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Wyszukujesz frazę ""Regulatory toxicology and pharmacology: RTP [Regul Toxicol Pharmacol] NLMUID: 8214983"" wg kryterium: JN


Tytuł :
Regulating human safety: How dose selection in toxicity studies impacts human health hazard assessment and subsequent risk management options.
Autorzy :
Woutersen M; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands. Electronic address: .
Muller A; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Pronk MEJ; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Cnubben NHP; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Hakkert BC; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jul; Vol. 114, pp. 104660. Date of Electronic Publication: 2020 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Risk Management*
Toxicity Tests*
Endocrine Disruptors/*toxicity
Hazardous Substances/*toxicity
European Union ; Humans
Czasopismo naukowe
Tytuł :
Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management.
Autorzy :
Heringa MB; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Cnubben NHP; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Slob W; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Pronk MEJ; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Muller A; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
Woutersen M; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands. Electronic address: .
Hakkert BC; National Institute for Public Health and the Environment (RIVM), Centre for Safety of Substances and Products (VSP), Bilthoven, the Netherlands.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jul; Vol. 114, pp. 104659. Date of Electronic Publication: 2020 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Toxicity Tests*
Hazardous Substances/*administration & dosage
Hazardous Substances/*toxicity
Dose-Response Relationship, Drug ; European Union ; Humans ; Kinetics ; Risk Management
Czasopismo naukowe
Tytuł :
New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop.
Autorzy :
Mahony C; Procter & Gamble, Egham, Surrey, UK. Electronic address: .
Ashton RS; Department of Biomedical Engineering & Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, 53715, USA. Electronic address: .
Birk B; BASF SE, Experimental Toxicology and Ecology, Carl-Bosch-Straβe 38, 67056, Ludwigshafen, Germany. Electronic address: .
Boobis AR; National Heart & Lung Institute, Imperial College London, London, W12 0NN, UK. Electronic address: .
Cull T; Unilever, Colworth Science Park, Sharnbrook, Bedford, MK44 1LQ, UK. Electronic address: .
Daston GP; Mason Business Center, The Procter & Gamble Company, Cincinnati, OH, 45040, USA. Electronic address: .
Ewart L; Veroli Consulting Limited, Cambridge, UK; Emulate Inc, 27 Dry Dock Avenue, Boston, MA, 02210, USA. Electronic address: .
Knudsen TB; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, 27711, USA. Electronic address: .
Manou I; European Partnership for Alternative Approaches to Animal Testing (EPAA) Industry Secretariat, Belgium. Electronic address: .
Maurer-Stroh S; Innovations in Chemical and Food Safety, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street #07-01 Matrix, Singapore, 138671, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, 117543, Singapore. Electronic address: .
Margiotta-Casaluci L; College of Health and Life Sciences, Brunel University London, London, UB8 3PH, UK. Electronic address: .
Müller BP; Symrise AG, Holzminden, Germany. Electronic address: .
Nordlund P; Department of Oncology and Pathology, Karolinska Institutet, 17177, Stockholm, Sweden; Institute of Molecular and Cellular Biology, A*STAR, 61 Biopolis Drive, 138673, Singapore. Electronic address: .
Roberts RA; School of Chemistry, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address: .
Steger-Hartmann T; Investigational Toxicology, Bayer AG, Pharmaceuticals, Müllerstraβe 178, 13353, Berlin, Germany. Electronic address: .
Vandenbossche E; Unilever, Colworth Science Park, Sharnbrook, Bedford, MK44 1LQ, UK. Electronic address: .
Viant MR; School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address: .
Vinken M; Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. Electronic address: .
Whelan M; European Commission, Joint Research Centre (JRC), Italy. Electronic address: .
Zvonimir Z; European Partnership for Alternative Approaches to Animal Testing (EPAA) Industry Secretariat, Belgium. Electronic address: .
Cronin MTD; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jul; Vol. 114, pp. 104668. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Animal Testing Alternatives*
Toxicity Tests*
Adverse Outcome Pathways ; Animals ; Chemical Safety ; Dose-Response Relationship, Drug ; Humans
Czasopismo naukowe
Tytuł :
Is there a rationale for direct dosing of chemicals to nursing pups in the EOGRTS (OECD 443)?
Autorzy :
Arts J; Nouryon Chemicals BV, Velperweg 76, 6824 BM, Arnhem, Netherlands. Electronic address: .
Beekhuijzen M; Charles River, Hambakenwetering 7, 5231 DD, 's-Hertogenbosch, Netherlands.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jun; Vol. 113, pp. 104641. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Agrochemicals/*standards
Organisation for Economic Co-Operation and Development/*standards
Toxicity Tests/*standards
Agrochemicals/adverse effects ; Agrochemicals/toxicity ; Animals ; Animals, Newborn ; Dose-Response Relationship, Drug ; Humans ; Infant, Newborn ; Risk Assessment
Czasopismo naukowe
Tytuł :
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Autorzy :
Prior H; National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London, NW1 2BE, UK. Electronic address: .
Baldrick P; Covance Laboratories Ltd, Otley Road, Harrogate, HG3 1PY, UK.
Beken S; Federal Agency for Medicines and Health Products (FAMHP), Victor Hortaplace 40/40, Brussels, 1060, Belgium.
Booler H; Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA.
Bower N; Eisai Inc, 155 Tice Blvd, Woodcliff Lake, NJ, 07677, USA.
Brooker P; Board member, NC3Rs, Gibbs Building, 215 Euston Road, London, NW1 2BE, UK.
Brown P; Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
Burlinson B; Covance, Huntingdon, Cambridgeshire, PE28 4HS, UK.
Burns-Naas LA; Gilead Sciences, Inc, 333 Lakeside Drive, Foster City, CA, 94404, USA.
Casey W; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
Chapman M; Oncology Safety, Clinical Pharmacology and Safety Sciences,R&D, AstraZeneca, Cambridge, UK.
Clarke D; Lilly Research Laboratories, Indianapolis, IN, 46285, USA.
de Haan L; Biologics and Advanced Therapeutics Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Doehr O; Bayer Pharma AG, Müllerstrasse 170, 13353, Berlin, Germany.
Downes N; Sequani Limited, Bromyard Rd, Ledbury, Herefordshire, HR8 1LH, UK.
Flaherty M; Takeda Pharmaceuticals, 300 Massachusetts Ave, Cambridge, MA, 02139, USA.
Gellatly N; National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London, NW1 2BE, UK.
Moesgaard SG; Novo Nordisk A/S, Novo Nordisk Park, Maaloev, Denmark.
Harris J; Association of British Pharmaceutical Industry (ABPI), 105 Victoria Street, London, SW1E 6QT, UK.
Holbrook M; VAST Pharma Solutions Ltd, Harrogate, UK.
Hui J; Celgene, 86 Morris Avenue, Summit, NJ, 07901, USA.
Jones D; Medicines Healthcare products Regulatory Agency (MHRA) 10 South Colonnade, Canary Wharf, London, E14 4PU, UK.
Jones K; CFMD Ltd, Peterborough, UK.
Kedar H; Teva Pharmaceuticals, Netanya Area, Israel.
Mahl A; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland.
Manninen A; Prekliniska Byran Sweden AB, Stockholm, Sweden.
McGuire A; Charles River Laboratories, Preclinical Services, Tranent, Edinburgh, EH33 2NE, UK.
Mortimer-Cassen E; Regulatory Safety Centre of Excellence, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Peraza M; Pfizer Drug Safety Research and Development, 300 Technology Square, Cambridge, MA, 02139, USA.
Pugsley MK; Cytokinetics, South San Francisco, CA, 94080, USA.
Richard J; Sanofi, 371 Rue du Professeur Blayac, Montpellier, 34000, France.
Roberts R; ApconiX, Alderley Park, Alderley Edge, Cheshire, SK10 4TG, UK.
Roosen W; Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium.
Rothfuss A; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, CH - 4070, Basel, Switzerland.
Schoenmakers A; Charles River Laboratories, Den Bosch B.V, the Netherlands.
Sewell F; National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London, NW1 2BE, UK.
Weaver R; Institut de Recherches Internationales Servier, Biopharmacy, 92284, Suresnes, Cedex, France.
Weir L; GlaxoSmithKline, Park Road, Ware, Hertfordshire, SG12 0DP, UK.
Wolfreys A; UCB Biopharma, Bath Rd, Slough, SL1 3WE, UK.
Kimber I; University of Manchester, Faculty of Biology, Medicine and Health, Oxford Rd, Manchester, M13 9PL, UK.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jun; Vol. 113, pp. 104624. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Toxicity Tests*
Drug Evaluation, Preclinical/*adverse effects
Animals ; Databases, Factual ; Humans ; Risk Assessment
Czasopismo naukowe
Tytuł :
Oral repeated-dose toxicity studies of BIA 10-2474 in Wistar rat.
Autorzy :
Hayes AW; University of South Florida College and Michigan State University, Tampa, FL, USA. Electronic address: .
Hardisty JF; EPL Inc., North Carolina, USA.
Harris SB; Stephen B. Harris Group, San Diego, CA, USA.
Okazaki Y; AnaPath GmbH, 4625, Oberbuchsiten, Switzerland.
Weber K; AnaPath GmbH, 4625, Oberbuchsiten, Switzerland.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Mar; Vol. 111, pp. 104540. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Toxicity Tests*
Cyclic N-Oxides/*administration & dosage
Cyclic N-Oxides/*toxicity
Medulla Oblongata/*drug effects
Pyridines/*administration & dosage
Pyridines/*toxicity
Spinal Cord/*drug effects
Administration, Oral ; Animals ; Cyclic N-Oxides/metabolism ; Female ; Male ; Medulla Oblongata/pathology ; No-Observed-Adverse-Effect Level ; Pyridines/metabolism ; Rats ; Rats, Wistar ; Spinal Cord/pathology
Czasopismo naukowe
Tytuł :
21 Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances: Workshop highlights.
Autorzy :
Sauer UG; Scientific Consultancy - Animal Welfare, Neubiberg, Germany. Electronic address: .
Barter RA; ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, USA.
Becker RA; American Chemistry Council, Washington DC, USA.
Benfenati E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Berggren E; European Commission, Joint Research Centre, Ispra, Italy.
Hubesch B; European Chemical Industry Council (Cefic), Brussels, Belgium; Hubesch Consult BVBA, Sint-Pieters-Leeuw, Belgium.
Hollnagel HM; Dow Europe GmbH, Horgen, Switzerland.
Inawaka K; Japan Chemical Industry Association, Tokyo, Japan.
Keene AM; Afton Chemical Corporation, Richmond, VA, USA.
Mayer P; Technical University of Denmark, Kongens Lyngby, Denmark.
Plotzke K; Dow, Midland, MI, USA.
Skoglund R; Covestro LLC, Pittsburgh, PA, USA.
Albert O; European Chemical Industry Council (Cefic), Brussels, Belgium.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Mar; Vol. 111, pp. 104583. Date of Electronic Publication: 2020 Jan 11.
Typ publikacji :
Congress; Historical Article
MeSH Terms :
Risk Assessment/*history
Toxicity Tests/*history
Animals ; History, 21st Century ; Humans
Tytuł :
State of the science on alternatives to animal testing and integration of testing strategies for food safety assessments: Workshop proceedings.
Autorzy :
Karmaus AL; Integrated Laboratory Systems, Inc, 601 Keystone Park Drive, Suite 200, Morrisville, NC, USA. Electronic address: .
Bialk H; PepsiCo Inc, 700 Anderson Hill Road, Purchase, NY, 10577, USA.
Fitzpatrick S; US Food and Drug Administration Center for Food Safety and Applied Nutrition, College Park, MD, USA.
Krishan M; ILSI North America, 740 15th Street NW, Suite 600, Washington, DC, 20005, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Feb; Vol. 110, pp. 104515. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Congress
MeSH Terms :
Animal Testing Alternatives*
Food Safety*
Toxicity Tests/*methods
Risk Assessment
Tytuł :
The Grouping and Assessment Strategy for Organic Pigments (GRAPE): Scientific evidence to facilitate regulatory decision-making.
Autorzy :
Sauer UG; Scientific Consultancy - Animal Welfare, Germany.
Kreiling R; Clariant Produkte (Deutschland) GmbH, Germany. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Dec; Vol. 109, pp. 104501. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Decision Making*
Animal Use Alternatives/*legislation & jurisprudence
Coloring Agents/*toxicity
Inhalation Exposure/*adverse effects
Toxicity Tests/*standards
Biological Availability ; Caco-2 Cells ; Cell Membrane Permeability ; Coloring Agents/chemistry ; Coloring Agents/pharmacokinetics ; European Union ; Humans ; Quantitative Structure-Activity Relationship ; Solubility
Czasopismo naukowe
Tytuł :
Applying non-animal strategies for assessing skin sensitisation report from an EPAA/cefic-LRI/IFRA Europe cross sector workshop, ECHA helsinki, February 7th and 8th 2019.
Autorzy :
Basketter D; DABMEB Consultancy Ltd, Sharnbrook, UK. Electronic address: .
Azam P; Solvay, Saint-Fons, France.
Casati S; European Commission, Joint Research Centre (JRC), Ispra, Italy.
Corvaro M; Corteva AgriSciences, Rome, Italy.
Ezendam J; National Institute for Public Health and the Environment, Centre for Health Protection, Bilthoven, the Netherlands.
Griem P; Symrise AG, Holzminden, Germany.
Hubesch B; Hubesch Consult BVBA, Sint-Pieters-Leeuw, Belgium; European Chemical Industry Council (Cefic), Brussels, Belgium.
Irizar A; The International Fragrance Association (IFRA), Geneva, Switzerland.
Kern P; Procter & Gamble, Strombeek-Bever, Belgium.
Manou I; European Partnership for Alternative Approaches to Animal Testing (EPAA), Brussels, Belgium.
Mehling A; BASF Personal Care and Nutrition GmbH, Duesseldorf, Germany.
Rossi LH; European Chemicals Agency (ECHA), Helsinki, Finland.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Dec; Vol. 109, pp. 104477. Date of Electronic Publication: 2019 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Animal Testing Alternatives*
Congresses as Topic*
Research Design/*standards
Skin/*drug effects
Toxicity Tests/*standards
Datasets as Topic ; Europe ; Skin/immunology ; Skin Tests/methods ; Skin Tests/standards
Czasopismo naukowe
Tytuł :
Finding synergies for the 3Rs - Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum.
Autorzy :
Laroche C; The International Fragrance Association (IFRA) Europe, Geneva, Switzerland; European Partnership for Alternative Approaches to Animal Testing (EPAA), Industry Secretariat, Belgium. Electronic address: .
Annys E; The European Chemical Industry Council (Cefic), Belgium. Electronic address: .
Bender H; Bonn, Germany. Electronic address: .
Botelho D; RIFM Research Institute for Fragrance Materials (RIFM) Inc., New Jersey, USA. Electronic address: .
Botham P; Syngenta, Jealott's Hill, Bracknell, Berkshire, RG42 6EY, United Kingdom. Electronic address: .
Brendler-Schwaab S; Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany. Electronic address: .
Clayton R; AnimalhealthEurope, Belgium. Electronic address: .
Corvaro M; Corteva Agriscience, 3B Milton Park Square, Abingdon, Oxfordshire, OX14 4RN, United Kingdom. Electronic address: .
Dal Negro G; GlaxoSmithKline, United Kingdom. Electronic address: .
Delannois F; GlaxoSmithKline, United Kingdom. Electronic address: .
Dent M; SEAC, Unilever, Colworth Science Park, Bedford, MK44 1LQ, United Kingdom. Electronic address: .
Desaintes C; European Commission, The Directorate-General (DG) for Research and Innovation (RTD), Belgium. Electronic address: .
Desprez B; Cosmetics Europe - The Personal Care Association, Belgium. Electronic address: .
Dhalluin S; L'Oréal Research & Innovation, France. Electronic address: .
Hartmann A; Novartis, Switzerland. Electronic address: .
Hoffmann-Doerr S; Henkel AG & Co KGaA, Germany. Electronic address: .
Hubesch B; Hubesch Consult BVBA, Belgium. Electronic address: .
Irizar A; The International Fragrance Association (IFRA) Europe, Geneva, Switzerland. Electronic address: .
Manou I; European Partnership for Alternative Approaches to Animal Testing (EPAA), Industry Secretariat, Belgium. Electronic address: .
Müller BP; Symrise AG, Mühlenfeldstr. 1, 37603, Holzminden, Germany. Electronic address: .
Nadzialek S; ECPA - the European Crop Protection Association, Belgium. Electronic address: .
Prieto P; European Commission, Joint Research Centre (JRC), Italy. Electronic address: .
Rasenberg M; European Chemicals Agency (ECHA), Finland. Electronic address: .
Roggeband R; Procter & Gamble Services NV/SA, Temselaan 100, 1853, Strombeek-Bever, Belgium. Electronic address: .
Rowan TG; EPAA Consultant, Cawton, York, United Kingdom. Electronic address: .
Schutte K; European Commission, The Directorate-General (DG) Environment (ENV), Belgium. Electronic address: .
van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, the Netherlands. Electronic address: .
Westmoreland C; SEAC, Unilever, Colworth Science Park, Bedford, MK44 1LQ, United Kingdom. Electronic address: .
Whelan M; European Commission, Joint Research Centre (JRC), Italy. Electronic address: .
Wilschut A; Royal DSM N.V., P.O. Box 6500, 6401 JH, Heerlen, the Netherlands. Electronic address: .
Zvonimir Z; European Partnership for Alternative Approaches to Animal Testing (EPAA), Industry Secretariat, Belgium. Electronic address: .
Cronin MTD; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, United Kingdom. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Nov; Vol. 108, pp. 104470. Date of Electronic Publication: 2019 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Animal Testing Alternatives*
Toxicity Tests/*methods
Animals ; Humans ; Risk Assessment
Czasopismo naukowe
Tytuł :
Dermal absorption study OECD TG 428 mass balance recommendations based on the EFSA database.
Autorzy :
Kluxen FM; ADAMA Deutschland GmbH, Edmund-Rumpler-Str. 6, 51149, Cologne, Germany. Electronic address: .
Grégoire S; L'Oreal Research & Innovation, 1 Avenue Eugène Schueller, 93600, Aulnay-Sous-Bois, France. Electronic address: .
Schepky A; Beiersdorf AG, Unnastraße 48, 20253, Hamburg, Germany. Electronic address: .
Hewitt NJ; Cosmetics Europe, Avenue Herrmann-Debroux 40, 1160, Brussels, Belgium. Electronic address: .
Klaric M; Cosmetics Europe, Avenue Herrmann-Debroux 40, 1160, Brussels, Belgium. Electronic address: .
Domoradzki JY; Corteva Agriscience, 9330 Zionsville Road, Indianapolis, IN, 46238, USA. Electronic address: .
Felkers E; ADAMA Deutschland GmbH, Edmund-Rumpler-Str. 6, 51149, Cologne, Germany. Electronic address: .
Fernandes J; Syngenta Ltd., Jealotts Hill Research Station, Warfield, Bracknell, RG42 6EY, UK. Electronic address: .
Fisher P; Bayer SAS, Crop Science Division, 16 Rue Jean-Marie Leclair, 69266, Lyon, France. Electronic address: .
McEuen SF; FMC Corporation, Stine Research Center, S300/427, P.O. Box 30, Newark, DE, 19714-0030, USA. Electronic address: .
Parr-Dobrzanski R; Syngenta Ltd., Jealotts Hill Research Station, Warfield, Bracknell, RG42 6EY, UK. Electronic address: .
Wiemann C; BASF Oesterreich GmbH, Handelskai 94-96, 1200, Vienna, Austria. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Nov; Vol. 108, pp. 104475. Date of Electronic Publication: 2019 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Skin Absorption*
Toxicity Tests/*methods
Databases, Factual ; European Union ; Food Safety ; Humans ; Organisation for Economic Co-Operation and Development
Czasopismo naukowe
Tytuł :
Control performance of fish short term reproduction assays with fathead minnow (Pimephales promelas).
Autorzy :
Wheeler JR; Corteva Agriscience™, Agriculture Division of DowDuPont™, 3B Park Square, Milton Park, Abingdon, Oxfordshire, OX14 4RN, UK. Electronic address: .
Valverde-Garcia P; Corteva Agriscience™, Agriculture Division of DowDuPont™, 9330 Zionsville Road, Indianapolis, IN, 46268, USA. Electronic address: .
Crane M; AG-HERA, 23 London Street, Faringdon, SN7 7AG, UK. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Nov; Vol. 108, pp. 104424. Date of Electronic Publication: 2019 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*
Control Groups*
Toxicity Tests*
Endocrine Disruptors/*toxicity
Reproduction/*drug effects
Animals ; Body Weight/drug effects ; Cyprinidae ; Female ; Fertility/drug effects ; Gonads/drug effects ; Laboratories ; Male ; Reproducibility of Results ; Vitellogenins/metabolism
Czasopismo naukowe
Tytuł :
Exposure assessments in reproductive and developmental toxicity testing: An IQ-DruSafe industry survey on current practices and experiences in support of exposure-based high dose selection.
Autorzy :
Andrews PA; Eisai Inc, Woodcliff Lake, NJ, USA. Electronic address: .
McNerney ME; Bristol-Myers Squibb, New Brunswick, NJ, USA.
DeGeorge JJ; Merck & Co., Inc, West Point, PA, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Oct; Vol. 107, pp. 104413. Date of Electronic Publication: 2019 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Evaluation, Preclinical*
Toxicity Tests*
Teratogens/*pharmacokinetics
Teratogens/*toxicity
Animals ; Drug Industry ; Drug-Related Side Effects and Adverse Reactions ; Embryonic Development/drug effects ; Female ; Fetal Development/drug effects ; Haplorhini ; Pregnancy ; Rabbits ; Rats ; Reproduction/drug effects ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
Statistical analysis of the reproducibility and predictive capacity of MCTT HCE™ eye irritation test, a me-too test method for OECD TG 492.
Autorzy :
Lim SE; College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea.
Lee D; Department of Statistics, Ewha Womans University, Seoul, 03760, Republic of Korea.
Bae S; College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: .
Lim KM; College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Oct; Vol. 107, pp. 104430. Date of Electronic Publication: 2019 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelium, Corneal/*drug effects
Irritants/*toxicity
Toxicity Tests/*statistics & numerical data
Humans ; In Vitro Techniques ; Organisation for Economic Co-Operation and Development ; Reproducibility of Results ; Toxicity Tests/methods
Czasopismo naukowe
Tytuł :
Testing developmental toxicity in a second species: are the differences due to species or replication error?
Autorzy :
Braakhuis HM; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Theunissen PT; Medicines Evaluation Board, Utrecht, the Netherlands.
Slob W; Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Rorije E; Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Piersma AH; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Oct; Vol. 107, pp. 104410. Date of Electronic Publication: 2019 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
Embryonic Development/*drug effects
Fetal Development/*drug effects
Hazardous Substances/*toxicity
Teratogens/*toxicity
Toxicity Tests/*methods
Animals ; Female ; Pregnancy ; Rabbits ; Rats ; Reproducibility of Results ; Risk Assessment ; Species Specificity
Czasopismo naukowe
Tytuł :
Exploring current read-across applications and needs among selected U.S. Federal Agencies.
Autorzy :
Patlewicz G; (a)National Center for Computational Toxicology, U.S. Environmental Protection Agency, 109 TW Alexander Dr, Research Triangle Park, NC, 27709, USA. Electronic address: .
Lizarraga LE; (b)National Center for Environmental Assessment, U.S. Environmental Protection Agency, 26 West Martin Luther King Drive, Cincinnati, OH, 45268, USA.
Rua D; Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
Allen DG; ILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA.
Daniel AB; ILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA.
Fitzpatrick SC; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, 20740, USA.
Garcia-Reyero N; Environmental Laboratory, U.S. Army Engineer Research and Developmental Center, 3909 Halls Ferry Rd., Vicksburg, MS, 39180, USA.
Gordon J; U.S. Consumer Product Safety Commission, 5 Research Place, Rockville, MD, 20850, USA.
Hakkinen P; National Library of Medicine, 6707 Democracy Blvd., Bethesda, MD, 20892, USA.
Howard AS; ILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA.
Karmaus A; ILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA.
Matheson J; U.S. Consumer Product Safety Commission, 5 Research Place, Rockville, MD, 20850, USA.
Mumtaz M; Agency for Toxic Substances and Disease Registry, 1600 Clifton Rd., Chamblee, GA, 30341, USA.
Richarz AN; European Commission, Joint Research Centre (JRC), Ispra, Italy.
Ruiz P; Agency for Toxic Substances and Disease Registry, 1600 Clifton Rd., Chamblee, GA, 30341, USA.
Scarano L; Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC, 20460, USA.
Yamada T; Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan.
Kleinstreuer N; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Aug; Vol. 106, pp. 197-209. Date of Electronic Publication: 2019 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Toxicity Tests*
United States Government Agencies*
Humans ; United States ; United States Environmental Protection Agency/organization & administration
Czasopismo naukowe
Tytuł :
Use of stem cells as alternative methods to animal experimentation in predictive toxicology.
Autorzy :
Kim TW; Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.
Che JH; Biomedical Center for Animal Resource and Development, Seoul National University College of Medicine, Seoul, Republic of Korea.
Yun JW; Department of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Jul; Vol. 105, pp. 15-29. Date of Electronic Publication: 2019 Mar 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Stem Cells/*drug effects
Toxicity Tests/*methods
Toxicology/*methods
Animal Experimentation ; Animal Testing Alternatives/methods ; Animals ; Cell Differentiation/physiology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/drug effects ; Species Specificity ; Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Analysis of exposure margins in developmental toxicity studies for detection of human teratogens.
Autorzy :
Andrews PA; Eisai Inc., Woodcliff Lake, NJ, USA. Electronic address: .
Blanset D; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
Costa PL; Agência Nacional de Vigilância Sanitária, Brasília, Brazil.
Green M; US Food and Drug Administration, Silver Spring, MD, USA.
Green ML; Merck & Co, Inc., West Point, PA, USA.
Jacobs A; US Food and Drug Administration, Silver Spring, MD, USA.
Kadaba R; Health Canada, Ottawa, Ontario, Canada.
Lebron JA; Merck & Co, Inc., West Point, PA, USA.
Mattson B; Merck & Co, Inc., West Point, PA, USA.
McNerney ME; Bristol-Myers Squibb, New Brunswick, NJ, USA.
Minck D; US Food and Drug Administration, Silver Spring, MD, USA.
Oliveira LC; Agência Nacional de Vigilância Sanitária, Brasília, Brazil.
Theunissen PT; CBG-MEB, Utrecht, the Netherlands.
DeGeorge JJ; Merck & Co, Inc., West Point, PA, USA.
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Jul; Vol. 105, pp. 62-68. Date of Electronic Publication: 2019 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Embryo, Mammalian/*drug effects
Risk Assessment/*methods
Teratogens/*toxicity
Toxicity Tests/*methods
Animals ; Area Under Curve ; Dose-Response Relationship, Drug ; Female ; Humans ; No-Observed-Adverse-Effect Level ; Pregnancy ; Rabbits ; Rats ; Retrospective Studies ; Species Specificity
Czasopismo naukowe
Tytuł :
Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data.
Autorzy :
Rasmussen K; European Commission, Joint Research Centre, Ispra, via E. Fermi 2749, 21027, Ispra, (VA), Italy. Electronic address: .
Rauscher H; European Commission, Joint Research Centre, Ispra, via E. Fermi 2749, 21027, Ispra, (VA), Italy. Electronic address: .
Kearns P; Organisation for Economic Co-operation and Development (OECD), Environment Directorate, 75775, Paris CEDEX 16, France. Electronic address: .
González M; Organisation for Economic Co-operation and Development (OECD), Environment Directorate, 75775, Paris CEDEX 16, France. Electronic address: .
Riego Sintes J; European Commission, Joint Research Centre, Ispra, via E. Fermi 2749, 21027, Ispra, (VA), Italy. Electronic address: .
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Źródło :
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Jun; Vol. 104, pp. 74-83. Date of Electronic Publication: 2019 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
Organisation for Economic Co-Operation and Development*
Nanostructures/*adverse effects
Nanostructures/*analysis
Toxicity Tests/*standards
Administration, Inhalation ; Animals ; Humans ; Nanostructures/administration & dosage
Czasopismo naukowe

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