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Tytuł:
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst.
Autorzy:
Phelps DW; Department of Molecular Biomedical Sciences, College of Veterinary Medicine.; Comparative Medicine Institute.; Center for Environmental and Health Effects of PFAS.
Palekar AI; Department of Molecular Biomedical Sciences, College of Veterinary Medicine.
Conley HE; Comparative Medicine Institute.; Department of Clinical Sciences, College of Veterinary Medicine.
Ferrero G; Department of Molecular Biomedical Sciences, College of Veterinary Medicine.; Center for Environmental and Health Effects of PFAS.
Driggers JH; Department of Molecular Biomedical Sciences, College of Veterinary Medicine.
Linder KE; Department of Population Health and Pathobiology, College of Veterinary Medicine.; Center for Human Health and the Environment.
Kullman SW; Center for Environmental and Health Effects of PFAS.; Center for Human Health and the Environment.; Department of Biological Sciences, College of Sciences.; Toxicology Program, North Carolina State University, Raleigh, NC.
Reif DM; Center for Environmental and Health Effects of PFAS.; Center for Human Health and the Environment.; Department of Biological Sciences, College of Sciences.; Toxicology Program, North Carolina State University, Raleigh, NC.
Sheats MK; Department of Clinical Sciences, College of Veterinary Medicine.
DeWitt JC; Center for Environmental and Health Effects of PFAS.; Center for Human Health and the Environment.; Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC.
Yoder JA; Department of Molecular Biomedical Sciences, College of Veterinary Medicine.; Comparative Medicine Institute.; Center for Environmental and Health Effects of PFAS.; Center for Human Health and the Environment.; Toxicology Program, North Carolina State University, Raleigh, NC.
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Źródło:
Journal of immunotoxicology [J Immunotoxicol] 2023 Dec; Vol. 20 (1), pp. 2176953.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Fluorocarbons*/toxicity
Alkanesulfonic Acids*/toxicity
Environmental Pollutants*
Animals ; Humans ; Zebrafish ; Neutrophils ; Reactive Oxygen Species ; Respiratory Burst
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy.
Autorzy:
Small GW; Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Akhtari FS; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Green AJ; Department of Biological Sciences, Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695, USA.
Havener TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sikes M; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Quintanhila J; Clinical Development, Foundation Medicine, Boston, MA 02141, USA.
Gonzalez RD; Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Reif DM; Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Motsinger-Reif AA; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
McLeod HL; Center for Precision Medicine and Functional Genomics, Utah Tech University, 225 South University Ave, St. George, UT 84770, USA.
Wiltshire T; Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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Źródło:
Cells [Cells] 2023 Jun 07; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*
Pharmacogenomic Testing*
Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/genetics ; Antigens, CD20/genetics ; Prednisolone ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients.
Autorzy:
Gonzalez RD; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Small GW; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Green AJ; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27606, USA.; Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27606, USA.
Akhtari FS; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Motsinger-Reif AA; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Quintanilha JCF; Clinical Development, Foundation Medicine, Boston, MA 02115, USA.
Havener TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Reif DM; Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
McLeod HL; Center for Precision Medicine and Functional Genomics, Utah Tech University, St. George, UT 84770, USA.
Wiltshire T; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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Źródło:
Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 May 17; Vol. 16 (5). Date of Electronic Publication: 2023 May 17.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients.
Autorzy:
Gonzalez RD; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Small GW; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Green AJ; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27606, USA.; Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27606, USA.
Akhtari FS; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Havener TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Quintanilha JCF; Clinical Development, Foundation Medicine, Boston, MA 02115, USA.
Cipriani AB; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Reif DM; Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
McLeod HL; Center for Precision Medicine and Functional Genomics, Utah Tech University, St. George, UT 84770, USA.
Motsinger-Reif AA; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Wiltshire T; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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Źródło:
Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 May 10; Vol. 16 (5). Date of Electronic Publication: 2023 May 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs.
Autorzy:
Akhtari FS; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
Green AJ; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
Small GW; Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Havener TM; Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
House JS; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, United States of America.
Roell KR; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
Reif DM; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
McLeod HL; Geriatric Oncology Consortium, Tampa, Florida, United States of America.; USF Taneja College of Pharmacy, Tampa, Florida, United States of America.
Wiltshire T; Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Motsinger-Reif AA; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Aug 26; Vol. 17 (8), pp. e1009732. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
Antineoplastic Agents/*pharmacology
Biomarkers, Pharmacological/*analysis
NAD(P)H Dehydrogenase (Quinone)/*genetics
Cell Line, Tumor ; Genome-Wide Association Study/methods ; High-Throughput Screening Assays/methods ; Humans ; NAD(P)H Dehydrogenase (Quinone)/drug effects ; NAD(P)H Dehydrogenase (Quinone)/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology.
Autorzy:
Green AJ; Department of Biological Sciences, and the Bioinformatics Research Center, NC State University, Raleigh, North Carolina, United States of America.
Mohlenkamp MJ; Department of Mathematics, Ohio University, Athens, Ohio, United States of America.
Das J; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Chaudhari M; Department of Computational Science and Engineering, North Carolina A&T State University, Greensboro, North Carolina, United States of America.
Truong L; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America.
Tanguay RL; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America.
Reif DM; Department of Biological Sciences, and the Bioinformatics Research Center, NC State University, Raleigh, North Carolina, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Jul 02; Vol. 17 (7), pp. e1009135. Date of Electronic Publication: 2021 Jul 02 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Computational Biology*
High-Throughput Screening Assays*
Neural Networks, Computer*
Toxicology*
Animals ; Embryo, Nonmammalian/drug effects ; Models, Chemical ; Toxicity Tests ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning.
Autorzy:
Marvel SW; Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University (NCSU), Raleigh, North Carolina, USA.
House JS; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Wheeler M; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Song K; Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University (NCSU), Raleigh, North Carolina, USA.
Zhou YH; Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University (NCSU), Raleigh, North Carolina, USA.
Wright FA; Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University (NCSU), Raleigh, North Carolina, USA.; Department of Statistics, NCSU, Raleigh, North Carolina, USA.
Chiu WA; Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Rusyn I; Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Motsinger-Reif A; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Reif DM; Bioinformatics Research Center, Department of Biological Sciences, North Carolina State University (NCSU), Raleigh, North Carolina, USA.
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Źródło:
Environmental health perspectives [Environ Health Perspect] 2021 Jan; Vol. 129 (1), pp. 17701. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
Data Visualization*
Machine Learning*
Models, Statistical*
COVID-19/*epidemiology
Health Status Indicators ; Humans ; Vulnerable Populations
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vivo assessment of respiratory burst inhibition by xenobiotic exposure using larval zebrafish.
Autorzy:
Phelps DW; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.
Fletcher AA; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Rodriguez-Nunez I; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Balik-Meisner MR; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Tokarz DA; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
Reif DM; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.
Germolec DR; National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Yoder JA; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
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Źródło:
Journal of immunotoxicology [J Immunotoxicol] 2020 Dec; Vol. 17 (1), pp. 94-104.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzo(a)pyrene/*adverse effects
Cytotoxicity Tests, Immunologic/*methods
Immunity, Innate/*drug effects
Reactive Oxygen Species/*analysis
Respiratory Burst/*drug effects
Animals ; Animals, Genetically Modified ; Blood Cell Count ; Embryo, Nonmammalian ; Estradiol/adverse effects ; Feasibility Studies ; High-Throughput Screening Assays/methods ; Macrophages/drug effects ; Macrophages/immunology ; Methoxychlor/adverse effects ; Neutrophils/drug effects ; Neutrophils/immunology ; Organometallic Compounds/adverse effects ; Phenanthrenes/adverse effects ; Reactive Oxygen Species/metabolism ; Respiratory Burst/immunology ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish.
Autorzy:
Truong L; Department of Environmental and Molecular Toxicology, Oregon State University , Corvallis , OR , USA.
Zaikova T; Department of Chemistry and Biochemistry, University of Oregon , Eugene , OR , USA.
Baldock BL; Department of Chemistry and Biochemistry, Merrimack College , North Andover , MA , USA.
Balik-Meisner M; Bioinformatics Research Center, North Carolina State University , Raleigh , NC , USA.
To K; Bioinformatics Research Center, North Carolina State University , Raleigh , NC , USA.
Reif DM; Bioinformatics Research Center, North Carolina State University , Raleigh , NC , USA.
Kennedy ZC; Pacific Northwest National Laboratory, National Security Directorate , Richland , WA , USA.
Hutchison JE; Department of Chemistry and Biochemistry, University of Oregon , Eugene , OR , USA.
Tanguay RL; Department of Environmental and Molecular Toxicology, Oregon State University , Corvallis , OR , USA.
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Źródło:
Nanotoxicology [Nanotoxicology] 2019 Sep; Vol. 13 (7), pp. 879-893. Date of Electronic Publication: 2019 Apr 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gold/*toxicity
Metal Nanoparticles/*toxicity
Animals ; Particle Size ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years.
Autorzy:
Kosnik MB; Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
Reif DM; Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.; Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, United States of America.
Lobdell DT; National Health and Environmental Effects Research Lab, U.S. EPA, Chapel Hill, North Carolina, United States of America.
Astell-Burt T; Population Wellbeing and Environment Research Lab, School of Health and Society, Faculty of Social Sciences, University of Wollongong, Wollongong, New South Wales, Australia.; Menzies Centre for Health Policy, University of Sydney, Sydney, New South Wales, Australia.; School of Public Health, Peking Union Medical College and The Chinese Academy of Medical Sciences, Beijing, China.
Feng X; Population Wellbeing and Environment Research Lab, School of Health and Society, Faculty of Social Sciences, University of Wollongong, Wollongong, New South Wales, Australia.; Menzies Centre for Health Policy, University of Sydney, Sydney, New South Wales, Australia.
Hader JD; ICF, Fairfax, Virginia, United States of America.
Hoppin JA; Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.; Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Mar 21; Vol. 14 (3), pp. e0214094. Date of Electronic Publication: 2019 Mar 21 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Kidney Failure, Chronic/*epidemiology
Adolescent ; Adult ; Aged ; Air Pollution/adverse effects ; Female ; Health Services Accessibility ; Humans ; Male ; Middle Aged ; Prevalence ; Proportional Hazards Models ; Risk Factors ; Socioeconomic Factors ; United States/epidemiology ; Water Quality ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.
Autorzy:
Balik-Meisner M; Bioinformatics Research Center, Center for Human Health and the Environment, Dept. of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Truong L; Sinnhuber Aquatic Research Laboratory, Dept. of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA.
Scholl EH; Bioinformatics Research Center, Center for Human Health and the Environment, Dept. of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
La Du JK; Sinnhuber Aquatic Research Laboratory, Dept. of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA.
Tanguay RL; Sinnhuber Aquatic Research Laboratory, Dept. of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA.
Reif DM; Bioinformatics Research Center, Center for Human Health and the Environment, Dept. of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
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Źródło:
Environmental health perspectives [Environ Health Perspect] 2018 Jun 28; Vol. 126 (6), pp. 067010. Date of Electronic Publication: 2018 Jun 28 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene-Environment Interaction*
Genetic Variation*
Ivermectin/*analogs & derivatives
Zebrafish/*genetics
Animals ; Embryo, Nonmammalian/drug effects ; Embryonic Development/drug effects ; Female ; Genome-Wide Association Study ; High-Throughput Screening Assays/methods ; Ivermectin/toxicity ; Male ; Phenotype ; Zebrafish/embryology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi.
Autorzy:
To KT; 1Bioinformatics Research Center, North Carolina State University, 1 Lampe Dr, Raleigh, 27695 NC USA.
Fry RC; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hilll, Chapel Hill, 27516 NC USA.
Reif DM; 1Bioinformatics Research Center, North Carolina State University, 1 Lampe Dr, Raleigh, 27695 NC USA.; 3Center for Human Health and the Environment, North Carolina State University, Raleigh, 27695 NC USA.; 4Department of Biological Sciences, North Carolina State University, Raleigh, 27695 NC USA.
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Źródło:
BioData mining [BioData Min] 2018 Jun 13; Vol. 11, pp. 10. Date of Electronic Publication: 2018 Jun 13 (Print Publication: 2018).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.
Autorzy:
Marvel SW; Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Box 7566, 1 Lampe Drive, Raleigh, NC, 27695, USA.
To K; Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Box 7566, 1 Lampe Drive, Raleigh, NC, 27695, USA.
Grimm FA; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
Wright FA; Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Box 7566, 1 Lampe Drive, Raleigh, NC, 27695, USA.
Rusyn I; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.
Reif DM; Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Box 7566, 1 Lampe Drive, Raleigh, NC, 27695, USA. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2018 Mar 05; Vol. 19 (1), pp. 80. Date of Electronic Publication: 2018 Mar 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Information Dissemination*
Models, Theoretical*
Software*
User-Computer Interface*
Cluster Analysis ; Information Storage and Retrieval
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Population genetic diversity in zebrafish lines.
Autorzy:
Balik-Meisner M; Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Ricks Hall 344, 1 Lampe Drive, Box 7566, Raleigh, NC, 27695, USA.
Truong L; Sinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA.
Scholl EH; Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Ricks Hall 344, 1 Lampe Drive, Box 7566, Raleigh, NC, 27695, USA.
Tanguay RL; Sinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA.
Reif DM; Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Ricks Hall 344, 1 Lampe Drive, Box 7566, Raleigh, NC, 27695, USA. .
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Źródło:
Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2018 Feb; Vol. 29 (1-2), pp. 90-100. Date of Electronic Publication: 2018 Jan 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Genetic Variation*
Genetics, Population*
Zebrafish/*genetics
Animals ; Gene Frequency ; Genome/genetics ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish.
Autorzy:
Zhang G; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
Truong L; Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, Oregon, United States of America.
Tanguay RL; Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, Oregon, United States of America.
Reif DM; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Jan 18; Vol. 12 (1), pp. e0169408. Date of Electronic Publication: 2017 Jan 18 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Models, Statistical*
Biometry/*methods
High-Throughput Screening Assays/*methods
Animals ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership.
Autorzy:
Kollitz EM; Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.; Nicholas School of the Environment, Duke University, Durham, NC, United States of America.
Zhang G; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
Hawkins MB; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
Whitfield GK; Department of Basic Medical Sciences, The University of Arizona College of Medicine, Phoenix, Arizona, United States of America.
Reif DM; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
Kullman SW; Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Dec 12; Vol. 11 (12), pp. e0168278. Date of Electronic Publication: 2016 Dec 12 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Biological Evolution*
Lithocholic Acid/*metabolism
Receptors, Calcitriol/*metabolism
Animals ; Hep G2 Cells ; Humans ; Vertebrates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database.
Autorzy:
Grondin CJ; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Davis AP
Wiegers TC
King BL
Wiegers JA
Reif DM
Hoppin JA
Mattingly CJ
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Źródło:
Environmental health perspectives [Environ Health Perspect] 2016 Oct; Vol. 124 (10), pp. 1592-1599. Date of Electronic Publication: 2016 May 12.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.
Autorzy:
Shah I; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
Setzer RW
Jack J
Houck KA
Judson RS
Knudsen TB
Liu J
Martin MT
Reif DM
Richard AM
Thomas RS
Crofton KM
Dix DJ
Kavlock RJ
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Źródło:
Environmental health perspectives [Environ Health Perspect] 2016 Jul; Vol. 124 (7), pp. 910-9. Date of Electronic Publication: 2015 Oct 16.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Environmental Pollutants/*toxicity
Toxicity Tests/*methods
High-Throughput Screening Assays ; Membrane Potential, Mitochondrial ; Risk Assessment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates.
Autorzy:
Kollitz EM; Program in Environmental and Molecular Toxicology, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
Zhang G; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America.
Hawkins MB; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
Whitfield GK; Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, United States of America.
Reif DM; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
Kullman SW; Program in Environmental and Molecular Toxicology, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America; Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Apr 09; Vol. 10 (4), pp. e0122853. Date of Electronic Publication: 2015 Apr 09 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Evolution, Molecular*
Phylogeny*
Fishes/*genetics
Petromyzon/*genetics
Receptors, Calcitriol/*genetics
Skates, Fish/*genetics
Animals ; Base Sequence ; Cloning, Molecular ; Computational Biology ; Electrophoretic Mobility Shift Assay ; Likelihood Functions ; Models, Genetic ; Molecular Sequence Data ; Protein Binding ; Protein Interaction Mapping ; Sequence Analysis, DNA ; Species Specificity ; Two-Hybrid System Techniques
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 37

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