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Wyszukujesz frazę ""Receptors, Nicotinic"" wg kryterium: Temat


Tytuł :
Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors.
Autorzy :
Prevost MS; Unité Récepteurs-Canaux, Institut Pasteur, UMR 3571, CNRS, 75015, Paris, France.
Bouchenaki H; Unité Récepteurs-Canaux, Institut Pasteur, UMR 3571, CNRS, 75015, Paris, France.
Barilone N; Unité Récepteurs-Canaux, Institut Pasteur, UMR 3571, CNRS, 75015, Paris, France.
Gielen M; Unité Récepteurs-Canaux, Institut Pasteur, UMR 3571, CNRS, 75015, Paris, France. .; Sorbonne Université, 21, rue de l'école de médecine, 75006, Paris, France. .
Corringer PJ; Unité Récepteurs-Canaux, Institut Pasteur, UMR 3571, CNRS, 75015, Paris, France. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Feb; Vol. 78 (3), pp. 1051-1064. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, Nicotinic/*metabolism
5' Untranslated Regions ; Acetylcholine/chemistry ; Acetylcholine/metabolism ; Acetylcholine/pharmacology ; Action Potentials/drug effects ; Amino Acid Sequence ; Animals ; Binding Sites ; Humans ; Mesylates/pharmacology ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Oocytes/physiology ; Oxadiazoles/pharmacology ; Patch-Clamp Techniques ; Protein Binding ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Pyridines/pharmacology ; Receptors, Nicotinic/chemistry ; Receptors, Nicotinic/genetics ; Xenopus/growth & development ; Xenopus/metabolism ; Xenopus Proteins/genetics ; beta-Globins/genetics
Czasopismo naukowe
Tytuł :
Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype.
Autorzy :
Bavo F; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
Pallavicini M; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
Gotti C; Institute of Neuroscience, CNR, Via Vanvitelli 32, I-20129 Milano, Italy.
Appiani R; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
Moretti M; Institute of Neuroscience, CNR, Via Vanvitelli 32, I-20129 Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Vanvitelli 32, I-20129 Milano, Italy.
Colombo SF; Institute of Neuroscience, CNR, Via Vanvitelli 32, I-20129 Milano, Italy.
Pucci S; Institute of Neuroscience, CNR, Via Vanvitelli 32, I-20129 Milano, Italy.; Hunimed University, Via Rita Levi-Montalcini 4, Pieve Emanuele, I-20090 Milan, Italy.
Viani P; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Vanvitelli 32, I-20129 Milano, Italy.
Budriesi R; Dipartimento di Farmacia e Biotecnologie, Università degli Studi di Bologna, Via Belmeloro 6, I-40126 Bologna, Italy.
Renzi M; Dipartimento di Fisiologia e Farmacologia, Sapienza Università di Roma, Piazzale Moro 5, 00185 Roma, Italy.
Fucile S; Dipartimento di Fisiologia e Farmacologia, Sapienza Università di Roma, Piazzale Moro 5, 00185 Roma, Italy.; I.R.C.C.S. Neuromed, Via Atinese 18, 86077 Pozzilli, Italy.
Bolchi C; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, I-20133 Milano, Italy.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 24; Vol. 63 (24), pp. 15668-15692. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dioxanes/*chemistry
Nicotinic Agonists/*chemistry
Receptors, Nicotinic/*chemistry
Binding Sites ; Cryoelectron Microscopy ; Dioxanes/chemical synthesis ; Dioxanes/metabolism ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Nicotinic Agonists/chemical synthesis ; Nicotinic Agonists/metabolism ; Nicotinic Antagonists/chemistry ; Nicotinic Antagonists/metabolism ; Pyrrolidines/chemistry ; Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Nicotinic Receptor Subunits Atlas in the Adult Human Lung.
Autorzy :
Diabasana Z; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
Perotin JM; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.; Department of Respiratory Diseases, Centre Hospitalier Universitaire de Reims, Hôpital Maison Blanche, 51092 Reims, France.
Belgacemi R; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
Ancel J; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.; Department of Respiratory Diseases, Centre Hospitalier Universitaire de Reims, Hôpital Maison Blanche, 51092 Reims, France.
Mulette P; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.; Department of Respiratory Diseases, Centre Hospitalier Universitaire de Reims, Hôpital Maison Blanche, 51092 Reims, France.
Delepine G; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.; Department of Thoracic Surgery, Centre Hospitalier Universitaire de Reims, Hôpital Maison Blanche, 51092 Reims, France.
Gosset P; CNRS UMR9017, Inserm U1019, University of Lille, Centre Hospitalier Régional Universitaire de Lille, Institut Pasteur, CIIL-Center for Infection and Immunity of Lille, 59000 Lille, France.
Maskos U; Integrative Neurobiology of Cholinergic Systems, Institut Pasteur, CNRS UMR 3571, 75015 Paris, France.
Polette M; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.; Department of Biopathology, Centre Hospitalier Universitaire de Reims, Hôpital Maison Blanche, 51092 Reims, France.
Deslée G; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.; Department of Respiratory Diseases, Centre Hospitalier Universitaire de Reims, Hôpital Maison Blanche, 51092 Reims, France.
Dormoy V; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 09; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Lung/*metabolism
Protein Subunits/*metabolism
Receptors, Nicotinic/*metabolism
Adult ; Age Factors ; Cell Cycle ; Epithelial Cells/metabolism ; Gene Expression Regulation ; Humans ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Receptors, Nicotinic/chemistry ; Receptors, Nicotinic/genetics ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Signal Detection, Psychological ; Smoking ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors.
Autorzy :
Paramonov AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.
Kocharovskaya MV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), 141701 Dolgoprudny, Moscow Region, Russia.
Tsarev AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), 141701 Dolgoprudny, Moscow Region, Russia.
Kulbatskii DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.
Loktyushov EV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.
Shulepko MA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.
Kirpichnikov MP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Lyukmanova EN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), 141701 Dolgoprudny, Moscow Region, Russia.
Shenkarev ZO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (National Research University), 141701 Dolgoprudny, Moscow Region, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 01; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*chemistry
Antigens, Ly/*chemistry
GPI-Linked Proteins/*chemistry
Neuropeptides/*chemistry
Receptors, Nicotinic/*chemistry
Urokinase-Type Plasminogen Activator/*chemistry
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Amino Acid Sequence ; Antigens, Ly/genetics ; Antigens, Ly/metabolism ; Binding Sites ; Cloning, Molecular ; Elapid Venoms/chemistry ; Elapid Venoms/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Urokinase-Type Plasminogen Activator/genetics ; Urokinase-Type Plasminogen Activator/metabolism
Czasopismo naukowe
Tytuł :
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
Autorzy :
Lynagh T; Sars International Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgate 55, 5008 Bergen, Norway.; Center for Biopharmaceuticals & Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Kiontke S; Division of Structural Biology, Department of Biology/Chemistry, University of Osnabrück, Barbarastraße 13, Osnabrück 49076, Germany.; Faculty of Biology, Department of Plant Physiology and Photobiology, Philipps-Universität Marburg, Karl-von-Frisch-Straße 8, 35032 Marburg, Germany.
Meyhoff-Madsen M; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Gless BH; Center for Biopharmaceuticals & Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Johannesen J; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Kattelmann S; Institute of Biochemistry, University of Münster, Corrensstraße 36, 48149 Münster, Germany.
Christiansen A; Fluid Array Systems and Technology, Nano and Bio-physical Systems, Department of Health Technology, Technical University of Denmark, Building 423 Produktionstorvet, DK-2800 Kongens Lyngby, Denmark.
Dufva M; Fluid Array Systems and Technology, Nano and Bio-physical Systems, Department of Health Technology, Technical University of Denmark, Building 423 Produktionstorvet, DK-2800 Kongens Lyngby, Denmark.
Laustsen AH; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Devkota K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Olsen CA; Center for Biopharmaceuticals & Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Kümmel D; Division of Structural Biology, Department of Biology/Chemistry, University of Osnabrück, Barbarastraße 13, Osnabrück 49076, Germany.; Institute of Biochemistry, University of Münster, Corrensstraße 36, 48149 Münster, Germany.
Pless SA; Center for Biopharmaceuticals & Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Lohse B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 13709-13718. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cobra Neurotoxin Proteins/*antagonists & inhibitors
Cobra Neurotoxin Proteins/*metabolism
Peptide Fragments/*metabolism
Peptide Fragments/*pharmacology
Receptors, Nicotinic/*metabolism
Animals ; Binding Sites/drug effects ; Binding Sites/physiology ; Cobra Neurotoxin Proteins/chemistry ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Female ; Peptide Fragments/chemistry ; Protein Structure, Secondary ; Receptors, Nicotinic/chemistry ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk.
Autorzy :
Jordahl KM; Department of Epidemiology, School of Public Health, University of Washington, Box 357236, Seattle, WA, 98195, USA. .; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. .
Phipps AI; Department of Epidemiology, School of Public Health, University of Washington, Box 357236, Seattle, WA, 98195, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Randolph TW; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Tinker LF; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nassir R; Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Anderson GL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kelsey KT; Departments of Epidemiology and Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
White E; Department of Epidemiology, School of Public Health, University of Washington, Box 357236, Seattle, WA, 98195, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Bhatti P; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Cancer Control Research, BC Cancer, Vancouver, BC, Canada.
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Źródło :
BMC medical genetics [BMC Med Genet] 2020 Nov 19; Vol. 21 (1), pp. 228. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Polymorphism, Single Nucleotide*
Antigens, Ly/*genetics
Carcinogenesis/*genetics
Carcinoma, Transitional Cell/*genetics
DNA, Neoplasm/*genetics
Receptors, Nicotinic/*genetics
Urinary Bladder Neoplasms/*genetics
Adult ; Aged ; Aged, 80 and over ; Antigens, Ly/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Carcinoma, Transitional Cell/metabolism ; Carcinoma, Transitional Cell/pathology ; Case-Control Studies ; Cigarette Smoking/physiopathology ; CpG Islands ; DNA Methylation ; DNA, Neoplasm/metabolism ; Female ; Humans ; Middle Aged ; Quantitative Trait Loci ; Receptors, Nicotinic/metabolism ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Backbone Cyclization Turns a Venom Peptide into a Stable and Equipotent Ligand at Both Muscle and Neuronal Nicotinic Receptors.
Autorzy :
Giribaldi J; Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.
Haufe Y; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Nußbaumstraße 26, 80336 Munich, Germany.
Evans ERJ; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland 4878, Australia.
Amar M; Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Durner A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Nußbaumstraße 26, 80336 Munich, Germany.
Schmidt C; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland 4878, Australia.
Faucherre A; Département de Physiologie, Institut de Génomique Fonctionnelle, CNRS/INSERM UMR 5203, Université de Montpellier, 34095 Montpellier, France.
Moha Ou Maati H; Département de Physiologie, Institut de Génomique Fonctionnelle, CNRS/INSERM UMR 5203, Université de Montpellier, 34095 Montpellier, France.
Enjalbal C; Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.
Molgó J; Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Servent D; Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Wilson DT; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland 4878, Australia.
Daly NL; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland 4878, Australia.
Nicke A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Nußbaumstraße 26, 80336 Munich, Germany.
Dutertre S; Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12682-12692. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ligands*
Muscles/*metabolism
Neurons/*metabolism
Nicotinic Antagonists/*chemistry
Peptides/*chemistry
Receptors, Nicotinic/*metabolism
Venoms/*metabolism
Amino Acid Sequence ; Animals ; Conotoxins/chemistry ; Cyclization ; Larva/drug effects ; Larva/physiology ; Locomotion/drug effects ; Mice ; Muscle Contraction/drug effects ; Nicotinic Antagonists/metabolism ; Nicotinic Antagonists/pharmacology ; Peptides/metabolism ; Peptides/pharmacology ; Protein Binding ; Protein Structure, Tertiary ; Receptors, Nicotinic/chemistry ; Zebrafish/growth & development ; Zebrafish/physiology
Czasopismo naukowe
Tytuł :
Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: nothing but good news?
Autorzy :
Grant S; Division of Chemistry and Chemical Engineering, and.
Lester HA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Nov 02; Vol. 130 (11), pp. 5685-5687.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Nicotinic Agonists*
Receptors, Nicotinic*/genetics
Acetylcholine ; Analgesics ; Animals ; Endoribonucleases ; Mice ; Protein-Serine-Threonine Kinases ; Receptors, Cholinergic
Czasopismo naukowe
Tytuł :
Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors.
Autorzy :
Huynh PN; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: .
Harvey PJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Gajewiak J; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Craik DJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Michael McIntosh J; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA; George E. Whalen Veterans Affairs Medical Center, Salt Lake City, UT 84112, USA; Department of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Nov; Vol. 181, pp. 114124. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amino Acid Substitution*
Amino Acids/*genetics
Conotoxins/*genetics
Receptors, Nicotinic/*metabolism
Amino Acid Sequence ; Amino Acids/chemistry ; Amino Acids/metabolism ; Animals ; Binding Sites/genetics ; Conotoxins/metabolism ; Conotoxins/pharmacology ; Humans ; Mollusk Venoms/chemistry ; Mollusk Venoms/metabolism ; Nicotinic Antagonists/metabolism ; Nicotinic Antagonists/pharmacology ; Oocytes/drug effects ; Oocytes/metabolism ; Oocytes/physiology ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Rats ; Receptors, Nicotinic/genetics ; Sequence Homology, Amino Acid ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Assessing the Binding of Venoms from Aquatic Elapids to the Nicotinic Acetylcholine Receptor Orthosteric Site of Different Prey Models.
Autorzy :
Harris RJ; Toxin Evolution Lab, University of Queensland, Biological Sciences, St. Lucia, QLD 4072, Australia.
Youngman NJ; Toxin Evolution Lab, University of Queensland, Biological Sciences, St. Lucia, QLD 4072, Australia.
Zdenek CN; Toxin Evolution Lab, University of Queensland, Biological Sciences, St. Lucia, QLD 4072, Australia.
Huynh TM; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Nouwens A; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.
Hodgson WC; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Harrich D; QIMR Berghofer, Royal Brisbane Hospital, Herston, QLD 4029, Australia.
Dunstan N; Venom Supplies, Tanunda, SA 5352, Australia.
Portes-Junior JA; Laboratório de Coleções Zoológicas, Instituto Butantan, São Paulo 05503-900, Brazil.
Fry BG; Toxin Evolution Lab, University of Queensland, Biological Sciences, St. Lucia, QLD 4072, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 06; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Elapid Venoms/*pharmacology
Receptors, Nicotinic/*drug effects
Animals ; Binding Sites ; Elapid Venoms/metabolism ; Elapidae ; Neurotoxins/pharmacology ; Protein Binding ; Receptors, Nicotinic/metabolism ; Species Specificity
Czasopismo naukowe
Tytuł :
Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives.
Autorzy :
Corrie LW; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Stokes C; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Wilkerson JL; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Carroll FI; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
McMahon LR; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Papke RL; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Oct; Vol. 98 (4), pp. 328-342. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Nicotinic Agonists/*pharmacology
Protein Subunits/*metabolism
Pyridines/*chemistry
Receptors, Nicotinic/*metabolism
Animals ; Animals, Genetically Modified ; Brain/metabolism ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Humans ; Molecular Structure ; Multiprotein Complexes/metabolism ; Nicotinic Agonists/chemistry ; Protein Subunits/genetics ; Receptors, Nicotinic/genetics ; Tropanes/chemistry ; Tropanes/pharmacology ; Xenopus/genetics
Czasopismo naukowe
Tytuł :
CRISPR-mediated gene knockout reveals nicotinic acetylcholine receptor (nAChR) subunit α6 as a target of spinosyns in Helicoverpa armigera.
Autorzy :
Wang J; College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Ma H; College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Zuo Y; College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Yang Y; College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Wu Y; College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
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Źródło :
Pest management science [Pest Manag Sci] 2020 Sep; Vol. 76 (9), pp. 2925-2931. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Insecticides*/pharmacology
Moths*/genetics
Moths*/metabolism
Receptors, Nicotinic*/genetics
Receptors, Nicotinic*/metabolism
Animals ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Knockout Techniques ; Insecticide Resistance/genetics
Czasopismo naukowe
Tytuł :
The functional role of the αM4 transmembrane helix in the muscle nicotinic acetylcholine receptor probed through mutagenesis and coevolutionary analyses.
Autorzy :
Thompson MJ; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Domville JA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Baenziger JE; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Aug 07; Vol. 295 (32), pp. 11056-11067. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Evolution*
Muscles/*metabolism
Receptors, Nicotinic/*metabolism
Amino Acid Substitution ; Animals ; Hydrophobic and Hydrophilic Interactions ; Ion Channel Gating ; Lipids/analysis ; Models, Molecular ; Mutagenesis ; Protein Conformation ; Receptors, Nicotinic/chemistry ; Receptors, Nicotinic/genetics ; Torpedo
Czasopismo naukowe
Tytuł :
Acute nicotine administration stimulates ciliary activity via α3β4 nAChR in the mouse trachea.
Autorzy :
Perniss A; Institute of Anatomy and Cell Biology, German Center for Lung Research, Justus-Liebig-University Giessen, Giessen, Germany. Electronic address: .
Latz A; Institute of Anatomy and Cell Biology, German Center for Lung Research, Justus-Liebig-University Giessen, Giessen, Germany.
Boseva I; Institute of Anatomy and Cell Biology, German Center for Lung Research, Justus-Liebig-University Giessen, Giessen, Germany.
Papadakis T; Institute of Anatomy and Cell Biology, German Center for Lung Research, Justus-Liebig-University Giessen, Giessen, Germany.
Dames C; Charité Berlin, Institute of Medical Immunology, Berlin, Germany.
Meisel C; Charité Berlin, Institute of Medical Immunology, Berlin, Germany.
Meisel A; Charité Berlin, Departments of Neurology and Experimental Neurology, NeuroCure Clinical Research Center, Berlin, Germany.
Scholze P; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University Vienna, Vienna, Austria.
Kummer W; Institute of Anatomy and Cell Biology, German Center for Lung Research, Justus-Liebig-University Giessen, Giessen, Germany.
Krasteva-Christ G; Institute of Anatomy and Cell Biology, German Center for Lung Research, Justus-Liebig-University Giessen, Giessen, Germany; Present address: Department of Anatomy and Cell Biology, Saarland University, Homburg/Saar, Germany.
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2020 Jul; Vol. 84, pp. 106496. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Cilia/*drug effects
Cilia/*metabolism
Movement/*drug effects
Nicotine/*pharmacology
Receptors, Nicotinic/*drug effects
Receptors, Nicotinic/*metabolism
Trachea/*drug effects
Animals ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nicotinic Agonists/pharmacology ; Nicotinic Antagonists/pharmacology ; Protein Subunits/physiology ; Receptors, Nicotinic/deficiency
Czasopismo naukowe
Tytuł :
Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products.
Autorzy :
Gu S; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121.
Knowland D; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121.
Matta JA; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121.
O'Carroll ML; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121.
Davini WB; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121.
Dhara M; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121.
Kweon HJ; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121.
Bredt DS; Neuroscience Discovery, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA 92121 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 29; Vol. 117 (39), pp. 24534-24544. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Deafness/*metabolism
Hair Cells, Auditory/*metabolism
Membrane Proteins/*metabolism
Receptors, Nicotinic/*metabolism
Animals ; Cochlea/metabolism ; Deafness/genetics ; Humans ; Ligands ; Membrane Proteins/genetics ; Mice ; Protein Binding ; Receptors, Nicotinic/genetics ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Chrna5 is Essential for a Rapid and Protected Response to Optogenetic Release of Endogenous Acetylcholine in Prefrontal Cortex.
Autorzy :
Venkatesan S; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Lambe EK; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada .; Department of Obstetrics & Gynecology, University of Toronto, Toronto, Ontario M5G 1E2, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Sep 16; Vol. 40 (38), pp. 7255-7268. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Synaptic Transmission*
Acetylcholine/*metabolism
Prefrontal Cortex/*metabolism
Receptors, Nicotinic/*metabolism
Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Nicotinic Agonists/pharmacology ; Optogenetics ; Oxadiazoles/pharmacology ; Prefrontal Cortex/cytology ; Prefrontal Cortex/physiology ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Pyramidal Cells/physiology ; Pyridines/pharmacology ; Receptors, Nicotinic/genetics
Czasopismo naukowe
Tytuł :
Low expression levels of nicotinic acetylcholine receptor subunits Boα1 and Boβ1 are associated with imidacloprid resistance in Bradysia odoriphaga.
Autorzy :
Shan T; Department of Entomology, China Agricultural University, Beijing, China.
Zhang H; Department of Entomology, China Agricultural University, Beijing, China.
Chen C; Department of Entomology, China Agricultural University, Beijing, China.
Chen A; Department of Entomology, China Agricultural University, Beijing, China.
Shi X; Department of Entomology, China Agricultural University, Beijing, China.
Gao X; Department of Entomology, China Agricultural University, Beijing, China.
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Źródło :
Pest management science [Pest Manag Sci] 2020 Sep; Vol. 76 (9), pp. 3038-3045. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Insecticides*/pharmacology
Receptors, Nicotinic*/genetics
Animals ; Insecticide Resistance/genetics ; Neonicotinoids/pharmacology ; Nitro Compounds/pharmacology
Czasopismo naukowe
Tytuł :
Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population?
Autorzy :
Olds JL; SCHAR School of Public Policy, George Mason University, Arlington, VA, USA.
Kabbani N; School of Systems Biology, George Mason University, Fairfax, VA, USA.
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Źródło :
The FEBS journal [FEBS J] 2020 Sep; Vol. 287 (17), pp. 3651-3655. Date of Electronic Publication: 2020 Mar 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Pandemics*
Angiotensin-Converting Enzyme 2/*genetics
COVID-19/*epidemiology
Nicotine/*adverse effects
Receptors, Nicotinic/*genetics
Smoking/*epidemiology
Spike Glycoprotein, Coronavirus/*genetics
Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/genetics ; COVID-19/physiopathology ; COVID-19/virology ; Female ; Gene Expression Regulation ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/genetics ; Humans ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Male ; Receptors, Nicotinic/metabolism ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Sex Factors ; Signal Transduction ; Smoking/genetics ; Smoking/physiopathology ; Spike Glycoprotein, Coronavirus/metabolism ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Nicotine inhibits MAPK signaling and spheroid invasion in ovarian cancer cells.
Autorzy :
Harmych SJ; Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, MS601, Toledo, OH, 43606, USA.
Kumar J; Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, MS601, Toledo, OH, 43606, USA.
Bouni ME; Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, MS601, Toledo, OH, 43606, USA.
Chadee DN; Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, MS601, Toledo, OH, 43606, USA. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Sep 01; Vol. 394 (1), pp. 112167. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Nicotine/*pharmacology
Ovarian Neoplasms/*drug therapy
Receptors, Nicotinic/*drug effects
Signal Transduction/*drug effects
Carcinoma, Ovarian Epithelial/drug therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Humans ; Imidazoles/pharmacology ; Ovarian Neoplasms/metabolism ; Phosphorylation/drug effects ; Pyridines/pharmacology ; Receptors, Nicotinic/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe

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