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Tytuł:
Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters.
Autorzy:
Dutta AK; Wayne State University, Department of Pharmaceutical Sciences, Detroit, MI, United States.
Santra S; Wayne State University, Department of Pharmaceutical Sciences, Detroit, MI, United States.
Sharma H; Wayne State University, Department of Pharmaceutical Sciences, Detroit, MI, United States.
Voshavar C; Wayne State University, Department of Pharmaceutical Sciences, Detroit, MI, United States.
Xu L; Wayne State University, Department of Pharmaceutical Sciences, Detroit, MI, United States.
Mabrouk O; University of Michigan, Department of Pharmacology and Chemistry, Ann Arbor, MI, United States.
Antonio T; New York University, Department of Psychiatry, New York, NY, United States.
Reith ME; New York University, Department of Psychiatry, New York, NY, United States; New York University, Department of Biochemistry and Molecular Pharmacology, New York, NY, United States.
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Źródło:
PloS one [PLoS One] 2014 Nov 26; Vol. 9 (11), pp. e113420. Date of Electronic Publication: 2014 Nov 26 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Amino Sugars/*pharmacology
Antidepressive Agents/*pharmacology
Benzylamines/*pharmacology
Dopamine Plasma Membrane Transport Proteins/*metabolism
Dopamine Uptake Inhibitors/*pharmacology
Norepinephrine Plasma Membrane Transport Proteins/*metabolism
Pyrans/*pharmacology
Serotonin Plasma Membrane Transport Proteins/*metabolism
Selective Serotonin Reuptake Inhibitors/*pharmacology
Administration, Oral ; Amino Sugars/chemical synthesis ; Amino Sugars/pharmacokinetics ; Animals ; Antidepressive Agents/chemical synthesis ; Antidepressive Agents/pharmacokinetics ; Behavior, Animal/drug effects ; Benzylamines/chemical synthesis ; Benzylamines/pharmacokinetics ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Major/physiopathology ; Dopamine/metabolism ; Dopamine Uptake Inhibitors/chemical synthesis ; Dopamine Uptake Inhibitors/pharmacokinetics ; HEK293 Cells ; Humans ; Male ; Norepinephrine/metabolism ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Pyrans/chemical synthesis ; Pyrans/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Serotonin/metabolism ; Selective Serotonin Reuptake Inhibitors/chemical synthesis ; Selective Serotonin Reuptake Inhibitors/pharmacokinetics ; Swimming
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation.
Autorzy:
Antonio T; Department of Psychiatry, New York University School of Medicine, New York, New York, United States of America ; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, United States of America.
Childers SR
Rothman RB
Dersch CM
King C
Kuehne M
Bornmann WG
Eshleman AJ
Janowsky A
Simon ER
Reith ME
Alper K
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Źródło:
PloS one [PLoS One] 2013 Oct 16; Vol. 8 (10), pp. e77262. Date of Electronic Publication: 2013 Oct 16 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bridged-Ring Compounds/*pharmacology
Ibogaine/*analogs & derivatives
Ibogaine/*pharmacology
Receptors, Opioid, mu/*metabolism
Thalamus/*drug effects
Animals ; Autoradiography ; CHO Cells ; Cricetulus ; Dose-Response Relationship, Drug ; Female ; Gene Expression ; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology ; HEK293 Cells ; Humans ; Organ Specificity ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, mu/agonists ; Receptors, Opioid, mu/antagonists & inhibitors ; Receptors, Opioid, mu/genetics ; Substance Withdrawal Syndrome/prevention & control ; Thalamus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors.
Autorzy:
Schmitt KC; Department of Pharmacology, New York University School of Medicine, New York, New York, United States of America.
Reith ME
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Źródło:
PloS one [PLoS One] 2011; Vol. 6 (10), pp. e25790. Date of Electronic Publication: 2011 Oct 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Benzhydryl Compounds/*pharmacology
Dopamine Plasma Membrane Transport Proteins/*antagonists & inhibitors
Cell Line ; Central Nervous System Stimulants ; Cocaine ; Dopamine Plasma Membrane Transport Proteins/genetics ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Dopamine Uptake Inhibitors/pharmacology ; Humans ; Modafinil ; Mutation ; Protein Binding ; Protein Conformation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse.
Autorzy:
Schmitt KC; Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA.
Reith ME
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2010 Feb; Vol. 1187, pp. 316-40.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Brain/*physiopathology
Central Nervous System Stimulants/*toxicity
Dopamine Plasma Membrane Transport Proteins/*physiology
Substance-Related Disorders/*physiopathology
Amphetamine-Related Disorders/physiopathology ; Animals ; Brain/drug effects ; Cocaine-Related Disorders/physiopathology ; Dopamine Plasma Membrane Transport Proteins/drug effects ; Humans ; Ligands ; MAP Kinase Signaling System/drug effects ; Methamphetamine/toxicity ; Models, Neurological ; Protein Kinase C/physiology ; Signal Transduction/drug effects ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Autorzy:
Zhou Z; Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
Zhen J
Karpowich NK
Law CJ
Reith ME
Wang DN
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2009 Jun; Vol. 16 (6), pp. 652-7. Date of Electronic Publication: 2009 May 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acid Transport Systems, Neutral/*chemistry
Fluoxetine/*pharmacology
Serotonin Plasma Membrane Transport Proteins/*chemistry
Serotonin Plasma Membrane Transport Proteins/*genetics
Selective Serotonin Reuptake Inhibitors/*chemistry
Sertraline/*pharmacology
Amino Acid Transport Systems, Neutral/metabolism ; Antidepressive Agents, Tricyclic/pharmacology ; Binding Sites ; Cell Line ; Crystallography, X-Ray/methods ; Dopamine/metabolism ; Drug Evaluation, Preclinical ; Humans ; Models, Chemical ; Mutation ; Norepinephrine/metabolism ; Protein Binding ; Selective Serotonin Reuptake Inhibitors/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen.
Autorzy:
Reith ME; NRC Institute for Marine Biosciences, 1411 Oxford Street, Halifax, NS, B3H 3Z1, Canada. michael.reith@nrc-cnrc.gc.ca
Singh RK
Curtis B
Boyd JM
Bouevitch A
Kimball J
Munholland J
Murphy C
Sarty D
Williams J
Nash JH
Johnson SC
Brown LL
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Źródło:
BMC genomics [BMC Genomics] 2008 Sep 18; Vol. 9, pp. 427. Date of Electronic Publication: 2008 Sep 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome, Bacterial*
Aeromonas salmonicida/*genetics
Fishes/*microbiology
Aeromonas hydrophila/genetics ; Aeromonas salmonicida/pathogenicity ; Animals ; DNA Transposable Elements ; Evolution, Molecular ; Sequence Analysis, DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors.
Autorzy:
Kharkar PS; Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202, USA.
Reith ME
Dutta AK
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Źródło:
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2008 Jan; Vol. 22 (1), pp. 1-17. Date of Electronic Publication: 2007 Dec 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Furans/*chemistry
Norepinephrine Plasma Membrane Transport Proteins/*antagonists & inhibitors
Serotonin Plasma Membrane Transport Proteins/*drug effects
Magnetic Resonance Spectroscopy ; Models, Molecular ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Autorzy:
Zhou Z; Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
Zhen J
Karpowich NK
Goetz RM
Law CJ
Reith ME
Wang DN
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Źródło:
Science (New York, N.Y.) [Science] 2007 Sep 07; Vol. 317 (5843), pp. 1390-3. Date of Electronic Publication: 2007 Aug 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidepressive Agents, Tricyclic/*metabolism
Bacterial Proteins/*metabolism
Desipramine/*metabolism
Neurotransmitter Uptake Inhibitors/*metabolism
Plasma Membrane Neurotransmitter Transport Proteins/*metabolism
Amino Acid Sequence ; Animals ; Antidepressive Agents, Tricyclic/chemistry ; Bacterial Proteins/chemistry ; Binding Sites ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/metabolism ; Cell Line ; Conserved Sequence ; Crystallography, X-Ray ; Desipramine/chemistry ; Dopamine/chemistry ; Dopamine/metabolism ; Dopamine Uptake Inhibitors/chemistry ; Dopamine Uptake Inhibitors/metabolism ; Drosophila Proteins/chemistry ; Drosophila Proteins/metabolism ; Humans ; Leucine/chemistry ; Leucine/metabolism ; Models, Molecular ; Molecular Sequence Data ; Neurotransmitter Uptake Inhibitors/chemistry ; Norepinephrine/chemistry ; Norepinephrine/metabolism ; Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors ; Norepinephrine Plasma Membrane Transport Proteins/chemistry ; Norepinephrine Plasma Membrane Transport Proteins/metabolism ; Plasma Membrane Neurotransmitter Transport Proteins/chemistry ; Protein Binding ; Protein Conformation ; Sequence Homology, Amino Acid ; Serotonin/chemistry ; Serotonin/metabolism ; Selective Serotonin Reuptake Inhibitors/chemistry ; Selective Serotonin Reuptake Inhibitors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Comprehensive EST analysis of Atlantic halibut (Hippoglossus hippoglossus), a commercially relevant aquaculture species.
Autorzy:
Douglas SE; Institute for Marine Biosciences,Halifax, Nova Scotia, Canada. />Knickle LC
Kimball J
Reith ME
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Źródło:
BMC genomics [BMC Genomics] 2007 Jun 04; Vol. 8, pp. 144. Date of Electronic Publication: 2007 Jun 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Expressed Sequence Tags*
Genome*
Microsatellite Repeats*
Flounder/*genetics
Genomics/*methods
Animals ; Contig Mapping ; Gene Expression Regulation ; Gene Library ; Genetic Markers ; Models, Genetic ; Oligonucleotide Array Sequence Analysis ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Nitric oxide inhibits uptake of dopamine and N-methyl-4-phenylpyridinium (MPP+) but not release of MPP+ in rat C6 glioma cells expressing human dopamine transporter.
Autorzy:
Cao BJ; Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, Peoria, IL 61656-1649, U.S.A.
Reith ME
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2002 Dec; Vol. 137 (8), pp. 1155-62.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Membrane Glycoproteins*
Nerve Tissue Proteins*
1-Methyl-4-phenylpyridinium/*metabolism
Dopamine/*metabolism
Membrane Transport Proteins/*biosynthesis
Nitric Oxide/*metabolism
Animals ; Dopamine Plasma Membrane Transport Proteins ; Dose-Response Relationship, Drug ; Humans ; Nitric Oxide Donors/pharmacology ; Rats ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Continuous cocaine treatment and monoamine transmission measured by microdialysis in the rat ventral tegmental area.
Autorzy:
Li MY; Department of Biomedical and Therapeutic Sciences, University of Illinois, College of Medicine, Peor ia, USA.
Reith ME; Department of Biomedical and Therapeutic Sciences, University of Illinois, College of Medicine, Peor ia, USA.
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Źródło:
Addiction biology [Addict Biol] 1998 Oct; Vol. 3 (4), pp. 447-51.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 22

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