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Wyszukujesz frazę ""Receptors, N-Methyl-D-Aspartate"" wg kryterium: Temat


Tytuł :
APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis.
Autorzy :
Ramakrishna S; Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India.; The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bangalore 560064, India.; Centre for Brain Research, Indian Institute of Science Campus, Bangalore 560012, India.
Jhaveri V; Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India.
Konings SC; Experimental Dementia Research Unit, Department of Experimental Medical Science, Lund University, Lund 22184, Sweden.
Nawalpuri B; Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India.; The Shanmugha Arts, Science, Technology and Research Academy, Thanjavur 613401, India.; Centre for Brain Research, Indian Institute of Science Campus, Bangalore 560012, India.
Chakraborty S; Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India.
Holst B; Bioneer A/S, Hørsholm 2970, Denmark.
Schmid B; Bioneer A/S, Hørsholm 2970, Denmark.
Gouras GK; Experimental Dementia Research Unit, Department of Experimental Medical Science, Lund University, Lund 22184, Sweden.
Freude KK; Department of Veterinary and Animal Sciences, Group of Stem Cell Models for Studies of Neurodegenerative Diseases, Section for Pathobiological Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Muddashetty RS; Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India .; Centre for Brain Research, Indian Institute of Science Campus, Bangalore 560012, India.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Oct 20; Vol. 41 (42), pp. 8686-8709. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoprotein E4/*toxicity
Calcium Signaling/*drug effects
Homeostasis/*drug effects
Neurons/*drug effects
Protein Biosynthesis/*drug effects
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Adolescent ; Animals ; Calcium Signaling/physiology ; Cells, Cultured ; Cerebral Cortex/cytology ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Homeostasis/physiology ; Humans ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neurons/metabolism ; Protein Biosynthesis/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/biosynthesis ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe
Tytuł :
The C-terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease.
Autorzy :
Warnet XL; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; The Danish Research Institute for Translational Neuroscience (DANDRITE), Aarhus University, Aarhus, Denmark.; The Center for Proteins in Memory (PROMEMO), Aarhus University, Aarhus, Denmark.
Bakke Krog H; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; The Danish Research Institute for Translational Neuroscience (DANDRITE), Aarhus University, Aarhus, Denmark.; The Center for Proteins in Memory (PROMEMO), Aarhus University, Aarhus, Denmark.
Sevillano-Quispe OG; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; The Danish Research Institute for Translational Neuroscience (DANDRITE), Aarhus University, Aarhus, Denmark.; The Center for Proteins in Memory (PROMEMO), Aarhus University, Aarhus, Denmark.
Poulsen H; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; The Danish Research Institute for Translational Neuroscience (DANDRITE), Aarhus University, Aarhus, Denmark.; The Center for Proteins in Memory (PROMEMO), Aarhus University, Aarhus, Denmark.
Kjaergaard M; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; The Danish Research Institute for Translational Neuroscience (DANDRITE), Aarhus University, Aarhus, Denmark.; The Center for Proteins in Memory (PROMEMO), Aarhus University, Aarhus, Denmark.
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2021 Oct; Vol. 54 (8), pp. 6713-6739. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Long-Term Potentiation*
Receptors, N-Methyl-D-Aspartate*/genetics
Receptors, N-Methyl-D-Aspartate*/metabolism
Neuronal Plasticity ; Signal Transduction ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
N-Methyl-D-aspartate (NMDA) and cannabinoid CB 2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.
Autorzy :
Rivas-Santisteban R; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain.; Departament de Bioquímica i Biomedicina Molecular, Universitat de Barcelona, 08028, Barcelona, Spain.
Lillo A; Institut de Neurociències, Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.
Lillo J; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain.; Departament de Bioquímica i Biomedicina Molecular, Universitat de Barcelona, 08028, Barcelona, Spain.
Rebassa JB; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.
Contestí JS; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.
Saura CA; Institut de Neurociències, Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.
Franco R; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain. .; Departament de Bioquímica i Biomedicina Molecular, Universitat de Barcelona, 08028, Barcelona, Spain. .; School of Chemistry, University of Barcelona, Barcelona, Spain. .
Navarro G; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain. .; Institut de Neurociències, Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain. .; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain. .
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Źródło :
Alzheimer's research & therapy [Alzheimers Res Ther] 2021 Nov 08; Vol. 13 (1), pp. 184. Date of Electronic Publication: 2021 Nov 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cannabinoids*
Microglia*/metabolism
Receptors, Cannabinoid*
Receptors, N-Methyl-D-Aspartate*/metabolism
Animals ; Hippocampus/metabolism ; Humans ; Mice ; N-Methylaspartate ; Neurons/metabolism
Czasopismo naukowe
Tytuł :
Altered EEG markers of synaptic plasticity in a human model of NMDA receptor deficiency: Anti-NMDA receptor encephalitis.
Autorzy :
Gefferie SR; Department of Neuropediatrics, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Stichting Epilepsie Instellingen Nederland (SEIN), 2103 SW, Heemstede, Netherlands.
Maric A; Department of Neurology, University Hospital Zurich, University of Zurich, 8091, Zurich, Switzerland.
Critelli H; Department of Neuropediatrics, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland.
Gueden S; Service de Pédiatrie, CHU d'Angers, 49933, Angers, France.
Kurlemann G; Children's Hospital Bonifatius Klinik, 49808, Lingen, Germany.
Kurth S; Pulmonary Clinic, University Hospital Zurich, University of Zurich, 8091, Zurich, Switzerland; Department of Psychology, University of Fribourg, 1700, Fribourg, Switzerland.
Nosadini M; Pediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padua, 35122, Padua, Italy.
Plecko B; Department of Neuropediatrics, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Department of Pediatrics and Adolescent Medicine, Division of General Pediatrics, Medical University of Graz, 8036, Graz, Austria.
Ringli M; Department of Neurology, Inselspital, University Hospital Bern, 3010, Bern, Switzerland.
Rostásy K; Department of Pediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, 58448, Datteln/Witten, Germany.
Sartori S; Pediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padua, 35122, Padua, Italy.
Schmitt B; Department of Neuropediatrics, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland.
Suppiej A; Pediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University of Padua, 35122, Padua, Italy; Department of Medical Sciences, Pediatric Section, University of Ferrara, 44121, Ferrara, Italy.
Van Bogaert P; Service de Pédiatrie, CHU d'Angers, 49933, Angers, France.
Wehrle FM; Children's Research Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Department of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland.
Huber R; Children's Research Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8091, Zurich, Switzerland.
Bölsterli BK; Department of Neuropediatrics, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, University of Zurich, 8032, Zurich, Switzerland. Electronic address: .
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Źródło :
NeuroImage [Neuroimage] 2021 Oct 01; Vol. 239, pp. 118281. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*physiopathology
Brain Waves/*physiology
Electroencephalography/*methods
Receptors, N-Methyl-D-Aspartate/*deficiency
Sleep Stages/*physiology
Adolescent ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnostic imaging ; Child ; Child, Preschool ; Female ; Humans ; Male ; Receptors, N-Methyl-D-Aspartate/immunology ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα.
Autorzy :
Amici M; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Lee Y; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Pope RJP; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Bradley CA; Neurosciences and Mental Health, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.
Cole A; Neurosignalling and Mood Disorders Group, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Collingridge GL; Glutamate Receptor Group, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Tanz Centre for Research in Neurodegenerative Disease, Department of Physiology, The University of Toronto, Toronto, ON, Canada.
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2021 Oct; Vol. 54 (8), pp. 6815-6825. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
1-Phosphatidylinositol 4-Kinase*
Receptors, N-Methyl-D-Aspartate*/metabolism
Animals ; Glycogen Synthase Kinase 3 ; Glycogen Synthase Kinase 3 beta ; Hippocampus/metabolism ; Phosphorylation ; Rats
Czasopismo naukowe
Tytuł :
Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain.
Autorzy :
Robinson S; Department of Psychology and Program in Neuroscience, Hamilton College, Clinton, NY, USA. Electronic address: .
Mogul AS; Department of Psychology and Program in Neuroscience, Hamilton College, Clinton, NY, USA.
Taylor-Yeremeeva EM; Department of Psychology and Program in Neuroscience, Hamilton College, Clinton, NY, USA.
Khan A; Department of Molecular, Cellular & Biomedical Sciences, The City University of New York School of Medicine, New York, NY, USA; Department of Biology, Neuroscience Program, Graduate School of the City University of New York, New York, NY, USA.
Tirabassi AD; Department of Psychology and Program in Neuroscience, Hamilton College, Clinton, NY, USA.
Wang HY; Department of Molecular, Cellular & Biomedical Sciences, The City University of New York School of Medicine, New York, NY, USA; Department of Biology, Neuroscience Program, Graduate School of the City University of New York, New York, NY, USA.
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Źródło :
Neuroscience [Neuroscience] 2021 Oct 01; Vol. 473, pp. 142-158. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain-Derived Neurotrophic Factor*/metabolism
Receptors, N-Methyl-D-Aspartate*/metabolism
Animals ; Hippocampus/metabolism ; Neurons/metabolism ; Rats ; Receptor, trkB/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Secreted Reporter Assay Enables Quantitative and Longitudinal Monitoring of Neuronal Activity.
Autorzy :
Santos AC; Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.; Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84112.
Chiola S; Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.
Yang G; Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.; Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84112.
Shcheglovitov A; Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.
Park S; Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112 .
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Źródło :
ENeuro [eNeuro] 2021 Sep 30; Vol. 8 (5). Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Neurons*/metabolism
Receptors, N-Methyl-D-Aspartate*
Animals ; Female ; Genes, Reporter ; Luciferases/genetics ; Male ; Mice ; Signal Transduction
Czasopismo naukowe
Tytuł :
Optical Control of N -Methyl-d-aspartate Receptors by Azobenzene Quaternary Ammonium Compounds.
Autorzy :
Nikolaev MV; Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Thorez pr. 44, 194223 Saint Petersburg, Russia.
Strashkov DM; Saint Petersburg National Research Academic University of the Russian Academy of Sciences, 8/3 Khlopina Street, 194021 Saint Petersburg, Russia.
Ryazantsev MN; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, 198504 Saint Petersburg, Russia.
Tikhonov DB; Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Thorez pr. 44, 194223 Saint Petersburg, Russia.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Sep 15; Vol. 12 (18), pp. 3347-3357. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Quaternary Ammonium Compounds*/pharmacology
Receptors, N-Methyl-D-Aspartate*
Animals ; Azo Compounds ; Rats ; Receptors, AMPA ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Czasopismo naukowe
Tytuł :
Chronic presence of blood circulating anti-NMDAR1 autoantibodies impairs cognitive function in mice.
Autorzy :
Yue W; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.
Caldwell S; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.; VA Research Service, VA San Diego Healthcare System, San Diego, California, United States of America.; VA Mental Illness Research and Clinical Core, VA San Diego Healthcare System, San Diego, California, United States of America.
Risbrough V; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.; VA Research Service, VA San Diego Healthcare System, San Diego, California, United States of America.; VA Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, United States of America.
Powell S; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.; VA Research Service, VA San Diego Healthcare System, San Diego, California, United States of America.; VA Mental Illness Research and Clinical Core, VA San Diego Healthcare System, San Diego, California, United States of America.
Zhou X; Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America.; VA Research Service, VA San Diego Healthcare System, San Diego, California, United States of America.; VA Mental Illness Research and Clinical Core, VA San Diego Healthcare System, San Diego, California, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Sep 02; Vol. 16 (9), pp. e0256972. Date of Electronic Publication: 2021 Sep 02 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cognition*
Autoantibodies/*blood
Autoantibodies/*immunology
Cognitive Dysfunction/*blood
Cognitive Dysfunction/*immunology
Nerve Tissue Proteins/*immunology
Receptors, N-Methyl-D-Aspartate/*immunology
Adjuvants, Immunologic/administration & dosage ; Animals ; Behavior, Animal ; Blood-Brain Barrier/immunology ; Freund's Adjuvant/administration & dosage ; Locomotion/immunology ; Male ; Memory, Short-Term ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Mycobacterium tuberculosis/immunology ; Nerve Tissue Proteins/chemistry ; Peptides/administration & dosage ; Peptides/immunology ; Receptors, N-Methyl-D-Aspartate/chemistry ; Spatial Memory ; Vaccination/methods
Czasopismo naukowe
Tytuł :
Interplay between NMDA receptor dynamics and the synaptic proteasome.
Autorzy :
Ferreira JS; IINS-Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, University of Bordeaux, Bordeaux, France.
Kellermayer B; IINS-Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, University of Bordeaux, Bordeaux, France.; CNC-Center for Neuroscience and Cell Biology of Coimbra, Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
Carvalho AL; CNC-Center for Neuroscience and Cell Biology of Coimbra, Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
Groc L; IINS-Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, University of Bordeaux, Bordeaux, France.
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Źródło :
The European journal of neuroscience [Eur J Neurosci] 2021 Sep; Vol. 54 (6), pp. 6000-6011. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteasome Endopeptidase Complex*
Receptors, N-Methyl-D-Aspartate*/metabolism
Animals ; Hippocampus/metabolism ; Rats ; Signal Transduction ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Long Noncoding RNA Expression Profiles of Rat Extrasynaptic and Synaptic Neurons Expressing the N-methyl-D-Aspartate Receptor Revealed by Microarray Analysis.
Autorzy :
Wang H; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hu S; Department of Pathology, Maternal and Children's Hospital of Hubei Province, Wuhan, China.
Gao S; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen K; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sun X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fang H; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
World neurosurgery [World Neurosurg] 2021 Sep; Vol. 153, pp. e168-e178. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Neurons/*metabolism
RNA, Long Noncoding/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Synapses/*metabolism
4-Aminopyridine/pharmacology ; Animals ; Bicuculline/pharmacology ; Cerebral Cortex/cytology ; Down-Regulation ; Excitatory Amino Acid Agonists/pharmacology ; GABA-A Receptor Antagonists/pharmacology ; Glycine/pharmacology ; Glycine Agents/pharmacology ; Microarray Analysis ; N-Methylaspartate/pharmacology ; Polymerase Chain Reaction ; Potassium Channel Blockers/pharmacology ; Primary Cell Culture ; Rats ; Receptors, N-Methyl-D-Aspartate/drug effects ; Synapses/drug effects ; Up-Regulation
Czasopismo naukowe
Tytuł :
Structural basis of ketamine action on human NMDA receptors.
Autorzy :
Zhang Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Ye F; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Zhang T; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Lv S; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhou L; University of Chinese Academy of Sciences, Beijing, China.; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Du D; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Lin H; Criminal Investigation Technology Department, The Third Research Institute of Ministry of Public Security, Shanghai, China.
Guo F; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Luo C; University of Chinese Academy of Sciences, Beijing, China. .; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. .
Zhu S; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. .; University of Chinese Academy of Sciences, Beijing, China. .; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China. .
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Źródło :
Nature [Nature] 2021 Aug; Vol. 596 (7871), pp. 301-305. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Ketamine/*chemistry
Ketamine/*pharmacology
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*ultrastructure
Antidepressive Agents/chemistry ; Antidepressive Agents/metabolism ; Antidepressive Agents/pharmacology ; Asparagine/chemistry ; Asparagine/metabolism ; Binding Sites ; Glutamic Acid/chemistry ; Glutamic Acid/metabolism ; Glutamic Acid/pharmacology ; Glycine/chemistry ; Glycine/metabolism ; Glycine/pharmacology ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Ketamine/metabolism ; Leucine/chemistry ; Leucine/metabolism ; Molecular Dynamics Simulation ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/ultrastructure ; Receptors, N-Methyl-D-Aspartate/chemistry ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
GluN2A and GluN2B NMDA receptors use distinct allosteric routes.
Autorzy :
Tian M; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
Stroebel D; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
Piot L; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
David M; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
Ye S; Unité INSERM U1195, Hôpital de Bicêtre, Université Paris-Saclay, Paris, Le Kremlin-Bicêtre, France. .
Paoletti P; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 05; Vol. 12 (1), pp. 4709. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, N-Methyl-D-Aspartate/*metabolism
Allosteric Regulation ; Animals ; Female ; HEK293 Cells ; Humans ; In Vitro Techniques ; Mice ; Models, Molecular ; Mutagenesis, Site-Directed ; Oocytes/metabolism ; Photochemistry ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Subunits ; Rats ; Receptors, N-Methyl-D-Aspartate/chemistry ; Receptors, N-Methyl-D-Aspartate/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Role of NMDA Receptors in Adult Neurogenesis and Normal Development of the Dentate Gyrus.
Autorzy :
Åmellem I; School of Biological Sciences, Nanyang Technological University, Singapore 308232.; Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Yovianto G; School of Biological Sciences, Nanyang Technological University, Singapore 308232.
Chong HT; School of Biological Sciences, Nanyang Technological University, Singapore 308232.
Nair RR; Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Cnops V; School of Biological Sciences, Nanyang Technological University, Singapore 308232.; Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Thanawalla A; School of Biological Sciences, Nanyang Technological University, Singapore 308232.
Tashiro 田代 歩 A; School of Biological Sciences, Nanyang Technological University, Singapore 308232 .; Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim 7491, Norway.
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Źródło :
ENeuro [eNeuro] 2021 Aug 05; Vol. 8 (4). Date of Electronic Publication: 2021 Aug 05 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neural Stem Cells*/metabolism
Receptors, N-Methyl-D-Aspartate*/genetics
Receptors, N-Methyl-D-Aspartate*/metabolism
Animals ; Dentate Gyrus/metabolism ; Mice ; Neurogenesis ; Neurons/metabolism
Czasopismo naukowe
Tytuł :
Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade.
Autorzy :
Raza MU; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, VA Building 7, Room 324, Maple Ave, Johnson City, TN, 37604, USA.
Sivarao DV; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, VA Building 7, Room 324, Maple Ave, Johnson City, TN, 37604, USA. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2021 Aug; Vol. 238 (8), pp. 2325-2334. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Excitatory Amino Acid Antagonists/*pharmacology
Gamma Rhythm/*drug effects
Gamma Rhythm/*physiology
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*physiology
Acoustic Stimulation/methods ; Acoustic Stimulation/standards ; Animals ; Dizocilpine Maleate/pharmacology ; Dose-Response Relationship, Drug ; Evoked Potentials, Auditory/drug effects ; Evoked Potentials, Auditory/physiology ; Excitatory Amino Acid Agonists/pharmacology ; Female ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/agonists ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
[Mechanism of Chuanxiong Rhizoma intervention on central sensitization of Panx1-Src-NMDAR-2B signaling pathway in neuropathic pain model rats].
Autorzy :
DU DD; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Zhang MY; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Liu Y; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Jiao Y; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Zhao XL; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Li T; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Wang ZG; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Miao YC; Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.
Sun J; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Weng XG; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Wu XX; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
Li YJ; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases Beijing 100700, China.
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Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2021 Aug; Vol. 46 (16), pp. 4175-4186.
Typ publikacji :
Journal Article
MeSH Terms :
Neuralgia*/drug therapy
Receptors, N-Methyl-D-Aspartate*/genetics
Receptors, N-Methyl-D-Aspartate*/metabolism
Animals ; Central Nervous System Sensitization ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.
Autorzy :
Gorecki L; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
Misiachna A; Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic; Department of Physiology, Faculty of Science, Charles University in Prague, Albertov 6, 12843, Prague 2, Czech Republic.
Damborsky J; Loschmidt Laboratories, Department of Experimental Biology and RECETOX, Masaryk University, Kamenice 5/A4, 625 00, Brno, Czech Republic; International Centre for Clinical Research, St. Anne's University Hospital, Pekarska 53, 656 91 Brno, Czech Republic.
Dolezal R; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
Korabecny J; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
Cejkova L; National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic.
Hakenova K; National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic.
Chvojkova M; National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic.
Karasova JZ; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.
Prchal L; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
Novak M; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho, 1203, Hradec Kralove, Czech Republic.
Kolcheva M; Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic.
Kortus S; Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic.
Vales K; National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic.
Horak M; Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic. Electronic address: .
Soukup O; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jul 05; Vol. 219, pp. 113434. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Cholinesterase Inhibitors/*chemistry
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Tacrine/*chemistry
Acetylcholinesterase/chemistry ; Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Animals ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Butyrylcholinesterase/chemistry ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/metabolism ; Cholinesterase Inhibitors/pharmacology ; Dogs ; Drug Design ; Half-Life ; Humans ; Locomotion/drug effects ; Male ; Membrane Potentials/drug effects ; Mice ; Mice, Inbred ICR ; Quantitative Structure-Activity Relationship ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Tacrine/metabolism ; Tacrine/pharmacology
Czasopismo naukowe
Tytuł :
Hypergravity-induced malfunction was moderated by the regulation of NMDA receptors in the vestibular nucleus.
Autorzy :
Kim G; Research Institute for Aerospace Medicine, Inha University, Incheon, Korea. .
Kim KS; Research Institute for Aerospace Medicine, Inha University, Incheon, Korea.; Department of Otolaryngology Head and Neck Surgery, Inha University Hospital, Incheon, Korea.
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Źródło :
Scientific reports [Sci Rep] 2021 Aug 31; Vol. 11 (1), pp. 17420. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Behavior, Animal*
Gene Expression Regulation*
Hypergravity*
Neuronal Plasticity*
Neurons/*pathology
Receptors, N-Methyl-D-Aspartate/*metabolism
Vestibular Nuclei/*pathology
Animals ; Male ; Neurons/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/genetics ; Vestibular Nuclei/metabolism
Czasopismo naukowe
Tytuł :
Fluorescence Probe for Imaging N -Methyl-d-aspartate Receptors and Monitoring GSH Selectively Using Two-Photon Microscopy.
Autorzy :
Kwon N; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
Lim CS; Department of Energy Systems Research, Ajou University, Suwon 443-749, Korea.
Ko G; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
Ha J; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
Lee D; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
Yin J; Key Laboratory of Pesticide and Chemical Biology, Ministry of Education; Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis; International Joint Research Center for Intelligent Biosensing Technology and Health; College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China.
Kim HM; Department of Energy Systems Research, Ajou University, Suwon 443-749, Korea.
Yoon J; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Aug 24; Vol. 93 (33), pp. 11612-11616. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescent Dyes*
Receptors, N-Methyl-D-Aspartate*
Glutathione/metabolism ; Microscopy, Fluorescence ; Photons
Czasopismo naukowe

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