Phosphatidylinositol metabolism of the renal proximal tubule S3 segment is disturbed in response to diabetes.
Autorzy:
Rietjens RGJ; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands. Wang G; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands. van der Velden AIM; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands. Koudijs A; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands. Avramut MC; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cell and Chemical Biology (Electron Microscopy), Leiden University Medical Center, Leiden, The Netherlands. Kooijman S; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine (Endocrinology), Leiden University Medical Center, Leiden, The Netherlands. RensenPCN; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine (Endocrinology), Leiden University Medical Center, Leiden, The Netherlands. van der Vlag J; Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands. Rabelink TJ; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands. Heijs B; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands.; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands. van den Berg BM; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands. b.m.van_den_.; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands. b.m.van_den_.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, The Netherlands. b.m.van_den_.
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Scientific reports [Sci Rep] 2023 Apr 17; Vol. 13 (1), pp. 6261. Date of Electronic Publication: 2023 Apr 17.
Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans.
Autorzy:
Borup A; Department of Clinical Biochemistry, Section 3-01-3, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Donkin I; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Boon MR; Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Frydland M; Department of Cardiology, Rigshospitalet, Copenhagen, Denmark. Martinez-Tellez B; Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Loft A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark. Keller SH; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark. Kjaer A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark. Kjaergaard J; Department of Cardiology, Rigshospitalet, Copenhagen, Denmark. Hassager C; Department of Cardiology, Rigshospitalet, Copenhagen, Denmark. Barrès R; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. RensenPCN; Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Christoffersen C; Department of Clinical Biochemistry, Section 3-01-3, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. .; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. .; Department of Clinical Biochemistry, Bispebjerg Hospitalet, Copenhagen, Denmark. .
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Scientific reports [Sci Rep] 2022 Nov 05; Vol. 12 (1), pp. 18753. Date of Electronic Publication: 2022 Nov 05.
Bone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes.
Autorzy:
Katiraei S; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. van Diepen JA; Department of Internal Medicine, Radboud UMC, Nijmegen, The Netherlands. Tavares LP; Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Hoving LR; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Pronk A; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands. Verschueren I; Department of Internal Medicine, Radboud UMC, Nijmegen, The Netherlands. RensenPCN; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands. Zwaginga JJ; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. Kostidis S; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands. Giera M; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands. Teixera M; Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands. .; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. .; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands. . Netea MG; Department of Internal Medicine, Radboud UMC, Nijmegen, The Netherlands. Berbée JFP; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands. van Harmelen V; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
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Scientific reports [Sci Rep] 2022 Apr 27; Vol. 12 (1), pp. 6883. Date of Electronic Publication: 2022 Apr 27.
Loss of glucocorticoid rhythm induces an osteoporotic phenotype in female mice.
Autorzy:
Schilperoort M; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands. Kroon J; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands. Kooijman S; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands. Smit AE; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands. Gentenaar M; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands. Mletzko K; Department of Osteology and Biomechanics (IOBM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Schmidt FN; Department of Osteology and Biomechanics (IOBM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. van Ruijven L; Department of Functional Anatomy, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. Busse B; Department of Osteology and Biomechanics (IOBM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Pereira AM; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands. Appelman-Dijkstra NM; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Medicine, Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands. Bravenboer N; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Medicine, Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Chemistry, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands. RensenPCN; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands. Meijer OC; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands. Winter EM; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.; Department of Medicine, Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands.
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Aging cell [Aging Cell] 2021 Oct; Vol. 20 (10), pp. e13474. Date of Electronic Publication: 2021 Sep 30.
Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice.
Autorzy:
Hoekstra M; Gorlaeus Laboratories, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. . Ren B; Gorlaeus Laboratories, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. Laurila PP; Department of Medical Genetics, University of Helsinki, Helsinki, Finland.; Genomics and Biobank Unit, National Institute for Health and Welfare, Biomedicum 1, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland. Hildebrand RB; Gorlaeus Laboratories, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. Soronen J; Genomics and Biobank Unit, National Institute for Health and Welfare, Biomedicum 1, Helsinki, Finland.; Pharmaceuticals Division, Bayer Oy BOF-PH-MRA-MA, Medical Affairs PO, Espoo, Finland. Frodermann V; Gorlaeus Laboratories, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. Li Z; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Boon MR; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Geerling JJ; Gorlaeus Laboratories, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. RensenPCN; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Jauhiainen M; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki, Finland. Van Eck M; Gorlaeus Laboratories, Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
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Scientific reports [Sci Rep] 2021 Aug 12; Vol. 11 (1), pp. 16419. Date of Electronic Publication: 2021 Aug 12.
Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults.
Autorzy:
Osuna-Prieto FJ; PROFITH (PROmoting FITness and Health Through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.; Department of Analytical Chemistry, University of Granada, Granada, Spain.; Research and Development of Functional Food Center (CIDAF), Granada, Spain. Martinez-Tellez B; PROFITH (PROmoting FITness and Health Through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.; Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands. Ortiz-Alvarez L; PROFITH (PROmoting FITness and Health Through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.; Department of Biochemistry and Molecular Biology II, 'José Mataix Verdú' Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), University of Granada, Granada, Spain. Di X; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands. Jurado-Fasoli L; PROFITH (PROmoting FITness and Health Through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. Xu H; PROFITH (PROmoting FITness and Health Through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.; Department of Biochemistry and Molecular Biology II, 'José Mataix Verdú' Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), University of Granada, Granada, Spain. Ceperuelo-Mallafré V; Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII-Institut d ́Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III, Madrid, Spain.; Rovira i Virgili University, Tarragona, Spain. Núñez-Roa C; Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII-Institut d ́Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III, Madrid, Spain. Kohler I; Division of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam, The Netherlands.; Center for Analytical Sciences Amsterdam, Amsterdam, The Netherlands. Segura-Carretero A; Department of Analytical Chemistry, University of Granada, Granada, Spain.; Research and Development of Functional Food Center (CIDAF), Granada, Spain. García-Lario JV; Hospital Universitario Clínico San Cecilio, Granada, Spain. Gil A; Department of Biochemistry and Molecular Biology II, 'José Mataix Verdú' Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), University of Granada, Granada, Spain.; Biohealth Research Institute in Granada (Ibs, GRANADA), Granada, Spain.; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Madrid, Spain. Aguilera CM; Department of Biochemistry and Molecular Biology II, 'José Mataix Verdú' Institute of Nutrition and Food Technology (INYTA), Biomedical Research Center (CIBM), University of Granada, Granada, Spain.; Biohealth Research Institute in Granada (Ibs, GRANADA), Granada, Spain.; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Madrid, Spain. Llamas-Elvira JM; Nuclear Medicine Service, Virgen de las Nieves University Hospital, Biohealth Research Institute in Granada (Ibs. GRANADA), Granada, Spain. RensenPCN; Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands. Vendrell J; Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII-Institut d ́Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III, Madrid, Spain.; Rovira i Virgili University, Tarragona, Spain. Ruiz JR; PROFITH (PROmoting FITness and Health Through Physical Activity) Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. . Fernández-Veledo S; Department of Endocrinology and Nutrition and Research Unit, University Hospital of Tarragona Joan XXIII-Institut d ́Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain. .; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III, Madrid, Spain. .
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Źródło:
Cardiovascular diabetology [Cardiovasc Diabetol] 2021 Jul 27; Vol. 20 (1), pp. 151. Date of Electronic Publication: 2021 Jul 27.
A hierarchical dynamic model used for investigating feed efficiency and its relationship with hepatic gene expression in APOE*3-Leiden.CETP mice.
Autorzy:
Zhang X; Department of Experimental Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.; Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. Paalvast Y; Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands. Wang Y; Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands.; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. RensenPCN; Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Groen AK; Department of Experimental Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Department of Pediatrics, University Medical Center Groningen, Groningen, The Netherlands.
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