The Ocular Pulse Decreases Aqueous Humour Outflow Resistance by Stimulating Nitric Oxide Production.
Autorzy :
Madekurozwa M; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom. Stamer WD; Dept. of Ophthalmology, Duke University, Durham, NC, United States. Reina-TorresE; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom. Sherwood JM; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom. Overby DR; Dept. of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom.
The vital role for nitric oxide in intraocular pressure homeostasis.
Autorzy :
Reina-TorresE; Department of Bioengineering, Imperial College London, London, UK. De Ieso ML; Department of Ophthalmology, Duke University, Durham, NC, USA. Pasquale LR; Eye and Vision Research Institute of New York Eye and Ear Infirmary at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Madekurozwaa M; Department of Bioengineering, Imperial College London, London, UK. Electronic address: . van Batenburg-Sherwooda J; Department of Bioengineering, Imperial College London, London, UK. Electronic address: . Overby DR; Department of Bioengineering, Imperial College London, London, UK. Electronic address: . Stamer WD; Department of Ophthalmology, Duke University, Durham, NC, USA. Electronic address: .
siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Autorzy :
Cassidy PS; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Kelly RA; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Reina-TorresE; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.; Department of Bioengineering, Imperial College London, London, UK. Sherwood JM; Department of Bioengineering, Imperial College London, London, UK. Humphries MM; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Kiang AS; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Farrar GJ; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. O'Brien C; Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland. Campbell M; Neurovascular Research Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. Stamer WD; Department of Ophthalmology, Duke University, Durham, NC, USA. Overby DR; Department of Bioengineering, Imperial College London, London, UK. Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. O'Callaghan J; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.; Neurovascular Research Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Aqueous Humor Outflow Requires Active Cellular Metabolism in Mice.
Autorzy :
Reina-TorresE; Department of Bioengineering, Imperial College London, London, United Kingdom. Boussommier-Calleja A; Department of Bioengineering, Imperial College London, London, United Kingdom.; ImVitro, Paris, France. Sherwood JM; Department of Bioengineering, Imperial College London, London, United Kingdom. Overby DR; Department of Bioengineering, Imperial College London, London, United Kingdom.
Reduced humidity experienced by mice in vivo coincides with reduced outflow facility measured ex vivo.
Autorzy :
Reina-TorresE; Department of Bioengineering, Imperial College London, London, United Kingdom; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland. Bertrand JA; Department of Bioengineering, Imperial College London, London, United Kingdom. O'Callaghan J; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland. Sherwood JM; Department of Bioengineering, Imperial College London, London, United Kingdom. Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland. Overby DR; Department of Bioengineering, Imperial College London, London, United Kingdom. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2019 Sep; Vol. 186, pp. 107745. Date of Electronic Publication: 2019 Jul 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Direct measurement of pressure-independent aqueous humour flow using iPerfusion.
Autorzy :
Madekurozwa M; Dept. of Bioengineering, Imperial College London, London SW7 2AZ, UK. Reina-TorresE; Dept. of Bioengineering, Imperial College London, London SW7 2AZ, UK. Overby DR; Dept. of Bioengineering, Imperial College London, London SW7 2AZ, UK. Electronic address: . Sherwood JM; Dept. of Bioengineering, Imperial College London, London SW7 2AZ, UK.
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Źródło :
Experimental eye research [Exp Eye Res] 2017 Sep; Vol. 162, pp. 129-138. Date of Electronic Publication: 2017 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.
Autorzy :
O'Callaghan J; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Crosbie DE; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Cassidy PS; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Sherwood JM; Department of Bioengineering, Imperial College London, London, SW7 2BX, UK. Flügel-Koch C; Department of Anatomy II, University of Erlangen-Nürnberg, D-91054 Erlangen, Germany. Lütjen-Drecoll E; Department of Anatomy II, University of Erlangen-Nürnberg, D-91054 Erlangen, Germany. Humphries MM; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Reina-TorresE; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Wallace D; Clinical Research Centre, UCD School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Kiang AS; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Campbell M; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Stamer WD; Departments of Ophthalmology and Biomedical Engineering, Duke University, Durham, NC, USA. Overby DR; Department of Bioengineering, Imperial College London, London, SW7 2BX, UK. O'Brien C; Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, D7, Ireland. Tam LCS; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland. Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin, D2, Ireland.
Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
Autorzy :
Chandrawati R; Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK. Chang JYH; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. Reina-TorresE; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. Jumeaux C; Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK. Sherwood JM; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. Stamer WD; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, 27710, USA. Zelikin AN; Department of Chemistry and iNANO Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C, 8000, Denmark. Overby DR; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. Stevens MM; Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.
Autorzy :
Tam LC; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland. Reina-TorresE; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland.; Department of Bioengineering, Imperial College London, London, UK. Sherwood JM; Department of Bioengineering, Imperial College London, London, UK. Cassidy PS; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland. Crosbie DE; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland. Lütjen-Drecoll E; Department of Anatomy, University of Erlangen-Nürnberg, Erlangen, Germany. Flügel-Koch C; Department of Anatomy, University of Erlangen-Nürnberg, Erlangen, Germany. Perkumas K; Department of Ophthalmology, Duke University, Durham, NC, USA. Humphries MM; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland. Kiang AS; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland. O'Callaghan J; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland. Callanan JJ; Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies. Read AT; Department of Ophthalmology and Vision Sciences, University of Toronto, Canada. Ethier CR; Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, USA. O'Brien C; Ophthalmology, Mater Hospital, UCD School of Medicine, Dublin, Ireland. Lawrence M; RxGen, Hamden, CT, USA. Campbell M; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland. Stamer WD; Department of Ophthalmology, Duke University, Durham, NC, USA. Overby DR; Department of Bioengineering, Imperial College London, London, UK. Humphries P; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland.
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Źródło :
Scientific reports [Sci Rep] 2017 Jan 16; Vol. 7, pp. 40717. Date of Electronic Publication: 2017 Jan 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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