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Wyszukujesz frazę ""Receptors, Opioid, kappa"" wg kryterium: Temat


Tytuł :
In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands.
Autorzy :
Stefanucci A; Department of Pharmacy, University G. d'Annunzio Chieti, Via dei Vestini 31, 66100 Chieti, Italy.
Iobbi V; Department of Pharmacy (DIFAR), University of Genova, 16128 Genova, Italy.
Della Valle A; Department of Pharmacy, University G. d'Annunzio Chieti, Via dei Vestini 31, 66100 Chieti, Italy.
Scioli G; Department of Pharmacy, University G. d'Annunzio Chieti, Via dei Vestini 31, 66100 Chieti, Italy.
Pieretti S; Centro Nazionale Ricerca e Valutazione Preclinica e Clinica dei Farmaci, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Minosi P; Centro Nazionale Ricerca e Valutazione Preclinica e Clinica dei Farmaci, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Mirzaie S; Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie L. Dan Faculty of Pharmacy, University of Toronto, 27 King's College Circle, Toronto, ON M5S 1A1, Canada.
Novellino E; NGN Healthcare, Via Nazionale Torrette, 207, 83013 Mercogliano, Italy.
Mollica A; Department of Pharmacy, University G. d'Annunzio Chieti, Via dei Vestini 31, 66100 Chieti, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 06; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Drug Design*
Oligopeptides/*chemistry
Oligopeptides/*metabolism
Receptors, Opioid, kappa/*metabolism
Ligands ; Molecular Dynamics Simulation ; Protein Conformation ; Receptors, Opioid, kappa/chemistry
Czasopismo naukowe
Tytuł :
Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain.
Autorzy :
Muratspahić E; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Tomašević N; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Koehbach J; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Duerrauer L; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia.
Hadžić S; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Castro J; Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia 5042, Australia.; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.
Schober G; Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia 5042, Australia.; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.
Sideromenos S; Center for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Clark RJ; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia.
Brierley SM; Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia 5042, Australia.; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.; Discipline of Medicine, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia.
Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Gruber CW; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 9042-9055. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Abdominal Pain/*drug therapy
Analgesics/*pharmacology
Peptides, Cyclic/*pharmacology
Plant Extracts/*pharmacology
Receptors, Opioid, kappa/*antagonists & inhibitors
Analgesics/chemical synthesis ; Analgesics/chemistry ; Animals ; Cells, Cultured ; Chronic Disease ; Dose-Response Relationship, Drug ; Drug Design ; HEK293 Cells ; Helianthus/chemistry ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/chemistry ; Plant Extracts/chemical synthesis ; Plant Extracts/chemistry ; Receptors, Opioid, kappa/metabolism ; Seeds/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Deciphering the molecular basis of the kappa opioid receptor selectivity: A Molecular Dynamics study.
Autorzy :
Saleh AH; University of Science and Technology, Biomedical Sciences Program, Zewail City of Science and Technology, October Gardens, 6th of October, Giza, 12578, Egypt.
Abdelwaly A; University of Science and Technology, Biomedical Sciences Program, Zewail City of Science and Technology, October Gardens, 6th of October, Giza, 12578, Egypt.
Darwish KM; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
Eissa AAHM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Chittiboyina A; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, United States.
Helal MA; University of Science and Technology, Biomedical Sciences Program, Zewail City of Science and Technology, October Gardens, 6th of October, Giza, 12578, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt. Electronic address: .
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2021 Jul; Vol. 106, pp. 107940. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
Receptors, Opioid, kappa*
Ligands ; Narcotic Antagonists ; Receptors, Opioid
Czasopismo naukowe
Tytuł :
The kappa opioid receptor may be a potential tumor suppressor by regulating angiogenesis in breast cancer.
Autorzy :
Shi Y; Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China.
Luo J; Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China.
Tian J; Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China.
Zou Q; Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China. Electronic address: .
Wang X; Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 May; Vol. 150, pp. 110568. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/drug therapy
Receptors, Opioid, kappa*
Analgesics ; Analgesics, Opioid ; Humans ; Receptors, Opioid, mu
Czasopismo naukowe
Tytuł :
κ‑opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathway.
Autorzy :
Fan J; Postgraduate Training Base of The General Hospital of Northern Theater Command, Jinzhou Medical University, Jinzhou, Liaoning 121013, P.R. China.
Li L; Department of Anesthesiology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China.
Qu P; Department of Anesthesiology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China.
Diao Y; Department of Anesthesiology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China.
Sun Y; Department of Anesthesiology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Apr; Vol. 23 (4). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/*pharmacology
Cardiopulmonary Bypass/*methods
Postoperative Cognitive Complications/*prevention & control
Proteins/*metabolism
Receptors, Opioid, kappa/*agonists
Signal Transduction/*drug effects
Animals ; Apoptosis/drug effects ; Cardiopulmonary Bypass/adverse effects ; Heme Oxygenase-1/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Phosphatidylinositol 3-Kinases/metabolism ; Postoperative Cognitive Complications/etiology ; Postoperative Cognitive Complications/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa/metabolism
Czasopismo naukowe
Tytuł :
Conformational Constraint between Aromatic Residue Side Chains in the "Message" Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist.
Autorzy :
Gisemba SA; Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Ferracane MJ; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.; Department of Chemistry, University of Redlands, Redlands, California 92373, United States.
Murray TF; Departments of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, Nebraska 68102, United States.
Aldrich JV; Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 3153-3164. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dynorphins/*chemistry
Dynorphins/*pharmacology
Receptors, Opioid, kappa/*antagonists & inhibitors
Cyclization ; Dynorphins/chemical synthesis ; Humans ; Models, Molecular ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/pharmacology ; Receptors, Opioid, kappa/metabolism
Czasopismo naukowe
Tytuł :
Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators.
Autorzy :
Wang H; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
Cao D; Center for Substance Abuse Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
Gillespie JC; Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Mendez RE; Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Selley DE; Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Liu-Chen LY; Center for Substance Abuse Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
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Źródło :
Future medicinal chemistry [Future Med Chem] 2021 Mar; Vol. 13 (6), pp. 551-573. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Receptors, Opioid, kappa/*metabolism
Receptors, Opioid, mu/*metabolism
Allosteric Regulation ; Allosteric Site ; Binding Sites ; Humans ; Ligands ; Molecular Docking Simulation ; Morphinans/chemistry ; Morphinans/metabolism ; Naltrexone/analogs & derivatives ; Naltrexone/chemistry ; Naltrexone/metabolism ; Protein Binding ; Receptors, Opioid, kappa/chemistry ; Receptors, Opioid, mu/chemistry ; Spiro Compounds/chemistry ; Spiro Compounds/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review.
Autorzy :
Kaski SW; From the Departments of Neuroscience and Behavioral Medicine & Psychiatry, West Virginia University, Morgantown, West Virginia.
White AN; From the Departments of Neuroscience and Behavioral Medicine & Psychiatry, West Virginia University, Morgantown, West Virginia.
Gross JD; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina.
Siderovski DP; Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2021 Feb 01; Vol. 132 (2), pp. 406-419.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Drug Design*
Narcotic Antagonists/*pharmacology
Nociception/*drug effects
Nociceptive Pain/*drug therapy
Opioid-Related Disorders/*prevention & control
Receptors, Opioid, kappa/*agonists
Receptors, Opioid, mu/*agonists
Animals ; Humans ; Molecular Structure ; Narcotic Antagonists/adverse effects ; Narcotic Antagonists/chemistry ; Nociceptive Pain/metabolism ; Nociceptive Pain/physiopathology ; Nociceptive Pain/psychology ; Opioid-Related Disorders/etiology ; RGS Proteins/metabolism ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/metabolism ; Signal Transduction ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Pharmacological and phosphoproteomic approaches to roles of protein kinase C in kappa opioid receptor-mediated effects in mice.
Autorzy :
Liu JJ; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.
Chiu YT; Center for Substance Abuse Research & Department of Pharmacology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Chen C; Center for Substance Abuse Research & Department of Pharmacology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Huang P; Center for Substance Abuse Research & Department of Pharmacology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.
Liu-Chen LY; Center for Substance Abuse Research & Department of Pharmacology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Dec 15; Vol. 181, pp. 108324. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Kinase C/*genetics
Receptors, Opioid, kappa/*genetics
Signal Transduction/*drug effects
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology ; Animals ; Avoidance Learning ; G-Protein-Coupled Receptor Kinases ; Male ; Mice ; Motor Activity/drug effects ; Phosphoproteins ; Phosphorylation ; Protein Kinase C/drug effects ; Protein Kinase C/radiation effects ; Protein Kinase Inhibitors ; Proteomics ; Receptor, Cannabinoid, CB1/drug effects ; Receptors, G-Protein-Coupled/drug effects ; Receptors, Opioid, kappa/drug effects ; Receptors, Opioid, kappa/radiation effects ; TOR Serine-Threonine Kinases/drug effects ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors.
Autorzy :
Eshleman AJ; Research Service, Veterans Affairs Portland Health Care System, Portland, OR, United States; Department of Psychiatry, Oregon Health and Science University, Portland, OR, United States; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United States.
Nagarajan S; Medicinal Chemistry Core, Oregon Health and Science University, Portland, OR, United States.
Wolfrum KM; Research Service, Veterans Affairs Portland Health Care System, Portland, OR, United States.
Reed JF; Research Service, Veterans Affairs Portland Health Care System, Portland, OR, United States.
Nilsen A; Medicinal Chemistry Core, Oregon Health and Science University, Portland, OR, United States.
Torralva R; Research Service, Veterans Affairs Portland Health Care System, Portland, OR, United States; Department of Psychiatry, Oregon Health and Science University, Portland, OR, United States.
Janowsky A; Research Service, Veterans Affairs Portland Health Care System, Portland, OR, United States; Department of Psychiatry, Oregon Health and Science University, Portland, OR, United States; Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, United States; The Methamphetamine Abuse Research Center, Oregon Health and Science University, Portland, OR, United States. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114293. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Models, Molecular*
Analgesics, Opioid/*metabolism
Fentanyl/*metabolism
Molecular Docking Simulation/*methods
Receptors, Opioid, kappa/*metabolism
Analgesics, Opioid/chemistry ; Analgesics, Opioid/pharmacology ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Fentanyl/analogs & derivatives ; Fentanyl/chemistry ; Fentanyl/pharmacology ; Furans/chemistry ; Furans/metabolism ; Furans/pharmacology ; Humans ; Protein Binding/drug effects ; Protein Binding/physiology ; Protein Structure, Secondary ; Receptors, Opioid, kappa/agonists ; Receptors, Opioid, kappa/chemistry ; Structure-Activity Relationship ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Development of Diphenethylamines as Selective Kappa Opioid Receptor Ligands and Their Pharmacological Activities.
Autorzy :
Schmidhammer H; Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Erli F; Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Guerrieri E; Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Spetea M; Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 02; Vol. 25 (21). Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Analgesics, Opioid*/chemistry
Analgesics, Opioid*/therapeutic use
Pain*/drug therapy
Pain*/metabolism
Receptors, Opioid, kappa*/agonists
Receptors, Opioid, kappa*/chemistry
Receptors, Opioid, kappa*/metabolism
Humans ; Ligands ; Receptors, Opioid, mu/agonists ; Receptors, Opioid, mu/chemistry ; Receptors, Opioid, mu/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists.
Autorzy :
Huang H
Li X
Guo W
Zhu C
Qian Y
Shen Q
Xu X; Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
Li W
Wang Y; Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
Fu W
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jan 20; Vol. 12 (2), pp. 285-299. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Opioid, kappa*
Receptors, Opioid, mu*
Analgesics, Opioid/pharmacology ; Piperidines/pharmacology ; Receptors, Opioid ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Differential effects of novel kappa opioid receptor antagonists on dopamine neurons using acute brain slice electrophysiology.
Autorzy :
Margolis EB; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States of America.
Wallace TL; BlackThorn Therapeutics, San Francisco, CA, United States of America.
Van Orden LJ; BlackThorn Therapeutics, San Francisco, CA, United States of America.
Martin WJ; BlackThorn Therapeutics, San Francisco, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 29; Vol. 15 (12), pp. e0232864. Date of Electronic Publication: 2020 Dec 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons/*drug effects
Membrane Potentials/*drug effects
Receptors, Opioid, kappa/*antagonists & inhibitors
Analgesics, Opioid/pharmacology ; Animals ; Benzamides/pharmacology ; Biphenyl Compounds/pharmacology ; Dopaminergic Neurons/metabolism ; Electrophysiology ; Enkephalin, D-Penicillamine (2,5)-/pharmacology ; Male ; Mesencephalon/metabolism ; Narcotic Antagonists/pharmacology ; Oxadiazoles/pharmacology ; Patch-Clamp Techniques/methods ; Piperidines/pharmacology ; Pyrrolidines/pharmacology ; Quinolines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/metabolism ; Sulfonamides/pharmacology ; Ventral Tegmental Area/drug effects
Czasopismo naukowe
Tytuł :
The kappa-opioid receptor agonist, nalfurafine, blocks acquisition of oxycodone self-administration and oxycodone's conditioned rewarding effects in male rats.
Autorzy :
Zamarripa CA; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Patel TR; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Williams BC; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Pareek T; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Schrock HM; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Prisinzano TE; School of Pharmacy, University of Kentucky, Lexington, Kentucky, USA.
Freeman KB; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
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Źródło :
Behavioural pharmacology [Behav Pharmacol] 2020 Dec; Vol. 31 (8), pp. 792-797.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Morphinans/*pharmacology
Opioid-Related Disorders/*drug therapy
Receptors, Opioid, kappa/*agonists
Spiro Compounds/*pharmacology
Analgesics, Opioid/pharmacology ; Animals ; Conditioning, Classical/drug effects ; Dose-Response Relationship, Drug ; Male ; Morphinans/metabolism ; Opioid-Related Disorders/prevention & control ; Oxycodone/adverse effects ; Oxycodone/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid/agonists ; Receptors, Opioid/metabolism ; Receptors, Opioid, kappa/metabolism ; Reinforcement, Psychology ; Reward ; Self Administration ; Spiro Compounds/metabolism ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/prevention & control
Czasopismo naukowe
Tytuł :
The kappa opioid receptor antagonist aticaprant reverses behavioral effects from unpredictable chronic mild stress in male mice.
Autorzy :
Jacobson ML; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
Wulf HA; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
Browne CA; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .
Lucki I; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .; Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Dec; Vol. 237 (12), pp. 3715-3728. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article
MeSH Terms :
Benzamides/*therapeutic use
Narcotic Antagonists/*therapeutic use
Pyrrolidines/*therapeutic use
Receptors, Opioid, kappa/*antagonists & inhibitors
Stress, Psychological/*drug therapy
Stress, Psychological/*psychology
Animals ; Benzamides/pharmacology ; Chronic Disease ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Male ; Mice ; Mice, Inbred C57BL ; Narcotic Antagonists/pharmacology ; Pyrrolidines/pharmacology ; Receptors, Opioid, kappa/physiology ; Swimming/psychology
Czasopismo naukowe
Tytuł :
Kinetic Modeling and Test-Retest Reproducibility of C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans.
Autorzy :
Naganawa M; Yale PET Center, Yale University, New Haven, Connecticut .
Li S; Yale PET Center, Yale University, New Haven, Connecticut.
Nabulsi N; Yale PET Center, Yale University, New Haven, Connecticut.
Lin SF; Yale PET Center, Yale University, New Haven, Connecticut.
Labaree D; Yale PET Center, Yale University, New Haven, Connecticut.
Ropchan J; Yale PET Center, Yale University, New Haven, Connecticut.
Gao H; Yale PET Center, Yale University, New Haven, Connecticut.
Mei M; Yale PET Center, Yale University, New Haven, Connecticut.
Henry S; Yale PET Center, Yale University, New Haven, Connecticut.
Matuskey D; Yale PET Center, Yale University, New Haven, Connecticut.
Carson RE; Yale PET Center, Yale University, New Haven, Connecticut.
Huang Y; Yale PET Center, Yale University, New Haven, Connecticut.
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Źródło :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2020 Nov; Vol. 61 (11), pp. 1636-1642. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Carbon Radioisotopes/*pharmacokinetics
Piperazines/*pharmacokinetics
Positron-Emission Tomography/*methods
Radiopharmaceuticals/*pharmacokinetics
Receptors, Opioid, kappa/*agonists
Adult ; Female ; Humans ; Kinetics ; Male ; Middle Aged ; Models, Biological ; Pyrrolidines/pharmacokinetics ; Radioactive Tracers ; Receptors, Opioid, kappa/analysis ; Reproducibility of Results ; Young Adult
Czasopismo naukowe
Tytuł :
Contribution of mesolimbic dopamine and kappa opioid systems to the transition from acute to chronic pain.
Autorzy :
Vergara F; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
Sardi NF; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
Pescador AC; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
Guaita GO; Department of Pharmacology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
Jark Stern CA; Department of Pharmacology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
Chichorro JG; Department of Pharmacology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
Fischer L; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Nov 01; Vol. 178, pp. 108226. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Pain/*metabolism
Chronic Pain/*metabolism
Dopaminergic Neurons/*metabolism
Nucleus Accumbens/*metabolism
Receptors, Opioid, kappa/*metabolism
Ventral Tegmental Area/*metabolism
Acute Pain/chemically induced ; Analgesics, Opioid/pharmacology ; Animals ; Chronic Pain/chemically induced ; Dinoprostone/toxicity ; Disease Progression ; Dopamine/metabolism ; Dopaminergic Neurons/drug effects ; Male ; Nucleus Accumbens/drug effects ; Oxidopamine/toxicity ; Rats ; Rats, Wistar ; Receptors, Opioid, kappa/agonists ; Ventral Tegmental Area/drug effects
Czasopismo naukowe
Tytuł :
Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling.
Autorzy :
Jacobson ML; Department of Pharmacology & Molecular Therapeutics, Uniformed Service University, Bethesda, MD, 20814, USA.
Wulf HA; Department of Pharmacology & Molecular Therapeutics, Uniformed Service University, Bethesda, MD, 20814, USA.
Tsuda MC; Department of Pharmacology & Molecular Therapeutics, Uniformed Service University, Bethesda, MD, 20814, USA; Rat Behavior Core, Uniformed Service University, Bethesda, MD, 20814, USA.
Browne CA; Department of Pharmacology & Molecular Therapeutics, Uniformed Service University, Bethesda, MD, 20814, USA.
Lucki I; Department of Pharmacology & Molecular Therapeutics, Uniformed Service University, Bethesda, MD, 20814, USA; Department of Psychiatry, Uniformed Service University, Bethesda, MD, 20814, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Oct 15; Vol. 177, pp. 108254. Date of Electronic Publication: 2020 Jul 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Sex Characteristics*
Nesting Behavior/*physiology
Receptors, Opioid, kappa/*metabolism
Signal Transduction/*physiology
Analgesics, Non-Narcotic/pharmacology ; Analgesics, Opioid/pharmacology ; Animals ; Female ; Locomotion/drug effects ; Locomotion/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Narcotic Antagonists/pharmacology ; Nesting Behavior/drug effects ; Receptors, Opioid, kappa/agonists ; Receptors, Opioid, kappa/antagonists & inhibitors ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Molecular Interaction Between Butorphanol and κ-Opioid Receptor.
Autorzy :
Ji J; From the Department of Anesthesiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.; Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Lin W; Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Biochemistry and Molecular Biology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Vrudhula A; Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Xi J; Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Yeliseev A; Laboratory of Membrane Biochemistry & Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland.
Grothusen JR; Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Bu W; Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Liu R; Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2020 Sep; Vol. 131 (3), pp. 935-942.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Analgesics, Opioid/*pharmacology
Butorphanol/*pharmacology
Neurons/*drug effects
Receptors, Opioid, kappa/*agonists
Analgesics, Opioid/chemistry ; Analgesics, Opioid/metabolism ; Analgesics, Opioid/toxicity ; Animals ; Butorphanol/chemistry ; Butorphanol/metabolism ; Butorphanol/toxicity ; Cell Line, Tumor ; Drug Partial Agonism ; HEK293 Cells ; Humans ; Mice ; Molecular Docking Simulation ; Neurons/metabolism ; Protein Binding ; Protein Conformation ; Receptors, Opioid, kappa/chemistry ; Receptors, Opioid, kappa/metabolism ; Signal Transduction ; Structure-Activity Relationship ; beta-Arrestins/metabolism
Czasopismo naukowe
Tytuł :
A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA A Receptor.
Autorzy :
Li G; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
Nieman AN; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Mian MY; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Zahn NM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Mikulsky BN; Pantherics Incorporated, La Jolla, CA 92037, USA.
Poe MM; Department of Chemistry, Western Michigan University, Kalamazoo, MI 49008, USA.
Methuku KR; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Liu Y; National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.
Cook JM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Stafford DC; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.; Pantherics Incorporated, La Jolla, CA 92037, USA.
Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.; Pantherics Incorporated, La Jolla, CA 92037, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Aug 25; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Azepines*/chemistry
Azepines*/pharmacology
GABA-A Receptor Agonists*/chemistry
GABA-A Receptor Agonists*/pharmacology
Receptors, GABA-A*/chemistry
Receptors, GABA-A*/genetics
Receptors, GABA-A*/metabolism
Receptors, Opioid, delta*/agonists
Receptors, Opioid, delta*/chemistry
Receptors, Opioid, delta*/genetics
Receptors, Opioid, delta*/metabolism
Receptors, Opioid, kappa*/agonists
Receptors, Opioid, kappa*/chemistry
Receptors, Opioid, kappa*/genetics
Receptors, Opioid, kappa*/metabolism
Receptors, Opioid, mu*/agonists
Receptors, Opioid, mu*/chemistry
Receptors, Opioid, mu*/genetics
Receptors, Opioid, mu*/metabolism
Animals ; HEK293 Cells ; Humans ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe

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