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Tytuł :
Intein-based Design Expands Diversity of Selenocysteine Reporters.
Autorzy :
Chung CZ; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA. Electronic address: .
Krahn N; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA. Electronic address: .
Crnković A; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA. Electronic address: .
Söll D; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA; Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06511, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2022 Apr 30; Vol. 434 (8), pp. 167199. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Reporter*
Inteins*/genetics
Mutagenesis, Site-Directed*/methods
Recombinant Proteins*/chemistry
Recombinant Proteins*/genetics
Selenocysteine*/genetics
Selenocysteine*/metabolism
Selenoproteins*/chemistry
Selenoproteins*/genetics
Codon, Terminator/genetics ; Codon, Terminator/metabolism ; Cysteine/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism
Czasopismo naukowe
Tytuł :
Long-term evaluation of the safety and efficacy of recombinant human pentraxin-2 (rhPTX-2) in patients with idiopathic pulmonary fibrosis (IPF): an open-label extension study.
Autorzy :
Raghu G; Center for Interstitial Lung Diseases, Department of Medicine and Laboratory Medicine, University of Washington, Seattle, WA, USA. .
Hamblin MJ; Pulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Brown AW; Inova Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA.
Golden JA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Ho LA; Center for Interstitial Lung Diseases, Department of Medicine and Laboratory Medicine, University of Washington, Seattle, WA, USA.
Wijsenbeek MS; Department of Respiratory Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Vasakova M; Department of Respiratory Medicine, First Faculty of Medicine of Charles University and Thomayer Hospital, Prague, Czech Republic.
Pesci A; School of Medicine and Surgery, University of Milano-Bicocca, ASST-Monza, Milano, Italy.
Antin-Ozerkis DE; Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Meyer KC; Department of Medicine, Division of Pulmonary and Critical Care, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Kreuter M; Center for Interstitial and Rare Lung Diseases, Department of Pneumology, Thoraxklinik, University of Heidelberg and German Center for Lung Research, Heidelberg, Germany.
Burgess T; Genentech, Inc., South San Francisco, CA, USA.
Kamath N; Roche Products Ltd., Welwyn Garden City, UK.
Donaldson F; Roche Products Ltd., Welwyn Garden City, UK.
Richeldi L; Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
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Źródło :
Respiratory research [Respir Res] 2022 May 21; Vol. 23 (1), pp. 129. Date of Electronic Publication: 2022 May 21.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms :
Idiopathic Pulmonary Fibrosis*/drug therapy
Recombinant Proteins*/adverse effects
Humans ; Treatment Outcome ; Vital Capacity
Czasopismo naukowe
Tytuł :
Molecular therapeutics of hemophilia A and B.
Autorzy :
Gong J; School of Medicine, University of Electronic Science and Technology of China, Sichuan, China.
Wang HL; School of Medicine, University of Electronic Science and Technology of China, Sichuan, China.
Chang LJ; School of Medicine, University of Electronic Science and Technology of China, Sichuan, China.; Geno-Immune Medical Institute, Shenzhen, China.
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Źródło :
Expert review of hematology [Expert Rev Hematol] 2022 May; Vol. 15 (5), pp. 431-441. Date of Electronic Publication: 2022 May 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hemophilia A*/genetics
Hemophilia A*/therapy
Hemophilia B*/genetics
Hemophilia B*/therapy
Recombinant Proteins*/therapeutic use
Factor IX/genetics ; Factor IX/therapeutic use ; Factor VIII/genetics ; Factor VIII/therapeutic use ; Humans ; Molecular Targeted Therapy/trends
Czasopismo naukowe
Tytuł :
Treatment of Short Stature in Aggrecan-deficient Patients With Recombinant Human Growth Hormone: 1-Year Response.
Autorzy :
Muthuvel G; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Dauber A; Division of Endocrinology, Children's National Hospital, Washington, DC 20010, USA.; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Alexandrou E; Division of Endocrinology, The University of Iowa Stead Family Children's Hospital, Iowa City, IA 52242, USA.; Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
Tyzinski L; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Andrew M; Division of Endocrinology, Children's National Hospital, Washington, DC 20010, USA.
Hwa V; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.
Backeljauw P; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Apr 19; Vol. 107 (5), pp. e2103-e2109.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dwarfism*/drug therapy
Dwarfism*/genetics
Human Growth Hormone*/adverse effects
Recombinant Proteins*/adverse effects
Aggrecans/genetics ; Body Height ; Child ; Child, Preschool ; Female ; Humans ; Male ; Prospective Studies
Czasopismo naukowe
Tytuł :
Eptacog beta, a novel recombinant factor VIIa, for the treatment of hemophilia.
Autorzy :
Watson N; Harvard Medical School, Boston, Massachusetts, USA.
Al-Samkari H; Harvard Medical School, Boston, Massachusetts, USA. .; Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
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Źródło :
Drugs of today (Barcelona, Spain : 1998) [Drugs Today (Barc)] 2022 Mar; Vol. 58 (3), pp. 105-116.
Typ publikacji :
Journal Article
MeSH Terms :
Factor VIIa*/therapeutic use
Hemophilia A*/drug therapy
Hemophilia B*/drug therapy
Recombinant Proteins*/therapeutic use
Animals ; Humans ; Rabbits
Czasopismo naukowe
Tytuł :
A rapid 2AB-UHPLC method based on magnetic beads extraction for N-glycan analysis of recombinant monoclonal antibody.
Autorzy :
Zhang Y; Department of Process Development, BeiGene Guangzhou Biologics Manufacturing Co, Ltd, Guangzhou, China. Electronic address: .
Bu R; Department of Process Development, BeiGene Guangzhou Biologics Manufacturing Co, Ltd, Guangzhou, China.
Cao Y; Department of Process Development, BeiGene Guangzhou Biologics Manufacturing Co, Ltd, Guangzhou, China.
Jin J; Department of Process Development, BeiGene Guangzhou Biologics Manufacturing Co, Ltd, Guangzhou, China.
Meng K; Department of Process Development, BeiGene Guangzhou Biologics Manufacturing Co, Ltd, Guangzhou, China.
Qiu F; Department of Process Development, BeiGene Guangzhou Biologics Manufacturing Co, Ltd, Guangzhou, China. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2022 Mar 01; Vol. 1192, pp. 123139. Date of Electronic Publication: 2022 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Polysaccharides*/analysis
Polysaccharides*/chemistry
Antibodies, Monoclonal/*chemistry
Chromatography, High Pressure Liquid/*methods
Recombinant Proteins/*chemistry
Antibodies, Monoclonal/analysis ; Magnets ; Recombinant Proteins/analysis ; Recombinant Proteins/standards ; Reproducibility of Results ; Solid Phase Extraction
Czasopismo naukowe
Tytuł :
Prokaryotic expression, evaluation, and prediction of the structure and function of the ecarin metalloproteinase domain.
Autorzy :
Mohammadi N; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Bandehpour M; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sotoodehnejadnematalahi F; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Kazemi B; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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Źródło :
Proteins [Proteins] 2022 Mar; Vol. 90 (3), pp. 802-809. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endopeptidases/*chemistry
Metalloproteases/*chemistry
Recombinant Proteins/*chemistry
Animals ; Endopeptidases/pharmacology ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Humans ; Metalloproteases/genetics ; Metalloproteases/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Thrombin/chemistry ; Thrombosis/drug therapy ; Viperidae
Czasopismo naukowe
Tytuł :
Multimodal approaches for the improvement of the cellular folding of a recombinant iron regulatory protein in E. coli.
Autorzy :
Ravitchandirane G; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.; Dr. Reddy's Laboratories Ltd., Hyderabad, India.
Bandhu S; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.
Chaudhuri TK; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. .
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Źródło :
Microbial cell factories [Microb Cell Fact] 2022 Feb 05; Vol. 21 (1), pp. 20. Date of Electronic Publication: 2022 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Folding*
Aconitate Hydratase/*chemistry
Escherichia coli/*metabolism
Iron-Regulatory Proteins/*chemistry
Recombinant Proteins/*chemistry
Aconitate Hydratase/genetics ; Aconitate Hydratase/metabolism ; Escherichia coli/chemistry ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Iron-Regulatory Proteins/genetics ; Iron-Regulatory Proteins/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Combined gene and environmental engineering offers a synergetic strategy to enhance r-protein production in Chinese hamster ovary cells.
Autorzy :
Torres M; Faculty of Science and Engineering, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.; Department of Chemical Engineering and Analytical Science, Biochemical and Bioprocess Engineering Group, University of Manchester, Manchester, UK.
Dickson AJ; Faculty of Science and Engineering, Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.; Department of Chemical Engineering and Analytical Science, Biochemical and Bioprocess Engineering Group, University of Manchester, Manchester, UK.
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Źródło :
Biotechnology and bioengineering [Biotechnol Bioeng] 2022 Feb; Vol. 119 (2), pp. 550-565. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Recombinant Proteins*/analysis
Recombinant Proteins*/genetics
Recombinant Proteins*/metabolism
Batch Cell Culture Techniques/*methods
Cell Engineering/*methods
Animals ; Butyric Acid/chemistry ; CHO Cells ; Cell Proliferation/genetics ; Cell Survival ; Cricetinae ; Cricetulus ; Culture Media ; Metabolomics/methods ; Positive Regulatory Domain I-Binding Factor 1/genetics ; Positive Regulatory Domain I-Binding Factor 1/metabolism
Czasopismo naukowe
Tytuł :
A novel method for purification of biologically active C-terminal fragment of human recombinant anti-mullerian hormone.
Autorzy :
Rak AY; State Research Institute of Highly Pure Biopreparations, St Petersburg, Russian Federation.
Protasov EA; State Research Institute of Highly Pure Biopreparations, St Petersburg, Russian Federation.
Trofimov AV; State Research Institute of Highly Pure Biopreparations, St Petersburg, Russian Federation.
Pigareva NV; State Research Institute of Highly Pure Biopreparations, St Petersburg, Russian Federation.
Ischenko AM; State Research Institute of Highly Pure Biopreparations, St Petersburg, Russian Federation.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2022 Feb; Vol. 36 (2), pp. e5259. Date of Electronic Publication: 2021 Nov 15.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Mullerian Hormone*/chemistry
Anti-Mullerian Hormone*/isolation & purification
Anti-Mullerian Hormone*/pharmacology
Recombinant Proteins*/chemistry
Recombinant Proteins*/isolation & purification
Recombinant Proteins*/pharmacology
Chromatography, High Pressure Liquid/*methods
Animals ; CHO Cells ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatography, Reverse-Phase/methods ; Cricetinae ; Cricetulus ; Humans ; Hydrophobic and Hydrophilic Interactions
Czasopismo naukowe
Tytuł :
Rational design of a new variant of Reteplase with optimized physicochemical profile and large-scale production in Escherichia coli.
Autorzy :
Seyedhosseini Ghaheh H; Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Sajjadi S; Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shafiee F; Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Barzegari E; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Moazen F; Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Mir Mohammad Sadeghi H; Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. .
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Źródło :
World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2022 Jan 06; Vol. 38 (2), pp. 29. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolic Engineering*
Recombinant Proteins/*biosynthesis
Tissue Plasminogen Activator/*biosynthesis
Bioreactors ; Biotechnology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fibrinolytic Agents/metabolism ; Gene Expression Regulation, Bacterial ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutagenesis ; Protein Folding ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/pharmacology ; Tissue Plasminogen Activator/chemistry ; Tissue Plasminogen Activator/genetics ; Tissue Plasminogen Activator/pharmacology
Czasopismo naukowe
Tytuł :
Non-clinical safety assessment and in vivo biodistribution of CoviFab, an RBD-specific F(ab')2 fragment derived from equine polyclonal antibodies.
Autorzy :
Salinas F; Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL) / Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina.
Marelli BE; Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL) / Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina; Facultad de Ciencias Veterinarias del Litoral, Universidad Nacional del Litoral (UNL), Esperanza, Santa Fe, Argentina.
Sanguineti S; INMUNOVA S.A., Av. Patricias Argentinas 435, Ciudad de Buenos Aires C1405BWE, Argentina.
Goldbaum F; INMUNOVA S.A., Av. Patricias Argentinas 435, Ciudad de Buenos Aires C1405BWE, Argentina; CRIP-Centro de Rediseño e Ingeniería de Proteínas UNSAM, Campus Miguelete, San Martín, Provincia de Buenos Aires, Argentina; Laboratorio de Inmunología y Microbiología Molecular, Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.
Muñoz L; INMUNOVA S.A., Av. Patricias Argentinas 435, Ciudad de Buenos Aires C1405BWE, Argentina.
Etchevers L; Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL) / Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina.
Silvestrini P; Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL) / Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina.
Notaro US; Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL) / Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina.
Salvetti NR; Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL) / Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina; Facultad de Ciencias Veterinarias del Litoral, Universidad Nacional del Litoral (UNL), Esperanza, Santa Fe, Argentina.
Zylberman V; INMUNOVA S.A., Av. Patricias Argentinas 435, Ciudad de Buenos Aires C1405BWE, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, (CONICET), Argentina.
Ortega HH; Centro de Medicina Comparada, Instituto de Ciencias Veterinarias del Litoral (ICiVet-Litoral), Universidad Nacional del Litoral (UNL) / Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Santa Fe, Argentina; Facultad de Ciencias Veterinarias del Litoral, Universidad Nacional del Litoral (UNL), Esperanza, Santa Fe, Argentina. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Jan 01; Vol. 434, pp. 115796. Date of Electronic Publication: 2021 Nov 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*metabolism
COVID-19/*drug therapy
Receptors, Immunologic/*metabolism
Recombinant Proteins/*metabolism
SARS-CoV-2/*metabolism
Administration, Intravenous ; Animals ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/adverse effects ; COVID-19/metabolism ; COVID-19/prevention & control ; HEK293 Cells ; Horses ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Receptors, Immunologic/administration & dosage ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; SARS-CoV-2/drug effects ; Spectroscopy, Near-Infrared/methods ; Tissue Distribution/drug effects ; Tissue Distribution/physiology
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
A framework for calculating orthogonal selectivities in multimodal systems directly from cell culture fluid.
Autorzy :
Vecchiarello N; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Timmick SM; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Cramer S; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
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Źródło :
Biotechnology and bioengineering [Biotechnol Bioeng] 2022 Jan; Vol. 119 (1), pp. 299-314. Date of Electronic Publication: 2021 Nov 08.
Typ publikacji :
Journal Article
MeSH Terms :
Recombinant Proteins*/analysis
Recombinant Proteins*/chemistry
Recombinant Proteins*/isolation & purification
Cell Culture Techniques/*methods
Chromatography, Reverse-Phase/*methods
High-Throughput Screening Assays/*methods
Animals ; CHO Cells ; Chromatography, High Pressure Liquid/methods ; Cricetinae ; Cricetulus ; Culture Media/chemistry ; Hydrogen-Ion Concentration ; Saccharomycetales
SCR Organism :
Komagataella pastoris
Czasopismo naukowe
Tytuł :
Recombinase-mediated cassette exchange-based screening of a CRISPR/Cas9 library for enhanced recombinant protein production in human embryonic kidney cells: Improving resistance to hyperosmotic stress.
Autorzy :
Shin S; Department of Biological Sciences, KAIST, Daejeon, 34141, Republic of Korea.
Kim SH; Department of Biological Sciences, KAIST, Daejeon, 34141, Republic of Korea.
Park JH; Department of Biological Sciences, KAIST, Daejeon, 34141, Republic of Korea.
Lee JS; Department of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea. Electronic address: .
Lee GM; Department of Biological Sciences, KAIST, Daejeon, 34141, Republic of Korea. Electronic address: .
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Źródło :
Metabolic engineering [Metab Eng] 2022 Jul; Vol. 72, pp. 247-258. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*
Recombinant Proteins*/biosynthesis
Recombinases*/genetics
Antibodies, Monoclonal ; HEK293 Cells ; Humans ; Kidney/metabolism ; Osmotic Pressure
Czasopismo naukowe
Tytuł :
Safety and Efficacy of Pegteograstim on Chemotherapy-induced Neutropenia in Children and Adolescents With Solid Tumors.
Autorzy :
Cho HW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Lee JW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Ju HY; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Hyun JK; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Yoo KH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Koo HH; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Kim K; Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center.; Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea.
Sung KW; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine.
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Źródło :
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2022 Mar 01; Vol. 44 (2), pp. e362-e367.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents*/adverse effects
Neoplasms*/drug therapy
Neutropenia*/chemically induced
Neutropenia*/drug therapy
Recombinant Proteins*/adverse effects
Adolescent ; Child ; Filgrastim/therapeutic use ; Granulocyte Colony-Stimulating Factor ; Humans ; Polyethylene Glycols/adverse effects
Czasopismo naukowe
Tytuł :
Intraperitoneal infusion of recombinant human endostatin improves prognosis in gastric cancer ascites.
Autorzy :
Zhan Z; Department of Medical Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Wang X; Department of Medical Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Yu J; Department of Medical Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Zheng J; Department of Medical Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Zeng Y; Department of Gastrointestinal Surgery, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Sun M; Department of Clinical Nutrition, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China.
Peng L; Department of Diagnostic Radiology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Guo Z; Department of Medical Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Chen B; Department of Radiotherapy, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
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Źródło :
Future oncology (London, England) [Future Oncol] 2022 Mar; Vol. 18 (10), pp. 1259-1271. Date of Electronic Publication: 2022 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Ascites/*drug therapy
Ascites/*etiology
Cisplatin/*administration & dosage
Endostatins/*administration & dosage
Recombinant Proteins/*administration & dosage
Stomach Neoplasms/*complications
Stomach Neoplasms/*drug therapy
Adult ; Aged ; Antineoplastic Agents/adverse effects ; Cisplatin/adverse effects ; Endostatins/adverse effects ; Female ; Humans ; Infusions, Parenteral ; Male ; Middle Aged ; Prognosis ; Quality of Life ; Recombinant Proteins/adverse effects ; Retrospective Studies
Czasopismo naukowe
Tytuł :
A genetically encoded sensor for in vivo imaging of orexin neuropeptides.
Autorzy :
Duffet L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Kosar S; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Panniello M; Optical Approaches to Brain Function Laboratory, Istituto Italiano di Tecnologia, Genova, Italy.
Viberti B; Center for Experimental Neurology (ZEN), Department of Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Bern, Switzerland.
Bracey E; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Zych AD; Circuits for Emotion Research Group, Max Planck Institute of Neurobiology, Martinsried, Germany.; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
Radoux-Mergault A; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Zhou X; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Dernic J; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Ravotto L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Tsai YC; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Figueiredo M; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Tyagarajan SK; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Optical Approaches to Brain Function Laboratory, Istituto Italiano di Tecnologia, Genova, Italy.
Weber B; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Optical Approaches to Brain Function Laboratory, Istituto Italiano di Tecnologia, Genova, Italy.
Stoeber M; Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Gogolla N; Circuits for Emotion Research Group, Max Planck Institute of Neurobiology, Martinsried, Germany.
Schmidt MH; Center for Experimental Neurology (ZEN), Department of Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Bern, Switzerland.
Adamantidis AR; Center for Experimental Neurology (ZEN), Department of Neurology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.; Department of Biomedical Research, University of Bern, Bern, Switzerland.
Fellin T; Optical Approaches to Brain Function Laboratory, Istituto Italiano di Tecnologia, Genova, Italy.
Burdakov D; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland.
Patriarchi T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. .; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland. .
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Źródło :
Nature methods [Nat Methods] 2022 Feb; Vol. 19 (2), pp. 231-241. Date of Electronic Publication: 2022 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Molecular Imaging/*methods
Orexin Receptors/*genetics
Orexins/*analysis
Recombinant Proteins/*metabolism
Animals ; Behavior, Animal ; Female ; HEK293 Cells ; Humans ; Male ; Mice, Inbred C57BL ; Orexin Receptors/metabolism ; Orexins/genetics ; Orexins/pharmacology ; Photons ; Recombinant Proteins/genetics ; Reproducibility of Results ; Sleep/physiology
Czasopismo naukowe
Tytuł :
Bronchoscopic intratumoral injections of cisplatin and endostar as concomitants of standard chemotherapy to treat malignant central airway obstruction.
Autorzy :
Jiang W; Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, China.
Yang X; Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, China.
Wang X; Department of Respiration, Qingdao Central Hospital, Qingdao, China.
Li Y; Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, China.
Yang X; Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, China.
Wang N; Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, China.
Yin B; Department of Respiratory Diseases, Qingdao Haici Hospital, Qingdao, China .
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Źródło :
Postgraduate medical journal [Postgrad Med J] 2022 Feb; Vol. 98 (1156), pp. 104-112. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Airway Obstruction/*drug therapy
Angiogenesis Inhibitors/*administration & dosage
Antineoplastic Agents/*administration & dosage
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cisplatin/*administration & dosage
Endostatins/*administration & dosage
Lung Neoplasms/*drug therapy
Recombinant Proteins/*administration & dosage
Aged ; Aged, 80 and over ; Airway Obstruction/etiology ; Angiogenesis Inhibitors/therapeutic use ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/complications ; Cisplatin/therapeutic use ; Endostatins/therapeutic use ; Female ; Humans ; Injections, Intralesional ; Lung Neoplasms/complications ; Male ; Middle Aged ; Quality of Life ; Recombinant Proteins/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł :
CRISPR/Cas9-mediated knockout of the DCL2 and DCL4 genes in Nicotiana benthamiana and its productivity of recombinant proteins.
Autorzy :
Matsuo K; Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo, 062-8517, Japan. .
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Źródło :
Plant cell reports [Plant Cell Rep] 2022 Feb; Vol. 41 (2), pp. 307-317. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Plant Proteins/*genetics
Recombinant Proteins/*metabolism
Tobacco/*genetics
CRISPR-Cas Systems ; Fibroblast Growth Factor 1/genetics ; Fibroblast Growth Factor 1/metabolism ; Gene Expression Regulation, Plant ; Gene Knockout Techniques ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Plant Proteins/metabolism ; Plants, Genetically Modified/genetics ; Recombinant Proteins/genetics ; Tobacco/metabolism
Czasopismo naukowe

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