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Wyszukujesz frazę ""Receptors, Presynaptic"" wg kryterium: Temat


Tytuł :
Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT1A Receptor Biased Agonists.
Autorzy :
Depoortere R; Neurolixis SAS, Castres, France, .
Bardin L; Laboratoires Pierre Fabre, Castres, France.
Auclair AL; Laboratoires Pierre Fabre, Castres, France.
Bruins Slot LA; Laboratoires Pierre Fabre, Castres, France.
Newman-Tancredi A; Neurolixis SAS, Castres, France.
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Źródło :
Pharmacology [Pharmacology] 2021; Vol. 106 (1-2), pp. 114-118. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Wiadomości
MeSH Terms :
Behavior, Animal/*drug effects
Receptor, Serotonin, 5-HT1A/*drug effects
Receptors, Presynaptic/*drug effects
Serotonin 5-HT1 Receptor Agonists/*administration & dosage
Serotonin 5-HT1 Receptor Agonists/*pharmacology
Aminopyridines/administration & dosage ; Aminopyridines/pharmacology ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Injections, Intraperitoneal ; Male ; Mice, Inbred Strains ; Obsessive-Compulsive Disorder/drug therapy ; Piperazines/administration & dosage ; Piperazines/pharmacology ; Piperidines/administration & dosage ; Piperidines/pharmacology ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacology ; Serotonin Antagonists/administration & dosage ; Serotonin Antagonists/pharmacology ; Synapses/drug effects
Periodyk
Tytuł :
Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain.
Autorzy :
Deng M; Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 110, Houston, TX, 77030, USA.; Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, 410013, Hunan, China.
Chen SR; Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 110, Houston, TX, 77030, USA.
Pan HL; Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 110, Houston, TX, 77030, USA. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 May; Vol. 76 (10), pp. 1889-1899. Date of Electronic Publication: 2019 Feb 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neuralgia/*physiopathology
Nociceptive Pain/*physiopathology
Receptors, N-Methyl-D-Aspartate/*physiology
Receptors, Presynaptic/*physiology
Spinal Cord/*physiopathology
Animals ; Mice ; Neuralgia/metabolism ; Nociception/physiology ; Nociceptive Pain/metabolism ; Nociceptors/metabolism ; Nociceptors/physiology ; Rats ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, Presynaptic/metabolism
Czasopismo naukowe
Tytuł :
BDNF Activates Postsynaptic TrkB Receptors to Induce Endocannabinoid Release and Inhibit Presynaptic Calcium Influx at a Calyx-Type Synapse.
Autorzy :
Wu Y; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, P.R. China 200438.
Liu Q; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, P.R. China 200438.
Guo B; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, P.R. China 200438.
Ye F; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, P.R. China 200438.
Ge J; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, P.R. China 200438.
Xue L; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, P.R. China 200438 .; Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, P.R. China 201102.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Oct 14; Vol. 40 (42), pp. 8070-8087. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain-Derived Neurotrophic Factor/*physiology
Calcium Signaling/*physiology
Endocannabinoids/*metabolism
Receptor, trkB/*physiology
Receptors, Presynaptic/*physiology
Synapses/*physiology
Animals ; Endocytosis/physiology ; Excitatory Postsynaptic Potentials/physiology ; Exocytosis/physiology ; Female ; In Vitro Techniques ; Male ; Rats ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism.
Autorzy :
Li S; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
Xiong GJ; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
Huang N; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
Sheng ZH; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA. .
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Źródło :
Nature metabolism [Nat Metab] 2020 Oct; Vol. 2 (10), pp. 1077-1095. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Energy Metabolism/*physiology
Mitochondria/*metabolism
Receptor Cross-Talk/*physiology
Synapses/*metabolism
Synapses/*physiology
AMP-Activated Protein Kinases/metabolism ; Actins/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Calcium/metabolism ; Excitatory Postsynaptic Potentials ; Female ; Male ; Membrane Potential, Mitochondrial ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Myosin Heavy Chains/metabolism ; Nerve Tissue Proteins/genetics ; Phosphorylation ; Primary Cell Culture ; Receptors, Presynaptic/metabolism ; p21-Activated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Presynaptic mGluRs Control the Duration of Endocannabinoid-Mediated DSI.
Autorzy :
Colmers PLW; Hotchkiss Brain Institute and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Bains JS; Hotchkiss Brain Institute and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2018 Dec 05; Vol. 38 (49), pp. 10444-10453. Date of Electronic Publication: 2018 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocannabinoids/*physiology
Inhibitory Postsynaptic Potentials/*physiology
Receptor, Cannabinoid, CB1/*metabolism
Receptors, Metabotropic Glutamate/*metabolism
Receptors, Presynaptic/*metabolism
Animals ; Endocannabinoids/pharmacology ; Female ; Glutamic Acid/metabolism ; Inhibitory Postsynaptic Potentials/drug effects ; Male ; Methoxyhydroxyphenylglycol/analogs & derivatives ; Methoxyhydroxyphenylglycol/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Optogenetics/methods ; Receptor, Cannabinoid, CB1/chemistry ; Receptors, Metabotropic Glutamate/chemistry ; Receptors, Presynaptic/chemistry ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Tytuł :
Towards resolving the presynaptic NMDA receptor debate.
Autorzy :
Bouvier G; University of California, San Francisco, Physiology Department, CA, USA.
Larsen RS; Allen Institute for Brain Science, Seattle, WA 98103, USA.
Rodríguez-Moreno A; Universidad Pablo de Olavide, Seville, Spain.
Paulsen O; University of Cambridge, Cambridge, United Kingdom.
Sjöström PJ; Centre for Research in Neuroscience, The BRAIN Program, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montréal, Québec H3G 1A4, Canada. Electronic address: .
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Źródło :
Current opinion in neurobiology [Curr Opin Neurobiol] 2018 Aug; Vol. 51, pp. 1-7. Date of Electronic Publication: 2018 Jan 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neuronal Plasticity/*physiology
Receptors, N-Methyl-D-Aspartate/*metabolism
Receptors, Presynaptic/*metabolism
Synapses/*physiology
Animals ; Receptors, Presynaptic/physiology
Czasopismo naukowe
Tytuł :
P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals.
Autorzy :
Currò D; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy.
Navarra P; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy.
Samengo I; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy.
Martire M; Institute of Pharmacology, School of Medicine, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168, Rome, Italy. .
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Źródło :
The journal of headache and pain [J Headache Pain] 2020 Jul 02; Vol. 21 (1), pp. 83. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Endings/*drug effects
Nerve Endings/*metabolism
Receptors, AMPA/*metabolism
Receptors, Presynaptic/*metabolism
Receptors, Purinergic P2X7/*physiology
Trigeminal Caudal Nucleus/*metabolism
Animals ; Excitatory Amino Acid Antagonists/pharmacology ; Male ; Purinergic P2X Receptor Agonists ; Purinergic P2X Receptor Antagonists/pharmacology ; Rats ; Synaptic Transmission ; Synaptosomes/drug effects ; Synaptosomes/metabolism
Czasopismo naukowe
Tytuł :
Administration of low doses of the 5-HT 1A receptor agonist 8-OH-DPAT attenuates the discriminative signal of amphetamine in the conditioned taste aversion procedure.
Autorzy :
Sandoval-Sánchez AR; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av de los Barrios 1, Los Reyes Iztacala, Tlalnepantla, Edo. de Mexico 54090, Mexico.
Cedillo Zavaleta LN; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av de los Barrios 1, Los Reyes Iztacala, Tlalnepantla, Edo. de Mexico 54090, Mexico.
Jiménez JC; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av de los Barrios 1, Los Reyes Iztacala, Tlalnepantla, Edo. de Mexico 54090, Mexico.
Ruíz-García I; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av de los Barrios 1, Los Reyes Iztacala, Tlalnepantla, Edo. de Mexico 54090, Mexico.
Miranda F; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Av de los Barrios 1, Los Reyes Iztacala, Tlalnepantla, Edo. de Mexico 54090, Mexico. Electronic address: .
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Źródło :
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Jun; Vol. 193, pp. 172932. Date of Electronic Publication: 2020 Apr 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
8-Hydroxy-2-(di-n-propylamino)tetralin/*administration & dosage
Amphetamine/*administration & dosage
Aversive Agents/*administration & dosage
Central Nervous System Stimulants/*administration & dosage
Serotonin 5-HT1 Receptor Agonists/*administration & dosage
Taste/*drug effects
Animals ; Dopamine/metabolism ; Extracellular Space/metabolism ; Male ; Microdialysis ; Nucleus Accumbens/metabolism ; Raphe Nuclei/metabolism ; Rats ; Rats, Wistar ; Receptor, Serotonin, 5-HT1A ; Receptors, Presynaptic/metabolism ; Serotonin 5-HT1 Receptor Antagonists/administration & dosage ; Signal Transduction/drug effects ; Ventral Tegmental Area/metabolism ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Tytuł :
Functional characterization of the antiepileptic drug candidate, padsevonil, on GABA A receptors.
Autorzy :
Niespodziany I; Neurosciences Therapeutic Area, UCB Pharma, Braine l'Alleud, Belgium.
Ghisdal P; Neurosciences Therapeutic Area, UCB Pharma, Braine l'Alleud, Belgium.
Mullier B; Neurosciences Therapeutic Area, UCB Pharma, Braine l'Alleud, Belgium.
Wood M; Neurosciences Therapeutic Area, UCB Pharma, Braine l'Alleud, Belgium.
Provins L; Neurosciences Therapeutic Area, UCB Pharma, Braine l'Alleud, Belgium.
Kaminski RM; Neurosciences Therapeutic Area, UCB Pharma, Braine l'Alleud, Belgium.
Wolff C; Neurosciences Therapeutic Area, UCB Pharma, Braine l'Alleud, Belgium.
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Źródło :
Epilepsia [Epilepsia] 2020 May; Vol. 61 (5), pp. 914-923. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants/*pharmacology
Imidazoles/*pharmacology
Pyrrolidinones/*pharmacology
Receptors, GABA-A/*drug effects
Thiadiazoles/*pharmacology
Animals ; CHO Cells ; Cricetulus ; Female ; Humans ; Neurons/drug effects ; Oocytes/drug effects ; Oocytes/physiology ; Patch-Clamp Techniques ; Rats, Wistar ; Receptors, Presynaptic/drug effects ; Recombinant Proteins ; Synaptic Potentials/drug effects ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Pre- and postsynaptic ionotropic glutamate receptors in the auditory system of mammals.
Autorzy :
Takago H; Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Saitama 359-8555, Japan. Electronic address: .
Oshima-Takago T; Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Saitama 359-8555, Japan.
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Źródło :
Hearing research [Hear Res] 2018 May; Vol. 362, pp. 1-13. Date of Electronic Publication: 2018 Feb 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Synaptic Transmission*
Auditory Pathways/*metabolism
Glutamic Acid/*metabolism
Receptors, Ionotropic Glutamate/*metabolism
Receptors, Presynaptic/*metabolism
Synaptic Membranes/*metabolism
Animals ; Calcium Signaling ; Humans ; Neuronal Plasticity ; Receptors, Ionotropic Glutamate/classification ; Receptors, Presynaptic/classification
Czasopismo naukowe
Tytuł :
Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus.
Autorzy :
Rebosio C; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Italy.
Balbi M; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Italy.
Passalacqua M; Department of Experimental Medicine, Section of Biochemistry and Italian Institute of Biostructures and Biosystems, University of Genova, Italy.
Ricciarelli R; Department of Experimental Medicine, Section of General Pathology, University of Genova, Italy.
Fedele E; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Italy.; Centre of Excellence for Biomedical Research, Pharmacology and Toxicology Unit, University of Genova, Italy.
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Źródło :
BioFactors (Oxford, England) [Biofactors] 2018 Mar; Vol. 44 (2), pp. 148-157. Date of Electronic Publication: 2017 Dec 19.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebral Cortex/*metabolism
Glucagon-Like Peptide-1 Receptor/*metabolism
Glutamic Acid/*metabolism
Hippocampus/*metabolism
Presynaptic Terminals/*metabolism
Receptors, Presynaptic/*metabolism
gamma-Aminobutyric Acid/*metabolism
Adenylyl Cyclases/genetics ; Adenylyl Cyclases/metabolism ; Animals ; Aspartic Acid/metabolism ; Cerebral Cortex/drug effects ; Cyclic AMP/metabolism ; Dideoxyadenosine/analogs & derivatives ; Dideoxyadenosine/pharmacology ; Evoked Potentials/drug effects ; Evoked Potentials/physiology ; Exenatide ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor/genetics ; Hippocampus/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Peptides/pharmacology ; Presynaptic Terminals/drug effects ; Receptors, Presynaptic/genetics ; Synaptosomes/drug effects ; Synaptosomes/metabolism ; Venoms/pharmacology
Czasopismo naukowe
Tytuł :
Regulation of Synaptic Development by Astrocyte Signaling Factors and Their Emerging Roles in Substance Abuse.
Autorzy :
Walker CD; Department of Biomedical Research, Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
Risher WC; Department of Biomedical Research, Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.
Risher ML; Department of Biomedical Research, Joan C. Edwards School of Medicine, Huntington, WV 25701, USA.; Neurobiology Research Laboratory, VA Medical Center, Huntington, WV 25704, USA.; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27701, USA.
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Źródło :
Cells [Cells] 2020 Jan 26; Vol. 9 (2). Date of Electronic Publication: 2020 Jan 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apolipoproteins/*metabolism
Astrocytes/*metabolism
Bone Morphogenetic Proteins/*metabolism
Netrins/*metabolism
Neuregulins/*metabolism
Synapses/*metabolism
Thrombospondins/*metabolism
Alcohol-Related Disorders/metabolism ; Cocaine-Related Disorders/metabolism ; Humans ; Receptors, Presynaptic/metabolism ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Postsynaptic GluN2B-containing NMDA receptors contribute to long-term depression induction in medial vestibular nucleus neurons of juvenile rats.
Autorzy :
Li YH; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China; National Engineering Research Center for Healthcare Devices. Guangzhou, Guangdong, 510500, PR China; The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, 710049, PR China. Electronic address: .
Li Y; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
Zheng L; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
Wang J; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
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Źródło :
Neuroscience letters [Neurosci Lett] 2020 Jan 10; Vol. 715, pp. 134674. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Synaptic Depression/*physiology
Receptors, N-Methyl-D-Aspartate/*physiology
Vestibular Nuclei/*physiology
Animals ; Diazonium Compounds/pharmacology ; Female ; Long-Term Synaptic Depression/drug effects ; Phenols/pharmacology ; Piperidines/pharmacology ; Pyridines/pharmacology ; Rats ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, Presynaptic/physiology ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
The therapeutic effect of quetiapine on cognitive impairment associated with 5-HT1A presynaptic receptor involved schizophrenia.
Autorzy :
Han D; Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China.; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, 311121, P. R. China.; Psychiatry Department, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China.
Shi S; Psychiatry Department, Huashan Hospital of Fudan University, Shanghai, 200090, P. R. China.
Luo H; Psychiatry Department, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P. R. China.
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Źródło :
Journal of integrative neuroscience [J Integr Neurosci] 2019 Sep 30; Vol. 18 (3), pp. 245-251.
Typ publikacji :
Journal Article
MeSH Terms :
Cognitive Dysfunction*/etiology
Cognitive Dysfunction*/metabolism
Schizophrenia*/complications
Schizophrenia*/metabolism
Antipsychotic Agents/*pharmacology
Quetiapine Fumarate/*pharmacology
Receptor, Serotonin, 5-HT1A/*drug effects
Animals ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Neurons/drug effects ; Neurons/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Presynaptic/drug effects
Czasopismo naukowe
Tytuł :
MAM-2201, a synthetic cannabinoid drug of abuse, suppresses the synaptic input to cerebellar Purkinje cells via activation of presynaptic CB1 receptors.
Autorzy :
Irie T; Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan. Electronic address: .
Kikura-Hanajiri R; Division of Pharmacognosy, Phytochemistry, and Narcotics, National Institute of Health Sciences, Tokyo, Japan.
Usami M; Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan.
Uchiyama N; Division of Pharmacognosy, Phytochemistry, and Narcotics, National Institute of Health Sciences, Tokyo, Japan.
Goda Y; Division of Drugs, National Institute of Health Sciences, Tokyo, Japan.
Sekino Y; Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2015 Aug; Vol. 95, pp. 479-91. Date of Electronic Publication: 2015 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Illicit Drugs/*pharmacology
Indoles/*pharmacology
Naphthalenes/*pharmacology
Psychotropic Drugs/*pharmacology
Purkinje Cells/*drug effects
Receptor, Cannabinoid, CB1/*agonists
Receptors, Presynaptic/*agonists
Animals ; Calcium/metabolism ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Dronabinol/pharmacology ; Glutamic Acid/metabolism ; Humans ; Illicit Drugs/chemistry ; Indoles/chemistry ; Interneurons/drug effects ; Interneurons/physiology ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Mice ; Naphthalenes/chemistry ; Patch-Clamp Techniques ; Psychotropic Drugs/chemistry ; Purkinje Cells/physiology ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB1/metabolism ; Receptors, Presynaptic/genetics ; Receptors, Presynaptic/metabolism ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Tissue Culture Techniques ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Tytuł :
How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch.
Autorzy :
Pagani M; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Albisetti GW; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Sivakumar N; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Wildner H; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Santello M; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Johannssen HC; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Zeilhofer HU; Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Drug Discovery Network Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 1-5/10, 8090 Zurich, Switzerland. Electronic address: .
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Źródło :
Neuron [Neuron] 2019 Jul 03; Vol. 103 (1), pp. 102-117.e5. Date of Electronic Publication: 2019 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrin-Releasing Peptide/*genetics
Pruritus/*physiopathology
Action Potentials/physiology ; Animals ; Behavior, Animal ; Female ; Immunohistochemistry ; Male ; Mice ; Mice, Transgenic ; Neurons ; Optogenetics ; Potassium Channel Blockers/pharmacology ; Pruritus/genetics ; Pruritus/psychology ; Receptors, Bombesin/antagonists & inhibitors ; Receptors, Bombesin/genetics ; Receptors, Glutamate/physiology ; Receptors, Presynaptic/metabolism ; Spinal Cord/cytology
Czasopismo naukowe
Tytuł :
Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.
Autorzy :
Zhang Y; F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.
Williams PR; F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: .
Jacobi A; F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.
Wang C; F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.
Goel A; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Hirano AA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; United States Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Brecha NC; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; United States Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Kerschensteiner D; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
He Z; F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.
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Źródło :
Neuron [Neuron] 2019 Jul 03; Vol. 103 (1), pp. 39-51.e5. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Axons/*physiology
Nerve Growth Factor/*physiology
Nerve Regeneration/*physiology
Receptors, Presynaptic/*physiology
Amacrine Cells/physiology ; Animals ; Cilia/metabolism ; Cilia/ultrastructure ; Insulin-Like Growth Factor I/pharmacology ; Mice ; Mice, Inbred C57BL ; Nerve Crush ; Optic Nerve Injuries/pathology ; RNA-Binding Proteins/genetics ; Receptor, IGF Type 1/metabolism ; Retina/metabolism ; Retinal Ganglion Cells/drug effects
Czasopismo naukowe
Tytuł :
Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes.
Autorzy :
Savtchouk I; Département de Neurosciences Fondamentales, Université de Lausanne, 1005 Lausanne, Switzerland.
Di Castro MA; Département de Neurosciences Fondamentales, Université de Lausanne, 1005 Lausanne, Switzerland.
Ali R; Département de Neurosciences Fondamentales, Université de Lausanne, 1005 Lausanne, Switzerland.
Stubbe H; Département de Neurosciences Fondamentales, Université de Lausanne, 1005 Lausanne, Switzerland.
Luján R; Synaptic Structure Laboratory, Instituto de Investigación en Discapacidades Neurológicas, Departamento Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, 02071 Albacete, Spain.
Volterra A; Département de Neurosciences Fondamentales, Université de Lausanne, 1005 Lausanne, Switzerland; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 02; Vol. 116 (27), pp. 13602-13610. Date of Electronic Publication: 2019 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*physiology
Dentate Gyrus/*physiology
Entorhinal Cortex/*physiology
Receptors, N-Methyl-D-Aspartate/*physiology
Receptors, Presynaptic/*physiology
Animals ; Autoreceptors/metabolism ; Autoreceptors/physiology ; Glutamic Acid/metabolism ; Mice ; Mice, Knockout ; Neural Pathways/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/physiology
Czasopismo naukowe
Tytuł :
Serotonin 1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons.
Autorzy :
Nagata A; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Department of Orthodontics, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan.
Nakayama K; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. Electronic address: .
Nakamura S; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
Mochizuki A; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
Gemba C; Department of Pediatric Dentistry, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya-shi, Aichi 464-8650, Japan.
Aoki R; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Department of Prosthodontics, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan.
Dantsuji M; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
Maki K; Department of Orthodontics, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ota-ku, Tokyo 145-8515, Japan.
Inoue T; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
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Źródło :
Brain research bulletin [Brain Res Bull] 2019 Jul; Vol. 149, pp. 260-267. Date of Electronic Publication: 2019 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Excitatory Postsynaptic Potentials/*drug effects
Mandibular Nerve/*metabolism
Receptor, Serotonin, 5-HT1B/*metabolism
Animals ; Brain Stem/drug effects ; Electric Stimulation ; Female ; Glutamic Acid/pharmacology ; Inhibition, Psychological ; Male ; Masseter Muscle/innervation ; Masseter Muscle/metabolism ; Motor Neurons/physiology ; Patch-Clamp Techniques ; Presynaptic Terminals/drug effects ; Proprioception/physiology ; Rats ; Rats, Wistar ; Receptors, Presynaptic/metabolism ; Serotonin/physiology ; Serotonin Antagonists/pharmacology ; Serotonin Receptor Agonists ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Long-term depression of presynaptic cannabinoid receptor function at parallel fibre synapses.
Autorzy :
Yang Y; University of Texas Health Science Center at San Antonio, Department of Cellular and Integrative Physiology, San Antonio, TX, USA.; Xiangya School of Medicine, Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, Hunan Province, China.
Kreko-Pierce T; University of Texas Health Science Center at San Antonio, Department of Cellular and Integrative Physiology, San Antonio, TX, USA.
Howell R; University of Texas Health Science Center at San Antonio, Department of Cellular and Integrative Physiology, San Antonio, TX, USA.; Present address: Oklahoma Medical Research Foundation & University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Pugh JR; University of Texas Health Science Center at San Antonio, Department of Cellular and Integrative Physiology, San Antonio, TX, USA.; Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
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Źródło :
The Journal of physiology [J Physiol] 2019 Jun; Vol. 597 (12), pp. 3167-3181. Date of Electronic Publication: 2019 May 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Receptor, Cannabinoid, CB1/*physiology
Receptors, Presynaptic/*physiology
Synapses/*physiology
Animals ; Cerebellum/physiology ; Female ; In Vitro Techniques ; Male ; Mice, Inbred C57BL ; Purkinje Cells/physiology
Czasopismo naukowe

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