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Wyszukujesz frazę ""Retinal Ganglion Cells"" wg kryterium: Temat


Tytuł :
Methylene blue promotes survival and GAP-43 expression of retinal ganglion cells after optic nerve transection.
Autorzy :
Fung JCL; School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address: .
Cho EYP; School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
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Źródło :
Life sciences [Life Sci] 2020 Dec 01; Vol. 262, pp. 118462. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
GAP-43 Protein/*genetics
Methylene Blue/*pharmacology
Neuroprotective Agents/*pharmacology
Optic Nerve Injuries/*drug therapy
Retinal Ganglion Cells/*drug effects
Animals ; Axons ; Cell Survival/drug effects ; Cricetinae ; Disease Models, Animal ; Female ; Intravitreal Injections ; Methylene Blue/administration & dosage ; Nerve Regeneration/drug effects ; Neuroprotective Agents/administration & dosage ; Optic Nerve/drug effects ; Optic Nerve/pathology ; Optic Nerve Injuries/physiopathology ; Retinal Ganglion Cells/cytology ; Time Factors
Czasopismo naukowe
Tytuł :
P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice.
Autorzy :
Romano GL; Biomedical and Biotechnological Sciences Department, University of Catania, Catania, Italy; Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, United States.
Amato R; Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, United States; Department of Biology, University of Pisa, Pisa, Italy.
Lazzara F; Biomedical and Biotechnological Sciences Department, University of Catania, Catania, Italy; Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, United States.
Porciatti V; Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, United States.
Chou TH; Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, United States.
Drago F; Biomedical and Biotechnological Sciences Department, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology - CERFO, University of Catania, Catania, Italy.
Bucolo C; Biomedical and Biotechnological Sciences Department, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology - CERFO, University of Catania, Catania, Italy.
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114199. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Glaucoma/*drug therapy
Glaucoma/*metabolism
Purinergic P2X Receptor Antagonists/*metabolism
Purinergic P2X Receptor Antagonists/*therapeutic use
Receptors, Purinergic P2X7/*metabolism
Retinal Ganglion Cells/*metabolism
Animals ; Electroretinography/methods ; Glaucoma/pathology ; Mice ; Mice, Inbred DBA ; Niacinamide/analogs & derivatives ; Niacinamide/metabolism ; Niacinamide/therapeutic use ; Piperazines/metabolism ; Piperazines/therapeutic use ; Retinal Ganglion Cells/pathology
Czasopismo naukowe
Tytuł :
Arousal Modulates Retinal Output.
Autorzy :
Schröder S; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK. Electronic address: .
Steinmetz NA; UCL Queen Square Institute of Neurology, University College London, London WC1E 6BT, UK.
Krumin M; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK.
Pachitariu M; HHMI Janelia Research Campus, Ashburn, VA 20147, USA.
Rizzi M; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK.
Lagnado L; School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.
Harris KD; UCL Queen Square Institute of Neurology, University College London, London WC1E 6BT, UK.
Carandini M; UCL Institute of Ophthalmology, University College London, London WC1E 6BT, UK.
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Źródło :
Neuron [Neuron] 2020 Aug 05; Vol. 107 (3), pp. 487-495.e9. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arousal/*physiology
Axons/*physiology
Neurons/*physiology
Orientation, Spatial/*physiology
Retinal Ganglion Cells/*physiology
Superior Colliculi/*physiology
Animals ; Axons/metabolism ; Locomotion ; Mice ; Neurons/cytology ; Neurons/metabolism ; Optic Tract ; Presynaptic Terminals/metabolism ; Retinal Ganglion Cells/cytology ; Retinal Ganglion Cells/metabolism ; Superior Colliculi/diagnostic imaging ; Superior Colliculi/metabolism ; Visual Pathways/physiology ; Wakefulness
Czasopismo naukowe
Tytuł :
mTORC1 and mTORC2 expression in inner retinal neurons and glial cells.
Autorzy :
Losiewicz MK; Ophthalmology & Visual Sciences, United States.
Elghazi L; Ophthalmology & Visual Sciences, United States.
Fingar DC; Biological Chemistry, United States.
Rajala RVS; Departments of Ophthalmology and Physiology, University of Oklahoma Health Sciences Center, United States.
Lentz SI; Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, United States.
Fort PE; Ophthalmology & Visual Sciences, United States; Molecular and Integrative Physiology, University of Michigan Medical School, United States.
Abcouwer SF; Ophthalmology & Visual Sciences, United States.
Gardner TW; Ophthalmology & Visual Sciences, United States; Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, United States; Molecular and Integrative Physiology, University of Michigan Medical School, United States. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2020 Aug; Vol. 197, pp. 108131. Date of Electronic Publication: 2020 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Mechanistic Target of Rapamycin Complex 1/*genetics
Mechanistic Target of Rapamycin Complex 2/*genetics
RNA/*genetics
Retinal Diseases/*genetics
Retinal Ganglion Cells/*metabolism
Animals ; Disease Models, Animal ; Humans ; Immunoblotting ; Male ; Mechanistic Target of Rapamycin Complex 1/biosynthesis ; Mechanistic Target of Rapamycin Complex 2/biosynthesis ; Mice ; Mice, Inbred C57BL ; RNA/metabolism ; Rats ; Rats, Sprague-Dawley ; Retinal Diseases/metabolism ; Retinal Diseases/pathology ; Retinal Ganglion Cells/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Viral delivery of multiple miRNAs promotes retinal ganglion cell survival and functional preservation after optic nerve crush injury.
Autorzy :
Mead B; School of Optometry and Vision Sciences, Cardiff University, Cardiff, CF24 4HQ, UK; Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: .
Cullather E; Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Nakaya N; Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Niu Y; Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Kole C; Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Ahmed Z; Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.
Tomarev S; Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2020 Aug; Vol. 197, pp. 108071. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nerve Regeneration*
MicroRNAs/*genetics
Optic Nerve Injuries/*pathology
Retinal Ganglion Cells/*metabolism
Animals ; Cell Survival ; Cells, Cultured ; Disease Models, Animal ; Electroretinography ; Female ; MicroRNAs/metabolism ; Optic Nerve/metabolism ; Optic Nerve/pathology ; Optic Nerve Injuries/metabolism ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/pathology
Czasopismo naukowe
Tytuł :
Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis.
Autorzy :
Lalitha S; Neuro Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram, Kerala, 695 014, India.; Research Centre, The University of Kerala, Thiruvananthapuram, Kerala, 695 014, India.
Basu B; Neuro Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram, Kerala, 695 014, India.; Regional Centre for Biotechnology, Faridabad, Haryana, 121 001, India.
Surya S; Neuro Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram, Kerala, 695 014, India.; Research Centre, The University of Kerala, Thiruvananthapuram, Kerala, 695 014, India.
Meera V; Neuro Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram, Kerala, 695 014, India.; Research Centre, The University of Kerala, Thiruvananthapuram, Kerala, 695 014, India.
Riya PA; Neuro Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram, Kerala, 695 014, India.; Research Centre, The University of Kerala, Thiruvananthapuram, Kerala, 695 014, India.
Parvathy S; Neuro Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram, Kerala, 695 014, India.; Research Centre, The University of Kerala, Thiruvananthapuram, Kerala, 695 014, India.
Das AV; Cancer Biology Programs-12, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695 014, India.
Sivakumar KC; Bioinformatics Facility, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695 014, India.
Nelson-Sathi S; Interdisciplinary Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, 695 014, India.
James J; Neuro Stem Cell Biology Laboratory, Neurobiology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram, Kerala, 695 014, India. .; Research Centre, The University of Kerala, Thiruvananthapuram, Kerala, 695 014, India. .; Regional Centre for Biotechnology, Faridabad, Haryana, 121 001, India. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 30; Vol. 10 (1), pp. 16075. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Axon Fasciculation/*physiology
Axon Guidance/*physiology
PAX6 Transcription Factor/*physiology
Retinal Ganglion Cells/*physiology
Animals ; Axon Fasciculation/genetics ; Axon Guidance/genetics ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Extracellular Matrix/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurogenesis/genetics ; Neurogenesis/physiology ; PAX6 Transcription Factor/deficiency ; PAX6 Transcription Factor/genetics ; Pregnancy ; RNA-Seq ; Receptor, EphB1/genetics ; Receptor, EphB1/physiology ; Retina/embryology ; Retina/growth & development ; Retina/physiology ; Retinal Ganglion Cells/cytology ; Semaphorins/genetics ; Semaphorins/physiology
Czasopismo naukowe
Tytuł :
Histone H2B induces retinal ganglion cell death through toll-like receptor 4 in the vitreous of acute primary angle closure patients.
Autorzy :
Munemasa Y; Department of Ophthalmology, St. Marianna University School of Medicine, 2-16-1 Sugao Miyamae, Kawasaki, Kanagawa, 2168511, Japan. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2020 Aug; Vol. 100 (8), pp. 1080-1089. Date of Electronic Publication: 2020 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Optic Nerve Diseases/*metabolism
Retinal Ganglion Cells/*metabolism
Toll-Like Receptor 4/*metabolism
Vitreous Body/*metabolism
Aged ; Animals ; Cell Death ; Cytokines/genetics ; Cytokines/metabolism ; Female ; Gene Expression Regulation ; Histones/administration & dosage ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Optic Nerve Diseases/genetics ; Optic Nerve Diseases/pathology ; Retina/drug effects ; Retina/metabolism ; Retinal Ganglion Cells/cytology ; Toll-Like Receptor 4/genetics ; Vitreous Body/pathology
Czasopismo naukowe
Tytuł :
Upregulation of heme oxygenase-1 by Brahma-related gene 1 through Nrf2 signaling confers protective effect against high glucose-induced oxidative damage of retinal ganglion cells.
Autorzy :
Sun W; Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China; Department of Ophthalmology, Xi'an No.4 Hospital, Xi'an, 710004, China.
Yu J; Department of Ophthalmology, Xi'an No.4 Hospital, Xi'an, 710004, China.
Kang Q; Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 May 15; Vol. 875, pp. 173038. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Helicases/*metabolism
Diabetic Retinopathy/*pathology
Glucose/*metabolism
Heme Oxygenase (Decyclizing)/*metabolism
NF-E2-Related Factor 2/*metabolism
Retinal Ganglion Cells/*metabolism
Transcription Factors/*metabolism
Animals ; Apoptosis/genetics ; Cell Nucleus/metabolism ; Cells, Cultured ; DNA Helicases/genetics ; Diabetic Retinopathy/blood ; Gene Knockdown Techniques ; Humans ; Oxidative Stress ; Primary Cell Culture ; Rats ; Reactive Oxygen Species/metabolism ; Retinal Ganglion Cells/cytology ; Retinal Ganglion Cells/pathology ; Signal Transduction ; Transcription Factors/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
VEGF is an autocrine/paracrine neuroprotective factor for injured retinal ganglion neurons.
Autorzy :
Froger N; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France. .
Matonti F; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France.; Centre Monticelli Paradis, 433 bis rue Paradis, 13008, Marseille, France.; Aix Marseille Univ, CNRS, INT, Inst Neurosci Timone, 13005, Marseille, France.
Roubeix C; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France.
Forster V; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France.
Ivkovic I; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France.
Brunel N; UMS 29 INSERM Plateforme FluExGen UPMC, 75012, Paris, France.
Baudouin C; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France.; CHNO Des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, 75012, Paris, France.
Sahel JA; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France.; CHNO Des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, 75012, Paris, France.; Fondation Ophtalmologique Adolphe de Rothschild, 75020, Paris, France.; Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Picaud S; Sorbonne Université, INSERM, CNRS, Institut de La Vision, 17 rue Moreau, 75012, Paris, France. .; Fondation Ophtalmologique Adolphe de Rothschild, 75020, Paris, France. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 24; Vol. 10 (1), pp. 12409. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glaucoma/*drug therapy
Retinal Ganglion Cells/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Aged ; Aged, 80 and over ; Animals ; Autocrine Communication/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/drug therapy ; Female ; Glaucoma/etiology ; Glaucoma/pathology ; Humans ; Intravitreal Injections ; Macular Degeneration/complications ; Macular Degeneration/drug therapy ; Macular Edema/complications ; Macular Edema/drug therapy ; Male ; Mesenchymal Stem Cells/metabolism ; Middle Aged ; Paracrine Communication/drug effects ; Primary Cell Culture ; Prospective Studies ; Ranibizumab/administration & dosage ; Rats ; Receptors, Vascular Endothelial Growth Factor/administration & dosage ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/pathology ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor B/genetics ; Vascular Endothelial Growth Factor B/metabolism ; Vascular Endothelial Growth Factor Receptor-1/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-1/metabolism
Czasopismo naukowe
Tytuł :
The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model.
Autorzy :
Deng C; .
Yao K; .
Peng F; .
Zhao B; .
Chen Z; .
Chen W; .
Zhao Y; .
Zhang H; .
Wang J; .
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Jul 01; Vol. 61 (8), pp. 40.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ocular Hypertension*/diagnosis
Ocular Hypertension*/diet therapy
Retinal Ganglion Cells*/drug effects
Retinal Ganglion Cells*/metabolism
Trabecular Meshwork*/drug effects
Trabecular Meshwork*/metabolism
Vitamin K 1*/administration & dosage
Vitamin K 1*/metabolism
Blood Coagulation/*drug effects
Animals ; Calcium-Binding Proteins/metabolism ; Dietary Supplements ; Extracellular Matrix Proteins/metabolism ; Immunohistochemistry ; Neuroprotective Agents ; Rats ; Treatment Outcome ; Vitamins/administration & dosage ; Vitamins/metabolism
Czasopismo naukowe
Tytuł :
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Autorzy :
Fan Y; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China. Electronic address: .
Xing Y; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China.
Xiong L; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China.
Wang J; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, China.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Jun 01; Vol. 324, pp. 109086. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Kelch-Like ECH-Associated Protein 1/*metabolism
NF-E2-Related Factor 2/*metabolism
Nuclear Proteins/*metabolism
Oxidative Stress/*physiology
Retinal Ganglion Cells/*metabolism
Animals ; Antioxidant Response Elements/physiology ; Apoptosis/drug effects ; Down-Regulation ; Hydrogen Peroxide/pharmacology ; Oxidative Stress/drug effects ; Rats ; Retinal Ganglion Cells/drug effects ; Signal Transduction/drug effects ; Up-Regulation
Czasopismo naukowe
Tytuł :
Emerging model systems and treatment approaches for Leber's hereditary optic neuropathy: Challenges and opportunities.
Autorzy :
Bahr T; University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States of America. Electronic address: .
Welburn K; University of the Incarnate Word School of Medicine, 7615 Kennedy Hill Drive, San Antonio, TX 78235, United States of America. Electronic address: .
Donnelly J; University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States of America. Electronic address: .
Bai Y; University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 Jun 01; Vol. 1866 (6), pp. 165743. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA, Mitochondrial/*genetics
Mitochondria/*genetics
Optic Atrophy, Hereditary, Leber/*genetics
Retinal Ganglion Cells/*metabolism
Cells, Cultured ; Humans ; Mitochondria/metabolism ; Mitochondria/pathology ; Models, Biological ; Mutation ; Optic Atrophy, Hereditary, Leber/drug therapy ; Optic Atrophy, Hereditary, Leber/metabolism ; Optic Atrophy, Hereditary, Leber/pathology ; Retinal Ganglion Cells/pathology
Czasopismo naukowe
Tytuł :
Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.
Autorzy :
Fazel MF; Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
Abu IF; Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
Mohamad MHN; Institute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur, Malaysia.
Agarwal R; School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
Iezhitsa I; School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
Bakar NS; Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia.
Juliana N; Faculty of Medicine & Health Sciences, Universiti Sains Islam Malaysia, Indah, Kuala Lumpur, Malaysia.
Mellor IR; School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, United Kingdom.
Franzyk H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
PloS one [PLoS One] 2020 Jul 24; Vol. 15 (7), pp. e0236450. Date of Electronic Publication: 2020 Jul 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuroprotective Agents*/pharmacology
Neuroprotective Agents*/therapeutic use
Phenols*/pharmacology
Phenols*/therapeutic use
Polyamines*/pharmacology
Polyamines*/therapeutic use
Optic Nerve/*drug effects
Optic Nerve Injuries/*drug therapy
Retinal Ganglion Cells/*drug effects
Animals ; Male ; N-Methylaspartate/toxicity ; Optic Nerve/pathology ; Optic Nerve Injuries/chemically induced ; Rats ; Rats, Sprague-Dawley ; Retinal Ganglion Cells/pathology ; Vision, Ocular/drug effects
Czasopismo naukowe
Tytuł :
Differential Responses to High-Frequency Electrical Stimulation in Brisk-Transient and Delta Retinal Ganglion Cells.
Autorzy :
Hadjinicolaou AE
Werginz P
Lee JI
Fried SI
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Źródło :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2020 Jul; Vol. 2020, pp. 3529-3532.
Typ publikacji :
Journal Article
MeSH Terms :
Retinal Degeneration*
Retinal Ganglion Cells*
Action Potentials ; Electric Stimulation ; Humans ; Retina
Czasopismo naukowe
Tytuł :
Towards Controlling Functionally-Distinct Retinal Ganglion Cells In Degenerate Retina.
Autorzy :
Muralidharan M
Guo T
Shivdasani MN
Tsai D
Fried S
Cameron M
Morley JW
Dokos S
Lovell NH
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Źródło :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2020 Jul; Vol. 2020, pp. 3598-3601.
Typ publikacji :
Journal Article
MeSH Terms :
Retina*
Retinal Ganglion Cells*
Electric Stimulation ; Humans ; Neural Pathways
Czasopismo naukowe
Tytuł :
Neuroprotective effects of topical coenzyme Q10 + vitamin E in mechanic optic nerve injury model.
Autorzy :
Ekicier Acar S; Eye Clinic, Ankara Kecioren Training and Research Hospital, Ankara, Turkey.
Sarıcaoğlu MS; Eye Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Çolak A; Pathology Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Aktaş Z; Department of Ophthalmology, Gazi University Faculty of Medicine, Ankara, Turkey.
Sepici Dinçel A; Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
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Źródło :
European journal of ophthalmology [Eur J Ophthalmol] 2020 Jul; Vol. 30 (4), pp. 714-722. Date of Electronic Publication: 2019 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Glaucoma/*drug therapy
Neuroprotective Agents/*therapeutic use
Optic Nerve Injuries/*drug therapy
Retinal Ganglion Cells/*drug effects
Ubiquinone/*analogs & derivatives
Vitamin E/*therapeutic use
Administration, Ophthalmic ; Animals ; Blotting, Western ; Calcium-Binding Proteins/metabolism ; Disease Models, Animal ; Drug Combinations ; Glaucoma/metabolism ; Glial Fibrillary Acidic Protein/metabolism ; Immunohistochemistry ; Male ; Microfilament Proteins/metabolism ; Ophthalmic Solutions ; Optic Nerve Injuries/metabolism ; Rats ; Rats, Wistar ; Retinal Ganglion Cells/metabolism ; Transcription Factor Brn-3A/metabolism ; Ubiquinone/therapeutic use ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Morphological multivariate cluster analysis of murine retinal ganglion cells selectively expressing yellow fluorescent protein.
Autorzy :
Iaboni DSM; Retina and Optic Nerve Research Laboratory, Dalhousie University, Sir Charles Tupper Medical Building 5850 College Street, B3H 4R2, Halifax, Nova Scotia, Canada; Dalhousie Medical School, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building 5850 College Street, B3H 4R2, Halifax, Nova Scotia, Canada.
Farrell SR; Retina and Optic Nerve Research Laboratory, Dalhousie University, Sir Charles Tupper Medical Building 5850 College Street, B3H 4R2, Halifax, Nova Scotia, Canada; Department of Medical Neuroscience, Dalhousie University, Sir Charles Tupper Medical Building 5850 College Street, B3H 4R2, Halifax, Nova Scotia, Canada; Nova Scotia Health Authority, 1276 South Park Street, 2W Victoria, B3H 2Y9, Halifax, Nova Scotia, Canada.
Chauhan BC; Retina and Optic Nerve Research Laboratory, Dalhousie University, Sir Charles Tupper Medical Building 5850 College Street, B3H 4R2, Halifax, Nova Scotia, Canada; Department of Medical Neuroscience, Dalhousie University, Sir Charles Tupper Medical Building 5850 College Street, B3H 4R2, Halifax, Nova Scotia, Canada; Nova Scotia Health Authority, 1276 South Park Street, 2W Victoria, B3H 2Y9, Halifax, Nova Scotia, Canada; Department of Physiology and Biophysics, Dalhousie University, Sir Charles Tupper Medical Building 5850 College Street, B3H 4R2, Halifax, Nova Scotia, Canada; Department of Ophthalmology and Visual Sciences, Dalhousie University, 1276 South Park Street, 2W Victoria, B3H 2Y9, Halifax, Nova Scotia, Canada. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2020 Jul; Vol. 196, pp. 108044. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Luminescent Proteins/*metabolism
Retinal Ganglion Cells/*cytology
Thy-1 Antigens/*metabolism
Animals ; Cell Count ; Cell Line ; Cluster Analysis ; Female ; Male ; Mice ; Mice, Transgenic ; Microscopy, Confocal ; Microscopy, Fluorescence ; Multivariate Analysis ; Retinal Ganglion Cells/metabolism
Czasopismo naukowe
Tytuł :
Responsiveness of Retinal Ganglion Cells Through Frequency Modulation of Electrical Stimulation: A Computational Modeling Study
Autorzy :
Paknahad J
Loizos K
Humayun M
Lazzi G
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Źródło :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2020 Jul; Vol. 2020, pp. 3393-3398.
Typ publikacji :
Journal Article
MeSH Terms :
Retinal Degeneration*
Retinal Ganglion Cells*
Electric Stimulation ; Humans ; Retina
Czasopismo naukowe
Tytuł :
Opa1 Deficiency Leads to Diminished Mitochondrial Bioenergetics With Compensatory Increased Mitochondrial Motility.
Autorzy :
Sun S; .
Erchova I; .
Sengpiel F; .; .
Votruba M; .; .
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Jun 03; Vol. 61 (6), pp. 42.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism*
Mutation*
GTP Phosphohydrolases/*deficiency
Mitochondria/*metabolism
Optic Atrophy, Autosomal Dominant/*genetics
Retinal Ganglion Cells/*metabolism
Animals ; Blotting, Western ; Cells, Cultured ; Disease Models, Animal ; GTP Phosphohydrolases/metabolism ; Mice ; Mice, Inbred C57BL ; Optic Atrophy, Autosomal Dominant/metabolism ; Optic Atrophy, Autosomal Dominant/pathology ; Retinal Ganglion Cells/pathology
Czasopismo naukowe

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