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Wyszukujesz frazę ""Ribonuclease H"" wg kryterium: Temat


Tytuł:
Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds.
Autorzy:
Al Nasr IS; Department of Biology, College of Science and Arts, Qassim University, Unaizah 51911, Saudi Arabia; Department of Science Laboratories, College of Science and Arts, Qassim University, Ar Rass 51921, Saudi Arabia.
Corona A; Laboratorio di Virologia Molecolare, Dipartimento di Scienze della Vita e Dell'Ambiente, Universitá degli Studi di Cagliari, Cittadella Universitaria di Monserrato SS554, 09042 Monserrato, Italy.
Koko WS; Department of Science Laboratories, College of Science and Arts, Qassim University, Ar Rass 51921, Saudi Arabia.
Khan TA; Department of Clinical Nutrition, College of Applied Health Sciences, Qassim University, Ar Rass 51921, Saudi Arabia.
Ben Said R; Laboratoire de Caractérisations, Applications et Modélisations des Matériaux, Faculté des Sciences de Tunis, Université Tunis El Manar, Tunis, Tunisia; Department of Chemistry, College of Science and Arts at Ar Rass, Qassim University, Ar Rass 51921, Saudi Arabia.
Daoud I; University Mohamed Khider, Department of Matter Sciences, BP 145 RP, Biskra, Algeria; Laboratory of Natural and Bio-active Substances, Faculty of Science, Tlemcen University, P.O. Box 119, Tlemcen, Algeria.
Rahali S; Department of Chemistry, College of Science and Arts at Ar Rass, Qassim University, Ar Rass 51921, Saudi Arabia.
Tramontano E; Laboratorio di Virologia Molecolare, Dipartimento di Scienze della Vita e Dell'Ambiente, Universitá degli Studi di Cagliari, Cittadella Universitaria di Monserrato SS554, 09042 Monserrato, Italy.
Schobert R; Organische Chemie I, Universität Bayreuth, Universitätsstrasse 30, 95447 Bayreuth, Germany.
Amdouni N; Laboratoire de Caractérisations, Applications et Modélisations des Matériaux, Faculté des Sciences de Tunis, Université Tunis El Manar, Tunis, Tunisia.
Biersack B; Organische Chemie I, Universität Bayreuth, Universitätsstrasse 30, 95447 Bayreuth, Germany. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Jul 15; Vol. 90, pp. 117376. Date of Electronic Publication: 2023 Jun 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ribonuclease H, Human Immunodeficiency Virus*
Reverse Transcriptase Inhibitors/pharmacology ; Ribonuclease H/metabolism ; Pyrimidines/pharmacology ; Pyrimidines/chemistry ; Antiparasitic Agents/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors.
Autorzy:
Zhang L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Wei F; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Borrego D; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Aut?onoma de Madrid), Madrid, Spain.
Zhao F; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Río JMD; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Aut?onoma de Madrid), Madrid, Spain.
Frutos-Beltrán E; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Aut?onoma de Madrid), Madrid, Spain.
Zhang J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Xu S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
López-Carrobles N; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Aut?onoma de Madrid), Madrid, Spain.
Gao S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China. Electronic address: .
Menéndez-Arias L; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Aut?onoma de Madrid), Madrid, Spain. Electronic address: .
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Oct 05; Vol. 240, pp. 114563. Date of Electronic Publication: 2022 Jun 26.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-HIV Agents*/chemistry
HIV-1*
Ribonuclease H, Human Immunodeficiency Virus*
HIV Reverse Transcriptase ; Humans ; Reverse Transcriptase Inhibitors/pharmacology ; Ribonuclease H ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.
Autorzy:
Zhang J; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Chen F; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Tang M; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Xu W; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Tian Y; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Liu Z; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.
Shu Y; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Yang H; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Zhu Q; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Lu X; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Peng B; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Cell Biology and Medical Genetics, Shenzhen University Medical School, Shenzhen 518055, China.
Liu X; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Xu X; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Cell Biology and Medical Genetics, Shenzhen University Medical School, Shenzhen 518055, China.
Gullerova M; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.
Zhu WG; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China; Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518055, China; School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui 241002, China; Department of Biochemistry and Molecular Biology, Peking University Health Science Centre, Beijing 100191, China. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2024 Feb 27; Vol. 43 (2), pp. 113779. Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
R-Loop Structures*
RNA*
Ribonuclease H*
Adenine/*analogs & derivatives
Humans ; Genomic Instability ; DNA-Binding Proteins/genetics ; Transcription Factors/genetics ; Methyltransferases/genetics
Czasopismo naukowe
Tytuł:
Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase.
Autorzy:
Ito Y; Laboratory of Molecular Design, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Lu H; Laboratory of Molecular Design, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Kitajima M; Laboratory of Middle Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Ishikawa H; Laboratory of Middle Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Nakata Y; Department of Infectious Diseases and Immunology, Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-0001, Japan.
Iwatani Y; Department of Infectious Diseases and Immunology, Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-0001, Japan.; Department of AIDS Research, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
Hoshino T; Laboratory of Molecular Design, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
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Źródło:
Journal of natural products [J Nat Prod] 2023 Nov 24; Vol. 86 (11), pp. 2487-2495. Date of Electronic Publication: 2023 Oct 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ribonuclease H*/metabolism
HIV Infections*
Humans ; Ions ; Anthraquinones/pharmacology ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/chemistry
Czasopismo naukowe
Tytuł:
Charge Engineering of the Nucleic Acid Binding Cleft of a Thermostable HIV-1 Reverse Transcriptase Reveals Key Interactions and a Novel Mechanism of RNase H Inactivation.
Autorzy:
Martínez Del Río J; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
López-Carrobles N; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
Mendieta-Moreno JI; Department of Theoretical Condensed Matter Physics, Universidad Autónoma de Madrid, Spain.
Herrera-Chacón Ó; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
Sánchez-Ibáñez A; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain.
Mendieta J; Department of Biotechnology, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain.
Menéndez-Arias L; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), c/ Nicolás Cabrera 1, Campus de Cantoblanco-UAM, Madrid, Spain. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2023 Sep 15; Vol. 435 (18), pp. 168219. Date of Electronic Publication: 2023 Aug 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Reverse Transcriptase*/chemistry
HIV Reverse Transcriptase*/genetics
HIV Reverse Transcriptase*/metabolism
Ribonuclease H*/chemistry
Ribonuclease H*/genetics
Ribonuclease H*/metabolism
Humans ; DNA, Complementary ; Protein Domains ; RNA/metabolism ; Amino Acid Substitution
Czasopismo naukowe
Tytuł:
Origin and Evolution of Plant Long Terminal Repeat Retrotransposons with Additional Ribonuclease H.
Autorzy:
Biryukov M; Sector of Molecular and Genetic Mechanisms of Regeneration, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.; Novosibirsk State University, Novosibirsk, Russia.
Ustyantsev K; Sector of Molecular and Genetic Mechanisms of Regeneration, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.
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Źródło:
Genome biology and evolution [Genome Biol Evol] 2023 Sep 04; Vol. 15 (9).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ribonuclease H*/genetics
Ferns*
Retroelements/genetics ; Cycadopsida ; Terminal Repeat Sequences/genetics
Czasopismo naukowe
Tytuł:
A pan-cancer analysis of RNASEH1, a potential regulator of the tumor microenvironment.
Autorzy:
Yi C; Key Laboratory of Nondestructive Testing, Ministry of Education, Nanchang Hangkong University, Jiangxi, 330063, China.; Department of Biomedical Engineering, Nanchang Hangkong University, Jiangxi, 330063, China.
Yang J; Key Laboratory of Nondestructive Testing, Ministry of Education, Nanchang Hangkong University, Jiangxi, 330063, China.; Department of Biomedical Engineering, Nanchang Hangkong University, Jiangxi, 330063, China.
Zhang T; Department of Biomedical Engineering, Nanchang Hangkong University, Jiangxi, 330063, China.
Xie S; Department of Biomedical Engineering, Nanchang Hangkong University, Jiangxi, 330063, China.
Li W; Department of Biomedical Engineering, Nanchang Hangkong University, Jiangxi, 330063, China.
Qin L; Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Chen D; Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China. .
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Źródło:
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2023 Aug; Vol. 25 (8), pp. 2569-2586. Date of Electronic Publication: 2023 Apr 06.
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasms*/genetics
Neoplasms*/immunology
Neoplasms*/mortality
Neoplasms*/pathology
Ribonuclease H*/analysis
Ribonuclease H*/genetics
Tumor Microenvironment*
Humans ; Gene Expression ; Mutation ; DNA Methylation ; Prognosis ; Survival Analysis ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Mitochondria/metabolism ; Mitochondria/pathology
Czasopismo naukowe
Tytuł:
C5-Propynyl modified 2'-fluoroarabinonucleic acids form stable duplexes with RNA that are RNase H competent.
Autorzy:
Pontarelli A; Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke St. W., Montréal, Québec H4B 1R6, Canada. .
Wilds CJ; Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke St. W., Montréal, Québec H4B 1R6, Canada. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2023 Sep 20; Vol. 21 (36), pp. 7437-7446. Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ribonuclease H*
Escherichia coli*
Cytidine/pharmacology ; Drug Delivery Systems ; RNA
Czasopismo naukowe
Tytuł:
RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.
Autorzy:
Liu C; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing 100101, China.
Wang L; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Li Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Guo M; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Hu J; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
Wang T; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Li M; Center for Reproductive Medicine, Shandong University, Jinan 250012, China.
Yang Z; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Lin R; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
Xu W; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Chen Y; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Luo M; Department of Tissue and Embryology, School of Basic Medical Sciences, Wuhan University, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430072, China.
Gao F; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Chen JY; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
Sun Q; Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
Liu H; Center for Reproductive Medicine, Shandong University, Jinan 250012, China.
Sun B; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Li W; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Aug 11; Vol. 51 (14), pp. 7357-7375.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Meiosis*
Ribonuclease H*/metabolism
Humans ; Male ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; DNA/genetics ; DNA/metabolism ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Recombinases/genetics ; Spermatocytes/metabolism
Czasopismo naukowe
Tytuł:
Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition.
Autorzy:
Giannakopoulou E; School of Health Sciences, Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece.
Pardali V; School of Health Sciences, Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece.
Edwards TC; Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, 63104, United States.
Woodson M; Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, 63104, United States.
Tajwar R; Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, 63104, United States.
Tavis JE; Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, 63104, United States.
Zoidis G; School of Health Sciences, Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece. Electronic address: .
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Źródło:
Antiviral research [Antiviral Res] 2024 Mar; Vol. 223, pp. 105833. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatitis B virus*
Antibodies*
DNA, Viral ; Imines ; Ribonuclease H
Czasopismo naukowe
Tytuł:
CRISPR/Cas9-mediated targeted knock-in of large constructs using nocodazole and RNase HII.
Autorzy:
Eghbalsaied S; Biotechnology/Stem Cell Physiology, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Höltystr. 10, 31535, Neustadt, Germany.; Department of Animal Science, Isfahan (Khorasgan) Branch, Islamic Azad University, Tehran, Iran.; School of Biosciences, Royal Parade, The University of Melbourne, Melbourne, VIC, Australia.
Kues WA; Biotechnology/Stem Cell Physiology, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Höltystr. 10, 31535, Neustadt, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Feb 15; Vol. 13 (1), pp. 2690. Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CRISPR-Cas Systems*
Ribonuclease H*/genetics
Animals ; Mice ; Nocodazole ; Animals, Genetically Modified ; DNA/genetics ; Recombinational DNA Repair ; DNA End-Joining Repair ; Gene Editing/methods ; Gene Knock-In Techniques ; Mammals/genetics
Czasopismo naukowe
Tytuł:
Dispersion Effect of Molecular Crowding on Ligand-Protein Surface Binding Sites of Escherichia coli RNase HI.
Autorzy:
Ota C; College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Suzuki H; Department of Biomolecular Chemistry, Kyoto Prefectural University, Sakyo-ku, Kyoto 606-8522, Japan.
Tanaka SI; Department of Biomolecular Chemistry, Kyoto Prefectural University, Sakyo-ku, Kyoto 606-8522, Japan.
Takano K; Department of Biomolecular Chemistry, Kyoto Prefectural University, Sakyo-ku, Kyoto 606-8522, Japan.
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Źródło:
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2022 Nov 29; Vol. 38 (47), pp. 14497-14507. Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Escherichia coli*/metabolism
Ribonuclease H*/chemistry
Ribonuclease H*/metabolism
Ligands ; Binding Sites ; Protein Binding
Czasopismo naukowe
Tytuł:
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart.
Autorzy:
Heuzé J; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Kemiha S; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Barthe A; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Vilarrubias AT; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Aouadi E; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Aiello U; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France.; Department of Genetics, Stanford University, Stanford, CA, USA.
Libri D; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France.
Lin YL; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Lengronne A; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
Poli J; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.; Institut Universitaire de France (IUF), Paris, France.
Pasero P; Institut de Génétique Humaine, Université de Montpellier, CNRS, Equipe labélisée Ligue contre le Cancer, Montpellier, France.
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Źródło:
The EMBO journal [EMBO J] 2023 Dec 01; Vol. 42 (23), pp. e113104. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Replication*
RNA*/genetics
Humans ; Ribonucleases/genetics ; DNA/metabolism ; Hydroxyurea/pharmacology ; Ribonuclease H/genetics ; Ribonuclease H/metabolism
Czasopismo naukowe
Tytuł:
DICER ribonuclease removes harmful R-loops.
Autorzy:
Camino LP; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, CSIC, 41092 Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain.
Dutta A; Greehey Children's Cancer Research Institute, Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Barroso S; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, CSIC, 41092 Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain.
Pérez-Calero C; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, CSIC, 41092 Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain.
Katz JN; Greehey Children's Cancer Research Institute, Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
García-Rubio M; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, CSIC, 41092 Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain.
Sung P; Greehey Children's Cancer Research Institute, Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: .
Gómez-González B; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, CSIC, 41092 Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain. Electronic address: .
Aguilera A; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla, CSIC, 41092 Seville, Spain; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2023 Oct 19; Vol. 83 (20), pp. 3707-3719.e5. Date of Electronic Publication: 2023 Oct 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
R-Loop Structures*/genetics
Ribonucleases*/genetics
Humans ; RNA/genetics ; DNA ; DNA Replication ; DNA Helicases/genetics ; Ribonuclease H/genetics ; Ribonuclease H/metabolism ; Genomic Instability
Czasopismo naukowe
Tytuł:
Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
Autorzy:
Lu H; Graduate School of Pharmaceutical Sciences, Chiba University Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan.
Komukai Y; Graduate School of Pharmaceutical Sciences, Chiba University Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan.
Usami K; Graduate School of Pharmaceutical Sciences, Chiba University Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan.
Guo Y; Graduate School of Pharmaceutical Sciences, Chiba University Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan.
Qiao X; Graduate School of Pharmaceutical Sciences, Chiba University Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan.
Nukaga M; Faculty of Pharmaceutical Sciences, Josai International University Gumyo 1, Togane-shi Chiba 283-8555, Japan.
Hoshino T; Graduate School of Pharmaceutical Sciences, Chiba University Inohana 1-8-1, Chuo-ku, Chiba 260-8675, Japan.
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Źródło:
Journal of chemical information and modeling [J Chem Inf Model] 2022 Dec 26; Vol. 62 (24), pp. 6762-6774. Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV-1*/drug effects
HIV-1*/enzymology
Ribonuclease H*/antagonists & inhibitors
Anti-HIV Agents*/chemistry
Anti-HIV Agents*/pharmacology
Humans ; Catalytic Domain ; Crystallography, X-Ray ; Furans/pharmacology ; Furans/chemistry ; HIV Reverse Transcriptase ; Metals/metabolism ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/chemistry
Czasopismo naukowe
Tytuł:
Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors.
Autorzy:
Zhang L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Wei F; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Zhang J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
Liu C; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China.
López-Carrobles N; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), 28049, Madrid, Spain.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China. Electronic address: .
Menéndez-Arias L; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), 28049, Madrid, Spain. Electronic address: .
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114760. Date of Electronic Publication: 2022 Sep 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
HIV-1*
Ribonuclease H*/antagonists & inhibitors
Chemistry, Pharmaceutical ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/chemistry ; RNA
Czasopismo naukowe
Tytuł:
Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H.
Autorzy:
Masaki Y; Department of Life Science and Technology, Tokyo Institute of Technology, 4259-J2-16 Nagatsuta, Midori, Yokohama, Kanagawa, 226-8501, Japan. .; PRESTO, JST, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.
Tabira A; Department of Life Science and Technology, Tokyo Institute of Technology, 4259-J2-16 Nagatsuta, Midori, Yokohama, Kanagawa, 226-8501, Japan. .
Hattori S; Department of Life Science and Technology, Tokyo Institute of Technology, 4259-J2-16 Nagatsuta, Midori, Yokohama, Kanagawa, 226-8501, Japan. .
Wakatsuki S; Department of Life Science and Technology, Tokyo Institute of Technology, 4259-J2-16 Nagatsuta, Midori, Yokohama, Kanagawa, 226-8501, Japan. .
Seio K; Department of Life Science and Technology, Tokyo Institute of Technology, 4259-J2-16 Nagatsuta, Midori, Yokohama, Kanagawa, 226-8501, Japan. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Nov 23; Vol. 20 (45), pp. 8917-8924. Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ribonuclease H*/chemistry
Oligonucleotides, Antisense*/chemistry
Deoxyribose ; Oligonucleotides/chemistry ; Phosphates
Czasopismo naukowe
Tytuł:
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion.
Autorzy:
Misic J; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.
Milenkovic D; Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
Al-Behadili A; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, PO Box 440, Gothenburg 405 30, Sweden.
Xie X; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, PO Box 440, Gothenburg 405 30, Sweden.
Jiang M; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China.
Jiang S; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.
Filograna R; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.
Koolmeister C; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.
Siira SJ; Harry Perkins Institute of Medical Research and ARC Centre of Excellence in Synthetic Biology, Nedlands, WA 6009, Australia.
Jenninger L; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, PO Box 440, Gothenburg 405 30, Sweden.
Filipovska A; Harry Perkins Institute of Medical Research and ARC Centre of Excellence in Synthetic Biology, Nedlands, WA 6009, Australia.; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, WA, Australia.
Clausen AR; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, PO Box 440, Gothenburg 405 30, Sweden.
Caporali L; IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Bologna, Italy.
Valentino ML; IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
La Morgia C; IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Bologna, Italy.
Carelli V; IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Nicholls TJ; Wellcome Centre for Mitochondrial Research, Biosciences Institute, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Wredenberg A; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.; Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
Falkenberg M; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, PO Box 440, Gothenburg 405 30, Sweden.
Larsson NG; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2022 Aug 26; Vol. 50 (15), pp. 8749-8766.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA, Mitochondrial*/chemistry
Ribonuclease H*/genetics
Ribonuclease H*/metabolism
Mice ; Animals ; RNA/chemistry ; DNA Replication/genetics ; Mitochondria/genetics ; Mammals/genetics
Czasopismo naukowe
Tytuł:
RNase H-Driven crRNA Switch Circuits for Rapid and Sensitive Detection of Various Analytical Targets.
Autorzy:
Li HD; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai 200237, China.
Fang GH; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai 200237, China.
Ye BC; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai 200237, China.; School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang 832000, China.; Institute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Yin BC; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai 200237, China.; School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang 832000, China.
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Źródło:
Analytical chemistry [Anal Chem] 2023 Dec 19; Vol. 95 (50), pp. 18549-18556. Date of Electronic Publication: 2023 Dec 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
RNA, Guide, CRISPR-Cas Systems*
Biosensing Techniques*
Ribonuclease H ; RNA ; CRISPR-Cas Systems/genetics ; DNA
Czasopismo naukowe

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