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Tytuł:
Box-Behnken design aided optimization and validation of developed reverse phase HPLC analytical method for simultaneous quantification of dolutegravir sodium and lamivudine co-loaded in nano-liposomes.
Autorzy:
Mutalik SP; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Mullick P; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Pandey A; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Kulkarni SS; Division of Virology, ICMR-National AIDS Research Institute (NARI), Pune, India.
Mutalik S; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
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Źródło:
Journal of separation science [J Sep Sci] 2021 Aug; Vol. 44 (15), pp. 2917-2931. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji:
Journal Article; Validation Study
MeSH Terms:
Drug Carriers*
Liposomes*
Nanoparticles*
Chromatography, High Pressure Liquid/*methods
Chromatography, Reverse-Phase/*methods
HIV Integrase Inhibitors/*analysis
Heterocyclic Compounds, 3-Ring/*analysis
Lamivudine/*analysis
Oxazines/*analysis
Piperazines/*analysis
Pyridones/*analysis
Reverse Transcriptase Inhibitors/*analysis
Drug Compounding ; Limit of Detection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).
Autorzy:
Ceckova M; Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic.
Reznicek J; Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic.
Deutsch B; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Fromm MF; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Staud F; Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
PloS one [PLoS One] 2018 Aug 16; Vol. 13 (8), pp. e0202706. Date of Electronic Publication: 2018 Aug 16 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzoxazines/*pharmacology
Kidney/*metabolism
Lamivudine/*pharmacology
Organic Cation Transport Proteins/*metabolism
Reverse Transcriptase Inhibitors/*pharmacology
Alkynes ; Animals ; Area Under Curve ; Cimetidine/pharmacology ; Cyclopropanes ; Dogs ; HEK293 Cells ; Half-Life ; Humans ; Lamivudine/pharmacokinetics ; Lamivudine/urine ; Madin Darby Canine Kidney Cells ; Male ; Metformin/metabolism ; Metformin/pharmacology ; Multidrug Resistance-Associated Protein 2 ; Multidrug Resistance-Associated Proteins/antagonists & inhibitors ; Multidrug Resistance-Associated Proteins/metabolism ; Organic Cation Transport Proteins/antagonists & inhibitors ; ROC Curve ; Rats ; Rats, Wistar ; Renal Elimination ; Reverse Transcriptase Inhibitors/pharmacokinetics ; Reverse Transcriptase Inhibitors/urine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficacy and safety of a single-tablet regimen containing tenofovir disoproxil fumarate 300 mg, lamivudine 300 mg and efavirenz 400 mg as a switch strategy in virologically suppressed HIV-1-infected subjects on nonnucleoside reverse transcriptase inhibitor-containing first-line antiretroviral therapy in Pune, India.
Autorzy:
Dravid A; Department of Medicine, Ruby Hall Clinic, Pune, Maharashtra, India.; Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.; Department of Medicine, Noble Hospital, Pune, Maharashtra, India.
Betha TP; Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
Sharma AK; Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
Gawali R; Department of Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
Mahajan U; Department of Biostatistics, VMK Diagnostics Private Limited, Pune, Maharashtra, India.
Kulkarni M; Department of Medicine, Ruby Hall Clinic, Pune, Maharashtra, India.
Saraf C; Department of Pathology, VMK Diagnostics Private Limited, Pune, Maharashtra, India.
Kore S; Department of Dermatology, Ashwini Sahakari Rugnalaya and Research Centre, Solapur, Maharashtra, India.
Dravid M; Infectious Disease Clinic, Dhule, Maharashtra, India.
Rathod N; Department of Medicine, Apex Hospital, Kolhapur, Maharashtra, India.
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Źródło:
HIV medicine [HIV Med] 2020 Oct; Vol. 21 (9), pp. 578-587. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji:
Journal Article; Multicenter Study; Observational Study
MeSH Terms:
Alkynes/*administration & dosage
Benzoxazines/*administration & dosage
Cyclopropanes/*administration & dosage
HIV Infections/*drug therapy
HIV-1/*genetics
Lamivudine/*administration & dosage
Tenofovir/*administration & dosage
Adult ; Alkynes/adverse effects ; Alkynes/pharmacology ; Benzoxazines/adverse effects ; Benzoxazines/pharmacology ; CD4 Lymphocyte Count ; Cyclopropanes/adverse effects ; Cyclopropanes/pharmacology ; Drug Combinations ; Female ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; Humans ; India ; Lamivudine/adverse effects ; Lamivudine/pharmacology ; Male ; Middle Aged ; Private Sector ; Retrospective Studies ; Reverse Transcriptase Inhibitors/therapeutic use ; Tablets ; Tenofovir/adverse effects ; Tenofovir/pharmacology ; Tertiary Care Centers ; Treatment Outcome ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Assessment of complex genomic alterations induced by AZT, 3TC, and the combination AZT +3TC.
Autorzy:
Grando AC; Laboratory of Genetic Toxicity and Cellular Toxic-Genetic Analysis, Graduate Program in Molecular and Cellular Biology Applied to Health (PPGBioSaúde), Lutheran University of Brazil, Canoas, Brazil.
Guimarães NN; Institute of Biological Science, Federal University of Goiás, Goiás, Brazil.
de Souza AP; Laboratory of Genetic Toxicity and Cellular Toxic-Genetic Analysis, Graduate Program in Molecular and Cellular Biology Applied to Health (PPGBioSaúde), Lutheran University of Brazil, Canoas, Brazil.
Lehmann M; Laboratory of Genetic Toxicity and Cellular Toxic-Genetic Analysis, Graduate Program in Molecular and Cellular Biology Applied to Health (PPGBioSaúde), Lutheran University of Brazil, Canoas, Brazil.
Cunha KS; Institute of Biological Science, Federal University of Goiás, Goiás, Brazil.
Dihl RR; Laboratory of Genetic Toxicity and Cellular Toxic-Genetic Analysis, Graduate Program in Molecular and Cellular Biology Applied to Health (PPGBioSaúde), Lutheran University of Brazil, Canoas, Brazil.
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Źródło:
Drug and chemical toxicology [Drug Chem Toxicol] 2020 Jul; Vol. 43 (4), pp. 429-434. Date of Electronic Publication: 2018 Sep 12.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Damage*
Anti-HIV Agents/*toxicity
Antiretroviral Therapy, Highly Active/*adverse effects
Lamivudine/*toxicity
Reverse Transcriptase Inhibitors/*toxicity
Zidovudine/*toxicity
Animals ; CHO Cells ; Cricetulus ; Lamivudine/administration & dosage ; Mutagenesis ; Mutation ; Zidovudine/administration & dosage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bioequivalence and Food Effect Assessment of 2 Fixed-Dose Combination Formulations of Dolutegravir and Lamivudine.
Autorzy:
Dumitrescu TP; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Peddiraju K; Pharma R&D, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Fu C; PAREXEL International, Durham, North Carolina, USA.
Bakshi K; Pharma R&D, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Yu S; PAREXEL International, Durham, North Carolina, USA.
Zhang Z; PAREXEL International, Durham, North Carolina, USA.
Tenorio AR; Clinical Development, ViiV Healthcare, Durham, North Carolina, USA.
Spancake C; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Joshi S; Biostatistics, GlaxoSmithKline India, Mumbai, India.
Wolstenholme A; Pharma R&D, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Adkison K; Clinical Pharmacology, ViiV Healthcare, Durham, North Carolina, USA.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2020 Feb; Vol. 9 (2), pp. 189-202. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Fasting/*metabolism
Food/*adverse effects
HIV Infections/*drug therapy
Heterocyclic Compounds, 3-Ring/*pharmacokinetics
Lamivudine/*pharmacokinetics
Oxazines/*pharmacokinetics
Piperazines/*pharmacokinetics
Pyridones/*pharmacokinetics
Administration, Oral ; Adult ; Area Under Curve ; Body Mass Index ; Drug Therapy, Combination ; Female ; HIV Infections/metabolism ; HIV Integrase Inhibitors/administration & dosage ; HIV Integrase Inhibitors/adverse effects ; HIV Integrase Inhibitors/pharmacokinetics ; HIV-1/drug effects ; HIV-1/isolation & purification ; Heterocyclic Compounds, 3-Ring/administration & dosage ; Heterocyclic Compounds, 3-Ring/adverse effects ; Humans ; Lamivudine/administration & dosage ; Lamivudine/adverse effects ; Male ; Middle Aged ; Oxazines/administration & dosage ; Oxazines/adverse effects ; Piperazines/administration & dosage ; Piperazines/adverse effects ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/pharmacokinetics ; Safety ; Therapeutic Equivalency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Zidovudine, tenofovir or abacavir? Different adverse effect profiles.
Źródło:
Prescrire international [Prescrire Int] 2016 Jul; Vol. 25 (173), pp. 180-183.
Typ publikacji:
Journal Article
MeSH Terms:
Dideoxynucleosides*/therapeutic use
HIV Infections*/drug therapy
Lamivudine*/therapeutic use
Reverse Transcriptase Inhibitors*/therapeutic use
Zidovudine*/therapeutic use
Drug Combinations ; Humans ; Tenofovir/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro.
Autorzy:
Wang RR; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Yang QH; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan, China.
Luo RH; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Peng YM; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan, China.
Dai SX; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Zhang XJ; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Chen H; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Cui XQ; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; College of Pharmacy and Chemistry, Dali University, Dali, Yunnan, China.
Liu YJ; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Huang JF; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Chang JB; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan, China.
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
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Źródło:
PloS one [PLoS One] 2014 Aug 21; Vol. 9 (8), pp. e105617. Date of Electronic Publication: 2014 Aug 21 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Viral*
Anti-HIV Agents/*pharmacology
Azides/*pharmacology
Deoxycytidine/*analogs & derivatives
HIV/*drug effects
Lamivudine/*pharmacology
Reverse Transcriptase Inhibitors/*pharmacology
Anti-HIV Agents/chemistry ; Azides/chemistry ; Cell Line ; Deoxycytidine/chemistry ; Deoxycytidine/pharmacology ; Genotype ; HIV/enzymology ; HIV/genetics ; HIV Reverse Transcriptase/chemistry ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Conformation ; Protein Binding ; Reverse Transcriptase Inhibitors/chemistry ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Preswitch Regimens Influence the Rate of Weight Gain After Switch to Tenofovir Disoproxil Fumarate, Lamivudine, and Dolutegravir (TLD): Study From an East African Cohort.
Autorzy:
Bourgi, Kassem (AUTHOR)
Ofner, Susan (AUTHOR)
Musick, Beverly (AUTHOR)
Wools-Kaloustian, Kara (AUTHOR)
Humphrey, John M (AUTHOR)
Diero, Lameck (AUTHOR)
Yiannoutsos, Constantin T (AUTHOR)
Gupta, Samir K (AUTHOR)
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Źródło:
Open Forum Infectious Diseases. Dec2023, Vol. 10 Issue 12, p1-7. 7p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparative efficacy of Lamivudine and emtricitabine: a systematic review and meta-analysis of randomized trials.
Autorzy:
Ford N; Department of HIV/AIDS, World Health Organization, Geneva, Switzerland.
Shubber Z
Hill A
Vitoria M
Doherty M
Mills EJ
Gray A
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Źródło:
PloS one [PLoS One] 2013 Nov 11; Vol. 8 (11), pp. e79981. Date of Electronic Publication: 2013 Nov 11 (Print Publication: 2013).
Typ publikacji:
Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; Systematic Review
MeSH Terms:
Anti-HIV Agents/*pharmacokinetics
Deoxycytidine/*analogs & derivatives
HIV Infections/*drug therapy
HIV-1/*drug effects
Lamivudine/*pharmacokinetics
Reverse Transcriptase Inhibitors/*pharmacokinetics
Adult ; Anti-HIV Agents/therapeutic use ; Databases, Bibliographic ; Deoxycytidine/pharmacokinetics ; Deoxycytidine/therapeutic use ; Emtricitabine ; Female ; HIV Infections/virology ; HIV-1/growth & development ; Humans ; Lamivudine/therapeutic use ; Male ; Randomized Controlled Trials as Topic ; Reverse Transcriptase Inhibitors/therapeutic use ; Therapeutic Equivalency ; Treatment Outcome ; Viral Load/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lamivudine and fingolimod co-administration in two patients with multiple sclerosis and occult hepatitis B virus infection.
Autorzy:
Saccà F; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy. .
Pane C; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
De Rosa A; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
Matarazzo M; Department of Translational Medical Sciences, University Federico II, Naples, Italy.
Brescia Morra V; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
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Źródło:
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2017 Mar; Vol. 38 (3), pp. 501-502. Date of Electronic Publication: 2016 Oct 03.
Typ publikacji:
Case Reports; Letter
MeSH Terms:
Fingolimod Hydrochloride/*therapeutic use
Hepatitis B/*drug therapy
Immunosuppressive Agents/*therapeutic use
Lamivudine/*therapeutic use
Multiple Sclerosis, Relapsing-Remitting/*drug therapy
Reverse Transcriptase Inhibitors/*therapeutic use
Adult ; Female ; Hepatitis B/complications ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/complications
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion.
Autorzy:
Bourry O; CEA, Division of Immuno-Virology, DSV/iMETI, Fontenay-aux-Roses, France.
Mannioui A
Sellier P
Roucairol C
Durand-Gasselin L
Dereuddre-Bosquet N
Benech H
Roques P
Le Grand R
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Źródło:
Retrovirology [Retrovirology] 2010 Sep 26; Vol. 7, pp. 78. Date of Electronic Publication: 2010 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Simian Immunodeficiency Virus*
HIV Protease Inhibitors/*therapeutic use
Indinavir/*therapeutic use
Lamivudine/*therapeutic use
Reverse Transcriptase Inhibitors/*therapeutic use
Simian Acquired Immunodeficiency Syndrome/*drug therapy
Zidovudine/*therapeutic use
Administration, Cutaneous ; Administration, Oral ; Animals ; Antiretroviral Therapy, Highly Active ; Drug Administration Schedule ; HIV Protease Inhibitors/administration & dosage ; HIV Protease Inhibitors/metabolism ; Indinavir/administration & dosage ; Indinavir/metabolism ; Lamivudine/administration & dosage ; Lamivudine/metabolism ; Macaca fascicularis ; Male ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/metabolism ; Simian Acquired Immunodeficiency Syndrome/metabolism ; Simian Acquired Immunodeficiency Syndrome/virology ; Time Factors ; Tissue Distribution ; Viremia/drug therapy ; Viremia/metabolism ; Viremia/virology ; Zidovudine/administration & dosage ; Zidovudine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Changes in bone turnover and bone loss in HIV-infected patients changing treatment to tenofovir-emtricitabine or abacavir-lamivudine.
Autorzy:
Haskelberg H; The Kirby Institute, University of New South Wales, Sydney, Australia. />Hoy JF
Amin J
Ebeling PR
Emery S
Carr A
STEAL Study Group
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (6), pp. e38377. Date of Electronic Publication: 2012 Jun 15.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Remodeling*
Adenine/*analogs & derivatives
Deoxycytidine/*analogs & derivatives
Dideoxynucleosides/*therapeutic use
HIV Infections/*drug therapy
Lamivudine/*therapeutic use
Organophosphonates/*therapeutic use
Reverse Transcriptase Inhibitors/*therapeutic use
Absorptiometry, Photon ; Adenine/administration & dosage ; Adenine/therapeutic use ; Adult ; Bone Density ; Deoxycytidine/administration & dosage ; Deoxycytidine/therapeutic use ; Dideoxynucleosides/administration & dosage ; Drug Therapy, Combination ; Emtricitabine ; Female ; HIV Infections/physiopathology ; Humans ; Lamivudine/administration & dosage ; Male ; Middle Aged ; Organophosphonates/administration & dosage ; Reverse Transcriptase Inhibitors/administration & dosage ; Tenofovir
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Potential and limitations of lamivudine monotherapy in chronic hepatitis B: evidence from genotyping.
Autorzy:
Kennedy PT; Centre for Hepatology, Royal Free and University College School of Medicine, Royal Free Hospital, London, UK.
Phillips N
Chandrasekhar J
Jacobs R
Jacobs M
Dusheiko G
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2008 May; Vol. 28 (5), pp. 699-704.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Resistance, Viral/*genetics
Hepatitis B virus/*genetics
Hepatitis B, Chronic/*drug therapy
Lamivudine/*therapeutic use
Reverse Transcriptase Inhibitors/*therapeutic use
Adult ; Aged ; Female ; Genotype ; Hepatitis B, Chronic/virology ; Humans ; Lamivudine/pharmacology ; Longitudinal Studies ; Male ; Middle Aged ; Phenotype ; Reverse Transcriptase Inhibitors/pharmacology ; Treatment Outcome ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil.
Autorzy:
Bottecchia M; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Av, Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil. .
Souto FJ
O KM
Amendola M
Brandão CE
Niel C
Gomes SA
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Źródło:
BMC microbiology [BMC Microbiol] 2008 Jan 22; Vol. 8, pp. 11. Date of Electronic Publication: 2008 Jan 22.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatitis B virus/*drug effects
Hepatitis B virus/*genetics
Hepatitis B, Chronic/*virology
Lamivudine/*pharmacology
Reverse Transcriptase Inhibitors/*pharmacology
Adult ; Aged ; Brazil ; Child ; Drug Resistance, Viral/genetics ; Female ; Hepatitis B virus/classification ; Hepatitis B, Chronic/drug therapy ; Hospitals ; Humans ; Lamivudine/therapeutic use ; Male ; Middle Aged ; Molecular Sequence Data ; Mutation ; Phylogeny ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Reverse Transcriptase Inhibitors/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Off-treatment durability of antiviral response to nucleoside analogues in patients with chronic hepatitis B.
Autorzy:
Nagata N; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan.
Kagawa T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan. .
Hirose S; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan.
Arase Y; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan.
Tsuruya K; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan.
Anzai K; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan.
Shiraishi K; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan.
Mine T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, 259-1193, Japan.
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2016 Mar 17; Vol. 16, pp. 38. Date of Electronic Publication: 2016 Mar 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiviral Agents/*therapeutic use
Carcinoma, Hepatocellular/*epidemiology
DNA, Viral/*blood
Guanine/*analogs & derivatives
Hepatitis B, Chronic/*drug therapy
Lamivudine/*therapeutic use
Liver Neoplasms/*epidemiology
Reverse Transcriptase Inhibitors/*therapeutic use
Adult ; Alanine Transaminase/blood ; Cohort Studies ; Disease Progression ; Female ; Follow-Up Studies ; Guanine/therapeutic use ; Hepatitis B Surface Antigens/blood ; Hepatitis B e Antigens/blood ; Hepatitis B, Chronic/blood ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Recurrence ; Remission Induction ; Retrospective Studies ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association between lamivudine sensitivity and the number of substitutions in the reverse transcriptase region of the hepatitis B virus polymerase.
Autorzy:
Fukai K; Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, Japan.
Zhang KY
Imazeki F
Kurihara T
Mikata R
Yokosuka O
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Źródło:
Journal of viral hepatitis [J Viral Hepat] 2007 Sep; Vol. 14 (9), pp. 661-6.
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Hepatitis B virus/*genetics
Hepatitis B, Chronic/*drug therapy
Lamivudine/*therapeutic use
RNA-Directed DNA Polymerase/*genetics
Reverse Transcriptase Inhibitors/*therapeutic use
Adult ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; DNA, Viral/blood ; Drug Resistance, Viral/genetics ; Female ; Hepatitis B virus/drug effects ; Hepatitis B virus/enzymology ; Hepatitis B, Chronic/virology ; Humans ; Lamivudine/pharmacology ; Male ; Middle Aged ; Reverse Transcriptase Inhibitors/pharmacology
Czasopismo naukowe
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