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Tytuł :
Pharmacodynamics of efavirenz 400 mg in treatment-naïve Chinese HIV-infected patients in a prospective cohort study.
Autorzy :
Xu L; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Peng W; Department of Pharmacy and Pharmacology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Song X; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Li Y; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Han Y; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Zhu T; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Fu Q; Department of Pharmacy and Pharmacology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Du X; Department of Pharmacy and Pharmacology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Cao W; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Li T; Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. .; Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China. .; Tsinghua University Medical College, Beijing, China. .
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2021 Jan 23; Vol. 21 (1), pp. 112. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*pharmacokinetics
Anti-HIV Agents/*pharmacokinetics
Benzoxazines/*pharmacokinetics
Cyclopropanes/*pharmacokinetics
HIV Infections/*drug therapy
HIV-1/*drug effects
Reverse Transcriptase Inhibitors/*pharmacokinetics
Adult ; Alkynes/administration & dosage ; Alkynes/adverse effects ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Benzoxazines/administration & dosage ; Benzoxazines/adverse effects ; CD4 Lymphocyte Count ; China ; Cyclopropanes/administration & dosage ; Cyclopropanes/adverse effects ; Drug Therapy, Combination ; Female ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Male ; Prospective Studies ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/adverse effects ; Treatment Outcome ; Viral Load/drug effects
Czasopismo naukowe
Tytuł :
Alkylated benzimidazoles: Design, synthesis, docking, DFT analysis, ADMET property, molecular dynamics and activity against HIV and YFV.
Autorzy :
Srivastava R; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002, India.
Gupta SK; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002, India.
Naaz F; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002, India.
Sen Gupta PS; Department of Chemical Sciences, Indian Institute of Science Education and Research Berhampur, Odisha 760010, India.
Yadav M; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002, India.
Singh VK; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002, India.
Singh A; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002, India.
Rana MK; Department of Chemical Sciences, Indian Institute of Science Education and Research Berhampur, Odisha 760010, India.
Gupta SK; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Schols D; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Singh RK; Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad, 211002, India. Electronic address: .
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Źródło :
Computational biology and chemistry [Comput Biol Chem] 2020 Dec; Vol. 89, pp. 107400. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Benzimidazoles/*pharmacology
HIV/*drug effects
Reverse Transcriptase Inhibitors/*pharmacology
Yellow fever virus/*drug effects
Animals ; Benzimidazoles/chemical synthesis ; Benzimidazoles/pharmacokinetics ; Catalytic Domain ; Chlorocebus aethiops ; Density Functional Theory ; HIV/enzymology ; HIV Reverse Transcriptase/chemistry ; HIV Reverse Transcriptase/metabolism ; Microbial Sensitivity Tests ; Models, Chemical ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Reverse Transcriptase Inhibitors/chemical synthesis ; Reverse Transcriptase Inhibitors/pharmacokinetics ; Structure-Activity Relationship ; Vero Cells ; Yellow fever virus/enzymology
Czasopismo naukowe
Tytuł :
2'-fluoro-modified pyrimidines enhance affinity of RNA oligonucleotides to HIV-1 reverse transcriptase.
Autorzy :
Gruenke PR; Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA.; Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA.
Alam KK; Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA.; Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA.
Singh K; Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA.; Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri 65211, USA.
Burke DH; Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA.; Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA.; Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, Missouri 65211, USA.; Department of Biological Engineering, University of Missouri, Columbia, Missouri 65211, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Nov; Vol. 26 (11), pp. 1667-1679. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aptamers, Nucleotide/*chemical synthesis
HIV Reverse Transcriptase/*antagonists & inhibitors
HIV-1/*enzymology
Pyridines/*chemistry
Reverse Transcriptase Inhibitors/*chemical synthesis
Aptamers, Nucleotide/chemistry ; Aptamers, Nucleotide/pharmacology ; Drug Evaluation, Preclinical ; Gene Library ; HIV-1/drug effects ; High-Throughput Nucleotide Sequencing ; Humans ; Nucleic Acid Conformation ; Reverse Transcriptase Inhibitors/chemistry ; Reverse Transcriptase Inhibitors/pharmacology ; SELEX Aptamer Technique
Czasopismo naukowe
Tytuł :
Membrane Permeable, Bioreversibly Modified Prodrugs of Nucleoside Diphosphate-γ-Phosphonates.
Autorzy :
Jia X; Organic Chemistry, Department of Chemistry, Faculty of Mathematics, Informatics and Natural Sciences, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
Weber S; Organic Chemistry, Department of Chemistry, Faculty of Mathematics, Informatics and Natural Sciences, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
Schols D; Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Meier C; Organic Chemistry, Department of Chemistry, Faculty of Mathematics, Informatics and Natural Sciences, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11990-12007. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
HIV Reverse Transcriptase/*antagonists & inhibitors
HIV-1/*drug effects
Prodrugs/*pharmacology
Reverse Transcriptase Inhibitors/*pharmacology
Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Cell Line ; Cell Membrane Permeability/drug effects ; Diphosphates/chemical synthesis ; Diphosphates/chemistry ; Diphosphates/pharmacology ; Dose-Response Relationship, Drug ; HIV Reverse Transcriptase/metabolism ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Nucleosides/chemical synthesis ; Nucleosides/chemistry ; Nucleosides/pharmacology ; Organophosphonates/chemical synthesis ; Organophosphonates/chemistry ; Organophosphonates/pharmacology ; Prodrugs/chemical synthesis ; Prodrugs/chemistry ; Reverse Transcriptase Inhibitors/chemical synthesis ; Reverse Transcriptase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
High nonnucleoside reverse transcriptase inhibitor resistance levels in HIV-1-infected Zambian mother-infant pairs.
Autorzy :
Bennett SJ; Nebraska Center for Virology.; School of Biological Sciences.
Chunda-Liyoka C; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.
Poppe LK; Nebraska Center for Virology.; School of Biological Sciences.
Meinders K; Nebraska Center for Virology.; School of Biological Sciences.
Chileshe C; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.
West JT; Nebraska Center for Virology.; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Wood C; Nebraska Center for Virology.; School of Biological Sciences.; Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
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Źródło :
AIDS (London, England) [AIDS] 2020 Oct 01; Vol. 34 (12), pp. 1833-1842.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
HIV Infections*/drug therapy
HIV Infections*/epidemiology
HIV Infections*/transmission
HIV-1*/drug effects
HIV-1*/genetics
Anti-HIV Agents/*therapeutic use
Reverse Transcriptase Inhibitors/*therapeutic use
Anti-HIV Agents/pharmacology ; Child ; Child, Preschool ; Drug Resistance, Viral ; Female ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Male ; Mothers ; Mutation/drug effects ; Reverse Transcriptase Inhibitors/pharmacology ; Zambia/epidemiology
Czasopismo naukowe
Tytuł :
Pharmacokinetics of nucleoside/nucleotide reverse transcriptase inhibitors for the treatment and prevention of HIV infection.
Autorzy :
Wonganan P; Department of Pharmacology, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.
Limpanasithikul W; Department of Pharmacology, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.
Jianmongkol S; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University , Bangkok, Thailand.
Kerr SJ; Biostatistics Excellence Centre, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.; HIV-NAT, Thai Red Cross AIDS Research Centre , Bangkok, Thailand.
Ruxrungtham K; HIV-NAT, Thai Red Cross AIDS Research Centre , Bangkok, Thailand.; Department of Medicine, Faculty of Medicine, Chulalongkorn University , Bangkok, Thailand.
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Źródło :
Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2020 Jul; Vol. 16 (7), pp. 551-564. Date of Electronic Publication: 2020 Jun 07.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-HIV Agents/*administration & dosage
HIV Infections/*drug therapy
Reverse Transcriptase Inhibitors/*administration & dosage
Anti-HIV Agents/adverse effects ; Anti-HIV Agents/pharmacokinetics ; Coinfection ; Drug Therapy, Combination ; HIV Infections/virology ; Hepatitis B/epidemiology ; Humans ; Pre-Exposure Prophylaxis/methods ; Reverse Transcriptase Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/pharmacokinetics
Czasopismo naukowe
Tytuł :
HIV-1 re-suppression on a first-line regimen despite the presence of phenotypic drug resistance.
Autorzy :
Basson AE; Centre for HIV and STIs, National Institute for Communicable Diseases of The National Health Laboratory Services, Johannesburg, Gauteng, South Africa.; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
Charalambous S; The Aurum Institute, Johannesburg, Gauteng, South Africa.; School of Public Health, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg, Gauteng, South Africa.
Hoffmann CJ; The Aurum Institute, Johannesburg, Gauteng, South Africa.; Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America.
Morris L; Centre for HIV and STIs, National Institute for Communicable Diseases of The National Health Laboratory Services, Johannesburg, Gauteng, South Africa.; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
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Źródło :
PloS one [PLoS One] 2020 Jun 18; Vol. 15 (6), pp. e0234937. Date of Electronic Publication: 2020 Jun 18 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents*/pharmacology
Anti-HIV Agents*/therapeutic use
Drug Resistance, Viral*/drug effects
Drug Resistance, Viral*/genetics
HIV Infections*/drug therapy
HIV Infections*/virology
HIV-1*/drug effects
HIV-1*/genetics
Reverse Transcriptase Inhibitors*/pharmacology
Reverse Transcriptase Inhibitors*/therapeutic use
Viral Load/*drug effects
Adult ; Cohort Studies ; Genotype ; Humans ; Male ; Phenotype
Czasopismo naukowe
Tytuł :
Development of a pseudovirus assay and evaluation to screen natural products for inhibition of HIV-1 subtype C reverse transcriptase.
Autorzy :
Mavhandu LG; HIV/AIDS & Global Health Research Programme, University of Venda, PMB X5050, Thohoyandou, 0950, South Africa. Electronic address: .
Cheng H; Myles H. Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, P.O. Box 800734, Charlottesville, VA, 22908, USA; Shanghai Municipal Center for Disease Control and Prevention, Department of HIV, STD and Leprosy, 1380 Zhongshan Road, Shanghai, 200336, China. Electronic address: .
Bor YC; Myles H. Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, P.O. Box 800734, Charlottesville, VA, 22908, USA; Ambassadors for Christ, 21 Ambassador Drive, Paradise, PA, 17562, USA. Electronic address: .
Tebit DM; HIV/AIDS & Global Health Research Programme, University of Venda, PMB X5050, Thohoyandou, 0950, South Africa; Myles H. Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, P.O. Box 800734, Charlottesville, VA, 22908, USA; Global Biomed Scientific LLC, PO Box 2368, Forest, VA, 24551, USA. Electronic address: .
Hammarskjold ML; HIV/AIDS & Global Health Research Programme, University of Venda, PMB X5050, Thohoyandou, 0950, South Africa; Myles H. Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, P.O. Box 800734, Charlottesville, VA, 22908, USA. Electronic address: .
Rekosh D; HIV/AIDS & Global Health Research Programme, University of Venda, PMB X5050, Thohoyandou, 0950, South Africa; Myles H. Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology, Immunology and Cancer Biology, University of Virginia, P.O. Box 800734, Charlottesville, VA, 22908, USA. Electronic address: .
Bessong PO; HIV/AIDS & Global Health Research Programme, University of Venda, PMB X5050, Thohoyandou, 0950, South Africa. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Aug 10; Vol. 258, pp. 112931. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-HIV Agents/*pharmacology
HIV Reverse Transcriptase/*antagonists & inhibitors
HIV-1/*drug effects
Plant Preparations/*pharmacology
Reverse Transcriptase Inhibitors/*pharmacology
Anti-HIV Agents/administration & dosage ; Dose-Response Relationship, Drug ; HEK293 Cells ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV-1/enzymology ; Humans ; Inhibitory Concentration 50 ; Nevirapine/administration & dosage ; Nevirapine/pharmacology ; Plant Preparations/administration & dosage ; Plants, Medicinal/chemistry ; Reproducibility of Results ; Reverse Transcriptase Inhibitors/administration & dosage ; Zidovudine/administration & dosage ; Zidovudine/pharmacology
Czasopismo naukowe
Tytuł :
A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration.
Autorzy :
Narendran S; .; .; .
Pereira F; .; .
Yerramothu P; .; .
Apicella I; .; .
Wang SB; .; .
Varshney A; .; .
Baker KL; .
Marion KM; .
Ambati M; .; .; .
Ambati VL; .
Ambati K; .; .
Sadda SR; .; .
Gelfand BD; .; .; .
Ambati J; .; .; .; .; .
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Aug 03; Vol. 61 (10), pp. 4.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Choroidal Neovascularization/*drug therapy
Geographic Atrophy/*drug therapy
Retinal Pigment Epithelium/*drug effects
Reverse Transcriptase Inhibitors/*therapeutic use
Zidovudine/*analogs & derivatives
Animals ; Blotting, Western ; Caspase 1/metabolism ; Choroidal Neovascularization/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Geographic Atrophy/metabolism ; Interleukin-1beta/metabolism ; Intravitreal Injections ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Reverse Transcriptase Inhibitors/administration & dosage ; Zidovudine/administration & dosage ; Zidovudine/therapeutic use ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.
Autorzy :
Inzaule SC; HIV/Hepatitis/STI Department, World Health Organization, Geneva, Switzerland.
Jordan MR; Tufts University School of Medicine, Boston, USA.
Bello G; Ministry of Health, Lilingwe, Malawi.
Wadonda-Kabondo N; Centers for Disease Control & Prevention, Lilongwe, Malawi.
Mounerou S; Faculty of Health Sciences, Molecular Biology Laboratory, University of Lomé, Lomé, Togo.
Mbulli IA; Global Health Systems Solutions, Douala, Cameroon.
Akanmu SA; Department of Haematology and Blood Transfusion, Lagos University Teaching Hospital, and College of Medicine of the University of Lagos, Lagos, Nigeria.
Vubil A; Instituto Nacional de Saúde, Maputo, Mozambique.
Hunt G; National Institute for Communicable Diseases, Johannesburg, South Africa.
Kaleebu P; Uganda Virus Research Institute, Entebbe, Uganda.
Mthethwa-Hleza S; Ministry of Health Eswatini, Mbabane, Eswatini.
Dzangare J; Ministry of Health and Child Care, Harare, Zimbabwe.
Njukeng P; Global Health Systems Solutions, Douala, Cameroon.
Penazzato M; HIV/Hepatitis/STI Department, World Health Organization, Geneva, Switzerland.
Rinke de Wit TF; Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam UMC, University of Amsterdam, The Netherlands.
Eshleman SH; Johns Hopkins University. School of Medicine, Baltimore, Maryland, USA.
Bertagnolio S; HIV/Hepatitis/STI Department, World Health Organization, Geneva, Switzerland.
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Corporate Authors :
Infant HIV Drug Resistance Survey Team
Źródło :
AIDS (London, England) [AIDS] 2020 Aug 01; Vol. 34 (10), pp. 1567-1570.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents*/therapeutic use
Drug Resistance, Viral*
HIV Infections*/drug therapy
Reverse Transcriptase Inhibitors*/therapeutic use
Infectious Disease Transmission, Vertical/*prevention & control
Africa South of the Sahara ; Female ; Humans ; Infant
Czasopismo naukowe
Tytuł :
A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial.
Autorzy :
Iwuji CC; Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, BN1 9PX, UK. .; Brighton and Sussex University Hospitals NHS Trust, Brighton, UK. .
Churchill D; Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.
Bremner S; Department of Primary Care and Public Health, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
Perry N; Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.
To Y; Brighton & Sussex Clinical Trials Unit, University of Sussex, Brighton, UK.
Lambert D; Brighton & Sussex Clinical Trials Unit, University of Sussex, Brighton, UK.
Bruce C; Brighton & Sussex Clinical Trials Unit, University of Sussex, Brighton, UK.
Waters L; The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, UK.
Orkin C; Barts Health NHS Trust, London, UK.; Queen Mary University of London, London, UK.
Geretti AM; Institute of Infection, University of Liverpool, Liverpool, UK.
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2020 Jul 20; Vol. 20 (1), pp. 524. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Clinical Trial, Phase IV; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Adenine/*analogs & derivatives
Drug Resistance, Viral/*genetics
Emtricitabine/*therapeutic use
HIV Infections/*drug therapy
HIV Integrase Inhibitors/*therapeutic use
HIV-1/*drug effects
Heterocyclic Compounds, 4 or More Rings/*therapeutic use
Protease Inhibitors/*therapeutic use
Reverse Transcriptase Inhibitors/*therapeutic use
Adenine/therapeutic use ; Adult ; Drug Combinations ; Emtricitabine/adverse effects ; Female ; HIV Infections/genetics ; HIV Infections/virology ; HIV Integrase Inhibitors/adverse effects ; Heterocyclic Compounds, 4 or More Rings/adverse effects ; Humans ; Male ; Mutation ; Pilot Projects ; Prospective Studies ; Protease Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Proximal renal tubular function in HIV-infected children on tenofovir disoproxil fumarate for treatment of HIV infection at two tertiary hospitals in Harare, Zimbabwe.
Autorzy :
Mashingaidze-Mano R; Department of Paediatrics, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Bwakura-Dangarembizi MF; Department of Paediatrics, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Maponga CC; School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.; Center for Integrated Global Biomedical Sciences, University at Buffalo, New York, United States of America.; International Pharmacotherapy Education and Research Initiative, Harare, Zimbabwe.
Morse GD; Center for Integrated Global Biomedical Sciences, University at Buffalo, New York, United States of America.
Monera-Penduka TG; School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Mtisi TJ; Department of Clinical Pharmacology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Mudzviti T; School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.; International Pharmacotherapy Education and Research Initiative, Harare, Zimbabwe.; Newlands Clinic, Highlands, Harare, Zimbabwe.
Mujuru HA; Department of Paediatrics, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
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Źródło :
PloS one [PLoS One] 2020 Jul 07; Vol. 15 (7), pp. e0235759. Date of Electronic Publication: 2020 Jul 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anti-HIV Agents/*therapeutic use
Fanconi Syndrome/*etiology
HIV Infections/*complications
Reverse Transcriptase Inhibitors/*therapeutic use
Tenofovir/*therapeutic use
Adolescent ; Anti-HIV Agents/adverse effects ; Child ; Cross-Sectional Studies ; Fanconi Syndrome/chemically induced ; Female ; Glomerular Filtration Rate ; HIV Infections/drug therapy ; Humans ; Male ; Proteinuria/etiology ; Reverse Transcriptase Inhibitors/adverse effects ; Tenofovir/adverse effects ; Tertiary Care Centers ; Zimbabwe
Czasopismo naukowe
Tytuł :
Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.
Autorzy :
Yuan D; Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, China.
Liu M; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Jia P; Department of Land Surveying and Geo-Informatics, The Hong Kong Polytechnic University, Hong Kong, China.; International Initiative on Spatial Lifecourse Epidemiology (ISLE), Hong Kong, China.
Li Y; Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, China.
Huang Y; Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, China.
Ye L; Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, China.
Api L; Butuo Center for Disease Control and Prevention, Butuo, China.
Chen M; Liangshan Center for Disease Control and Prevention, Xichang, China.
Yao L; Butuo County People's Hospital, Butuo, China.
Wang Z; Centre for Health Behaviours Research, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
Liu H; Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, China.
Liang S; Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, China. .
Yang S; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. .; International Initiative on Spatial Lifecourse Epidemiology (ISLE), Hong Kong, China. .
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2020 Jun 23; Vol. 20 (1), pp. 443. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Variation*
Minority Groups*
Acquired Immunodeficiency Syndrome/*drug therapy
Acquired Immunodeficiency Syndrome/*epidemiology
Anti-HIV Agents/*therapeutic use
Drug Resistance, Viral/*genetics
HIV-1/*genetics
Reverse Transcriptase Inhibitors/*therapeutic use
Acquired Immunodeficiency Syndrome/blood ; Acquired Immunodeficiency Syndrome/transmission ; Adolescent ; Adult ; Anti-HIV Agents/adverse effects ; China/epidemiology ; Female ; Genes, pol ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; Male ; Mutation ; Prevalence ; Reverse Transcriptase Inhibitors/adverse effects ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors.
Autorzy :
Forezi LDSM; Laboratório LNHC, Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus Valonguinho, 24020-150, Niterói-RJ, Brazil.
Ribeiro MMJ; Laboratório de Modelagem Molecular e QSAR (ModMolQSAR), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Marttorelli A; Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil; National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil.
Abrantes JL; Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil; National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil.
Rodrigues CR; Laboratório de Modelagem Molecular e QSAR (ModMolQSAR), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Castro HC; Laboratório de Antibióticos, Bioquímica, Ensino e Modelagem Molecular (LABiEMol), Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Souza TML; Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil; National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil.
Boechat FDCS; Laboratório LNHC, Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus Valonguinho, 24020-150, Niterói-RJ, Brazil.
de Souza AMT; Laboratório de Modelagem Molecular e QSAR (ModMolQSAR), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: .
de Souza MCBV; Laboratório LNHC, Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus Valonguinho, 24020-150, Niterói-RJ, Brazil. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 May 15; Vol. 194, pp. 112255. Date of Electronic Publication: 2020 Mar 20.
Typ publikacji :
Journal Article
MeSH Terms :
4-Quinolones/*pharmacology
Anti-HIV Agents/*pharmacology
HIV Reverse Transcriptase/*antagonists & inhibitors
HIV-1/*drug effects
Reverse Transcriptase Inhibitors/*pharmacology
Ribonucleosides/*pharmacology
4-Quinolones/chemical synthesis ; 4-Quinolones/chemistry ; Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Dose-Response Relationship, Drug ; Drug Design ; HIV Reverse Transcriptase/metabolism ; HIV-1/metabolism ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Reverse Transcriptase Inhibitors/chemical synthesis ; Reverse Transcriptase Inhibitors/chemistry ; Ribonucleosides/chemical synthesis ; Ribonucleosides/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties.
Autorzy :
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012 Jinan, Shandong, PR China.
Feng D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.
Sun Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.
Fang Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.; The Second Hospital of Shandong University, No. 247 Beiyuan Avenue, 250033 Jinan, Shandong, P.R. China.
Wei F; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.
De Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000 Leuven, Belgium.
Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000 Leuven, Belgium.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012 Jinan, Shandong, PR China.
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012 Jinan, Shandong, PR China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4837-4848. Date of Electronic Publication: 2020 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
HIV Reverse Transcriptase/*antagonists & inhibitors
HIV-1/*drug effects
Pyrimidines/*pharmacology
Reverse Transcriptase Inhibitors/*pharmacology
Thiophenes/*pharmacology
Animals ; Anti-HIV Agents/metabolism ; Anti-HIV Agents/pharmacokinetics ; Cell Line, Tumor ; Enzyme Assays ; HIV Reverse Transcriptase/genetics ; HIV Reverse Transcriptase/metabolism ; HIV-1/enzymology ; Humans ; Mice ; Microbial Sensitivity Tests ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Mutation ; Protein Binding ; Pyrimidines/metabolism ; Pyrimidines/pharmacokinetics ; Reverse Transcriptase Inhibitors/metabolism ; Reverse Transcriptase Inhibitors/pharmacokinetics ; Thiophenes/metabolism ; Thiophenes/pharmacokinetics
Czasopismo naukowe
Tytuł :
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP.
Autorzy :
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China; Suzhou Research Institute, Shandong University, Room 522, Building H of NUSP, NO.388 Ruoshui Road, SIP, Suzhou, 215123, Jiangsu, PR China. Electronic address: .
Feng D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Jing L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Sun Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Wei F; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Jiang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Wu G; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
De Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 May 01; Vol. 193, pp. 112237. Date of Electronic Publication: 2020 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Anti-HIV Agents/*pharmacology
HIV Reverse Transcriptase/*antagonists & inhibitors
HIV-1/*drug effects
Reverse Transcriptase Inhibitors/*pharmacology
Triazoles/*pharmacology
Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Binding Sites/drug effects ; Click Chemistry ; Dose-Response Relationship, Drug ; HIV Reverse Transcriptase/metabolism ; HIV-1/enzymology ; Humans ; Hydrophobic and Hydrophilic Interactions ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Reverse Transcriptase Inhibitors/chemical synthesis ; Reverse Transcriptase Inhibitors/chemistry ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine.
Autorzy :
Tateishi Y; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
Ohe T; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan. Electronic address: .
Yasuda D; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
Takahashi K; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
Nakamura S; Department of Chemistry, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino, Tokyo, Japan.
Kazuki Y; Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori, Japan; Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, Japan.
Mashino T; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan.
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Źródło :
Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2020 Apr; Vol. 35 (2), pp. 238-243. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Nevirapine/*metabolism
Reverse Transcriptase Inhibitors/*metabolism
Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Hep G2 Cells ; Humans ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure ; Nevirapine/chemical synthesis ; Nevirapine/pharmacology ; Reverse Transcriptase Inhibitors/chemical synthesis ; Reverse Transcriptase Inhibitors/pharmacology ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Plasma nucleotide reverse transcriptase inhibitor concentration and their associations with liver and renal parameters in people living with HIV.
Autorzy :
Wang X; Imperial College London.
Boffito M; Imperial College London.; Chelsea and Westminster Hospital.
Dickinson L; University of Liverpool.
Bagkeris E; University College London.
Khoo S; University of Liverpool.
Post FA; Kings College Hospital NHS Foundation Trust, London.
Vera J; Brighton and Sussex Medical School, Brighton.
Williams I; University College London.
Ndoutoumou A; Imperial Clinical Trials Unit, London.
Anderson J; Homerton University Hospital NHS Trust, London, UK.
Mallon P; University College Dublin, Dublin, Ireland.
McClure M; Imperial College London.
Winston A; Imperial College London.
Sabin C; University College London.
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Corporate Authors :
POPPY Study
Źródło :
AIDS (London, England) [AIDS] 2020 Apr 01; Vol. 34 (5), pp. 790-793.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Emtricitabine/*blood
HIV Infections/*drug therapy
Kidney/*metabolism
Lamivudine/*blood
Liver/*metabolism
Nucleotides/*blood
Reverse Transcriptase Inhibitors/*blood
Anti-HIV Agents/adverse effects ; Anti-HIV Agents/blood ; Cohort Studies ; Cross-Sectional Studies ; Drug Combinations ; Emtricitabine/adverse effects ; Emtricitabine/therapeutic use ; ErbB Receptors/drug effects ; HIV Infections/complications ; Humans ; Lamivudine/adverse effects ; Lamivudine/therapeutic use ; Nucleotides/adverse effects ; Nucleotides/therapeutic use ; Reverse Transcriptase Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/therapeutic use ; Treatment Outcome ; Viral Load
Czasopismo naukowe
Tytuł :
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs.
Autorzy :
Li TT; Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Zhuang CL; Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
Chen FE; Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.; Department of Chemistry, Fudan University, Shanghai 200433, China.; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Mar 30; Vol. 25 (7). Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
HIV Reverse Transcriptase*/antagonists & inhibitors
HIV Reverse Transcriptase*/metabolism
Molecular Docking Simulation*
Reverse Transcriptase Inhibitors*/chemical synthesis
Reverse Transcriptase Inhibitors*/chemistry
Reverse Transcriptase Inhibitors*/pharmacology
HIV-1/*enzymology
Alkynes/chemistry ; Alkynes/pharmacology ; Benzoxazines/chemistry ; Benzoxazines/pharmacology ; Cell Line ; Cyclopropanes/chemistry ; Cyclopropanes/pharmacology ; Humans
Czasopismo naukowe
Tytuł :
Safety, pharmacokinetics, and antiretroviral activity of islatravir (ISL, MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor, following single-dose administration to treatment-naive adults infected with HIV-1: an open-label, phase 1b, consecutive-panel trial.
Autorzy :
Schürmann D; Charité Research Organisation, Berlin, Germany; Department of Infectious Diseases and Pulmonary Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
Rudd DJ; Merck & Co Inc, Kenilworth, NJ, USA.
Zhang S; Merck & Co Inc, Kenilworth, NJ, USA.
De Lepeleire I; Merck Sharp & Dohme (Europe) Inc, Brussels, Belgium.
Robberechts M; Merck Sharp & Dohme (Europe) Inc, Brussels, Belgium.
Friedman E; Merck & Co Inc, Kenilworth, NJ, USA.
Keicher C; Charité Research Organisation, Berlin, Germany.
Hüser A; Charité Research Organisation, Berlin, Germany.
Hofmann J; Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany; Labor Berlin - Charité Vivantes, Berlin, Germany.
Grobler JA; Merck & Co Inc, Kenilworth, NJ, USA.
Stoch SA; Merck & Co Inc, Kenilworth, NJ, USA.
Iwamoto M; Merck & Co Inc, Kenilworth, NJ, USA.
Matthews RP; Merck & Co Inc, Kenilworth, NJ, USA. Electronic address: .
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Źródło :
The lancet. HIV [Lancet HIV] 2020 Mar; Vol. 7 (3), pp. e164-e172. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacokinetics
Deoxyadenosines/*pharmacokinetics
HIV Infections/*drug therapy
Reverse Transcriptase Inhibitors/*pharmacokinetics
Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Deoxyadenosines/administration & dosage ; Deoxyadenosines/adverse effects ; Female ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/enzymology ; HIV-1/physiology ; Humans ; Male ; Middle Aged ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/adverse effects ; Young Adult
Czasopismo naukowe

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