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    Wyświetlanie 1-5 z 5
    Tytuł:
    A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus.
    Autorzy:
    Choi H; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Kudchodkar SB; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Ho M; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Reuschel EL; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Reynolds E; Department of Microbiology and Immunology, SUNY Center for Environmental Health and Medicine, SUNY Upstate Medical University, Syracuse, New York, United States of America.
    Xu Z; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Bordoloi D; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Ugen KE; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America.
    Tebas P; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
    Kim J; R&D, Inovio Pharmaceuticals, Plymouth Meeting, Pennsylvania, United States of America.
    Abdel-Mohsen M; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Thangamani S; Department of Microbiology and Immunology, SUNY Center for Environmental Health and Medicine, SUNY Upstate Medical University, Syracuse, New York, United States of America.
    Weiner DB; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
    Muthumani K; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
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    Źródło:
    PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Oct 29; Vol. 14 (10), pp. e0008788. Date of Electronic Publication: 2020 Oct 29 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Encephalitis Viruses, Tick-Borne/*immunology
    Encephalitis, Tick-Borne/*immunology
    Vaccines, DNA/*immunology
    Viral Vaccines/*immunology
    Animals ; Antibodies, Viral/immunology ; Encephalitis Viruses, Tick-Borne/genetics ; Encephalitis, Tick-Borne/prevention & control ; Encephalitis, Tick-Borne/virology ; Female ; Humans ; Immunity ; Immunization ; Mice ; Mice, Inbred C57BL ; Vaccines, DNA/administration & dosage ; Vaccines, DNA/chemical synthesis ; Vaccines, DNA/genetics ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Protective immunity by an engineered DNA vaccine for Mayaro virus.
    Autorzy:
    Choi H; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Kudchodkar SB; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Reuschel EL; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Asija K; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Borole P; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Ho M; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Wojtak K; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Reed C; Inovio Pharmaceuticals, Plymouth Meeting, PA, United States of America.
    Ramos S; Inovio Pharmaceuticals, Plymouth Meeting, PA, United States of America.
    Bopp NE; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, United States of America.
    Aguilar PV; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, United States of America.; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX, United States of America.
    Weaver SC; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America.; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, United States of America.; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX, United States of America.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States of America.
    Kim JJ; Inovio Pharmaceuticals, Plymouth Meeting, PA, United States of America.
    Humeau L; Inovio Pharmaceuticals, Plymouth Meeting, PA, United States of America.
    Tebas P; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
    Weiner DB; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
    Muthumani K; Vaccine & Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States of America.
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    Źródło:
    PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2019 Feb 07; Vol. 13 (2), pp. e0007042. Date of Electronic Publication: 2019 Feb 07 (Print Publication: 2019).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Communicable Diseases, Emerging/*prevention & control
    Togaviridae/*classification
    Togaviridae Infections/*prevention & control
    Viral Vaccines/*immunology
    Adoptive Transfer ; Animals ; Cell Survival ; Chlorocebus aethiops ; Communicable Diseases, Emerging/virology ; Female ; Genetic Engineering ; HEK293 Cells ; Humans ; Macrophages ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptor, Interferon alpha-beta/genetics ; Spleen/cytology ; Vaccines, DNA/immunology ; Vero Cells
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
    Autorzy:
    Finkel TH; Division of Rheumatology, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA. .; Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, Philadelphia, PA, USA. .; Present Address: Department of Pediatrics, Nemours Research Institute, Nemours Children's Hospital, 32827, Orlando, FL, USA. .
    Li J; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Wei Z; Department of Computer Science, New Jersey Institute of Technology, 07102, New Jersey, NJ, USA.
    Wang W; Department of Computer Science, New Jersey Institute of Technology, 07102, New Jersey, NJ, USA.
    Zhang H; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Behrens EM; Division of Rheumatology, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.; Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, Philadelphia, PA, USA.
    Reuschel EL; Division of Rheumatology, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.; Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, Philadelphia, PA, USA.
    Limou S; Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research Inc., Frederick National Laboratory, 21702, Frederick, MD, USA.
    Wise C; Sarah M. and Charles E. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, 75219, Dallas, TX, USA.
    Punaro M; Division of Rheumatology, Texas Scottish Rite Hospital, 75219, Dallas, TX, USA.
    Becker ML; Division of Rheumatology, Children's Mercy- Kansas City, 64108, Kansas City, MO, USA.
    Munro JE; Murdoch Childrens Research Institute, 3052, Parkville, VIC, Australia.; Paediatric Rheumatology Unit, Royal Children's Hospital, 3052, Parkville, VIC, Australia.
    Flatø B; Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Norway.
    Førre Ø; Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Norway.
    Thompson SD; Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA.
    Langefeld CD; Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, 27157, Winston-Salem, NC, USA.
    Glass DN; Cincinnati Children's Hospital Medical Center, 45229, Cincinnati, OH, USA.
    Glessner JT; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Kim CE; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Frackelton E; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Shivers DK; Division of Rheumatology, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Thomas KA; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Chiavacci RM; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Hou C; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Xu K; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Snyder J; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Qiu H; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Mentch F; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.
    Wang K; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA.; Department of Psychiatry and Behavioral Sciences, UUniversity of Southern California, 90089, Los Angeles, CA, USA.
    Winkler CA; Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research Inc., Frederick National Laboratory, 21702, Frederick, MD, USA.
    Lie BA; Institute of Immunology, Oslo University Hospital, 0027, Rikshospitalet, Oslo, Norway.
    Ellis JA; Murdoch Childrens Research Institute, 3052, Parkville, VIC, Australia.; Department of Paediatrics, University of Melbourne, 3010, Melbourne, Australia.
    Hakonarson H; Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, Philadelphia, PA, USA. .; The Center for Applied Genomics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA. .; Division of Human Genetics, The Children's Hospital of Philadelphia, 19104, Philadelphia, PA, USA. .
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    Źródło:
    BMC medical genetics [BMC Med Genet] 2016 Mar 22; Vol. 17, pp. 24. Date of Electronic Publication: 2016 Mar 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
    MeSH Terms:
    Genetic Predisposition to Disease*
    Arthritis, Juvenile/*genetics
    Receptors, CXCR4/*genetics
    Adolescent ; Amino Acid Sequence ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Genetic Loci ; Genome-Wide Association Study ; Genotyping Techniques ; Humans ; Male ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Principal Component Analysis ; Sequence Analysis, DNA ; White People/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    REDD1 Is Essential for Optimal T Cell Proliferation and Survival.
    Autorzy:
    Reuschel EL; Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
    Wang J; Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
    Shivers DK; Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
    Muthumani K; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
    Weiner DB; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
    Ma Z; Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
    Finkel TH; Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
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    Źródło:
    PloS one [PLoS One] 2015 Aug 24; Vol. 10 (8), pp. e0136323. Date of Electronic Publication: 2015 Aug 24 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Autophagy/*genetics
    Cell Proliferation/*genetics
    Cell Survival/*genetics
    Transcription Factors/*genetics
    Animals ; Autophagy/drug effects ; Cell Proliferation/drug effects ; DNA Damage/genetics ; Dexamethasone/administration & dosage ; Mice ; Mice, Knockout ; T-Lymphocytes/metabolism ; Thymocytes/metabolism ; Thymocytes/pathology ; Transcription Factors/metabolism ; Transcriptional Activation/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model.
    Autorzy:
    Yan J; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Tingey C; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Lyde R; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Gorham TC; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Choo DK; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Muthumani A; 1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA [2] Cherry Hill High School East, Cherry Hill, NJ, USA.
    Myles D; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Weiner LP; Department of Nutritional Sciences, Rutgers, The State University of New Jersey-New Brunswick, New Brunswick, NJ, USA.
    Kraynyak KA; Inovio Pharmaceutics, Blue Bell, PA, USA.
    Reuschel EL; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Finkel TH; Department of Pediatrics and Nemours Research Institute, Nemours Children's Hospital, Orlando, FL, USA.
    Kim JJ; Inovio Pharmaceutics, Blue Bell, PA, USA.
    Sardesai NY; Inovio Pharmaceutics, Blue Bell, PA, USA.
    Ugen KE; Department of Molecular Medicine and Center for Molecular Delivery, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
    Muthumani K; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Weiner DB; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
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    Źródło:
    Cancer gene therapy [Cancer Gene Ther] 2014 Dec; Vol. 21 (12), pp. 507-17. Date of Electronic Publication: 2014 Nov 14.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cancer Vaccines/*immunology
    Melanoma/*immunology
    Melanoma/*therapy
    Monophenol Monooxygenase/*immunology
    Myeloid Cells/*immunology
    Vaccines, DNA/*immunology
    Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cancer Vaccines/administration & dosage ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunization ; Immunomodulation ; Melanoma/genetics ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/prevention & control ; Melanoma, Experimental ; Mice ; Monophenol Monooxygenase/antagonists & inhibitors ; Monophenol Monooxygenase/genetics ; Myeloid Cells/metabolism ; T-Cell Antigen Receptor Specificity ; Tumor Burden/immunology ; Tumor Microenvironment ; Vaccines, DNA/administration & dosage
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-5 z 5

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