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Wyszukujesz frazę ""Receptors, Virus"" wg kryterium: Temat


Tytuł :
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.
Autorzy :
Barker H; Faculty of Medicine and Health Technology, Tampere University and Fimlab Ltd, Tampere University Hospital, Tampere, Finland.
Parkkila S; Faculty of Medicine and Health Technology, Tampere University and Fimlab Ltd, Tampere University Hospital, Tampere, Finland.
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Źródło :
PloS one [PLoS One] 2020 Oct 28; Vol. 15 (10), pp. e0240647. Date of Electronic Publication: 2020 Oct 28 (Print Publication: 2020).
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Computational Biology*
Pandemics*
Betacoronavirus/*physiology
Coronavirus Infections/*virology
Peptidyl-Dipeptidase A/*physiology
Pneumonia, Viral/*virology
Receptors, Virus/*physiology
Aging/metabolism ; Binding Sites ; Carrier Proteins/biosynthesis ; Carrier Proteins/genetics ; Female ; Gene Expression Regulation, Enzymologic ; Gene Ontology ; Humans ; Interferons/physiology ; Lung/metabolism ; Male ; Metalloproteases/biosynthesis ; Metalloproteases/genetics ; Neovascularization, Physiologic/physiology ; Organ Specificity ; Peptidyl-Dipeptidase A/biosynthesis ; Peptidyl-Dipeptidase A/genetics ; Promoter Regions, Genetic ; RNA, Messenger/biosynthesis ; Receptors, Virus/biosynthesis ; Receptors, Virus/genetics ; Renin-Angiotensin System/physiology ; Sex Characteristics ; Single-Cell Analysis ; Transcription Factors/metabolism ; Transcription Initiation Site ; Virus Attachment
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
A systematic review of SARS-CoV-2 vaccine candidates.
Autorzy :
Dong Y; The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China.; Life Sciences Institute and Innovation Center for Cell Signaling Network, Hangzhou, 310058, China.
Dai T; Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123, China.
Wei Y; Anhui Anlong Gene Technology Co., Ltd, Hefei, 230041, China.
Zhang L; Life Sciences Institute and Innovation Center for Cell Signaling Network, Hangzhou, 310058, China.
Zheng M; The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China. .
Zhou F; Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2020 Oct 13; Vol. 5 (1), pp. 237. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Antibodies, Viral/*biosynthesis
Coronavirus Infections/*prevention & control
Pandemics/*prevention & control
Peptidyl-Dipeptidase A/*genetics
Pneumonia, Viral/*prevention & control
Receptors, Virus/*genetics
Viral Vaccines/*biosynthesis
Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; Clinical Trials as Topic ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Gene Expression Regulation/drug effects ; Humans ; Immunity, Innate/drug effects ; Immunization Schedule ; Immunogenicity, Vaccine ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Middle East Respiratory Syndrome Coronavirus/immunology ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; Patient Safety ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Protein Binding ; Receptors, Virus/antagonists & inhibitors ; Receptors, Virus/metabolism ; SARS Virus/drug effects ; SARS Virus/immunology ; SARS Virus/pathogenicity ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/virology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Vaccines, Attenuated ; Vaccines, DNA ; Vaccines, Subunit ; Vaccines, Virus-Like Particle ; Viral Vaccines/administration & dosage
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
ACE2, the Receptor that Enables Infection by SARS-CoV-2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators.
Autorzy :
Gross LZF; Chemical Biology of Regulatory Mechanisms, IBioBA-CONICET-Partner Institute of the Max Planck Society, Godoy Cruz 2390, Buenos Aires, Argentina.
Sacerdoti M; Chemical Biology of Regulatory Mechanisms, IBioBA-CONICET-Partner Institute of the Max Planck Society, Godoy Cruz 2390, Buenos Aires, Argentina.
Piiper A; Internal Medicine I, Frankfurt University Hospital, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.
Zeuzem S; Internal Medicine I, Frankfurt University Hospital, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.
Leroux AE; Chemical Biology of Regulatory Mechanisms, IBioBA-CONICET-Partner Institute of the Max Planck Society, Godoy Cruz 2390, Buenos Aires, Argentina.
Biondi RM; Chemical Biology of Regulatory Mechanisms, IBioBA-CONICET-Partner Institute of the Max Planck Society, Godoy Cruz 2390, Buenos Aires, Argentina.; Internal Medicine I, Frankfurt University Hospital, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.
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Źródło :
ChemMedChem [ChemMedChem] 2020 Sep 16; Vol. 15 (18), pp. 1682-1690. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Angiotensin-Converting Enzyme Inhibitors/*metabolism
Betacoronavirus/*chemistry
Peptidyl-Dipeptidase A/*metabolism
Receptors, Virus/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Allosteric Regulation ; Angiotensin-Converting Enzyme Inhibitors/chemistry ; Catalytic Domain ; Humans ; Peptidyl-Dipeptidase A/chemistry ; Protein Binding ; Protein Domains ; Receptors, Virus/antagonists & inhibitors ; Receptors, Virus/chemistry ; Spike Glycoprotein, Coronavirus/chemistry
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk.
Autorzy :
Nelson CP; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Sama IE; Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands (I.E.S., A.A.V.).
Codd V; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Webb TR; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Ye S; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Lang CC; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee Ninewells Hospital and Medical School, United Kingdom (C.C..).
Voors AA; Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands (I.E.S., A.A.V.).
Ng LL; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
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Źródło :
Circulation [Circulation] 2020 Sep 15; Vol. 142 (11), pp. 1117-1119. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus*
Polymorphism, Single Nucleotide*
Sex Characteristics*
Chromosomes, Human, Pair 12/*genetics
Chromosomes, Human, Pair 21/*genetics
Chromosomes, Human, X/*genetics
Coronavirus Infections/*genetics
Gene Expression Regulation, Enzymologic/*genetics
Peptidyl-Dipeptidase A/*blood
Pneumonia, Viral/*genetics
Receptors, Virus/*blood
Aged ; Aged, 80 and over ; Alleles ; Coronavirus Infections/blood ; Coronavirus Infections/enzymology ; Coronavirus Infections/epidemiology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Humans ; INDEL Mutation ; Linkage Disequilibrium ; Male ; Middle Aged ; Pandemics ; Peptidyl-Dipeptidase A/biosynthesis ; Peptidyl-Dipeptidase A/genetics ; Pneumonia, Viral/blood ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/epidemiology ; Receptors, Virus/biosynthesis ; Receptors, Virus/genetics ; Risk ; Sex Distribution ; Transcriptional Regulator ERG/genetics
SCR Disease Name :
COVID-19
Raport
Tytuł :
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Autorzy :
Chan KK; Orthogonal Biologics, Champaign, IL 61821, USA.
Dorosky D; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Sharma P; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Kranz DM; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Procko E; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Sep 04; Vol. 369 (6508), pp. 1261-1265. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering*
Betacoronavirus/*metabolism
Peptidyl-Dipeptidase A/*genetics
Peptidyl-Dipeptidase A/*metabolism
Receptors, Virus/*genetics
Receptors, Virus/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Substitution ; Binding Sites ; Binding, Competitive ; Cell Line ; Humans ; Models, Molecular ; Mutagenesis ; Mutation ; Peptidyl-Dipeptidase A/chemistry ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Receptors, Virus/chemistry ; Spike Glycoprotein, Coronavirus/chemistry
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19.
Autorzy :
Malek Mahdavi A; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
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Źródło :
Reviews in medical virology [Rev Med Virol] 2020 Sep; Vol. 30 (5), pp. e2119. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acute Lung Injury/*prevention & control
Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
Betacoronavirus/*pathogenicity
Coronavirus Infections/*drug therapy
Peptidyl-Dipeptidase A/*genetics
Pneumonia, Viral/*drug therapy
Receptors, Virus/*genetics
Vitamin D/*therapeutic use
Acute Lung Injury/pathology ; Acute Lung Injury/virology ; Angiotensin I/genetics ; Angiotensin I/metabolism ; Betacoronavirus/genetics ; Betacoronavirus/metabolism ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Gene Expression Regulation/drug effects ; Humans ; Pandemics ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Protein Binding ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 1/metabolism ; Receptors, Virus/antagonists & inhibitors ; Receptors, Virus/metabolism ; Renin-Angiotensin System/drug effects ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein.
Autorzy :
Behloul N; College of Basic Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
Baha S; Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu Province, China.
Shi R; Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu Province, China. Electronic address: .
Meng J; College of Basic Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. Electronic address: .
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Źródło :
Virus research [Virus Res] 2020 Sep; Vol. 286, pp. 198058. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*chemistry
Middle East Respiratory Syndrome Coronavirus/*chemistry
Peptidyl-Dipeptidase A/*chemistry
Receptors, Virus/*chemistry
SARS Virus/*chemistry
Spike Glycoprotein, Coronavirus/*chemistry
Amino Acid Sequence ; Animals ; Betacoronavirus/genetics ; Betacoronavirus/metabolism ; Binding Sites ; Chiroptera ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Evolution, Molecular ; Gene Expression ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/genetics ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Middle East Respiratory Syndrome Coronavirus/metabolism ; Models, Molecular ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS Virus/genetics ; SARS Virus/metabolism ; Sequence Alignment ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Structural Homology, Protein ; Thermodynamics ; Virus Attachment
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV.
Autorzy :
Lubbe L; Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, Republic of South Africa.
Cozier GE; Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
Oosthuizen D; Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, Republic of South Africa.
Acharya KR; Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
Sturrock ED; Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, Republic of South Africa.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Nov 13; Vol. 134 (21), pp. 2851-2871.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Virus Internalization*
Betacoronavirus/*pathogenicity
Coronavirus Infections/*enzymology
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*enzymology
Receptors, Virus/*metabolism
Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Host-Pathogen Interactions ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/chemistry ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Protein Conformation ; Receptors, Virus/chemistry ; Structure-Activity Relationship
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery.
Autorzy :
Lores E; Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U.S.A.
Wysocki J; Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U.S.A.
Batlle D; Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, U.S.A.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Nov 13; Vol. 134 (21), pp. 2791-2805.
Typ publikacji :
Historical Article; Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Betacoronavirus/*pathogenicity
Coronavirus Infections/*enzymology
Kidney/*enzymology
Kidney Diseases/*enzymology
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*enzymology
Receptors, Virus/*metabolism
Acute Kidney Injury/enzymology ; Acute Kidney Injury/virology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Diabetes Mellitus/enzymology ; Diabetes Mellitus/physiopathology ; History, 21st Century ; Host-Pathogen Interactions ; Humans ; Hypertension/enzymology ; Hypertension/physiopathology ; Kidney/physiopathology ; Kidney Diseases/drug therapy ; Kidney Diseases/physiopathology ; Pandemics ; Peptidyl-Dipeptidase A/history ; Peptidyl-Dipeptidase A/therapeutic use ; Pneumonia, Viral/virology ; Receptors, Virus/history
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
SARS-CoV-2 host tropism: An in silico analysis of the main cellular factors.
Autorzy :
Rangel HR; Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Ortega JT; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Maksoud S; Department of Neurology and Experimental Therapeutics and Molecular Imaging Laboratory, Massachusetts General Hospital, MA 02129, USA.
Pujol FH; Laboratorio de Virología Molecular, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Serrano ML; Unidad de Química Medicinal, Facultad de Farmacia, Universidad Central de Venezuela, Caracas 1041-A, Venezuela. Electronic address: .
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Źródło :
Virus research [Virus Res] 2020 Nov; Vol. 289, pp. 198154. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Viral Tropism*
Betacoronavirus/*physiology
Coronavirus Infections/*virology
Heat-Shock Proteins/*chemistry
Mammals/*metabolism
Peptidyl-Dipeptidase A/*chemistry
Pneumonia, Viral/*virology
Receptors, Virus/*chemistry
Serine Endopeptidases/*chemistry
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Sequence ; Animals ; Antiviral Agents/pharmacology ; Cats ; Dogs ; Ferrets ; Guanidines/pharmacology ; Heat-Shock Proteins/metabolism ; Humans ; Mice ; Models, Molecular ; Molecular Docking Simulation ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Protein Conformation ; Receptors, Virus/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Serine Endopeptidases/metabolism ; Species Specificity ; Swine ; Virus Attachment ; Virus Internalization
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Angiotensin Converting Enzyme-2 (ACE2) Receptors, asthma and severe COVID-19 infection risk.
Autorzy :
Öztürk AB; Division of Allergy and Immunology, Department of Pulmonary Medicine, School of Medicine, Koç University, Istanbul, Turkey.
Çağlayan B; Department of Pulmonary Medicine, School of Medicine, Koç University, Istanbul, Turkey.
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Źródło :
European annals of allergy and clinical immunology [Eur Ann Allergy Clin Immunol] 2020 Nov; Vol. 52 (6), pp. 282-285. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Letter
MeSH Terms :
Asthma/*pathology
Coronavirus Infections/*pathology
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*pathology
Receptors, Virus/*metabolism
Asthma/complications ; Betacoronavirus ; Comorbidity ; Coronavirus Infections/complications ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Pneumonia, Viral/complications ; Receptors, Virus/genetics ; Risk Factors ; Serine Endopeptidases/metabolism
SCR Disease Name :
COVID-19
Opinia redakcyjna
Tytuł :
Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19.
Autorzy :
Choudhary S; Molecular Modelling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, 147002, India.
Silakari O; Molecular Modelling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, 147002, India. Electronic address: .
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Źródło :
Virus research [Virus Res] 2020 Nov; Vol. 289, pp. 198146. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Pandemics*
Antiviral Agents/*chemistry
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Indoles/*chemistry
Peptidyl-Dipeptidase A/*drug effects
Pneumonia, Viral/*drug therapy
Receptors, Virus/*drug effects
Virus Attachment/*drug effects
Algorithms ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Betacoronavirus/physiology ; Biological Availability ; Drug Design ; Humans ; Indoles/metabolism ; Indoles/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Peptide Hydrolases/physiology ; Peptidyl-Dipeptidase A/metabolism ; Protein Binding ; Protein Domains ; Receptors, Virus/metabolism ; Serine Endopeptidases/drug effects ; Serine Endopeptidases/metabolism ; Spike Glycoprotein, Coronavirus/drug effects ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship ; Virus Internalization ; Virus Replication
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients.
Autorzy :
Dai YJ; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangzhou, 510060, China.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Zhang WN; Department of Hematology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.
Wang WD; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangzhou, 510060, China.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
He SY; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Liang CC; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China.; State Key Laboratory of Oncology in South China, Guangzhou, 510060, China.
Wang DW; National Research Center for Translational Medicine, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 197, Ruijin Road II, Shanghai, 200025, China.
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Źródło :
International journal of biological sciences [Int J Biol Sci] 2020 Sep 30; Vol. 16 (15), pp. 3028-3036. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Membrane Proteins/*physiology
Neoplasms/*metabolism
RNA-Binding Proteins/*physiology
Receptors, Virus/*physiology
Serine Endopeptidases/*physiology
Betacoronavirus ; Coronavirus Infections/genetics ; Coronavirus Infections/metabolism ; DNA Mutational Analysis ; Gene Expression Regulation ; Healthy Volunteers ; Humans ; Membrane Proteins/genetics ; Neoplasms/diagnosis ; Neoplasms/genetics ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/genetics ; Pneumonia, Viral/metabolism ; Prognosis ; RNA-Binding Proteins/genetics ; Receptors, Virus/genetics ; Serine Endopeptidases/genetics ; Tissue Distribution
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.
Autorzy :
Li Y; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Ivica NA; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Dong T; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Papageorgiou DP; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
He Y; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Brown DR; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Kleyman M; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Hu G; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Chen WW; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.; Boston Combined Residency Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Sullivan LB; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Del Rosario A; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Hammond PT; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Vander Heiden MG; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Dana-Farber Cancer Institute, Boston, MA, 02115, USA.
Chen J; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 24; Vol. 11 (1), pp. 4837. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Heme/*metabolism
Membrane Transport Proteins/*metabolism
Mitochondria/*metabolism
Receptors, Virus/*metabolism
Thermogenesis/*physiology
Animals ; Cytochrome-c Oxidase Deficiency ; Electron Transport Complex III ; Electron Transport Complex IV ; Energy Metabolism/physiology ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Membrane Transport Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondrial Membranes/metabolism ; Protein Domains ; Receptors, Virus/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Signal Transduction ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Autorzy :
Huo J; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Le Bas A; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Ruza RR; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Duyvesteyn HME; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Mikolajek H; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Malinauskas T; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Rijal P; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Centre for Translational Immunology, Chinse Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Dumoux M; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.
Ward PN; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Ren J; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Zhou D; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Harrison PJ; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK.
Weckener M; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.
Clare DK; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Vogirala VK; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Radecke J; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Moynié L; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK.
Zhao Y; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Gilbert-Jaramillo J; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Knight ML; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Tree JA; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Buttigieg KR; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Coombes N; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Elmore MJ; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Carroll MW; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Carrique L; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
Shah PNM; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.
James W; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Townsend AR; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.; Centre for Translational Immunology, Chinse Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Stuart DI; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Owens RJ; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK. .; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK. .; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK. .
Naismith JH; Structural Biology, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Didcot, UK. .; Division of Structural Biology, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK. .; Protein Production UK, The Rosalind Franklin Institute - Diamond Light Source, The Research Complex at Harwell, Harwell Science & Innovation Campus, Didcot, UK. .
Pokaż więcej
Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Sep; Vol. 27 (9), pp. 846-854. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Infections*
Pandemics*
Pneumonia, Viral*
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Peptidyl-Dipeptidase A/*metabolism
Receptors, Virus/*metabolism
Single-Domain Antibodies/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Amino Acid Sequence ; Antibodies, Neutralizing/metabolism ; Antibodies, Neutralizing/ultrastructure ; Antibodies, Viral/metabolism ; Antibodies, Viral/ultrastructure ; Antibody Affinity ; Antigen-Antibody Reactions/immunology ; Betacoronavirus/metabolism ; Binding, Competitive ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Epitopes/immunology ; Humans ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/immunology ; Models, Molecular ; Peptide Library ; Peptidyl-Dipeptidase A/ultrastructure ; Protein Binding ; Protein Conformation ; Receptors, Virus/ultrastructure ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/metabolism ; Sequence Homology, Amino Acid ; Single-Domain Antibodies/metabolism ; Single-Domain Antibodies/ultrastructure ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/ultrastructure
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection.
Autorzy :
Tan HW; Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Xu YM; Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Lau ATY; Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People's Republic of China.
Pokaż więcej
Źródło :
Reviews in medical virology [Rev Med Virol] 2020 Sep; Vol. 30 (5), pp. e2122. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Betacoronavirus/*genetics
Coronavirus Infections/*virology
Peptidyl-Dipeptidase A/*genetics
Pneumonia, Viral/*virology
Receptors, Virus/*genetics
SARS Virus/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Animals ; Betacoronavirus/classification ; Betacoronavirus/pathogenicity ; Biological Evolution ; Chiroptera/virology ; Coronavirus Infections/physiopathology ; Eutheria/virology ; Gene Expression Regulation ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Phylogeny ; Pneumonia, Viral/physiopathology ; Protein Binding ; Receptors, Virus/metabolism ; SARS Virus/classification ; SARS Virus/pathogenicity ; Severe Acute Respiratory Syndrome/physiopathology ; Severe Acute Respiratory Syndrome/virology ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Highly conserved binding region of ACE2 as a receptor for SARS-CoV-2 between humans and mammals.
Autorzy :
Hayashi T; National Hospital Organization Kyoto Medical Center, Kyoto, Japan.; START, Japan Science and Technology Agency (JST), Tokyo, Japan.
Abiko K; National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Mandai M; Department of Obstetrics and Gynecology, Kyoto University School of Medicine, Kyoto, Japan.
Yaegashi N; Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Miyagi, Japan.
Konishi I; National Hospital Organization Kyoto Medical Center, Kyoto, Japan.; Department of Obstetrics and Gynecology, Kyoto University School of Medicine, Kyoto, Japan.; Immediate Past President of Asian Society of Gynecologic Oncology, Tokyo, Japan.
Pokaż więcej
Źródło :
The veterinary quarterly [Vet Q] 2020 Dec; Vol. 40 (1), pp. 243-249.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*metabolism
Coronavirus Infections/*transmission
Peptidyl-Dipeptidase A/*metabolism
Pneumonia, Viral/*transmission
Receptors, Virus/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Sequence ; Animals ; Betacoronavirus/genetics ; Cats ; Coronavirus Infections/prevention & control ; Dogs ; Humans ; Mink ; Pandemics/prevention & control ; Peptidyl-Dipeptidase A/chemistry ; Phylogeny ; Pneumonia, Viral/prevention & control ; Receptors, Virus/chemistry ; Receptors, Virus/genetics ; Sequence Alignment ; Spike Glycoprotein, Coronavirus/chemistry ; Tigers
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents.
Autorzy :
Gelman R; Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Bayatra A; Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Kessler A; Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Schwartz A; Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Ilan Y; Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Pokaż więcej
Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 1397-1406.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Resistance, Viral*
Antiviral Agents/*pharmacology
Betacoronavirus/*physiology
Coronavirus Infections/*immunology
Pneumonia, Viral/*immunology
Receptors, Virus/*antagonists & inhibitors
Algorithms ; Animals ; Betacoronavirus/drug effects ; Betacoronavirus/genetics ; Coronavirus Infections/drug therapy ; Coronavirus Infections/genetics ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/genetics ; Pneumonia, Viral/virology ; Receptors, Virus/genetics ; Receptors, Virus/immunology
SCR Disease Name :
COVID-19
Czasopismo naukowe

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