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Wyszukujesz frazę ""Recombinant Fusion Proteins"" wg kryterium: Temat


Tytuł :
Characterization of the Chimeric PriB-SSBc Protein.
Autorzy :
Lin ES; Department of Beauty Science, National Taichung University of Science and Technology, No. 193, Sec.1, San-Min Rd., Taichung City 403, Taiwan.
Huang YH; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
Huang CY; School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, No. 110, Sec.1, Chien-Kuo N. Rd., Taichung City 402, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 07; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Klebsiella pneumoniae/*metabolism
Recombinant Fusion Proteins/*chemistry
Recombinant Fusion Proteins/*metabolism
Amino Acid Sequence ; Bacterial Proteins/genetics ; Crystallography, X-Ray ; DNA Replication ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Models, Molecular ; Protein Conformation ; Protein Interaction Domains and Motifs ; Recombinant Fusion Proteins/genetics ; Sequence Homology
Czasopismo naukowe
Tytuł :
Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.
Autorzy :
Pennington LF; Department of Structural Biology, Stanford University School of Medicine, Stanford, Calif; Program in Immunology, Stanford University School of Medicine, Stanford, Calif; Sean N. Parker Center for Allergy Research at Stanford University, Stanford, Calif.
Gasser P; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland.
Brigger D; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland.
Guntern P; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland.
Eggel A; Department of Rheumatology and Immunology, Bern University Hospital, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland. Electronic address: .
Jardetzky TS; Department of Structural Biology, Stanford University School of Medicine, Stanford, Calif; Program in Immunology, Stanford University School of Medicine, Stanford, Calif; Sean N. Parker Center for Allergy Research at Stanford University, Stanford, Calif. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Oct; Vol. 148 (4), pp. 1049-1060. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Recombinant Fusion Proteins*/chemistry
Recombinant Fusion Proteins*/immunology
Recombinant Fusion Proteins*/pharmacology
Recombinant Fusion Proteins*/therapeutic use
Anaphylaxis/*drug therapy
Immunoglobulin E/*immunology
Allergens/immunology ; Anaphylaxis/immunology ; Animals ; Basophils/drug effects ; Basophils/immunology ; Drug Design ; Humans ; Immunoglobulin E/chemistry ; Immunoglobulin E/genetics ; Mice, Transgenic ; Molecular Structure ; Ovalbumin/immunology ; Receptors, IgE/chemistry ; Receptors, IgE/genetics ; Receptors, IgE/immunology
Czasopismo naukowe
Tytuł :
A Split-Cre system designed to detect simultaneous expression of two genes based on SpyTag/SpyCatcher conjugation and Split-GFP dimerization.
Autorzy :
Wei X; Center of Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Zhang J; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Cui J; Department of General Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Xu W; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Zhou X; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China. Electronic address: .
Ma J; Center of Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101119. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Escherichia coli*/genetics
Escherichia coli*/metabolism
Gene Expression*
Green Fluorescent Proteins*/biosynthesis
Green Fluorescent Proteins*/genetics
Integrases*/genetics
Integrases*/metabolism
Microorganisms, Genetically-Modified*/genetics
Microorganisms, Genetically-Modified*/metabolism
Recombinant Fusion Proteins*/biosynthesis
Recombinant Fusion Proteins*/genetics
Protein Multimerization
Czasopismo naukowe
Tytuł :
Biodistribution of onasemnogene abeparvovec DNA, mRNA and SMN protein in human tissue.
Autorzy :
Thomsen G; Novartis Gene Therapies, Bannockburn, IL, USA.
Burghes AHM; Department of Neurology, The Ohio State University, Columbus, OH, USA. .; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA. .
Hsieh C; Novartis Gene Therapies, Bannockburn, IL, USA.
Do J; Novartis Gene Therapies, Bannockburn, IL, USA.
Chu BTT; Novartis Gene Therapies, Bannockburn, IL, USA.
Perry S; Novartis Gene Therapies, Bannockburn, IL, USA.
Barkho B; Novartis Gene Therapies, Bannockburn, IL, USA.
Kaufmann P; Novartis Gene Therapies, Bannockburn, IL, USA.
Sproule DM; Novartis Gene Therapies, Bannockburn, IL, USA.
Feltner DE; Novartis Gene Therapies, Bannockburn, IL, USA.
Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
McGovern VL; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.
Hevner RF; Department of Pathology, University of California, San Diego, CA, USA.
Conces M; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pathology, The Ohio State University, Columbus, OH, USA.
Pierson CR; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pathology, The Ohio State University, Columbus, OH, USA.
Scoto M; National Institute for Health Research, Great Ormond Street Institute of Child Health Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Hospital Trust, London, UK.
Muntoni F; National Institute for Health Research, Great Ormond Street Institute of Child Health Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Hospital Trust, London, UK.
Mendell JR; Department of Neurology, The Ohio State University, Columbus, OH, USA.; Center for Gene Therapy, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Foust KD; Novartis Gene Therapies, Bannockburn, IL, USA.
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Źródło :
Nature medicine [Nat Med] 2021 Oct; Vol. 27 (10), pp. 1701-1711. Date of Electronic Publication: 2021 Oct 04.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Products/*adverse effects
Genetic Therapy/*adverse effects
Recombinant Fusion Proteins/*adverse effects
Spinal Muscular Atrophies of Childhood/*therapy
Survival of Motor Neuron 1 Protein/*genetics
Autopsy ; Biological Products/administration & dosage ; DNA/genetics ; Female ; Genetic Vectors/administration & dosage ; Genetic Vectors/adverse effects ; Genetic Vectors/genetics ; Humans ; Infant ; Infant, Newborn ; Male ; Motor Neurons/drug effects ; Motor Neurons/pathology ; RNA, Messenger/genetics ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/genetics ; Spinal Muscular Atrophies of Childhood/genetics ; Spinal Muscular Atrophies of Childhood/mortality ; Spinal Muscular Atrophies of Childhood/pathology ; Tissue Distribution/drug effects
Czasopismo naukowe
Tytuł :
A Chimeric IL-15/IL-15Rα Molecule Expressed on NFκB-Activated Dendritic Cells Supports Their Capability to Activate Natural Killer Cells.
Autorzy :
Bosch NC; Institute of Medical Immunology, Martin-Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany.; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN, NCT WERA, 91054 Erlangen, Germany.
Martin LM; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Voskens CJ; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN, NCT WERA, 91054 Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
Berking C; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-EMN, NCT WERA, 91054 Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
Seliger B; Institute of Medical Immunology, Martin-Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany.; Fraunhofer Institute for Cell Therapy and Immunology (IZI), 04103 Leipzig, Germany.
Schuler G; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Schaft N; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Dörrie J; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 23; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Dendritic Cells/*immunology
Interleukin-15/*biosynthesis
Killer Cells, Natural/*immunology
Receptors, Interleukin-15/*biosynthesis
Recombinant Fusion Proteins/*biosynthesis
Dendritic Cells/drug effects ; Electroporation ; Humans ; I-kappa B Kinase/biosynthesis ; I-kappa B Kinase/genetics ; Immunotherapy ; Interleukin-15/chemistry ; Interleukin-15/genetics ; Killer Cells, Natural/drug effects ; Leukocytes, Mononuclear ; NF-kappa B/pharmacology ; Primary Cell Culture ; Receptors, Interleukin-15/chemistry ; Receptors, Interleukin-15/genetics ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
Expression and affinity purification of recombinant mammalian mitochondrial ribosomal small subunit (MRPS) proteins and protein-protein interaction analysis indicate putative role in tumourigenic cellular processes.
Autorzy :
Revathi Paramasivam O; Department of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai 600020, Tamil Nadu, India.
Gopisetty G; Department of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai 600020, Tamil Nadu, India.
Subramani J; Department of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai 600020, Tamil Nadu, India.
Thangarajan R; Department of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai 600020, Tamil Nadu, India.
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Źródło :
Journal of biochemistry [J Biochem] 2021 Sep 07; Vol. 169 (6), pp. 675-692.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Interaction Maps*
Breast Neoplasms/*pathology
Mitochondrial Proteins/*metabolism
Recombinant Fusion Proteins/*metabolism
Ribosomal Proteins/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Chromatography, Affinity ; Female ; Glutathione Transferase/genetics ; Glutathione Transferase/metabolism ; Humans ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/isolation & purification ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/isolation & purification ; Ribosomal Proteins/genetics ; Ribosomal Proteins/isolation & purification ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Clinical overview and practical considerations for optimizing romiplostim therapy in patients with immune thrombocytopenia.
Autorzy :
Kuter DJ; Hematology Division, Massachusetts General Hospital, Suite 118, Room 110, Zero Emerson Place, Boston, MA 02114, USA. Electronic address: .
Tarantino MD; The Bleeding and Clotting Disorders Institute, 9128 North Lindbergh Drive, Peoria, IL 61615, USA. Electronic address: .
Lawrence T; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: .
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Źródło :
Blood reviews [Blood Rev] 2021 Sep; Vol. 49, pp. 100811. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Receptors, Fc/*therapeutic use
Recombinant Fusion Proteins/*therapeutic use
Thrombopoietin/*therapeutic use
Clinical Trials as Topic ; Humans ; Protein Conformation ; Receptors, Fc/administration & dosage ; Receptors, Fc/chemistry ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/chemistry ; Thrombopoietin/administration & dosage ; Thrombopoietin/adverse effects ; Thrombopoietin/chemistry ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Effects of GLP-1 receptor agonists on myokine levels and pro-inflammatory cytokines in patients with type 2 diabetes mellitus.
Autorzy :
Guarnotta V; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Italy.
Bianco MJ; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Italy.
Vigneri E; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Italy.
Panto' F; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Italy.
Lo Sasso B; Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy; Dipartimento di Medicina di laboratorio, AOUP 'P. Giaccone', Palermo, Italy.
Ciaccio M; Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy; Dipartimento di Medicina di laboratorio, AOUP 'P. Giaccone', Palermo, Italy.
Pizzolanti G; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Italy. Electronic address: .
Giordano C; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro' (PROMISE), Sezione di Malattie Endocrine, del Ricambio e della Nutrizione, Università di Palermo, Italy. Electronic address: .
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Oct 28; Vol. 31 (11), pp. 3193-3201. Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Blood Glucose/*drug effects
Diabetes Mellitus, Type 2/*drug therapy
Fibronectins/*blood
Glucagon-Like Peptide-1 Receptor/*agonists
Glucagon-Like Peptides/*analogs & derivatives
Hypoglycemic Agents/*therapeutic use
Immunoglobulin Fc Fragments/*therapeutic use
Incretins/*therapeutic use
Interleukin-6/*blood
Liraglutide/*therapeutic use
Recombinant Fusion Proteins/*therapeutic use
Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; Cholesterol/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Drug Therapy, Combination ; Female ; Glucagon-Like Peptides/adverse effects ; Glucagon-Like Peptides/therapeutic use ; Humans ; Hypoglycemic Agents/adverse effects ; Immunoglobulin Fc Fragments/adverse effects ; Incretins/adverse effects ; Inflammation Mediators/blood ; Insulin/therapeutic use ; Liraglutide/adverse effects ; Male ; Middle Aged ; Recombinant Fusion Proteins/adverse effects ; Time Factors ; Treatment Outcome ; Waist Circumference
Czasopismo naukowe
Tytuł :
Anti-CD40 Antibodies Fused to CD40 Ligand Have Superagonist Properties.
Autorzy :
Ceglia V; Baylor Scott & White Immunology Research, Dallas, TX.; Université Paris-Est Créteil, Créteil, France.; Vaccine Research Institute, INSERM, Institut Mondor de Recherche Biomédicale, Créteil, France.
Zurawski S; Baylor Scott & White Immunology Research, Dallas, TX.; Vaccine Research Institute, INSERM, Institut Mondor de Recherche Biomédicale, Créteil, France.
Montes M; Baylor Scott & White Immunology Research, Dallas, TX.; Vaccine Research Institute, INSERM, Institut Mondor de Recherche Biomédicale, Créteil, France.
Bouteau A; Institute of Biomedical Studies, Baylor University, Waco, TX; and.; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA.
Wang Z; Baylor Scott & White Immunology Research, Dallas, TX.; Vaccine Research Institute, INSERM, Institut Mondor de Recherche Biomédicale, Créteil, France.
Ellis J; Baylor Scott & White Immunology Research, Dallas, TX.; Vaccine Research Institute, INSERM, Institut Mondor de Recherche Biomédicale, Créteil, France.
Igyártó BZ; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA.
Lévy Y; Université Paris-Est Créteil, Créteil, France.; Vaccine Research Institute, INSERM, Institut Mondor de Recherche Biomédicale, Créteil, France.
Zurawski G; Baylor Scott & White Immunology Research, Dallas, TX; .; Vaccine Research Institute, INSERM, Institut Mondor de Recherche Biomédicale, Créteil, France.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Oct 15; Vol. 207 (8), pp. 2060-2076. Date of Electronic Publication: 2021 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*metabolism
B-Lymphocytes/*immunology
CD40 Antigens/*agonists
CD40 Ligand/*metabolism
Dendritic Cells/*immunology
Recombinant Fusion Proteins/*metabolism
T-Lymphocytes/*immunology
Animals ; Antibodies, Monoclonal/genetics ; CD40 Antigens/immunology ; CD40 Ligand/genetics ; CHO Cells ; Cell Differentiation ; Cricetulus ; Cytokines/metabolism ; Humans ; Lymphocyte Activation ; Receptor Aggregation ; Recombinant Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
Enhanced Production of a Thermostable Carbonic Anhydrase in Escherichia coli by Using a Modified NEXT Tag.
Autorzy :
Hwang IS; Division of Applied Life Science, Gyeongsang National University, Jinju 52828, Korea.
Kim JH; Division of Life Science, Gyeongsang National University, Jinju 52828, Korea.
Jo BH; Division of Life Science and Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 26; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins/*metabolism
Carbonic Anhydrases/*chemistry
Carbonic Anhydrases/*metabolism
Escherichia coli/*metabolism
Neisseria gonorrhoeae/*enzymology
Recombinant Fusion Proteins/*metabolism
Bacterial Proteins/genetics ; Carbonic Anhydrases/genetics ; Enzyme Stability ; Escherichia coli/genetics ; Recombinant Fusion Proteins/genetics ; Solubility ; Temperature
Czasopismo naukowe
Tytuł :
Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging.
Autorzy :
Crossley MP; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA.
Brickner JR; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA.
Song C; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA.
Zar SMT; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA.
Maw SS; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA.
Chédin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA.
Tsai MS; Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA.
Cimprich KA; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Sep 06; Vol. 220 (9). Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Inverted Repeat Sequences*
DNA/*metabolism
RNA, Double-Stranded/*metabolism
Recombinant Fusion Proteins/*metabolism
Ribonuclease H/*metabolism
Staining and Labeling/*methods
Antibodies/chemistry ; Antibodies/metabolism ; BRCA1 Protein/antagonists & inhibitors ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; Cloning, Molecular ; DNA/chemistry ; DNA/ultrastructure ; DNA Helicases/antagonists & inhibitors ; DNA Helicases/genetics ; DNA Helicases/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Gene Expression ; Genes, Reporter ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HeLa Cells ; Heterocyclic Compounds, 4 or More Rings/chemistry ; Heterocyclic Compounds, 4 or More Rings/metabolism ; Humans ; Multifunctional Enzymes/antagonists & inhibitors ; Multifunctional Enzymes/genetics ; Multifunctional Enzymes/metabolism ; Nucleic Acid Hybridization ; Optical Imaging/methods ; Protein Binding ; RNA Helicases/antagonists & inhibitors ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA, Double-Stranded/chemistry ; RNA, Double-Stranded/ultrastructure ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Recombinant Fusion Proteins/genetics ; Ribonuclease H/genetics
Czasopismo naukowe
Tytuł :
Modified recombinant human IgG1-Fc is superior to natural intravenous immunoglobulin at inhibiting immune-mediated demyelination.
Autorzy :
Baksmeier C; Department of Neurology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Blundell P; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Steckel J; Department of Neurology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Schultz V; Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Gu Q; Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Da Silva Filipe A; Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Kohl A; Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Linnington C; Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Lu D; Department of Life Sciences, Imperial College London, London, UK.
Dell A; Department of Life Sciences, Imperial College London, London, UK.
Haslam S; Department of Life Sciences, Imperial College London, London, UK.
Wang J; Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Czajkowsky D; State Key Laboratory for Oncogenes and Related Genes and Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Goebels N; Department of Neurology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Pleass RJ; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
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Źródło :
Immunology [Immunology] 2021 Sep; Vol. 164 (1), pp. 90-105. Date of Electronic Publication: 2021 May 09.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoantibodies/*therapeutic use
Cerebellum/*pathology
Demyelinating Diseases/*therapy
Immunoglobulin Fc Fragments/*therapeutic use
Immunoglobulin G/*therapeutic use
Oligodendroglia/*pathology
Recombinant Fusion Proteins/*therapeutic use
Animals ; Autoantibodies/genetics ; Cerebellum/drug effects ; Demyelinating Diseases/immunology ; HEK293 Cells ; Humans ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin G/genetics ; Immunoglobulins, Intravenous/therapeutic use ; Mice ; Mice, Inbred C57BL ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Oligodendroglia/drug effects ; Organ Culture Techniques ; Recombinant Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
Design and biological evaluation of novel long-acting adalimumab Fab conjugated with the albumin binding domain.
Autorzy :
Zhang Q; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Qian M; School of Pharmacy, Fudan University, Shanghai, 201203, China.
Wu Y; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China; Shanghai Duomirui Biotechnology Co., Ltd., Shanghai, 201203, China.
Wang Y; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Shangguan W; School of Pharmacy, Fudan University, Shanghai, 201203, China.
Lu J; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China; Shanghai Duomirui Biotechnology Co., Ltd., Shanghai, 201203, China.
Zhao W; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China; Shanghai Duomirui Biotechnology Co., Ltd., Shanghai, 201203, China.
Feng J; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China; Shanghai Duomirui Biotechnology Co., Ltd., Shanghai, 201203, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Aug 05; Vol. 904, pp. 174152. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Adalimumab/*biosynthesis
Adalimumab/*pharmacology
Albumins/*metabolism
Anti-Inflammatory Agents/*pharmacology
Immunoglobulin Fab Fragments/*biosynthesis
Recombinant Fusion Proteins/*biosynthesis
Recombinant Fusion Proteins/*pharmacology
Albumins/immunology ; Animals ; Anti-Inflammatory Agents/immunology ; Cell Death/drug effects ; Cell Line, Tumor ; Chemical and Drug Induced Liver Injury/prevention & control ; Drug Design ; Female ; Galactosamine/administration & dosage ; Galactosamine/toxicity ; Half-Life ; Humans ; Hydrogen-Ion Concentration ; Immunoglobulin Fab Fragments/pharmacology ; Injections, Intraperitoneal ; Mice, Inbred BALB C ; Necrosis/chemically induced ; Necrosis/prevention & control ; Protein Binding/genetics ; Protein Domains/genetics ; Receptors, Fc/immunology ; Receptors, Fc/metabolism ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/immunology ; Serum Albumin, Human/immunology ; Serum Albumin, Human/metabolism ; Tumor Necrosis Factor-alpha/administration & dosage ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/immunology ; Tumor Necrosis Factor-alpha/toxicity
Czasopismo naukowe
Tytuł :
Production in Escherichia coli of recombinant COVID-19 spike protein fragments fused to CRM197.
Autorzy :
Bellone ML; PhD Program in Drug Discovery and Development, Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Puglisi A; Department of Pharmacy and Biotechnology, University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy.
Dal Piaz F; Department of Medicine, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Hochkoeppler A; Department of Pharmacy and Biotechnology, University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy; CSGI, University of Firenze, Via della Lastruccia 3, 50019, Sesto Fiorentino, FI, Italy. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jun 18; Vol. 558, pp. 79-85. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Escherichia coli*/genetics
Escherichia coli*/metabolism
SARS-CoV-2*/chemistry
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
Bacterial Proteins/*chemistry
Bacterial Proteins/*genetics
Recombinant Fusion Proteins/*biosynthesis
Recombinant Fusion Proteins/*genetics
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*genetics
Bacterial Proteins/biosynthesis ; Bacterial Proteins/isolation & purification ; Base Sequence ; COVID-19 Vaccines/chemistry ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Inclusion Bodies/chemistry ; Inclusion Bodies/metabolism ; Mass Spectrometry ; Models, Molecular ; Protein Refolding ; Protein Stability ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/isolation & purification ; Spike Glycoprotein, Coronavirus/biosynthesis ; Spike Glycoprotein, Coronavirus/isolation & purification ; Temperature ; Time Factors
Czasopismo naukowe
Tytuł :
A BMP/Activin A Chimera Induces Posterolateral Spine Fusion in Nonhuman Primates at Lower Concentrations Than BMP-2.
Autorzy :
Seeherman HJ; Orthopedic Research and Pharmaceutical Development Consultant, Cambridge, Massachusetts.
Wilson CG; Bioventus Surgical, Bioventus LLC, Boston, Massachusetts.
Vanderploeg EJ; Bioventus Surgical, Bioventus LLC, Boston, Massachusetts.
Brown CT; Bioventus Surgical, Bioventus LLC, Boston, Massachusetts.
Morales PR; Mannheimer Foundation Inc., Homestead, Florida.
Fredricks DC; Bone Healing Research Lab and Iowa Spine Research Lab Orthopedic Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Wozney JM; Orthopedic Research and Pharmaceutical Development Consultant, Hudson, Massachusetts.
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Źródło :
The Journal of bone and joint surgery. American volume [J Bone Joint Surg Am] 2021 Aug 18; Vol. 103 (16), pp. e64.
Typ publikacji :
Journal Article
MeSH Terms :
Recombinant Fusion Proteins/*administration & dosage
Spinal Diseases/*therapy
Spinal Fusion/*methods
Activins/genetics ; Animals ; Bone Morphogenetic Protein 2/genetics ; Bone Morphogenetic Protein 6/genetics ; Dose-Response Relationship, Drug ; Humans ; Iodine Radioisotopes/chemistry ; Macaca mulatta ; Male ; Models, Animal ; Rats ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model.
Autorzy :
Yu EM; Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea.
Cho E; Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea.
Singh R; Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea.
Kim SH; Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea.
Han C; Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea.
Han S; Division of Tumor Immunology, National Cancer Center, Goyang 10408, Korea.
Lee DG; Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea.
Kim YH; Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea.; Eutilex, Co., Ltd., Geumcheon-gu, Seoul 08594, Korea.
Kwon BS; Eutilex, Co., Ltd., Geumcheon-gu, Seoul 08594, Korea.; Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Choi BK; Biomedicine Production Branch, Program for Immunotherapy Research, National Cancer Center, Goyang 10408, Korea.
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Źródło :
Cells [Cells] 2021 Aug 07; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoglobulin Fc Fragments/*immunology
Immunotherapy, Adoptive/*methods
Interleukin-7/*immunology
Lymphopenia/*immunology
Melanoma, Experimental/*therapy
Recombinant Fusion Proteins/*administration & dosage
Animals ; Bone Marrow/drug effects ; Bone Marrow/immunology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/drug effects ; Cell Differentiation/immunology ; Humans ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/metabolism ; Interleukin-7/genetics ; Interleukin-7/metabolism ; Leukocyte Count ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Lymphopenia/metabolism ; Melanoma, Experimental/genetics ; Melanoma, Experimental/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Myeloid Cells/cytology ; Myeloid Cells/drug effects ; Myeloid Cells/immunology ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
Engineering of Bio-Adhesive Ligand Containing Recombinant RGD and PHSRN Fibronectin Cell-Binding Domains in Fusion with a Colored Multi Affinity Tag: Simple Approach for Fragment Study from Expression to Adsorption.
Autorzy :
Ben Abla A; EBInnov®, Ecole de Biologie Industrielle, 49 Avenue des Genottes, 95000 Cergy, France.; Unité de Recherche Biomatériaux Innovants et Interfaces URB2i, Université Paris Sorbonne Nord, 74 Rue Marcel Cachin, 93017 Bobigny, France.
Boeuf G; EBInnov®, Ecole de Biologie Industrielle, 49 Avenue des Genottes, 95000 Cergy, France.
Elmarjou A; Plateforme de Production D'Anticorps et de Protéines Recombinantes, Institut Curie/CNRS UMR144, 75248 Paris, France.
Dridi C; EBInnov®, Ecole de Biologie Industrielle, 49 Avenue des Genottes, 95000 Cergy, France.; Unité de Recherche Biomatériaux Innovants et Interfaces URB2i, Université Paris Sorbonne Nord, 74 Rue Marcel Cachin, 93017 Bobigny, France.
Poirier F; Unité de Recherche Biomatériaux Innovants et Interfaces URB2i, Université Paris Sorbonne Nord, 74 Rue Marcel Cachin, 93017 Bobigny, France.
Changotade S; Unité de Recherche Biomatériaux Innovants et Interfaces URB2i, Université Paris Sorbonne Nord, 74 Rue Marcel Cachin, 93017 Bobigny, France.
Lutomski D; Unité de Recherche Biomatériaux Innovants et Interfaces URB2i, Université Paris Sorbonne Nord, 74 Rue Marcel Cachin, 93017 Bobigny, France.
Elm'selmi A; EBInnov®, Ecole de Biologie Industrielle, 49 Avenue des Genottes, 95000 Cergy, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 08; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Affinity Labels*
Biomimetic Materials*
Fibronectins*
Oligopeptides*
Peptide Fragments*
Recombinant Fusion Proteins/*chemistry
Adsorption ; Cell Adhesion ; Coated Materials, Biocompatible ; Escherichia coli ; Extracellular Matrix/chemistry ; Genetic Vectors ; Integrin alpha5beta1/metabolism ; Ligands ; Mass Spectrometry ; Polystyrenes ; Protein Binding ; Protein Domains ; Protein Engineering ; Recombinant Fusion Proteins/isolation & purification ; Recombinant Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
New Indication for Rilonacept.
Autorzy :
Aschenbrenner DS; Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch: .
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Źródło :
The American journal of nursing [Am J Nurs] 2021 Jul 01; Vol. 121 (7), pp. 24-25.
Typ publikacji :
Wiadomości
MeSH Terms :
Pericarditis/*drug therapy
Recombinant Fusion Proteins/*administration & dosage
Drug Repositioning ; Humans ; Injections, Subcutaneous ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/pharmacology
Periodyk
Tytuł :
PLGA Nanoparticles Decorated with Anti-HER2 Affibody for Targeted Delivery and Photoinduced Cell Death.
Autorzy :
Shipunova VO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy per., 141701 Dolgoprudny, Russia.; Department of Nanobiomedicine, Sirius University of Science and Technology, 1 Olympic Ave, 354340 Sochi, Russia.
Sogomonyan AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.
Zelepukin IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy per., 141701 Dolgoprudny, Russia.
Nikitin MP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Moscow Institute of Physics and Technology, 9 Institutskiy per., 141701 Dolgoprudny, Russia.; Department of Nanobiomedicine, Sirius University of Science and Technology, 1 Olympic Ave, 354340 Sochi, Russia.
Deyev SM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.; Institute of Engineering Physics for Biomedicine (PhysBio), MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Shosse, 115409 Moscow, Russia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 28; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry
Polylactic Acid-Polyglycolic Acid Copolymer*/pharmacology
Recombinant Fusion Proteins*/chemistry
Recombinant Fusion Proteins*/pharmacology
Neoplasms/*therapy
Receptor, ErbB-2/*metabolism
A549 Cells ; Animals ; CHO Cells ; Cell Death/drug effects ; Cricetulus ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe

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