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Wyszukujesz frazę ""Recombinant Proteins"" wg kryterium: Temat


Tytuł:
POFUT1-mediated O-fucosylation of glycoproteins expressed in the baculovirus Sf9 insect cell expression system.
Autorzy:
Haymour L; Univ. Limoges, LABCiS, UR 22722, Limoges 22722, France.
Pennarubia F; Univ. Limoges, LABCiS, UR 22722, Limoges 22722, France.
Le Faou CC; Univ. Limoges, LABCiS, UR 22722, Limoges 22722, France.
Pinault E; Univ. Limoges, CNRS, Inserm, CHU Limoges, BISCEm, UAR 2015, US 42, Limoges F-87000, France.
Germot A; Univ. Limoges, LABCiS, UR 22722, Limoges 22722, France.
Maftah A; Univ. Limoges, LABCiS, UR 22722, Limoges 22722, France.
Legardinier S; Univ. Limoges, LABCiS, UR 22722, Limoges 22722, France. Electronic address: .
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Źródło:
Journal of biotechnology [J Biotechnol] 2024 Jan 10; Vol. 379, pp. 53-64. Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article
MeSH Terms:
Recombinant Proteins*/chemistry
Recombinant Proteins*/genetics
Recombinant Proteins*/metabolism
Fucosyltransferases*/chemistry
Fucosyltransferases*/genetics
Fucosyltransferases*/metabolism
Spodoptera/enzymology ; Spodoptera/genetics ; Spodoptera/metabolism ; Humans ; Animals ; Mice ; CHO Cells ; Cricetulus ; Sf9 Cells ; Glycosylation ; Consensus Sequence ; Fucose/metabolism ; Protein Domains
Czasopismo naukowe
Tytuł:
Production of Bioactive Porcine Lactoferrin through a Novel Glucose-Inducible Expression System in Pichia pastoris : Unveiling Antimicrobial and Anticancer Functionalities.
Autorzy:
Yen CC; Department of Internal Medicine, China Medical University Hospital, College of Health Care, China Medical University, Taichung 404, Taiwan.; Department of Life Sciences, Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Wu PY; Department of Life Sciences, Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Ou-Yang H; Department of Life Sciences, Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Chen HL; Department of Biomedical Science, Da-Yeh University, Changhua 515, Taiwan.
Chong KY; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Hyperbaric Oxygen Medical Research Laboratory, Bone and Joint Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Chang RL; Department of Life Sciences, Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Chen CM; Department of Life Sciences, Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.; The iEGG and Animal Biotechnology Center, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 02; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Infective Agents*/pharmacology
Lactoferrin*/biosynthesis
Lactoferrin*/genetics
Lactoferrin*/pharmacology
Recombinant Proteins*/biosynthesis
Recombinant Proteins*/genetics
Recombinant Proteins*/pharmacology
Animals ; Cattle ; Humans ; Escherichia coli/metabolism ; Fermentation ; Glucose/metabolism ; Pichia/metabolism ; Saccharomycetales ; Staphylococcus aureus/drug effects ; Swine
SCR Organism:
Komagataella pastoris
Czasopismo naukowe
Tytuł:
The dangerous liaisons in innate immunity involving recombinant proteins and endotoxins: Examples from the literature and the Leptospira field.
Autorzy:
Bonhomme D; Institut Pasteur, Université Cité Paris, CNRS UMR6047, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, France.
Cavaillon JM; Institut Pasteur, Paris, France.
Werts C; Institut Pasteur, Université Cité Paris, CNRS UMR6047, INSERM U1306, Unité de Biologie et Génétique de la Paroi Bactérienne, Paris, France. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105506. Date of Electronic Publication: 2023 Nov 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Immunity, Innate*
Lipopolysaccharides*/toxicity
Recombinant Proteins*/metabolism
Leptospira*/metabolism
Humans ; Escherichia coli/genetics
Czasopismo naukowe
Tytuł:
The discovery and evaluation of [ F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement.
Autorzy:
Donnelly DJ; Small Molecule Drug Discovery-PET Radiochemical Synthesis, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, NJ, 08543, USA. .
Kim J; Imaging, Bristol Myers Squibb, Princeton, USA.
Tran T; Small Molecule Drug Discovery-PET Radiochemical Synthesis, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, NJ, 08543, USA.
Scola PM; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, USA.
Tenney D; Biology, Bristol Myers Squibb, Princeton, USA.
Pena A; Imaging, Bristol Myers Squibb, Princeton, USA.
Petrone T; Imaging, Bristol Myers Squibb, Princeton, USA.
Zhang Y; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, USA.
Boy KM; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, USA.
Poss MA; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, USA.
Cole EL; Small Molecule Drug Discovery-PET Radiochemical Synthesis, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, NJ, 08543, USA.
Soars MG; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Cambridge, USA.
Johnson BM; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Cambridge, USA.
Cohen D; Biologics and Platforms, Bristol Myers Squibb, Princeton, USA.
Batalla D; Small Molecule Drug Discovery-PET Radiochemical Synthesis, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, NJ, 08543, USA.
Chow PL; Imaging, Bristol Myers Squibb, Princeton, USA.
Shorts AO; Imaging, Bristol Myers Squibb, Princeton, USA.
Du S; Imaging, Bristol Myers Squibb, Princeton, USA.
Meanwell NA; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, USA.
Bonacorsi SJ Jr; Small Molecule Drug Discovery-PET Radiochemical Synthesis, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, NJ, 08543, USA.
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Mar; Vol. 51 (4), pp. 978-990. Date of Electronic Publication: 2023 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*
Lung Neoplasms*
Fibronectin Type III Domain*
Fluorine Radioisotopes*
Recombinant Proteins*
Humans ; Mice ; Animals ; B7-H1 Antigen/metabolism ; Ligands ; Macaca fascicularis/metabolism ; Positron-Emission Tomography/methods ; Peptides/chemistry
Czasopismo naukowe
Tytuł:
Endostar acts as a pneumonitis protectant in patients with locally advanced non-small cell lung cancer receiving concurrent chemoradiotherapy.
Autorzy:
Chen K; Taizhou hospital of Zhejiang Province, Shaoxing University, Zhejiang Province, Taizhou, 317000, China.; Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou, 317000, China.
Li S; Taizhou hospital of Zhejiang Province, Shaoxing University, Zhejiang Province, Taizhou, 317000, China.; Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou, 317000, China.
Chen M; Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou, 317000, China.
Jin Z; Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou, 317000, China.
Sun X; Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou, 317000, China.
Zhou S; Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou, 317000, China. .
Yang H; Taizhou hospital of Zhejiang Province, Shaoxing University, Zhejiang Province, Taizhou, 317000, China. .; Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Taizhou, Radiation Oncology Institute of Enze Medical Health Academy, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang Province, Taizhou, 317000, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Feb 23; Vol. 24 (1), pp. 257. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/radiotherapy
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/radiotherapy
Lung Neoplasms*/drug therapy
Pneumonia*/chemically induced
Pneumonia*/epidemiology
Radiation Pneumonitis*/epidemiology
Radiation Pneumonitis*/etiology
Recombinant Proteins*
Endostatins*
Humans ; Retrospective Studies ; Chemoradiotherapy/adverse effects ; Chemoradiotherapy/methods
Czasopismo naukowe
Tytuł:
Multi-omics sequencing revealed endostar combined with cisplatin treated non small cell lung cancer via anti-angiogenesis.
Autorzy:
Wang Y; Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, 710061, Shanxi, Xi'an, Shanxi, P.R. China.; Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, 010050, Hohhot, Inner Mongolia, P.R. China.
Ren H; Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, 710061, Shanxi, Xi'an, Shanxi, P.R. China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Feb 08; Vol. 24 (1), pp. 187. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Recombinant Proteins*
Endostatins*
Humans ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Multiomics ; Vascular Endothelial Growth Factor A/metabolism ; Cell Line, Tumor ; Methyltransferases/genetics
Czasopismo naukowe
Tytuł:
Real-life impacts of olipudase alfa: The experience of patients and families taking an enzyme replacement therapy for acid sphingomyelinase deficiency.
Autorzy:
Raebel EM; Rare Disease Research Partners, MPS House, Repton Place, White Lion Road, Amersham, HP7 9LP, UK.
Wiseman S; Rare Disease Research Partners, MPS House, Repton Place, White Lion Road, Amersham, HP7 9LP, UK.
Donnelly C; International Niemann-Pick Disease Registry, Suite 2 Vermont House, Washington, Tyne and Wear, NE37 2SQ, UK. .
Mathieson T; Niemann-Pick UK, Suite 2 Vermont House, Washington, Tyne and Wear, NE37 2SQ, UK.
Pountney J; Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK.
Crowe J; NNPDF, PO Box 49, Fort Atkinson, WI, 53538, USA.
Hopkin J; Rochester, USA.
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Źródło:
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2024 Feb 01; Vol. 19 (1), pp. 36. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Replacement Therapy*/methods
Niemann-Pick Diseases*/therapy
Recombinant Proteins*/therapeutic use
Sphingomyelin Phosphodiesterase*/therapeutic use
Child ; Humans ; Infant ; Quality of Life
Czasopismo naukowe
Tytuł:
Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
Autorzy:
Xue M; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.; The Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.
Jackson CJ; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.
Lin H; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.; The Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.
Zhao R; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.
Liang HPH; Sutton Arthritis Research Laboratory, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.
Weiler H; Versiti Blood Research Institute, Milwaukee, WI 53226, USA.; Department of Physiology, The Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Griffin JH; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
March L; The Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Protein C*/metabolism
Dermatitis, Allergic Contact*/drug therapy
Recombinant Proteins*
Animals ; Mice ; Endothelial Protein C Receptor/metabolism ; Receptor, PAR-1/metabolism ; Signal Transduction ; Cytokines/pharmacology
Czasopismo naukowe
Tytuł:
The effect of pegbovigrastim administration on the nonspecific immunity of calves.
Autorzy:
Dudek K; Department of Cattle and Sheep Diseases, National Veterinary Research Institute, Pulawy, Poland.
Szacawa E; Department of Cattle and Sheep Diseases, National Veterinary Research Institute, Pulawy, Poland.
Bednarek D; Department of Cattle and Sheep Diseases, National Veterinary Research Institute, Pulawy, Poland.
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Źródło:
Journal of veterinary internal medicine [J Vet Intern Med] 2024 Jan-Feb; Vol. 38 (1), pp. 505-513. Date of Electronic Publication: 2023 Dec 05.
Typ publikacji:
Observational Study, Veterinary; Randomized Controlled Trial, Veterinary; Journal Article
MeSH Terms:
Immunity, Innate*
Granulocytes*
Recombinant Proteins*
Cattle ; Animals ; Female ; Granulocyte Colony-Stimulating Factor ; Leukocytes
Czasopismo naukowe
Tytuł:
Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer.
Autorzy:
Rinaldi F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.
Schipani F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.
Balboni B; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.
Catalano F; Electron Microscopy Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
Marotta R; Electron Microscopy Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
Myers SH; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.
Previtali V; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.
Veronesi M; Structural Biophysics, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
Scietti L; Biochemistry and Structural Biology Unit, Department of Experimental Oncology, IRCCS European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy.
Cecatiello V; Biochemistry and Structural Biology Unit, Department of Experimental Oncology, IRCCS European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy.; Current address: Structural Biology Research Centre, Human Technopole Milan, Italy Palazzo Italia Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.
Pasqualato S; Biochemistry and Structural Biology Unit, Department of Experimental Oncology, IRCCS European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy.; Current address: Structural Biology Research Centre, Human Technopole Milan, Italy Palazzo Italia Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.
Ortega JA; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.
Girotto S; Structural Biophysics, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
Cavalli A; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy.
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Źródło:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Dec 18; Vol. 62 (51), pp. e202312517. Date of Electronic Publication: 2023 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Homologous Recombination*
Neoplasms*/genetics
Rad51 Recombinase*/chemistry
Rad51 Recombinase*/genetics
Rad51 Recombinase*/isolation & purification
Recombinant Proteins*/chemistry
Recombinant Proteins*/genetics
Recombinant Proteins*/isolation & purification
Humans ; DNA Damage ; DNA Repair ; Mutation ; Protein Stability ; Protein Domains
Czasopismo naukowe
Tytuł:
Functional GPCR Expression in Eukaryotic LEXSY System.
Autorzy:
Luginina A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Maslov I; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia; Dynamic Bioimaging Lab, Advanced Optical Microscopy Centre, Biomedical Research Institute, Agoralaan C (BIOMED), Hasselt University, Diepenbeek, Belgium; Laboratory for Photochemistry and Spectroscopy, Division for Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, Leuven, Belgium.
Khorn P; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Volkov O; No affiliation.
Khnykin A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Kuzmichev P; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Shevtsov M; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Belousov A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Kapranov I; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Dashevskii D; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Kornilov D; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Bestsennaia E; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Hofkens J; Laboratory for Photochemistry and Spectroscopy, Division for Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, Leuven, Belgium; Max Planck Institute for Polymer Research, Mainz, Germany.
Hendrix J; Dynamic Bioimaging Lab, Advanced Optical Microscopy Centre, Biomedical Research Institute, Agoralaan C (BIOMED), Hasselt University, Diepenbeek, Belgium; Laboratory for Photochemistry and Spectroscopy, Division for Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, Leuven, Belgium.
Gensch T; Laboratory for Photochemistry and Spectroscopy, Division for Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, Leuven, Belgium.
Cherezov V; Bridge Institute, Department of Chemistry, University of Southern California, Los Angeles, CA, USA.
Ivanovich V; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Mishin A; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Borshchevskiy V; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia; Joint Institute for Nuclear Research, Dubna, Russia. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Dec 01; Vol. 435 (23), pp. 168310. Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, G-Protein-Coupled*/biosynthesis
Receptors, G-Protein-Coupled*/chemistry
Recombinant Proteins*/biosynthesis
Recombinant Proteins*/chemistry
Receptor, Adenosine A2A*/biosynthesis
Receptor, Adenosine A2A*/chemistry
Humans ; Drug Discovery ; Leishmania ; Protein Conformation ; Ligands ; Protein Stability
Czasopismo naukowe
Tytuł:
Efbemalenograstim alfa, an Fc fusion protein, long-acting granulocyte-colony stimulating factor for reducing the risk of febrile neutropenia following chemotherapy: results of a phase III trial.
Autorzy:
Glaspy J; UCLA School of Medicine, UCLA Medical Plaza, 100Suite 550, Los Angeles, CA, 90095-6956, USA. .
Bondarenko I; Oncology and Medical Radiology Dept, Dnepropetrovsk Medical Academy, Dnepropetrovsk, Ukraine.
Burdaeva O; Arkhangelsk Regional Clinical Hospital, Arkhangelsk, Russia.
Chen J; Evive Biotechnology (Shanghai) Ltd, Shanghai, China.
Rutty D; Everest Clinical Research, Markham, ON, Canada.
Li R; Evive Biotechnology (Shanghai) Ltd, Shanghai, China.
Wang S; Evive Biotechnology (Shanghai) Ltd, Shanghai, China.
Hou Q; Evive Biotechnology (Shanghai) Ltd, Shanghai, China.
Li S; Evive Biotechnology (Shanghai) Ltd, Shanghai, China.
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Źródło:
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Dec 16; Vol. 32 (1), pp. 34. Date of Electronic Publication: 2023 Dec 16.
Typ publikacji:
Randomized Controlled Trial; Clinical Trial, Phase III; Journal Article
MeSH Terms:
Breast Neoplasms*/drug therapy
Febrile Neutropenia*/chemically induced
Febrile Neutropenia*/prevention & control
Recombinant Proteins*/adverse effects
Female ; Humans ; Granulocyte Colony-Stimulating Factor/adverse effects ; Neutrophils
Czasopismo naukowe
Tytuł:
Safety and efficacy of zinpentraxin alfa as monotherapy or in combination with ruxolitinib in myelofibrosis: stage I of a phase II trial.
Autorzy:
Verstovsek S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX. .
Foltz L; St Paul's Hospital, University of British Columbia, Vancouver.
Gupta V; Princess Margaret Cancer Centre, University of Toronto, Toronto.
Hasserjian R; Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Manshouri T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Mascarenhas J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Mesa R; Mays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, TX.
Pozdnyakova O; Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ritchie E; Weill Cornell Medicine, New York, NY.
Veletic I; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Gamel K; F. Hoffmann-La Roche, Ltd., Basel.
Hamidi H; Genentech Inc, South San Francisco, CA.
Han L; Genentech Inc, South San Francisco, CA.
Higgins B; Genentech Inc, South San Francisco, CA.
Trunzer K; F. Hoffmann-La Roche, Ltd., Basel.
Uguen M; F. Hoffmann-La Roche, Ltd., Basel.
Wang D; F. Hoffmann-La Roche, Ltd., Basel.
El-Galaly TC; F. Hoffmann-La Roche, Ltd., Basel, Switzerland; Current affiliation: Department of Hematology, Aalborg University Hospital, Aalborg.
Todorov B; F. Hoffmann-La Roche, Ltd., Basel.
Gotlib J; Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA.
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Źródło:
Haematologica [Haematologica] 2023 Oct 01; Vol. 108 (10), pp. 2730-2742. Date of Electronic Publication: 2023 Oct 01.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Primary Myelofibrosis*/diagnosis
Primary Myelofibrosis*/drug therapy
Recombinant Proteins*/adverse effects
Humans ; Anemia ; Fibrosis ; Treatment Outcome ; Drug Therapy, Combination/adverse effects
Czasopismo naukowe
Tytuł:
Stable Mammalian Serum Albumins Designed for Bacterial Expression.
Autorzy:
Khersonsky O; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: .
Goldsmith M; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Zaretsky I; Antibody Engineering Unit, Weizmann Institute of Science, Rehovot 7610001, Israel.
Hamer-Rogotner S; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot 7610001, Israel.
Dym O; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot 7610001, Israel.
Unger T; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot 7610001, Israel.
Yona M; Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot 7610001, Israel.
Fridmann-Sirkis Y; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Sep 01; Vol. 435 (17), pp. 168191. Date of Electronic Publication: 2023 Jun 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Serum Albumin*/genetics
Serum Albumin*/chemistry
Recombinant Proteins*/chemistry
Recombinant Proteins*/genetics
Animals ; Humans ; Disulfides ; Escherichia coli/genetics ; Reproducibility of Results ; Serum Albumin, Human/chemistry ; Serum Albumin, Human/genetics ; Protein Stability
Czasopismo naukowe
Tytuł:
Characterization of a novel recombinant calcium-binding protein from Arca subcrenata and its anti-hepatoma activities in vitro and in vivo.
Autorzy:
Shi H; Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China.
Panjikar S; ANSTO, Australian Synchrotron, Melbourne, Victoria, Australia.
Li C; Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
Ou X; Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
Zhou Y; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhang K; Department of Life Science, Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China.
Song L; Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
Yu R; Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China; Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China. Electronic address: .
Sun L; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: .
Zhu J; Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China; Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2023 Aug 01; Vol. 245, pp. 125513. Date of Electronic Publication: 2023 Jun 21.
Typ publikacji:
Journal Article
MeSH Terms:
Bivalvia*/chemistry
Calcium-Binding Proteins*/genetics
Calcium-Binding Proteins*/metabolism
Calcium-Binding Proteins*/pharmacology
Calcium-Binding Proteins*/therapeutic use
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/drug therapy
Liver Neoplasms*/pathology
Recombinant Proteins*/genetics
Recombinant Proteins*/metabolism
Recombinant Proteins*/pharmacology
Recombinant Proteins*/therapeutic use
Xenograft Model Antitumor Assays*
Animals ; Humans ; Mice ; Binding Sites ; Cell Proliferation/drug effects ; Competitive Bidding ; Crystallography, X-Ray ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Escherichia coli ; Hep G2 Cells ; Hydrogen Bonding ; Molecular Dynamics Simulation ; Signal Transduction ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł:
Protein engineering of a nanoCLAMP antibody mimetic scaffold as a platform for producing bioprocess-compatible affinity capture ligands.
Autorzy:
Suderman RJ; Nectagen, Inc, Kansas City, Kansas, USA. Electronic address: .
Gibson SD; Nectagen, Inc, Kansas City, Kansas, USA; University of Washington, Seattle, Washington, USA.
Strecker M; Nectagen, Inc, Kansas City, Kansas, USA; Two Dot Consulting, Arvada, Colorado, USA.
Bonner AM; Nectagen, Inc, Kansas City, Kansas, USA.
Chao DM; Nectagen, Inc, Kansas City, Kansas, USA.
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104910. Date of Electronic Publication: 2023 Jun 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies*/chemistry
Antibodies*/immunology
Antibodies*/metabolism
Chromatography, Affinity*/methods
Ligands*
Protein Engineering*/methods
Recombinant Proteins*/immunology
Recombinant Proteins*/isolation & purification
Recombinant Proteins*/metabolism
Antibody Affinity*
Molecular Mimicry*
Sodium Hydroxide/pharmacology ; Protein Stability/drug effects ; Hot Temperature ; Trypsin/metabolism ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł:
Kaleidoscope megamolecules synthesis and application using self-assembly technology.
Autorzy:
Zhou S; School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: .
Wei Y; School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
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Źródło:
Biotechnology advances [Biotechnol Adv] 2023 Jul-Aug; Vol. 65, pp. 108147. Date of Electronic Publication: 2023 Apr 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Protein Engineering*
Recombinant Proteins*
Technology
Czasopismo naukowe
Tytuł:
Double-Labeling Method for Visualization and Quantification of Membrane-Associated Proteins in Lactococcus lactis .
Autorzy:
Hoang MN; Institute of Immunology, Department of Human Medicine, Carl von Ossietzky University of Oldenburg, 26129 Oldenburg, Germany.
Peterbauer C; Institute of Food Technology, Department of Food Science and Technology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 24; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 24.
Typ publikacji:
Journal Article
MeSH Terms:
Membrane Proteins*/analysis
Membrane Proteins*/biosynthesis
Bacterial Proteins*/analysis
Bacterial Proteins*/biosynthesis
Lactococcus lactis*/chemistry
Recombinant Proteins*/analysis
Recombinant Proteins*/biosynthesis
Staining and Labeling*/methods
Histidine ; Cell Membrane Permeability
Czasopismo naukowe
Tytuł:
Safety and Effectiveness of Rasburicase in the Control of Hyperuricemia in Pediatric Patients with Non-Hodgkin's Lymphoma and Acute Leukemia: An Open-Label, Single-Arm, Multi-center, Interventional Study.
Autorzy:
Wang T; Department of Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education; Hematology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Nanlishi Road No. 56, Xicheng District, Beijing, 100045, People's Republic of China. .
Zhu X; Department of Hematology, Chinese Academy of Medical Sciences, Hematology Hospital, Heping District, Tianjing, China.
Chen Y; Department of Hematology, Chinese Academy of Medical Sciences, Hematology Hospital, Heping District, Tianjing, China.
Shen S; Department of Hematology, Shanghai Children's Medical Center, Dongfang Road, Shanghai, China.
Tang Y; Department/Center of Hematology-Oncology, Children's Hospital of Zhejiang University School of Medicine, Pediatric Leukemia Diagnostic and Therapeutic Technology Research Center of Zhejiang Province, National Clinical Research Center for Child Health, Gongshu District, Hangzhou City, Zhejiang Province, China.
Zhang J; Department/Center of Hematology-Oncology, Children's Hospital of Zhejiang University School of Medicine, Pediatric Leukemia Diagnostic and Therapeutic Technology Research Center of Zhejiang Province, National Clinical Research Center for Child Health, Gongshu District, Hangzhou City, Zhejiang Province, China.
He Y; Department of Pediatric Hematology/Oncology, Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Guangzhou, China.
Zhang H; Department of Pediatric Hematology/Oncology, Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Guangzhou, China.
Gao J; Department of Hematology, West China Second University Hospital, Chengdu, Sichuan Province, China.
Fang J; Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, West Yanjiang Road, Guangzhou, China.
Liu R; Department of Hematology, Children's Hospital Capital Institute of Pediatrics, Chaoyang District, Beijing, China.
Wu X; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sun J; Medical Department, Sanofi, Shanghai, China.
Zhang M; Medical Department, Sanofi, Shanghai, China.
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Źródło:
Drugs in R&D [Drugs R D] 2023 Jun; Vol. 23 (2), pp. 129-140. Date of Electronic Publication: 2023 May 10.
Typ publikacji:
Clinical Trial, Phase IV; Journal Article; Multicenter Study
MeSH Terms:
Hyperuricemia*/complications
Hyperuricemia*/drug therapy
Lymphoma, Non-Hodgkin*/complications
Leukemia*/complications
Recombinant Proteins*/adverse effects
Recombinant Proteins*/therapeutic use
Uric Acid ; China ; Humans ; Male ; Female ; Child, Preschool ; Child
Czasopismo naukowe
Tytuł:
Characterization of beta subunit variants of recombinant human chorionic gonadotrophin.
Autorzy:
Deng Q; Livzon MabPharm Inc., Zhuhai, Guangdong, China.
He L; Livzon MabPharm Inc., Zhuhai, Guangdong, China.
Xu F; Livzon MabPharm Inc., Zhuhai, Guangdong, China.
Deng Q; Livzon MabPharm Inc., Zhuhai, Guangdong, China.
Xu T; Livzon MabPharm Inc., Zhuhai, Guangdong, China.
Jiang J; Livzon MabPharm Inc., Zhuhai, Guangdong, China.
Hu Z; Livzon MabPharm Inc., Zhuhai, Guangdong, China.
Yang J; Livzon MabPharm Inc., Zhuhai, Guangdong, China. Electronic address: .
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Źródło:
Analytical biochemistry [Anal Biochem] 2023 May 01; Vol. 668, pp. 115089. Date of Electronic Publication: 2023 Feb 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chorionic Gonadotropin, beta Subunit, Human*/chemistry
Chorionic Gonadotropin, beta Subunit, Human*/pharmacology
Recombinant Proteins*/chemistry
Recombinant Proteins*/pharmacology
Humans ; Glycosylation ; HEK293 Cells ; Electrophoresis, Polyacrylamide Gel
Czasopismo naukowe

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