplinary Studies, National University of Defense Technology, Changsha, 410073, Hunan, China. .
Deng M; Department of Biochemistry and Molecular Biology and Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China. .; Hunan Key Laboratory of Animal Models for Human Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China. .
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Źródło:
Cellular and molecular neurobiology [Cell Mol Neurobiol] 2023 Jan; Vol. 43 (1), pp. 155-175. Date of Electronic Publication: 2022 Jan 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*/metabolism
Chronic Pain*/drug therapy
Humans ; Phosphorylation ; src-Family Kinases/metabolism ; Protein Kinase C/metabolism
Czasopismo naukowe
Tytuł:
Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice.
Autorzy:
Alfaro-Ruiz R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, Albacete, Spain.
Aguado C; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, Albacete, Spain.
Martín-Belmonte A; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, Albacete, Spain.
Moreno-Martínez AE; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, Albacete, Spain.
Merchán-Rubira J; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Hernández F; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, ISCIII, Madrid, Spain.
Ávila J; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, ISCIII, Madrid, Spain.
Fukazawa Y; Division of Brain Structure and Function, Faculty of Medical Science, University of Fukui, Fukui, Japan.; Life Science Innovation Center, University of Fukui, Fukui, Japan.
Luján R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas (IDINE), Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Campus Biosanitario, Albacete, Spain.
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Źródło:
Brain pathology (Zurich, Switzerland) [Brain Pathol] 2023 Jan; Vol. 33 (1), pp. e13115. Date of Electronic Publication: 2022 Sep 04.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*
Hippocampus*/metabolism
Mice ; Animals ; Mice, Transgenic ; CA1 Region, Hippocampal ; Dendrites ; Synapses/metabolism
Czasopismo naukowe
Tytuł:
How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway.
Autorzy:
Bonansco C; Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.
Cerpa W; Laboratorio de Función y Patología Neuronal, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.; Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas 6200000, Chile.
Inestrosa NC; Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas 6200000, Chile.; Centro de Envejecimiento y Regeneración (CARE UC), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 31; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Wnt Signaling Pathway*
Receptors, N-Methyl-D-Aspartate*/metabolism
Synapses/metabolism ; Synaptic Transmission/physiology ; Neurons/metabolism
Czasopismo naukowe
Tytuł:
Rho-Kinase/ROCK Phosphorylates PSD-93 Downstream of NMDARs to Orchestrate Synaptic Plasticity.
Autorzy:
Hossen E; Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Nagoya 466-8550, Japan.; Division of Cell Biology, International Center for Brain Science, Fujita Health University, Toyoake 470-1192, Japan.
Funahashi Y; Division of Cell Biology, International Center for Brain Science, Fujita Health University, Toyoake 470-1192, Japan.
Faruk MO; Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Nagoya 466-8550, Japan.; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Dhaka, Dhaka 1000, Bangladesh.
Ahammad RU; Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Nagoya 466-8550, Japan.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Amano M; Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Nagoya 466-8550, Japan.
Yamada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Nagoya 466-8550, Japan.
Kaibuchi K; Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Nagoya 466-8550, Japan.; Division of Cell Biology, International Center for Brain Science, Fujita Health University, Toyoake 470-1192, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 26; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 26.
Typ publikacji:
Journal Article
MeSH Terms:
rho-Associated Kinases*/metabolism
Receptors, N-Methyl-D-Aspartate*/metabolism
Chromatography, Liquid ; Tandem Mass Spectrometry ; Neuronal Plasticity/physiology ; Synaptic Transmission/physiology ; Disks Large Homolog 4 Protein/metabolism ; Synapses/metabolism ; Hippocampus/metabolism
Czasopismo naukowe
Tytuł:
Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats.
Autorzy:
Zhang M; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Chen Y; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Liu J; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Yang Y; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Wang R; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Zhang D; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
Zhu T; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
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Źródło:
Frontiers in neural circuits [Front Neural Circuits] 2022 Dec 15; Vol. 16, pp. 1065374. Date of Electronic Publication: 2022 Dec 15 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anesthetics, Inhalation*/pharmacology
Electroencephalography*/drug effects
Receptors, N-Methyl-D-Aspartate*/metabolism
Cerebral Cortex*/drug effects
Cerebral Cortex*/embryology
Animals ; Rats ; Isoflurane/pharmacology ; Sevoflurane/pharmacology
Czasopismo naukowe
Tytuł:
Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects.
Autorzy:
Burgdorf JS; Gate Neurosciences, Inc., Carmel, Indiana, USA.
Zhang XL; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, USA.
Stanton PK; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York, USA.
Moskal JR; Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Illinois, USA.
Donello JE; Gate Neurosciences, Inc., Carmel, Indiana, USA.
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Źródło:
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2022 Dec 12; Vol. 25 (12), pp. 979-991.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, N-Methyl-D-Aspartate*
Depressive Disorder, Major*/drug therapy
Animals ; Rats ; Mice ; Rats, Sprague-Dawley ; Antidepressive Agents/therapeutic use ; Long-Term Potentiation/physiology ; Phencyclidine/pharmacology
Czasopismo naukowe

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