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Wyszukujesz frazę ""Receptors, N-Methyl-D-Aspartate"" wg kryterium: Temat


Tytuł :
Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants.
Autorzy :
Yan J; Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.
Bengtson CP; Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.
Buchthal B; Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.
Hagenston AM; Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.
Bading H; Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Oct 09; Vol. 370 (6513).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Cyclic AMP Response Element-Binding Protein/*metabolism
Neurodegenerative Diseases/*metabolism
Neuroprotective Agents/*chemistry
Receptors, N-Methyl-D-Aspartate/*metabolism
Recombinant Proteins/*metabolism
TRPM Cation Channels/*metabolism
Animals ; Calcium Signaling ; Cyclic AMP/metabolism ; Cyclic AMP Response Element-Binding Protein/genetics ; Gene Knockdown Techniques ; Humans ; Mice ; Neurodegenerative Diseases/drug therapy ; Protein Domains ; Receptors, N-Methyl-D-Aspartate/chemistry ; Receptors, N-Methyl-D-Aspartate/therapeutic use ; Recombinant Proteins/chemistry ; Recombinant Proteins/therapeutic use ; TRPM Cation Channels/genetics ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
L-serine synthesis via the phosphorylated pathway in humans.
Autorzy :
Murtas G; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.
Marcone GL; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.
Sacchi S; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.
Pollegioni L; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Dec; Vol. 77 (24), pp. 5131-5148. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*genetics
Brain/*metabolism
Receptors, N-Methyl-D-Aspartate/*genetics
Serine/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Brain/pathology ; Glycolysis/genetics ; Humans ; Neurons/metabolism ; Neurons/pathology ; Phosphoglycerate Dehydrogenase/genetics ; Phosphorylation/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Serine/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
[Dopamine and NMDA Receptors in Basal Ganglia Circuits and Their Roles regarding Motor Control and Learning].
Autorzy :
Saito N; Department of Comparative and Experimental Medicine, Brain Research Institute, Niigata University.
Sasaoka T
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Źródło :
Brain and nerve = Shinkei kenkyu no shinpo [Brain Nerve] 2020 Nov; Vol. 72 (11), pp. 1135-1142.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Dopamine*
Receptors, N-Methyl-D-Aspartate*
Animals ; Basal Ganglia ; Humans ; Mice ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2
Czasopismo naukowe
Tytuł :
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
Autorzy :
Yu H; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China. Electronic address: .
Ma L; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China.
Liu D; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China.
Wang Y; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China.
Pei X; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China.
Duan Z; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China.
Ma M; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China.
Zhang Y; Department of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, People's Republic of China.
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2020 Nov; Vol. 266 (Pt 1), pp. 115055. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Hippocampus*
Receptors, N-Methyl-D-Aspartate*
Animals ; Benzhydryl Compounds ; Disks Large Homolog 4 Protein ; Female ; Nitric Oxide Synthase Type I ; Phenols ; Pregnancy ; Rats
Czasopismo naukowe
Tytuł :
Memantine effects on ingestion microstructure and the effect of administration time: A within-subject study.
Autorzy :
Galistu A; Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
D'Aquila PS; Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy.
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Źródło :
PloS one [PLoS One] 2020 Sep 16; Vol. 15 (9), pp. e0239270. Date of Electronic Publication: 2020 Sep 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Feeding Behavior/*drug effects
Memantine/*pharmacology
Memory/*drug effects
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Animals ; Conditioning, Classical/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drinking Behavior/drug effects ; Eating ; Humans ; Memantine/adverse effects ; Memory/physiology ; Rats ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe
Tytuł :
PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function.
Autorzy :
Wang Y; Department of Neuroscience, Genentech Inc., South San Francisco, CA, 94080, USA. .
Kerrisk Campbell M; Department of Neuroscience, Genentech Inc., South San Francisco, CA, 94080, USA.; Alkahest Inc., San Carlos, CA, 94070, USA.
Tom I; Department of OMNI-Biomarker, Genentech Inc., South San Francisco, CA, 94080, USA.
Foreman O; Department of Pathology, Genentech Inc., South San Francisco, CA, 94080, USA.
Hanson JE; Department of Neuroscience, Genentech Inc., South San Francisco, CA, 94080, USA.
Sheng M; Department of Neuroscience, Genentech Inc., South San Francisco, CA, 94080, USA. .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 02; Vol. 10 (1), pp. 10951. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Synaptic Transmission*
Cadherins/*metabolism
Dendritic Spines/*physiology
Hippocampus/*cytology
Neurons/*physiology
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Cadherins/genetics ; Female ; Hippocampus/physiology ; Neurons/cytology ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Influence of retinal NMDA receptor activity during autoimmune optic neuritis.
Autorzy :
Bojcevski J; Department of Neurology, University Clinic Heidelberg, Heidelberg, Germany.; CCU Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Stojic A; Department of Neurology, University Clinic Heidelberg, Heidelberg, Germany.; CCU Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Hoffmann DB; Department of Neurology, Saarland University, Homburg, Germany.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Williams SK; Department of Neurology, University Clinic Heidelberg, Heidelberg, Germany.; CCU Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Müller A; Department of Diagnostic and Interventional Radiology, Saarland University, Homburg, Germany.
Diem R; Department of Neurology, University Clinic Heidelberg, Heidelberg, Germany.; CCU Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Fairless R; Department of Neurology, University Clinic Heidelberg, Heidelberg, Germany.; CCU Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), Heidelberg, Germany.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Jun; Vol. 153 (6), pp. 693-709. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Optic Neuritis/*metabolism
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*metabolism
Retina/*metabolism
Animals ; Dizocilpine Maleate/pharmacology ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Evoked Potentials, Visual/drug effects ; Evoked Potentials, Visual/physiology ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Myelin-Oligodendrocyte Glycoprotein/toxicity ; Optic Nerve/drug effects ; Optic Nerve/immunology ; Optic Nerve/metabolism ; Optic Neuritis/chemically induced ; Optic Neuritis/immunology ; Rats ; Rats, Inbred BN ; Receptors, N-Methyl-D-Aspartate/immunology ; Retina/drug effects ; Retina/immunology
Czasopismo naukowe
Tytuł :
Desensitization of NMDA channels requires ligand binding to both GluN1 and GluN2 subunits to constrict the pore beside the activation gate.
Autorzy :
Chen YS; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Tu YC; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Lai YC; Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.
Liu E; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.
Yang YC; Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Tao-Yuan, Taiwan.
Kuo CC; Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Jun; Vol. 153 (5), pp. 549-566. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutamic Acid/*metabolism
Glycine/*metabolism
Ion Channel Gating/*physiology
Nerve Tissue Proteins/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists/metabolism ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Amino Acid Antagonists/metabolism ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Glutamic Acid/pharmacology ; Glycine/pharmacology ; Ion Channel Gating/drug effects ; Ligands ; Nerve Tissue Proteins/agonists ; Nerve Tissue Proteins/antagonists & inhibitors ; Protein Binding/drug effects ; Protein Binding/physiology ; Rats ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/genetics ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice.
Autorzy :
Shin W; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Kim K; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Serraz B; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
Cho YS; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Kim D; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Kang M; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Lee EJ; Department of Neurology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
Lee H; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Bae YC; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Paoletti P; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
Kim E; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
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Źródło :
PLoS biology [PLoS Biol] 2020 Apr 30; Vol. 18 (4), pp. e3000717. Date of Electronic Publication: 2020 Apr 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anxiety/*genetics
Hippocampus/*physiology
Long-Term Synaptic Depression/*physiology
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Anxiety/physiopathology ; Behavior, Animal/drug effects ; Cycloserine/pharmacology ; Excitatory Postsynaptic Potentials/genetics ; Gene Knock-In Techniques ; Haploinsufficiency/genetics ; Heterozygote ; Hippocampus/metabolism ; Long-Term Synaptic Depression/drug effects ; Mice, Mutant Strains ; Mutation ; Nerve Tissue Proteins/metabolism ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons.
Autorzy :
Garst-Orozco J; Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America.
Malik R; Department of Psychiatry and UCSF Weill Institute for Neurosciences, San Francisco, California, United States of America.; Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California, United States of America.; Sloan-Swartz Center for Theoretical Neurobiology, University of California San Francisco, San Francisco, California, United States of America.
Lanz TA; Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America.
Weber ML; Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America.
Xi H; Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America.
Arion D; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Enwright JF 3rd; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Lewis DA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
O'Donnell P; Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America.
Sohal VS; Department of Psychiatry and UCSF Weill Institute for Neurosciences, San Francisco, California, United States of America.; Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California, United States of America.; Sloan-Swartz Center for Theoretical Neurobiology, University of California San Francisco, San Francisco, California, United States of America.
Buhl DL; Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Jun 04; Vol. 15 (6), pp. e0233895. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Interneurons/*metabolism
Parvalbumins/*metabolism
Prefrontal Cortex/*physiology
Receptors, N-Methyl-D-Aspartate/*metabolism
Action Potentials ; Adult ; Animals ; Female ; Gene Expression ; Humans ; Male ; Mice, Inbred C57BL ; Middle Aged ; Neural Inhibition ; Pyramidal Cells/metabolism ; RNA, Messenger/genetics ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe
Tytuł :
Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task.
Autorzy :
Phenis D; Department of Psychology, The Ohio State University, Columbus, OH, USA.; Department of Neuroscience, The Ohio State University, Columbus, OH, USA.
Vunck SA; Department of Psychology, The Ohio State University, Columbus, OH, USA.
Valentini V; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Arias H; Department of Pharmacology and Physiology, College of Osteopathic Medicine, Oklahoma State University Center for Health Sciences, Tahlequah, OK, USA.
Schwarcz R; Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Bruno JP; Department of Psychology, The Ohio State University, Columbus, OH, USA. .; Department of Neuroscience, The Ohio State University, Columbus, OH, USA. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Jun; Vol. 237 (6), pp. 1723-1735. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Brain/*metabolism
Memory, Short-Term/*physiology
Psychomotor Performance/*physiology
Receptors, N-Methyl-D-Aspartate/*metabolism
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Analgesics/pharmacology ; Animals ; Brain/drug effects ; Kynurenic Acid/pharmacology ; Kynurenine/pharmacology ; Male ; Memory, Short-Term/drug effects ; Nicotine/pharmacology ; Psychomotor Performance/drug effects ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/agonists ; alpha7 Nicotinic Acetylcholine Receptor/agonists
Czasopismo naukowe
Tytuł :
Heterogeneous glutamatergic receptor mRNA expression across phrenic motor neurons in rats.
Autorzy :
Rana S; Departments of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Sieck GC; Departments of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Departments of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Mantilla CB; Departments of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Departments of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Jun; Vol. 153 (5), pp. 586-598. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Motor Neurons/*metabolism
Phrenic Nerve/*metabolism
RNA, Messenger/*biosynthesis
Receptors, AMPA/*biosynthesis
Receptors, N-Methyl-D-Aspartate/*biosynthesis
Recruitment, Neurophysiological/*physiology
Animals ; Female ; Gene Expression ; Male ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/genetics ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe
Tytuł :
Effects of N-methyl-d-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice.
Autorzy :
Kiyohara S; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Department of Implant Dentistry, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota, Tokyo, 145-8515, Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Sakai N; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Handa K; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Department of Orthopedic Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Yamakawa T; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Department of Orthopedic Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Ishikawa K; Department of Orthopedic Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Chatani M; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Karakawa A; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Azetsu Y; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Munakata M; Department of Implant Dentistry, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota, Tokyo, 145-8515, Japan. Electronic address: .
Ozeki M; Department of Implant Dentistry, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota, Tokyo, 145-8515, Japan. Electronic address: .
Negishi-Koga T; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato, Tokyo, 108-8639, Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
Takami M; Department of Pharmacology, Showa University School of Dentistry, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555 Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai Shinagawa, Tokyo, 142-8555, Japan. Electronic address: .
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Źródło :
Journal of oral biosciences [J Oral Biosci] 2020 Jun; Vol. 62 (2), pp. 131-138. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dizocilpine Maleate*
Receptors, N-Methyl-D-Aspartate*
Animals ; Homeostasis ; Mice ; N-Methylaspartate ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
Inhibition of MicroRNA 219 Expression Protects Synaptic Plasticity via Activating NMDAR1, CaMKIIγ, and p-CREB after Microwave Radiation.
Autorzy :
Zhao L; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xiong L; Beijing Institute of Radiation Medicine, Beijing 100850, China;Department of Pathology, Beijing Zhongguancun Hospital, Beijing 100190, China.
Hao YH; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Li WC; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Dong J; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Zhang J; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yao BW; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xu XP; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Wang LF; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Zhou HM; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Peng RY; Beijing Institute of Radiation Medicine, Beijing 100850, China.
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Źródło :
Biomedical and environmental sciences : BES [Biomed Environ Sci] 2020 May 20; Vol. 33 (5), pp. 359-364.
Typ publikacji :
Letter
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*genetics
Cyclic AMP Response Element-Binding Protein/*genetics
MicroRNAs/*radiation effects
Microwaves/*adverse effects
Neuronal Plasticity/*radiation effects
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Male ; Random Allocation ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/metabolism
Opinia redakcyjna
Tytuł :
Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders.
Autorzy :
Espadinha M; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.
Viejo L; Instituto Teófilo Hernando and Departamento Farmacología y Terapéutica, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo, 4, 28029, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, C/ Diego de León, 62, 28006, Madrid, Spain.
Lopes RMRM; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.
Herrera-Arozamena C; Instituto de Química Médica (IQM-CSIC), C/ Juan de la Cierva, 3, 28006, Madrid, Spain.
Molins E; Institut de Ciència de Materials de Barcelona (CSIC), Campus UAB, 08193, Cerdanyola, Spain.
Dos Santos DJVA; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal; , Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007, Porto, Portugal.
Gonçalves L; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.
Rodríguez-Franco MI; Instituto de Química Médica (IQM-CSIC), C/ Juan de la Cierva, 3, 28006, Madrid, Spain.
Ríos CL; Instituto Teófilo Hernando and Departamento Farmacología y Terapéutica, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo, 4, 28029, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, C/ Diego de León, 62, 28006, Madrid, Spain.
Santos MMM; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 May 15; Vol. 194, pp. 112242. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
Lactams/*pharmacology
Nervous System Diseases/*drug therapy
Neuroprotective Agents/*pharmacology
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Blood-Brain Barrier/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; HEK293 Cells ; Hep G2 Cells ; Humans ; Lactams/chemical synthesis ; Lactams/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Nervous System Diseases/metabolism ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Receptors, N-Methyl-D-Aspartate/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Protopanaxadiol ginsenoside Rd protects against NMDA receptor-mediated excitotoxicity by attenuating calcineurin-regulated DAPK1 activity.
Autorzy :
Zhang C; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Neurology, Characteristic Medical Center of Rocket Force Military, Beijing, China.
Liu X; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Xu H; Institute of Neurosciences, Fourth Military Medical University, Xi'an, China.
Hu G; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhang X; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Xie Z; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Feng D; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Wu R; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhao G; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Shi M; Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 15; Vol. 10 (1), pp. 8078. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia/*drug therapy
Calcineurin/*pharmacology
Death-Associated Protein Kinases/*antagonists & inhibitors
Ginsenosides/*pharmacology
Neuroprotective Agents/*pharmacology
Receptors, N-Methyl-D-Aspartate/*metabolism
Sapogenins/*pharmacology
Stroke/*drug therapy
Animals ; Brain Ischemia/etiology ; Brain Ischemia/pathology ; Death-Associated Protein Kinases/genetics ; Death-Associated Protein Kinases/pharmacology ; Male ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Panax/chemistry ; Phosphorylation ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/genetics ; Signal Transduction ; Stroke/etiology ; Stroke/pathology
Czasopismo naukowe
Tytuł :
The NMDA receptor regulates competition of epithelial cells in the Drosophila wing.
Autorzy :
Banreti AR; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. .; Université Côte D'Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France. .
Meier P; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 May 06; Vol. 11 (1), pp. 2228. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Drosophila/*metabolism
Drosophila Proteins/*metabolism
Epithelial Cells/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Transcription Factors/*metabolism
Wings, Animal/*metabolism
Animals ; Apoptosis/genetics ; Drosophila/genetics ; Drosophila Proteins/genetics ; Lactic Acid/metabolism ; MAP Kinase Signaling System/genetics ; Mitochondria/metabolism ; Receptors, N-Methyl-D-Aspartate/genetics ; Signal Transduction/genetics ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Wings, Animal/growth & development
Czasopismo naukowe
Tytuł :
N-Methyl-D-Aspartate Receptor Antibodies in Autoimmune Encephalopathy Alter Oligodendrocyte Function.
Autorzy :
Matute C; Achucarro Basque Center for Neuroscience, Biomedical Research Networking Center on Neurodegenerative Diseases and Department of Neurosciences, University of the Basque Country, Leioa, Spain.
Palma A; Achucarro Basque Center for Neuroscience, Biomedical Research Networking Center on Neurodegenerative Diseases and Department of Neurosciences, University of the Basque Country, Leioa, Spain.
Serrano-Regal MP; Achucarro Basque Center for Neuroscience, Biomedical Research Networking Center on Neurodegenerative Diseases and Department of Neurosciences, University of the Basque Country, Leioa, Spain.
Maudes E; August Pi i Sunyer Biomedical Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Barman S; Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Sánchez-Gómez MV; Achucarro Basque Center for Neuroscience, Biomedical Research Networking Center on Neurodegenerative Diseases and Department of Neurosciences, University of the Basque Country, Leioa, Spain.
Domercq M; Achucarro Basque Center for Neuroscience, Biomedical Research Networking Center on Neurodegenerative Diseases and Department of Neurosciences, University of the Basque Country, Leioa, Spain.
Goebels N; Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Dalmau J; August Pi i Sunyer Biomedical Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.; Department of Neurology, University of Pennsylvania, Philadelphia, PA.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
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Źródło :
Annals of neurology [Ann Neurol] 2020 May; Vol. 87 (5), pp. 670-676. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*metabolism
Autoantibodies/*immunology
Oligodendroglia/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Adolescent ; Adult ; Animals ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/immunology ; Autoantibodies/cerebrospinal fluid ; Autoantibodies/pharmacology ; Autoantigens/immunology ; Cells, Cultured ; Child ; Female ; Glucose Transporter Type 1/biosynthesis ; Humans ; Male ; Oligodendroglia/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Hippocampal and prefrontal cortical NMDA receptors mediate the interactive effects of olanzapine and lithium in memory retention in rats: the involvement of CAMKII-CREB signaling pathways.
Autorzy :
Amiri S; Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Jafari-Sabet M; Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. .; Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. .
Keyhanfar F; Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Falak R; Immunology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Shabani M; Kerman Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
Rezayof A; Department of Animal Biology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, Tehran, Iran.
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 May; Vol. 237 (5), pp. 1383-1396. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Cyclic AMP Response Element-Binding Protein/*metabolism
Lithium Carbonate/*administration & dosage
Memory Consolidation/*physiology
Olanzapine/*administration & dosage
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Avoidance Learning/drug effects ; Avoidance Learning/physiology ; Dizocilpine Maleate/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Memory Consolidation/drug effects ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe

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