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Tytuł:
Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway.
Autorzy:
Miyano K; Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Yoshida Y; Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278-8510, Japan.
Hirayama S; Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Takahashi H; Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Ono H; Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Meguro Y; Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University School of Medicine, Tochigi 329-0498, Japan.
Manabe S; Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Komatsu A; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo 105-8461, Japan.; Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
Nonaka M; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Mizuguchi T; Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Fujii H; Department of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Higami Y; Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278-8510, Japan.
Narita M; Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.; Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142-8501, Japan.
Uezono Y; Department of Pain Control Research, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
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Źródło:
Cells [Cells] 2021 Oct 04; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*/drug effects
GTP-Binding Proteins/*metabolism
Oxytocin/*pharmacology
Receptors, Opioid, delta/*metabolism
Receptors, Opioid, kappa/*metabolism
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology ; Allosteric Regulation/drug effects ; Animals ; Binding Sites ; CHO Cells ; Cricetulus ; Cyclic AMP/metabolism ; Diprenorphine/pharmacology ; Dynorphins/pharmacology ; Electric Impedance ; Endocytosis/drug effects ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Receptors, Opioid, delta/agonists ; Receptors, Opioid, kappa/agonists
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA A Receptor.
Autorzy:
Li G; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
Nieman AN; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Mian MY; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Zahn NM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Mikulsky BN; Pantherics Incorporated, La Jolla, CA 92037, USA.
Poe MM; Department of Chemistry, Western Michigan University, Kalamazoo, MI 49008, USA.
Methuku KR; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Liu Y; National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.
Cook JM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Stafford DC; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.; Pantherics Incorporated, La Jolla, CA 92037, USA.
Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.; Pantherics Incorporated, La Jolla, CA 92037, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Aug 25; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 25.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Azepines*/chemistry
Azepines*/pharmacology
GABA-A Receptor Agonists*/chemistry
GABA-A Receptor Agonists*/pharmacology
Receptors, GABA-A*/chemistry
Receptors, GABA-A*/genetics
Receptors, GABA-A*/metabolism
Receptors, Opioid, delta*/agonists
Receptors, Opioid, delta*/chemistry
Receptors, Opioid, delta*/genetics
Receptors, Opioid, delta*/metabolism
Receptors, Opioid, kappa*/agonists
Receptors, Opioid, kappa*/chemistry
Receptors, Opioid, kappa*/genetics
Receptors, Opioid, kappa*/metabolism
Receptors, Opioid, mu*/agonists
Receptors, Opioid, mu*/chemistry
Receptors, Opioid, mu*/genetics
Receptors, Opioid, mu*/metabolism
Animals ; HEK293 Cells ; Humans ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of a Novel Delta Opioid Receptor Agonist Chemotype with Potential Negative Allosteric Modulator Capabilities.
Autorzy:
Meqbil YJ; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.; Computational Interdisciplinary Life Sciences, Purdue University, West Lafayette, IN 47907, USA.
Su H; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Cassell RJ; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Mores KL; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Gutridge AM; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Cummins BR; Department of Chemistry, College of Science, Purdue University, West Lafayette, IN 47907, USA.
Chen L; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.
van Rijn RM; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Nov 29; Vol. 26 (23). Date of Electronic Publication: 2021 Nov 29.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Opioid, delta/*agonists
Allosteric Regulation/drug effects ; Amino Acids/chemistry ; Binding Sites ; Cyclic AMP/metabolism ; Enkephalin, Leucine/chemistry ; Enkephalin, Leucine/pharmacology ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Molecular Dynamics Simulation ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/metabolism ; beta-Arrestins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems.
Autorzy:
Wawrzczak-Bargieła A; Department of Molecular Neuropharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Ziółkowska B; Department of Molecular Neuropharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Piotrowska A; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Starnowska-Sokół J; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Rojewska E; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Mika J; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Przewłocka B; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Przewłocki R; Department of Molecular Neuropharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2020 Apr; Vol. 37 (4), pp. 800-814. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Neuralgia/*metabolism
Pain Measurement/*methods
Prosencephalon/*metabolism
Receptors, Dopamine/*biosynthesis
Receptors, Opioid, delta/*biosynthesis
Receptors, Opioid, kappa/*biosynthesis
Animals ; Corpus Striatum/metabolism ; Enkephalins/biosynthesis ; Enkephalins/genetics ; Gene Expression ; Male ; Mice ; Neuralgia/genetics ; Protein Precursors/biosynthesis ; Protein Precursors/genetics ; Receptors, Dopamine/genetics ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, kappa/genetics ; Receptors, Opioid, mu/biosynthesis ; Receptors, Opioid, mu/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development and Biological Applications of Fluorescent Opioid Ligands.
Autorzy:
Drakopoulos A; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, 97074, Würzburg, Germany.
Decker M; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, 97074, Würzburg, Germany.
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Źródło:
ChemPlusChem [Chempluschem] 2020 Jun; Vol. 85 (6), pp. 1354-1364.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Fluorescent Dyes/*chemistry
Receptors, Opioid, delta/*metabolism
Receptors, Opioid, kappa/*metabolism
Receptors, Opioid, mu/*metabolism
Animals ; Humans ; Ligands ; Microscopy, Confocal ; Microscopy, Fluorescence ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration.
Autorzy:
Stevenson GW; Department of Psychology, University of New England, Biddeford, ME, 04005, USA. .; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, USA. .
Giuvelis D; Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005, USA.
Cormier J; Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005, USA.
Cone K; Department of Psychology, University of New England, Biddeford, ME, 04005, USA.
Atherton P; Department of Psychology, University of New England, Biddeford, ME, 04005, USA.
Krivitsky R; Department of Psychology, University of New England, Biddeford, ME, 04005, USA.
Warner E; Department of Psychology, University of New England, Biddeford, ME, 04005, USA.
St Laurent B; Department of Psychology, University of New England, Biddeford, ME, 04005, USA.
Dutra J; Department of Psychology, University of New England, Biddeford, ME, 04005, USA.
Bidlack JM; Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Szabò L; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA.
Polt R; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA.
Bilsky EJ; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, USA.; Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005, USA.; Department of Biomedical Sciences College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, Yakima, WA, 98901, USA.
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2020 Apr; Vol. 237 (4), pp. 1195-1208. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji:
Journal Article
MeSH Terms:
Analgesics, Opioid/*administration & dosage
Neuralgia/*drug therapy
Pain Measurement/*drug effects
Receptors, Opioid, delta/*agonists
Receptors, Opioid, mu/*agonists
Respiratory Mechanics/*drug effects
Analgesics, Opioid/chemistry ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/psychology ; Male ; Mice ; Morphine/administration & dosage ; Neuralgia/metabolism ; Neuralgia/psychology ; Pain Measurement/psychology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, delta/metabolism ; Receptors, Opioid, kappa/agonists ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/metabolism ; Respiratory Mechanics/physiology ; Self Administration
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships.
Autorzy:
Journigan VB; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA, 94043, USA.; Marshall University School of Pharmacy, Department of Pharmaceutical Sciences, One John Marshall Drive, Huntington, WV 25755, USA.
Polgar WE; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA, 94043, USA.
Tuan EW; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA, 94043, USA.
Lu J; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA, 94043, USA.
Daga PR; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA, 94043, USA.
Zaveri NT; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA, 94043, USA. .
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Źródło:
Scientific reports [Sci Rep] 2017 Oct 16; Vol. 7 (1), pp. 13255. Date of Electronic Publication: 2017 Oct 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Narcotic Antagonists/*chemistry
Opioid Peptides/*chemistry
Receptors, Opioid/*chemistry
Receptors, Opioid, delta/*antagonists & inhibitors
Receptors, Opioid, kappa/*antagonists & inhibitors
Receptors, Opioid, mu/*antagonists & inhibitors
Humans ; Narcotic Antagonists/pharmacology ; Receptors, Opioid, delta/chemistry ; Receptors, Opioid, kappa/chemistry ; Receptors, Opioid, mu/chemistry ; Structure-Activity Relationship ; Nociceptin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis.
Autorzy:
Estomba H; Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain.
Muñoa-Hoyos I; Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain.
Gianzo M; Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain.
Urizar-Arenaza I; Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain.
Casis L; Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain.
Irazusta J; Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain.
Subirán N; Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Bizkaia, Spain.
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Źródło:
PloS one [PLoS One] 2016 Mar 31; Vol. 11 (3), pp. e0152162. Date of Electronic Publication: 2016 Mar 31 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Spermatogenesis*/drug effects
Receptors, Opioid, delta/*analysis
Receptors, Opioid, kappa/*analysis
Receptors, Opioid, mu/*analysis
Spermatozoa/*cytology
Testis/*cytology
Animals ; Cells, Cultured ; Male ; Mice ; Real-Time Polymerase Chain Reaction ; Receptors, Opioid, delta/agonists ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, kappa/agonists ; Receptors, Opioid, kappa/genetics ; Receptors, Opioid, mu/agonists ; Receptors, Opioid, mu/genetics ; Spermatozoa/drug effects ; Spermatozoa/metabolism ; Testis/drug effects ; Testis/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Prenatal ethanol increases ethanol intake throughout adolescence, alters ethanol-mediated aversive learning, and affects μ but not δ or κ opioid receptor mRNA expression.
Autorzy:
Fabio MC; Instituto de Investigación Médica M. y M. Ferreyra (INIMEC - CONICET-UNC), Friuli 2434, Córdoba, C.P. 5000, Argentina.; Facultad de Psicología, Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Macchione AF; Instituto de Investigación Médica M. y M. Ferreyra (INIMEC - CONICET-UNC), Friuli 2434, Córdoba, C.P. 5000, Argentina.
Nizhnikov ME; Department of Psychology, Southern Connecticut State University, New Haven, CT, USA.
Pautassi RM; Instituto de Investigación Médica M. y M. Ferreyra (INIMEC - CONICET-UNC), Friuli 2434, Córdoba, C.P. 5000, Argentina.; Facultad de Psicología, Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2015 Jun; Vol. 41 (12), pp. 1569-79. Date of Electronic Publication: 2015 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alcohol Drinking/*physiopathology
Avoidance Learning/*drug effects
Central Nervous System Depressants/*toxicity
Ethanol/*toxicity
Prenatal Exposure Delayed Effects/*chemically induced
Receptors, Opioid, delta/*metabolism
Receptors, Opioid, kappa/*metabolism
Age Factors ; Animals ; Female ; Male ; Pregnancy ; Prenatal Exposure Delayed Effects/physiopathology ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, kappa/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
An analysis of genetic association in opioid dependence susceptibility.
Autorzy:
Nagaya D; Cluster for Regenerative Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Minden, Penang, Malaysia.; Penang Medical College, George Town, Penang, Malaysia.
Zahari Z; Department of Pharmacy, Hospital Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Saleem M; GenomixLab, Advanced Genomics Sdn Bhd, Petaling Jaya, Malaysia.
Yahaya BH; Cluster for Regenerative Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Minden, Penang, Malaysia.
Tan SC; Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden, Penang, Malaysia.
Yusoff NM; Cluster for Regenerative Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Minden, Penang, Malaysia.
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Źródło:
Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2018 Feb; Vol. 43 (1), pp. 80-86. Date of Electronic Publication: 2017 Jun 27.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Predisposition to Disease/*genetics
Opioid-Related Disorders/*genetics
Polymorphism, Single Nucleotide/*genetics
Receptors, Opioid, delta/*genetics
Receptors, Opioid, kappa/*genetics
Adult ; Alleles ; Gene Frequency/genetics ; Genotype ; Humans ; Male
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Determination of μ-, δ- and κ-opioid receptors in forebrain cortex of rats exposed to morphine for 10 days: Comparison with animals after 20 days of morphine withdrawal.
Autorzy:
Ujcikova H; Department of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Hlouskova M; Department of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Cechova K; Department of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
Stolarova K; Department of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Roubalova L; Department of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Svoboda P; Department of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
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Źródło:
PloS one [PLoS One] 2017 Oct 20; Vol. 12 (10), pp. e0186797. Date of Electronic Publication: 2017 Oct 20 (Print Publication: 2017).
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Substance Withdrawal Syndrome*
Morphine/*administration & dosage
Prosencephalon/*metabolism
Receptors, Opioid, delta/*metabolism
Receptors, Opioid, kappa/*metabolism
Receptors, Opioid, mu/*metabolism
Animals ; Blotting, Western ; Electrophoresis, Gel, Two-Dimensional ; Electrophoresis, Polyacrylamide Gel ; Male ; Morphine/adverse effects ; Rats ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model.
Autorzy:
Nielsen LM; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christrup LL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sato H; Interstitial Lung Disease Unit, Royal Brompton Hospital & National Heart and Lung Institute, Imperial College London, London, UK.
Drewes AM; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Olesen AE; Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2017 Jul; Vol. 121 (1), pp. 6-12. Date of Electronic Publication: 2017 Mar 14.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Analgesics, Opioid/*pharmacology
Catechol O-Methyltransferase/*genetics
Morphine/*pharmacology
Pain/*genetics
Receptors, Opioid, delta/*genetics
Receptors, Opioid, mu/*genetics
Adult ; Analgesia/methods ; Analgesics, Opioid/therapeutic use ; Biological Variation, Population/genetics ; Cross-Over Studies ; Double-Blind Method ; Female ; Genotype ; Human Experimentation ; Humans ; Male ; Morphine/therapeutic use ; Pain/drug therapy ; Pain/etiology ; Pain Management/methods ; Pain Measurement ; Polymorphism, Single Nucleotide ; Receptors, Opioid, kappa/genetics ; Sex Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.
Autorzy:
Ansonoff MA; Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA.
Portoghese PS
Pintar JE
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2010 Jun; Vol. 210 (2), pp. 161-8. Date of Electronic Publication: 2010 Mar 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Pain/*physiopathology
Receptors, Opioid, delta/*agonists
Receptors, Opioid, delta/*antagonists & inhibitors
Receptors, Opioid, kappa/*agonists
Receptors, Opioid, kappa/*antagonists & inhibitors
Amides/pharmacology ; Animals ; Dose-Response Relationship, Drug ; Enkephalin, D-Penicillamine (2,5)-/pharmacology ; Guanidines/pharmacology ; Ligands ; Male ; Mice ; Mice, Knockout ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Oligopeptides/pharmacology ; Pain/metabolism ; Protein Multimerization ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, kappa/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats.
Autorzy:
Kim HJ; Department of Anesthesiology and Pain Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.
Seol TK
Lee HJ
Yaksh TL
Jun JH
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Źródło:
Journal of anesthesia [J Anesth] 2011 Dec; Vol. 25 (6), pp. 884-91. Date of Electronic Publication: 2011 Oct 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adrenergic alpha-2 Receptor Agonists/*pharmacology
Hyperalgesia/*drug therapy
Receptors, Opioid, delta/*agonists
Receptors, Opioid, kappa/*agonists
Receptors, Opioid, mu/*agonists
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology ; Animals ; Burns/complications ; Burns/drug therapy ; Clonidine/analogs & derivatives ; Clonidine/pharmacology ; Enkephalin, D-Penicillamine (2,5)-/pharmacology ; Hyperalgesia/etiology ; Male ; Morphine/pharmacology ; Pain Threshold/drug effects ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, delta/administration & dosage ; Receptors, Opioid, kappa/administration & dosage ; Receptors, Opioid, mu/administration & dosage ; Spinal Cord/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
N-methylated cyclic enkephalin analogues retain high opioid receptor binding affinity.
Autorzy:
Weltrowska G; Clinical Research Institute of Montreal, Quebec, Canada.
Berezowska I
Lemieux C
Chung NN
Wilkes BC
Schiller PW
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2010 Feb; Vol. 75 (2), pp. 182-8. Date of Electronic Publication: 2009 Dec 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Enkephalins/*chemistry
Receptors, Opioid, delta/*chemistry
Receptors, Opioid, kappa/*chemistry
Receptors, Opioid, mu/*chemistry
Amino Acid Sequence ; Animals ; Computer Simulation ; Enkephalins/chemical synthesis ; Guinea Pigs ; Methylation ; Mice ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/chemistry ; Protein Structure, Tertiary ; Receptors, Opioid, delta/agonists ; Receptors, Opioid, kappa/agonists ; Receptors, Opioid, mu/agonists
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis and SAR study of opioid receptor ligands: mono- and bis-indolomorphinans.
Autorzy:
Li F; Synthetic Organic and Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yin C
Chen J
Liu J
Xie X
Zhang A
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2009 Oct; Vol. 74 (4), pp. 335-42. Date of Electronic Publication: 2009 Aug 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Analgesics, Opioid/*chemical synthesis
Morphinans/*chemical synthesis
Receptors, Opioid, delta/*agonists
Receptors, Opioid, kappa/*agonists
Receptors, Opioid, mu/*agonists
Analgesics, Opioid/chemistry ; Analgesics, Opioid/pharmacology ; Animals ; Ligands ; Morphinans/chemistry ; Morphinans/pharmacology ; Rats ; Receptors, Opioid, delta/metabolism ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Autorzy:
Pacheco Dda F; Department of Pharmacology, Institute of Biological Sciences, UFMG, Av. Antônio Carlos, Belo Horizonte, Brazil.
Klein A
Perez AC
Pacheco CM
de Francischi JN
Reis GM
Duarte ID
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2009 Sep; Vol. 158 (1), pp. 225-31. Date of Electronic Publication: 2009 Jul 07.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Morphine/*pharmacology
Pain Measurement/*drug effects
Receptor, Cannabinoid, CB1/*physiology
Receptors, Opioid, delta/*physiology
Receptors, Opioid, kappa/*physiology
Receptors, Opioid, mu/*physiology
Analgesics, Opioid/pharmacology ; Animals ; Indoles/pharmacology ; Male ; Mice ; Pain Measurement/methods ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Receptors, Opioid, delta/metabolism ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/agonists
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.
Autorzy:
Jones JD; Division of Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, 10032, New York, New York.
Luba RR; Division of Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, 10032, New York, New York.
Vogelman JL; Division of Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, 10032, New York, New York.
Comer SD; Division of Substance Abuse, New York Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, 10032, New York, New York.
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Źródło:
The American journal on addictions [Am J Addict] 2016 Jan; Vol. 25 (1), pp. 41-8. Date of Electronic Publication: 2015 Dec 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Polymorphism, Genetic*
Opioid-Related Disorders/*genetics
Receptors, Opioid, delta/*genetics
Receptors, Opioid, kappa/*genetics
Receptors, Opioid, mu/*genetics
Substance Withdrawal Syndrome/*genetics
Adult ; Animals ; Female ; Genotype ; Heroin Dependence/genetics ; Humans ; Male ; Middle Aged ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.
Autorzy:
Zhang H; VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA.
Kranzler HR
Yang BZ
Luo X
Gelernter J
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Źródło:
Molecular psychiatry [Mol Psychiatry] 2008 May; Vol. 13 (5), pp. 531-43. Date of Electronic Publication: 2007 Jul 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Polymorphism, Single Nucleotide*
Alcoholism/*genetics
Receptors, Opioid, delta/*physiology
Receptors, Opioid, kappa/*physiology
Substance-Related Disorders/*genetics
Adolescent ; Adult ; Aged ; Case-Control Studies ; Cocaine-Related Disorders/genetics ; Europe/ethnology ; Exons/genetics ; Female ; Genetic Predisposition to Disease ; Haplotypes/genetics ; Heroin Dependence/genetics ; Humans ; Linkage Disequilibrium ; Male ; Middle Aged ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, kappa/genetics ; Risk ; United States/epidemiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats.
Autorzy:
Solinas M; Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, Division of Intramural Research, National Institute of Health, Room 318, 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA. />Goldberg SR
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2005 Jun; Vol. 179 (4), pp. 804-12. Date of Electronic Publication: 2004 Dec 24.
Typ publikacji:
Journal Article
MeSH Terms:
Discrimination, Psychological/*drug effects
Dronabinol/*pharmacology
Hallucinogens/*pharmacology
Receptors, Opioid, delta/*drug effects
Receptors, Opioid, kappa/*drug effects
Receptors, Opioid, mu/*drug effects
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology ; Analgesics, Non-Narcotic/pharmacology ; Animals ; Benzamides/pharmacology ; Conditioning, Operant/drug effects ; Discrimination Learning/drug effects ; Dose-Response Relationship, Drug ; Dronabinol/antagonists & inhibitors ; Food ; Hallucinogens/antagonists & inhibitors ; Heroin/pharmacology ; Male ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Narcotic Antagonists/pharmacology ; Narcotics/pharmacology ; Piperazines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, delta/agonists ; Receptors, Opioid, delta/antagonists & inhibitors ; Receptors, Opioid, kappa/agonists ; Receptors, Opioid, kappa/antagonists & inhibitors ; Receptors, Opioid, mu/agonists ; Receptors, Opioid, mu/antagonists & inhibitors ; Reinforcement, Psychology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 31

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