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    Wyświetlanie 1-11 z 11
    Tytuł:
    Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones.
    Autorzy:
    Resende DISP; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Durães F; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Zubarioglu S; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
    Freitas-Silva J; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
    Szemerédi N; Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, 6725 Szeged, Hungary.
    Pinto M; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Pinto E; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.; Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
    Martins da Costa P; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
    Spengler G; Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, 6725 Szeged, Hungary.
    Sousa E; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
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    Źródło:
    Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Feb 06; Vol. 17 (2). Date of Electronic Publication: 2024 Feb 06.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Evaluation of the Cytotoxic and Antiviral Effects of Small Molecules Selected by In Silico Studies as Inhibitors of SARS-CoV-2 Cell Entry.
    Autorzy:
    Carvalhal F; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, 4408-208 Matosinhos, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
    Magalhães AC; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
    Rebelo R; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
    Palmeira A; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, 4408-208 Matosinhos, Portugal.
    Resende DISP; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, 4408-208 Matosinhos, Portugal.
    Durães F; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, 4408-208 Matosinhos, Portugal.
    Maia M; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, 4408-208 Matosinhos, Portugal.
    Xavier CPR; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
    Pereira L; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
    Sousa E; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, 4408-208 Matosinhos, Portugal.
    Correia-da-Silva M; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, 4408-208 Matosinhos, Portugal.
    Vasconcelos MH; FFUP-Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2023 Oct 21; Vol. 28 (20). Date of Electronic Publication: 2023 Oct 21.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    COVID-19*
    Antineoplastic Agents*/pharmacology
    Humans ; SARS-CoV-2 ; Angiotensin-Converting Enzyme 2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization ; Protein Binding ; Antiviral Agents/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Natural and Synthetic Xanthone Derivatives Counteract Oxidative Stress via Nrf2 Modulation in Inflamed Human Macrophages.
    Autorzy:
    Gallorini M; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
    Carradori S; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
    Resende DISP; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
    Saso L; Department of Physiology and Pharmacology 'Vittorio Erspamer', Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.
    Ricci A; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
    Palmeira A; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
    Cataldi A; Department of Pharmacy, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
    Pinto M; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
    Sousa E; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2022 Nov 01; Vol. 23 (21). Date of Electronic Publication: 2022 Nov 01.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    NF-E2-Related Factor 2*
    Xanthones*/pharmacology
    Humans ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Macrophages ; Oxidative Stress
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens.
    Autorzy:
    Resende DISP; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, 4450-208 Matosinhos, Portugal.; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
    Jesus A; Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
    Sousa Lobo JM; Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
    Sousa E; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, 4450-208 Matosinhos, Portugal.; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
    Cruz MT; Faculty of Pharmacy, University of Coimbra, 3004-531 Coimbra, Portugal.; Center for Neuroscience and Cell Biology, 3004-504 Coimbra, Portugal.
    Cidade H; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, 4450-208 Matosinhos, Portugal.; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
    Almeida IF; Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
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    Źródło:
    Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Mar 18; Vol. 15 (3). Date of Electronic Publication: 2022 Mar 18.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Determination of the Absolute Configuration of Bioactive Indole-Containing Pyrazino[2,1- b ]quinazoline-3,6-diones and Study of Their In Vitro Metabolic Profile.
    Autorzy:
    Long S; LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Department of Bioegineering, Faculty of Engineering, Royal University of Phnom Penh, Russian Federation Blevd, Phnom Penh 12156, Cambodia.
    Furlani IL; SEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.
    Oliveira JM; SEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.
    Resende DISP; LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, Matosinhos, 4450-208 Porto, Portugal.
    Silva AMS; LAQV-REQUIMTE-Departamento de Química, Universidade de Aveiro, 3810-193 Aveiro, Portugal.
    Gales L; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.; i3S-IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4050-313 Porto, Portugal.
    Pereira JA; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
    Kijjoa A; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, Matosinhos, 4450-208 Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
    Cass QB; SEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.
    Oliveira RV; SEPARARE-Núcleo de Pesquisa em Cromatografia, Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luiz, km 235, São Carlos 13565-905, Brazil.
    Sousa E; LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, Matosinhos, 4450-208 Porto, Portugal.
    Pinto MMM; LQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, Matosinhos, 4450-208 Porto, Portugal.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2021 Aug 21; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 21.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-Bacterial Agents/*metabolism
    Biological Products/*metabolism
    Metabolome/*genetics
    Pyrazines/*metabolism
    Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Chromatography, High Pressure Liquid ; Circular Dichroism ; Crystallography, X-Ray ; Fungi/drug effects ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Indoles/metabolism ; Mass Spectrometry ; Molecular Structure ; Pyrazines/chemical synthesis ; Pyrazines/chemistry ; Quinazolines/chemical synthesis ; Quinazolines/chemistry ; Quinazolines/metabolism ; Stereoisomerism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.
    Autorzy:
    Resende DISP; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
    Ferreira MS; Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
    Sousa-Lobo JM; Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
    Sousa E; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
    Almeida IF; Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
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    Źródło:
    Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2021 Jul 21; Vol. 14 (8). Date of Electronic Publication: 2021 Jul 21.
    Typ publikacji:
    Journal Article; Review
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones.
    Autorzy:
    Pinto MMM; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Palmeira A; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Fernandes C; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Resende DISP; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Sousa E; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Cidade H; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Tiritan ME; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal.
    Correia-da-Silva M; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
    Cravo S; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2021 Jan 15; Vol. 26 (2). Date of Electronic Publication: 2021 Jan 15.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Biological Products/*chemistry
    Biological Products/*pharmacology
    Small Molecule Libraries/*chemistry
    Xanthones/*chemistry
    Xanthones/*pharmacology
    Animals ; Biological Products/isolation & purification ; Chemistry, Pharmaceutical ; Humans ; Small Molecule Libraries/isolation & purification ; Small Molecule Libraries/pharmacology ; Xanthones/isolation & purification
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Towards Identification of Bioactive Compounds to Fight Skin Photoaging.
    Autorzy:
    Resende DISP; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
    Almeida MC; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
    Maciel B; Laboratório de Tecnologia Farmacêutica, Departamento do Medicamento, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
    Carmo H; UCIBIO, REQUIMTE, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
    Sousa Lobo J; UCIBIO/REQUIMTE, MedTec-Laboratório de Tecnologia Farmacêutica, Departamento de Ciências do Medicamento, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
    Dal Pozzo C; University of Ferrara, Dept. of Life Sciences and Biotechnology, Via Fossato di Mortara 17/1944121 Ferrara, Italy.
    Cravo SM; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
    Rosa GP; cE3c-Centre for Ecology, Evolution and Environmental Changes / Azorean Biodiversity Group, 9500-321 Ponta Delgada, Portugal.; Faculdade de Ciências e Tecnologia, Universidade dos Açores, 9500-321 Ponta Delgada, Portugal.
    Kane-Pagès A; Faculdade de Ciências e Tecnologia, Universidade dos Açores, 9500-321 Ponta Delgada, Portugal.
    do Carmo Barreto M; cE3c-Centre for Ecology, Evolution and Environmental Changes / Azorean Biodiversity Group, 9500-321 Ponta Delgada, Portugal.; Faculdade de Ciências e Tecnologia, Universidade dos Açores, 9500-321 Ponta Delgada, Portugal.
    Almeida IF; UCIBIO/REQUIMTE, MedTec-Laboratório de Tecnologia Farmacêutica, Departamento de Ciências do Medicamento, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
    de Sousa ME; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
    Pinto MMM; Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.; CIIMAR-Centro Interdisciplinar de Investigação Marinha e Ambiental, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2020 Jun 16; Vol. 25 (12). Date of Electronic Publication: 2020 Jun 16.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antioxidants*/adverse effects
    Antioxidants*/chemistry
    Antioxidants*/pharmacology
    Sunscreening Agents*/adverse effects
    Sunscreening Agents*/chemistry
    Sunscreening Agents*/pharmacology
    Xanthones*/adverse effects
    Xanthones*/chemistry
    Xanthones*/pharmacology
    Keratinocytes/*metabolism
    Skin/*metabolism
    Skin Aging/*drug effects
    Drug Evaluation, Preclinical ; Humans ; Keratinocytes/pathology ; Skin/pathology ; Skin Aging/radiation effects ; Ultraviolet Rays/adverse effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Synthesis of a Small Library of Nature-Inspired Xanthones and Study of Their Antimicrobial Activity.
    Autorzy:
    Resende DISP; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; Laboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    Pereira-Terra P; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    Moreira J; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; Laboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    Freitas-Silva J; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    Lemos A; Laboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    Gales L; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.; i3S - Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.; IBMC - Instituto de Biologia Molecular e Celular Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
    Pinto E; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    de Sousa ME; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; Laboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    da Costa PM; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    Pinto MMM; CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.; Laboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
    Pokaż więcej
    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2020 May 21; Vol. 25 (10). Date of Electronic Publication: 2020 May 21.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-Bacterial Agents/*chemistry
    Biofilms/*drug effects
    Small Molecule Libraries/*chemistry
    Xanthones/*chemistry
    Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/pathogenicity ; Biofilms/growth & development ; Candida albicans/drug effects ; Candida albicans/pathogenicity ; Crystallography, X-Ray ; Humans ; Microbial Sensitivity Tests ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/pharmacology ; X-Ray Diffraction ; Xanthones/chemical synthesis ; Xanthones/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects.
    Autorzy:
    Long S; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .
    Resende DISP; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), 4450-208 Matosinhos, Portugal. .
    Kijjoa A; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), 4450-208 Matosinhos, Portugal. .; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal. .
    Silva AMS; Organic Chemistry and Natural Products Unit (QOPNA), Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. .
    Fernandes R; Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal. .; Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135, Porto, Portugal. .
    Xavier CPR; Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal. .; Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135, Porto, Portugal. .
    Vasconcelos MH; Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, 4200-135 Porto, Portugal. .; Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135, Porto, Portugal. .; Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. .
    Sousa E; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), 4450-208 Matosinhos, Portugal. .
    Pinto MMM; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), 4450-208 Matosinhos, Portugal. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Feb 01; Vol. 24 (3). Date of Electronic Publication: 2019 Feb 01.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Alkaloids/*chemical synthesis
    Antineoplastic Agents/*chemical synthesis
    Neuroprotective Agents/*chemical synthesis
    Peptidomimetics/*chemical synthesis
    Quinazolinones/*chemical synthesis
    Alkaloids/pharmacology ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Humans ; Inhibitory Concentration 50 ; Molecular Structure ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/pharmacology ; Peptidomimetics/pharmacology ; Quinazolinones/pharmacology ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Lichen Xanthones as Models for New Antifungal Agents.
    Autorzy:
    Resende DISP; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. .
    Pereira-Terra P; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. .; Laboratory of Microbiology, Department of Aquatic Production, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .
    Inácio ÂS; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. .; Laboratory of Microbiology, Department of Aquatic Production, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .
    Costa PMD; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. .; Laboratory of Microbiology, Department of Aquatic Production, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .
    Pinto E; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. .; Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .
    Sousa E; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. .
    Pinto MMM; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. .; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. .
    Pokaż więcej
    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2018 Oct 12; Vol. 23 (10). Date of Electronic Publication: 2018 Oct 12.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-Infective Agents/*chemical synthesis
    Anti-Infective Agents/*pharmacology
    Lichens/*chemistry
    Xanthones/*chemical synthesis
    Xanthones/*pharmacology
    Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/chemistry ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Enterococcus faecalis/drug effects ; Epidermophyton/drug effects ; Halogenation ; Microbial Sensitivity Tests ; Microsporum/drug effects ; Molecular Structure ; Plant Extracts/chemistry ; Staphylococcus aureus/drug effects ; Trichophyton/drug effects ; Xanthones/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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