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Wyszukujesz frazę ""Ribonuclease H, Human Immunodeficiency Virus"" wg kryterium: Temat

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    Wyświetlanie 1-14 z 14
    Tytuł:
    Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction.
    Autorzy:
    Álvarez M; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
    Sapena-Ventura E; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
    Luczkowiak J; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
    Martín-Alonso S; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
    Menéndez-Arias L; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
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    Źródło:
    Viruses [Viruses] 2021 Jan 18; Vol. 13 (1). Date of Electronic Publication: 2021 Jan 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genome, Viral*
    HIV Long Terminal Repeat*
    RNA, Viral*/chemistry
    HIV Infections/*virology
    HIV-1/*physiology
    Ribonuclease H, Human Immunodeficiency Virus/*metabolism
    Base Sequence ; HIV Infections/drug therapy ; HIV-1/drug effects ; Humans ; Models, Molecular ; Molecular Conformation ; Mutagenesis ; Protein Binding ; Proteolysis ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/therapeutic use ; Ribonuclease H, Human Immunodeficiency Virus/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.
    Autorzy:
    Massari S; a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy.
    Corona A; b Department of Life and Environmental Sciences , University of Cagliari, Cittadella Universitaria di Monserrato , Monserrato , Cagliari , Italy.
    Distinto S; b Department of Life and Environmental Sciences , University of Cagliari, Cittadella Universitaria di Monserrato , Monserrato , Cagliari , Italy.
    Desantis J; a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy.; c Department of Chemistry , Biology and Biotechnology, University of Perugia , Perugia , Italy.
    Caredda A; b Department of Life and Environmental Sciences , University of Cagliari, Cittadella Universitaria di Monserrato , Monserrato , Cagliari , Italy.
    Sabatini S; a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy.
    Manfroni G; a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy.
    Felicetti T; a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy.
    Cecchetti V; a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy.
    Pannecouque C; d Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven , K.U. Leuven , Leuven , Belgium.
    Maccioni E; b Department of Life and Environmental Sciences , University of Cagliari, Cittadella Universitaria di Monserrato , Monserrato , Cagliari , Italy.
    Tramontano E; b Department of Life and Environmental Sciences , University of Cagliari, Cittadella Universitaria di Monserrato , Monserrato , Cagliari , Italy.; e Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR) , Monserrato , Italy.
    Tabarrini O; a Department of Pharmaceutical Sciences , University of Perugia , Perugia , Italy.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 55-74.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-HIV Agents/*pharmacology
    HIV/*drug effects
    Oxazines/*pharmacology
    Reverse Transcriptase Inhibitors/*pharmacology
    Ribonuclease H, Human Immunodeficiency Virus/*antagonists & inhibitors
    Thiophenes/*pharmacology
    Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Cell Line ; Dose-Response Relationship, Drug ; HIV/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Oxazines/chemical synthesis ; Oxazines/chemistry ; Reverse Transcriptase Inhibitors/chemical synthesis ; Reverse Transcriptase Inhibitors/chemistry ; Ribonuclease H, Human Immunodeficiency Virus/metabolism ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors.
    Autorzy:
    Gao P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Wang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Sun L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Cheng X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Poongavanam V; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense M, Denmark.
    Kongsted J; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense M, Denmark.
    Álvarez M; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), Madrid, Spain.
    Luczkowiak J; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), Madrid, Spain.
    Pannecouque C; Rega Institute for Medical Research, K.U.Leuven, Leuven, Belgium.
    De Clercq E; Rega Institute for Medical Research, K.U.Leuven, Leuven, Belgium.
    Lee KH; Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina.
    Chen CH; Surgical Science, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
    Liu H; Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
    Menéndez-Arias L; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), Madrid, Spain.
    Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
    Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
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    Źródło:
    Chemical biology & drug design [Chem Biol Drug Des] 2019 Apr; Vol. 93 (4), pp. 582-589. Date of Electronic Publication: 2019 Jan 24.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    Anti-HIV Agents/*chemical synthesis
    HIV-1/*enzymology
    Ribonuclease H, Human Immunodeficiency Virus/*antagonists & inhibitors
    Tropolone/*analogs & derivatives
    Anti-HIV Agents/chemistry ; Anti-HIV Agents/pharmacology ; Benzoic Acid/chemistry ; Binding Sites ; Catalytic Domain ; HIV-1/drug effects ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Ribonuclease H, Human Immunodeficiency Virus/metabolism ; Structure-Activity Relationship ; Tropolone/chemical synthesis ; Tropolone/chemistry ; Tropolone/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.
    Autorzy:
    Ngcapu S; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella, Durban 4013, South Africa. .; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Private Bag X7, Congella, Durban 4013, South Africa. .
    Theys K; Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven-University of Leuven, 3000 Leuven, Belgium. .
    Libin P; Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven-University of Leuven, 3000 Leuven, Belgium. .; Artificial Intelligence Lab, Department of Computer Science, Vrije Universiteit Brussel, Brussels, 1050 Elsene, Belgium. .
    Marconi VC; Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA. .
    Sunpath H; Infectious Diseases Unit, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Private Bag X7, Congella, Durban 4013, South Africa. .
    Ndung'u T; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella, Durban 4013, South Africa. .; Africa Health Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella, Durban 4013, South Africa. .; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA 01239, USA. .; Max Planck Institute for Infection Biology, Chariteplatz, D-10117 Berlin, Germany. .
    Gordon ML; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella, Durban 4013, South Africa. .
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    Źródło:
    Viruses [Viruses] 2017 Nov 08; Vol. 9 (11). Date of Electronic Publication: 2017 Nov 08.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Mutation*
    HIV-1/*genetics
    Reverse Transcriptase Inhibitors/*therapeutic use
    Ribonuclease H, Human Immunodeficiency Virus/*antagonists & inhibitors
    Ribonuclease H, Human Immunodeficiency Virus/*genetics
    Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Bayes Theorem ; Databases, Genetic ; Drug Resistance, Viral/genetics ; Genotype ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV-1/drug effects ; Humans ; Ribonuclease H, Human Immunodeficiency Virus/chemistry ; Ribonuclease H, Human Immunodeficiency Virus/metabolism ; Sequence Analysis, DNA
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H.
    Autorzy:
    Tocco G; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
    Esposito F; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
    Caboni P; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
    Laus A; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
    Beutler JA; Molecular Targets Program, National Cancer Institute, Frederick, MD, USA.
    Wilson JA; Molecular Targets Program, National Cancer Institute, Frederick, MD, USA.
    Corona A; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
    Le Grice SFJ; Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA.
    Tramontano E; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1953-1963.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Anti-HIV Agents/*chemical synthesis
    HIV Reverse Transcriptase/*metabolism
    Pyrimidinones/*chemistry
    Quinazolinones/*chemical synthesis
    Reverse Transcriptase Inhibitors/*chemical synthesis
    Ribonuclease H, Human Immunodeficiency Virus/*antagonists & inhibitors
    Anti-HIV Agents/pharmacology ; Catalytic Domain ; Drug Design ; Humans ; Models, Molecular ; Protein Binding ; Protein Multimerization ; Quinazolinones/pharmacology ; Reverse Transcriptase Inhibitors/pharmacology ; Structure-Activity Relationship ; Thiophenes/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Targeting HIV-1 RNase H: N' -(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants.
    Autorzy:
    Corona A; Department of Life and Environmental Sciences University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy.
    Ballana E; AIDS Research Institute-IrsiCaixa, 08916 Badalona, Spain.
    Distinto S; Department of Life and Environmental Sciences University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy.
    Rogolino D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
    Del Vecchio C; Department of Molecular Medicine, University of Padova, 35122 Padova, Italy.
    Carcelli M; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
    Badia R; AIDS Research Institute-IrsiCaixa, 08916 Badalona, Spain.
    Riveira-Muñoz E; AIDS Research Institute-IrsiCaixa, 08916 Badalona, Spain.
    Esposito F; Department of Life and Environmental Sciences University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy.
    Parolin C; Department of Molecular Medicine, University of Padova, 35122 Padova, Italy.
    Esté JA; AIDS Research Institute-IrsiCaixa, 08916 Badalona, Spain.; CienciaTraducida, 08391 Barcelona, Spain.
    Grandi N; Department of Life and Environmental Sciences University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy.
    Tramontano E; Department of Life and Environmental Sciences University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy.; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), 09042 Monserrato, Cagliari, Italy.
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    Źródło:
    Viruses [Viruses] 2020 Jul 06; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 06.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anti-HIV Agents/*therapeutic use
    HIV-1/*drug effects
    Ribonuclease H, Human Immunodeficiency Virus/*antagonists & inhibitors
    Anti-HIV Agents/pharmacology ; Binding Sites ; Drug Resistance, Viral ; HIV-1/enzymology ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Ribonuclease H
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    HIV‑1 integrase inhibitors targeting various DDE transposases: Retroviral integration versus RAG‑mediated recombination (Review).
    Autorzy:
    Mușat MG; Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania.
    Nițulescu GM; Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania.
    Surleac M; National Institute for Infectious Diseases 'Matei Bals', 021105 Bucharest, Romania.
    Tsatsakis A; Department of Forensic Sciences and Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
    Spandidos DA; Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
    Margină D; Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania.
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    Źródło:
    Molecular medicine reports [Mol Med Rep] 2019 Dec; Vol. 20 (6), pp. 4749-4762. Date of Electronic Publication: 2019 Oct 30.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Dichlorodiphenyl Dichloroethylene*
    DNA-Binding Proteins/*metabolism
    HIV-1/*genetics
    Homeodomain Proteins/*metabolism
    Integrase Inhibitors/*pharmacology
    Nuclear Proteins/*metabolism
    Recombination, Genetic/*genetics
    Transposases/*drug effects
    Catalytic Domain ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; HIV-1/metabolism ; Heterocyclic Compounds, 3-Ring ; Histone-Lysine N-Methyltransferase ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/genetics ; Integrase Inhibitors/chemistry ; Molecular Docking Simulation ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Oxazines ; Piperazines ; Protein Conformation ; Pyridones ; Retroviridae/genetics ; Ribonuclease H, Human Immunodeficiency Virus/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6.
    Autorzy:
    Corona A; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
    Meleddu R; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
    Esposito F; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
    Distinto S; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
    Bianco G; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
    Masaoka T; National Cancer Institute, Frederick, Maryland, United States of America.
    Maccioni E; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
    Menéndez-Arias L; Centro de Biología Molecular 'Severo Ochoa' (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Madrid, Spain.
    Alcaro S; Dipartimento di Scienze della Salute, Università Magna Graecia di Catanzaro, Campus 'S. Venuta', Viale Europa, 88100, Catanzaro, Italy.
    Le Grice SF; National Cancer Institute, Frederick, Maryland, United States of America.
    Tramontano E; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
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    Źródło:
    PloS one [PLoS One] 2016 Jan 22; Vol. 11 (1), pp. e0147225. Date of Electronic Publication: 2016 Jan 22 (Print Publication: 2016).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anti-HIV Agents/*pharmacology
    Enzyme Inhibitors/*pharmacology
    HIV Reverse Transcriptase/*antagonists & inhibitors
    Hydrazones/*pharmacology
    Isatin/*analogs & derivatives
    Reverse Transcriptase Inhibitors/*pharmacology
    Ribonuclease H, Human Immunodeficiency Virus/*antagonists & inhibitors
    Alkynes ; Benzoxazines/antagonists & inhibitors ; Benzoxazines/pharmacology ; Binding Sites ; Cyclopropanes ; HIV-1/enzymology ; Humans ; Isatin/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Virus Replication/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A polymorphism at position 400 in the connection subdomain of HIV-1 reverse transcriptase affects sensitivity to NNRTIs and RNaseH activity.
    Autorzy:
    Wright DW; Centre for Computational Science, Department of Chemistry, University College London, United Kingdom.
    Deuzing IP
    Flandre P
    van den Eede P
    Govaert M
    Setiawan L
    Coveney PV
    Marcelin AG
    Calvez V
    Boucher CA
    Beerens N
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2013 Oct 02; Vol. 8 (10), pp. e74078. Date of Electronic Publication: 2013 Oct 02 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Polymorphism, Genetic*
    HIV Reverse Transcriptase/*chemistry
    HIV Reverse Transcriptase/*metabolism
    HIV-1/*drug effects
    HIV-1/*enzymology
    Reverse Transcriptase Inhibitors/*pharmacology
    Ribonuclease H, Human Immunodeficiency Virus/*metabolism
    Drug Resistance, Viral/genetics ; Genomics ; HIV Reverse Transcriptase/genetics ; HIV-1/physiology ; Molecular Dynamics Simulation ; Protein Structure, Tertiary ; Virus Replication/drug effects ; Virus Replication/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
    Autorzy:
    Tavis JE; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA. />Cheng X
    Hu Y
    Totten M
    Cao F
    Michailidis E
    Aurora R
    Meyers MJ
    Jacobsen EJ
    Parniak MA
    Sarafianos SG
    Pokaż więcej
    Źródło:
    PLoS pathogens [PLoS Pathog] 2013 Jan; Vol. 9 (1), pp. e1003125. Date of Electronic Publication: 2013 Jan 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Design*
    Antiviral Agents/*pharmacology
    Hepatitis B virus/*enzymology
    Molecular Targeted Therapy/*methods
    Ribonuclease H, Human Immunodeficiency Virus/*antagonists & inhibitors
    Drug Evaluation, Preclinical ; Genotype ; HIV Integrase Inhibitors/pharmacology ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Humans ; In Vitro Techniques ; Recombinant Proteins ; Viral Load ; Virus Replication/drug effects ; Virus Replication/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Subtype-associated differences in HIV-1 reverse transcription affect the viral replication.
    Autorzy:
    Iordanskiy S; Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, 4240 Fair Street, East Campus, Lincoln, NE 68583-0900 USA. />Waltke M
    Feng Y
    Wood C
    Pokaż więcej
    Źródło:
    Retrovirology [Retrovirology] 2010 Oct 12; Vol. 7, pp. 85. Date of Electronic Publication: 2010 Oct 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Gene Products, pol/*physiology
    HIV Infections/*virology
    HIV Reverse Transcriptase/*metabolism
    HIV-1/*physiology
    Reassortant Viruses/*physiology
    Cell Line ; HIV Reverse Transcriptase/chemistry ; HIV-1/chemistry ; HIV-1/classification ; Humans ; Point Mutation ; Protein Structure, Tertiary/physiology ; Proviruses/genetics ; Reassortant Viruses/chemistry ; Reassortant Viruses/classification ; Ribonuclease H, Human Immunodeficiency Virus/physiology ; Virus Integration/physiology ; Virus Replication
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Developing and validating predictive decision tree models from mining chemical structural fingerprints and high-throughput screening data in PubChem.
    Autorzy:
    Han L; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. />Wang Y
    Bryant SH
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    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2008 Sep 25; Vol. 9, pp. 401. Date of Electronic Publication: 2008 Sep 25.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Intramural
    MeSH Terms:
    Decision Trees*
    Quantitative Structure-Activity Relationship*
    Biological Assay/*methods
    Biological Assay/*statistics & numerical data
    Information Storage and Retrieval/*methods
    Pattern Recognition, Automated/*methods
    Artificial Intelligence ; Decision Support Techniques ; Drug Discovery/methods ; Ribonuclease H, Human Immunodeficiency Virus/antagonists & inhibitors ; Sensitivity and Specificity ; Serotonin Plasma Membrane Transport Proteins/agonists
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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