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Tytuł :
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
Autorzy :
Poirier EZ; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK. .
Buck MD; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK.
Chakravarty P; Bioinformatics and Biostatistics, Francis Crick Institute, London NW1 1AT, UK.
Carvalho J; Experimental Histopathology, Francis Crick Institute, London NW1 1AT, UK.
Frederico B; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK.
Cardoso A; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK.
Healy L; Human Embryo and Stem Cell Unit, Francis Crick Institute, London NW1 1AT, UK.
Ulferts R; Cell Biology of Infection Laboratory, Francis Crick Institute, London NW1 1AT, UK.
Beale R; Cell Biology of Infection Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Division of Medicine, University College London, London WC1E 6BT, UK.
Reis E Sousa C; Immunobiology laboratory, Francis Crick Institute, London NW1 1AT, UK. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jul 09; Vol. 373 (6551), pp. 231-236.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Interference*
DEAD-box RNA Helicases/*genetics
DEAD-box RNA Helicases/*metabolism
RNA Viruses/*physiology
RNA, Viral/*metabolism
Ribonuclease III/*genetics
Ribonuclease III/*metabolism
Stem Cells/*enzymology
Stem Cells/*virology
Alternative Splicing ; Animals ; Brain/enzymology ; Brain/virology ; Cell Line ; DEAD-box RNA Helicases/chemistry ; Humans ; Immunity, Innate ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mice ; Organoids/enzymology ; Organoids/virology ; RNA Virus Infections/enzymology ; RNA Virus Infections/immunology ; RNA Virus Infections/virology ; RNA Viruses/genetics ; RNA Viruses/immunology ; RNA, Double-Stranded/metabolism ; RNA, Small Interfering/metabolism ; Ribonuclease III/chemistry ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Virus Replication ; Zika Virus/genetics ; Zika Virus/immunology ; Zika Virus/physiology ; Zika Virus Infection/enzymology ; Zika Virus Infection/immunology ; Zika Virus Infection/virology
Czasopismo naukowe
Tytuł :
In Vitro Identification and In Vivo Confirmation of Inhibitors for Sweet Potato Chlorotic Stunt Virus RNA Silencing Suppressor, a Viral RNase III.
Autorzy :
Wang L; Department of Agricultural Sciences, University of Helsinki, Helsinki, Finland .
Poque S; Department of Agricultural Sciences, University of Helsinki, Helsinki, Finland.
Laamanen K; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Saarela J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Poso A; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.; Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany.
Laitinen T; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Valkonen JPT; Department of Agricultural Sciences, University of Helsinki, Helsinki, Finland .
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Źródło :
Journal of virology [J Virol] 2021 May 24; Vol. 95 (12). Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Crinivirus/*drug effects
Enzyme Inhibitors/*pharmacology
Ipomoea batatas/*virology
Plant Diseases/*virology
Ribonuclease III/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Crinivirus/enzymology ; Crinivirus/physiology ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; High-Throughput Screening Assays ; Molecular Docking Simulation ; Photosynthesis/drug effects ; RNA Interference ; Ribonuclease III/chemistry ; Ribonuclease III/metabolism ; Small Molecule Libraries/chemistry ; Viral Proteins/antagonists & inhibitors
SCR Organism :
Sweet potato chlorotic stunt virus
Czasopismo naukowe
Tytuł :
A ribonuclease III involved in virulence of Mucorales fungi has evolved to cut exclusively single-stranded RNA.
Autorzy :
Cánovas-Márquez JT; Department of Genetics and Microbiology (Associated Unit to IQFR-CSIC), Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
Falk S; Department of Structural and Computational Biology, Max Perutz Labs, A-1030 Vienna, Austria.
Nicolás FE; Department of Genetics and Microbiology (Associated Unit to IQFR-CSIC), Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
Padmanabhan S; Instituto de Química Física 'Rocasolano,' Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.
Zapata-Pérez R; Department of Biochemistry and Molecular Biology-A, Faculty of Biology, Regional Campus of International Excellence 'Campus Mare Nostrum,' University of Murcia, Campus Espinardo, 30100, Murcia, Spain.
Sánchez-Ferrer Á; Department of Biochemistry and Molecular Biology-A, Faculty of Biology, Regional Campus of International Excellence 'Campus Mare Nostrum,' University of Murcia, Campus Espinardo, 30100, Murcia, Spain.
Navarro E; Department of Genetics and Microbiology (Associated Unit to IQFR-CSIC), Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
Garre V; Department of Genetics and Microbiology (Associated Unit to IQFR-CSIC), Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 May 21; Vol. 49 (9), pp. 5294-5307.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fungal Proteins/*chemistry
Fungal Proteins/*metabolism
Mucor/*enzymology
Ribonuclease III/*chemistry
Ribonuclease III/*metabolism
Evolution, Molecular ; Fungal Proteins/genetics ; Models, Molecular ; Mucorales/enzymology ; Mucorales/pathogenicity ; Protein Domains ; RNA/metabolism ; Ribonuclease III/genetics ; Virulence
Czasopismo naukowe
Tytuł :
Single-molecule analysis of processive double-stranded RNA cleavage by Drosophila Dicer-2.
Autorzy :
Naganuma M; Laboratory of RNA Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.; RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Tadakuma H; Laboratory of RNA Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. .; School of Life Science and Technology, ShanghaiTech University, Shanghai, People's Republic of China. .
Tomari Y; Laboratory of RNA Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. .; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 13; Vol. 12 (1), pp. 4268. Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila Proteins/*metabolism
RNA Helicases/*metabolism
RNA, Double-Stranded/*genetics
Ribonuclease III/*metabolism
Single Molecule Imaging/*methods
Animals ; Drosophila ; Drosophila Proteins/genetics ; Models, Theoretical ; RNA Helicases/genetics ; RNA Interference/physiology ; Ribonuclease III/genetics
Czasopismo naukowe
Tytuł :
RNA structure probing reveals the structural basis of Dicer binding and cleavage.
Autorzy :
Luo QJ; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.
Zhang J; Ministry of Education Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.; Tsinghua-Peking Center for Life Sciences, Beijing, China.
Li P; Ministry of Education Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.; Tsinghua-Peking Center for Life Sciences, Beijing, China.
Wang Q; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Faculty of Preventive Medicine, A Key Laboratory of Guangzhou Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Zhang Y; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Freenome Holdings Inc., South San Francisco, CA, USA.
Roy-Chaudhuri B; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Impossible Foods Inc., Redwood City, CA, USA.
Xu J; Department of Pediatrics, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.
Kay MA; Department of Pediatrics, Stanford University, Stanford, CA, USA. .; Department of Genetics, Stanford University, Stanford, CA, USA. .
Zhang QC; Ministry of Education Key Laboratory of Bioinformatics, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China. .; Tsinghua-Peking Center for Life Sciences, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3397. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleic Acid Conformation*
DEAD-box RNA Helicases/*metabolism
RNA/*chemistry
Ribonuclease III/*metabolism
Computational Biology ; DEAD-box RNA Helicases/genetics ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Mutagenesis, Site-Directed ; Protein Binding/genetics ; RNA/genetics ; RNA/metabolism ; RNA Probes ; RNA-Seq ; Ribonuclease III/genetics ; Substrate Specificity/genetics
Czasopismo naukowe
Tytuł :
RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity.
Autorzy :
Koralewska N; Department of Molecular and Systems Biology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Szczepanska A; Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland.
Ciechanowska K; Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland.
Wojnicka M; Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland.
Pokornowska M; Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland.
Milewski MC; Department of Molecular and Systems Biology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Gudanis D; Department of Biomolecular NMR, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Baranowski D; Department of Biomolecular NMR, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Nithin C; Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, 02-109, Warsaw, Poland.
Bujnicki JM; Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, 02-109, Warsaw, Poland.; Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 61-614, Poznan, Poland.
Gdaniec Z; Department of Biomolecular NMR, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Figlerowicz M; Department of Molecular and Systems Biology, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704, Poznan, Poland.
Kurzynska-Kokorniak A; Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Apr; Vol. 78 (7), pp. 3709-3724. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
G-Quadruplexes*
DEAD-box RNA Helicases/*antagonists & inhibitors
DEAD-box RNA Helicases/*genetics
DNA/*metabolism
Enzyme Inhibitors/*pharmacology
MicroRNAs/*metabolism
RNA/*metabolism
Ribonuclease III/*antagonists & inhibitors
Ribonuclease III/*genetics
DEAD-box RNA Helicases/metabolism ; DNA/chemistry ; DNA/genetics ; Enzyme Inhibitors/chemistry ; Humans ; MicroRNAs/genetics ; Nucleic Acid Conformation ; Protein Conformation ; RNA/chemistry ; RNA/genetics ; Ribonuclease III/metabolism
Czasopismo naukowe
Tytuł :
Dicer-like proteins influence Arabidopsis root microbiota independent of RNA-directed DNA methylation.
Autorzy :
Kaushal R; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
Peng L; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
Singh SK; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
Zhang M; Department of Statistics, University of Georgia, Athens, GA, 30602, USA.
Zhang X; Department of Statistics, University of Georgia, Athens, GA, 30602, USA.
Vílchez JI; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
Wang Z; Department of Statistics, University of Georgia, Athens, GA, 30602, USA.
He D; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Yang Y; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
Lv S; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Xu Z; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.; Current address: Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Morcillo RJL; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.; Current address: Institute for Water Research and Department of Microbiology, University of Granada, Granada, Spain.
Wang W; Shanghai Chenshan Botanical Garden, Shanghai, 201602, China.
Huang W; Shanghai Chenshan Botanical Garden, Shanghai, 201602, China.
Paré PW; Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA.
Song CP; State Key Laboratory of Crop Stress Adaptation and Improvement, Henan University, Kaifeng, 475004, China.
Zhu JK; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.; Department of Horticulture & Landscape Architecture, Purdue University, West Lafayette, IN, 47906, USA.
Liu R; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.; Current address: Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Zhong W; Department of Statistics, University of Georgia, Athens, GA, 30602, USA.
Ma P; Department of Statistics, University of Georgia, Athens, GA, 30602, USA.
Zhang H; Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China. .; State Key Laboratory of Crop Stress Adaptation and Improvement, Henan University, Kaifeng, 475004, China. .
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Źródło :
Microbiome [Microbiome] 2021 Feb 26; Vol. 9 (1), pp. 57. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media
MeSH Terms :
Microbiota*/genetics
RNA, Plant*
Arabidopsis/*metabolism
Arabidopsis/*microbiology
DNA Methylation/*genetics
Plant Roots/*microbiology
Ribonuclease III/*metabolism
Arabidopsis/genetics ; Gene Expression Regulation, Plant/genetics ; Plant Roots/genetics ; RNA, Ribosomal, 16S/genetics ; Ribonuclease III/genetics
Czasopismo naukowe
Tytuł :
ReCGBM: a gradient boosting-based method for predicting human dicer cleavage sites.
Autorzy :
Liu P; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, 611-0011, Japan.
Song J; Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.
Lin CY; Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices, National Chiao Tung University, Hsinchu, 300, Taiwan.
Akutsu T; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, 611-0011, Japan. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Feb 10; Vol. 22 (1), pp. 63. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
DEAD-box RNA Helicases*/genetics
MicroRNAs*/genetics
RNA Precursors*
Ribonuclease III*/genetics
Humans ; RNA Cleavage
Czasopismo naukowe
Tytuł :
Impact of PNPase on the transcriptome of Rhodobacter sphaeroides and its cooperation with RNase III and RNase E.
Autorzy :
Spanka DT; Institute of Microbiology and Molecular Biology, Justus Liebig University Giessen, IFZ, Giessen, Germany.
Reuscher CM; Institute of Microbiology and Molecular Biology, Justus Liebig University Giessen, IFZ, Giessen, Germany.
Klug G; Institute of Microbiology and Molecular Biology, Justus Liebig University Giessen, IFZ, Giessen, Germany. .
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Źródło :
BMC genomics [BMC Genomics] 2021 Feb 06; Vol. 22 (1), pp. 106. Date of Electronic Publication: 2021 Feb 06.
Typ publikacji :
Journal Article
MeSH Terms :
Rhodobacter sphaeroides*/genetics
Rhodobacter sphaeroides*/metabolism
Ribonuclease III*/genetics
Anti-Bacterial Agents ; Endoribonucleases ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Polyribonucleotide Nucleotidyltransferase/genetics ; Polyribonucleotide Nucleotidyltransferase/metabolism ; RNA Stability ; RNA, Bacterial/genetics ; Transcriptome
Czasopismo naukowe
Tytuł :
Functional Atlas of Primary miRNA Maturation by the Microprocessor.
Autorzy :
Rice GM; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: .
Shivashankar V; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.
Ma EJ; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.
Baryza JL; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.
Nutiu R; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Dec 03; Vol. 80 (5), pp. 892-902.e4. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MicroRNAs*/chemistry
MicroRNAs*/genetics
MicroRNAs*/metabolism
Multiprotein Complexes*/chemistry
Multiprotein Complexes*/metabolism
Nucleic Acid Conformation*
RNA Processing, Post-Transcriptional*
RNA-Binding Proteins*/chemistry
RNA-Binding Proteins*/metabolism
Ribonuclease III*/chemistry
Ribonuclease III*/metabolism
Animals ; Humans ; Sf9 Cells ; Spodoptera
Czasopismo naukowe
Tytuł :
A pan-cancer atlas of somatic mutations in miRNA biogenesis genes.
Autorzy :
Galka-Marciniak P; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Urbanek-Trzeciak MO; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Nawrocka PM; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Kozlowski P; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 601-620.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
DEAD-box RNA Helicases/*genetics
MicroRNAs/*biosynthesis
Neoplasm Proteins/*genetics
Neoplasms/*genetics
RNA, Neoplasm/*biosynthesis
Ribonuclease III/*genetics
Smad2 Protein/*genetics
Smad4 Protein/*genetics
DEAD-box RNA Helicases/metabolism ; Datasets as Topic ; Gene Expression Regulation, Neoplastic ; Genes, Neoplasm ; Genome-Wide Association Study ; Humans ; MicroRNAs/genetics ; Models, Molecular ; Mutation, Missense ; Neoplasm Proteins/metabolism ; Neoplasms/metabolism ; Neoplasms/mortality ; Protein Conformation ; RNA, Neoplasm/genetics ; Ribonuclease III/metabolism ; Smad2 Protein/chemistry ; Smad2 Protein/metabolism ; Smad4 Protein/chemistry ; Smad4 Protein/metabolism
Czasopismo naukowe
Tytuł :
Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition.
Autorzy :
Shi Z; School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong.
To SKY; School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong.
Zhang S; State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Deng S; School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong.
Artemenko M; School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong.
Zhang M; State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Tang J; State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Zeng JZ; State Key Laboratory of Cellular Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.
Wong AST; School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong.
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Źródło :
Theranostics [Theranostics] 2021 Jan 19; Vol. 11 (7), pp. 3376-3391. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*genetics
Class I Phosphatidylinositol 3-Kinases/*genetics
Colorectal Neoplasms/*genetics
DEAD-box RNA Helicases/*genetics
Hypoxia/*genetics
Liver Neoplasms/*genetics
MicroRNAs/*genetics
Nuclear Receptor Subfamily 4, Group A, Member 1/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Ribonuclease III/*genetics
Adenocarcinoma/metabolism ; Adenocarcinoma/mortality ; Adenocarcinoma/secondary ; Animals ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; DEAD-box RNA Helicases/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia/metabolism ; Hypoxia/mortality ; Hypoxia/pathology ; Liver Neoplasms/metabolism ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Mice ; Mice, Nude ; MicroRNAs/metabolism ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Nuclear Receptor Subfamily 4, Group A, Member 1/antagonists & inhibitors ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Ribonuclease III/metabolism ; Signal Transduction ; Survival Analysis ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tumor Burden ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei.
Autorzy :
Gao Y; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Liu H; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200438, China.
Zhang C; College of Life Sciences, Sichuan University, Chengdu 610041, China.
Su S; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200438, China.
Chen Y; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Chen X; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200438, China.
Li Y; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Shao Z; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Zhang Y; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Shao Q; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Li J; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Huang Z; College of Life Sciences, Sichuan University, Chengdu 610041, China.
Ma J; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200438, China.
Gan J; Shanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 568-583.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protozoan Proteins/*chemistry
RNA Stability/*physiology
RNA, Guide/*metabolism
RNA, Protozoan/*metabolism
Ribonuclease III/*chemistry
Trypanosoma brucei brucei/*enzymology
Amino Acid Sequence ; Base Sequence ; Crystallography, X-Ray ; Gene Expression Regulation ; Models, Molecular ; Nucleic Acid Conformation ; Protein Conformation ; Protein Domains ; Protozoan Proteins/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Ribonuclease III/metabolism ; Structure-Activity Relationship ; Substrate Specificity ; Zinc Fingers
Czasopismo naukowe
Tytuł :
Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a.
Autorzy :
Le CT; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Nguyen TL; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Nguyen TD; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Nguyen TA; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Dec; Vol. 26 (12), pp. 1777-1786. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Single Nucleotide*
RNA Processing, Post-Transcriptional*
Disease/*genetics
MicroRNAs/*genetics
Ribonuclease III/*chemistry
Humans ; MicroRNAs/chemistry ; MicroRNAs/metabolism ; Ribonuclease III/metabolism
Czasopismo naukowe
Tytuł :
Somatic DICER1 Mutations in a Pubertal Girl with Cervical Embryonal Rhabdomyosarcoma and Papillary Thyroid Adenoma.
Autorzy :
Zhang L; Department of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Ye H; Department of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Jin Y; Department of Pathology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Zhong P; Department of Pathology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Duan H; Department of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Electronic address: .
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Źródło :
Journal of pediatric and adolescent gynecology [J Pediatr Adolesc Gynecol] 2020 Dec; Vol. 33 (6), pp. 742-744. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Case Reports
MeSH Terms :
Mutation*
DEAD-box RNA Helicases/*genetics
DNA, Neoplasm/*genetics
Rhabdomyosarcoma, Embryonal/*genetics
Ribonuclease III/*genetics
Thyroid Neoplasms/*genetics
Uterine Cervical Neoplasms/*genetics
Adolescent ; DEAD-box RNA Helicases/metabolism ; DNA Mutational Analysis ; Diagnosis, Differential ; Female ; Humans ; Rhabdomyosarcoma, Embryonal/complications ; Rhabdomyosarcoma, Embryonal/diagnosis ; Ribonuclease III/metabolism ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/diagnosis ; Uterine Cervical Neoplasms/complications ; Uterine Cervical Neoplasms/diagnosis
Raport
Tytuł :
In vitro studies provide insight into effects of Dicer-2 helicase mutations in Drosophila melanogaster .
Autorzy :
Donelick HM; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Talide L; Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.
Bellet M; Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.
Aruscavage PJ; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Lauret E; Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.
Aguiar ERGR; Centro de Biotecnologia e Genética, Universidade Estadual de Santa Cruz, Ilhéus 45662-900, Bahia, Brazil.
Marques JT; Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.; Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, CEP 31270-901, Brazil.
Meignin C; Université de Strasbourg, CNRS UPR9022, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.
Bass BL; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Dec; Vol. 26 (12), pp. 1847-1861. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Adenosine Triphosphate/*metabolism
DNA Helicases/*metabolism
Drosophila Proteins/*metabolism
Drosophila melanogaster/*genetics
RNA Helicases/*metabolism
RNA, Double-Stranded/*metabolism
Ribonuclease III/*metabolism
Animals ; DNA Helicases/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/enzymology ; Drosophila melanogaster/growth & development ; Female ; In Vitro Techniques ; Male ; MicroRNAs/genetics ; RNA Helicases/genetics ; RNA, Double-Stranded/genetics ; RNA, Small Interfering/genetics ; Ribonuclease III/genetics
Czasopismo naukowe
Tytuł :
Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets.
Autorzy :
Shiromoto Y; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Sakurai M; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Qu H; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Kossenkov AV; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Nishikura K; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Dec; Vol. 26 (12), pp. 1801-1814. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alu Elements*
RNA Processing, Post-Transcriptional*
Adenosine Deaminase/*metabolism
Argonaute Proteins/*metabolism
DEAD-box RNA Helicases/*metabolism
RNA/*metabolism
RNA, Small Interfering/*metabolism
RNA-Binding Proteins/*metabolism
Ribonuclease III/*metabolism
3' Untranslated Regions ; Adenosine Deaminase/genetics ; Argonaute Proteins/genetics ; DEAD-box RNA Helicases/genetics ; HeLa Cells ; Hep G2 Cells ; Humans ; Nucleic Acid Conformation ; RNA/chemistry ; RNA/genetics ; RNA Editing ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/genetics ; Ribonuclease III/genetics
Czasopismo naukowe
Tytuł :
Mini-III RNase-based dual-color system for in vivo mRNA tracking.
Autorzy :
Zhang L; Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China.
Chen L; Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China.
Chen J; Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China.
Shen W; Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China.
Meng A; Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China .
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Źródło :
Development (Cambridge, England) [Development] 2020 Nov 30; Vol. 147 (22). Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescein*/chemistry
Fluorescein*/pharmacology
RNA, Antisense*/chemistry
RNA, Antisense*/pharmacology
Staphylococcus epidermidis*/enzymology
Staphylococcus epidermidis*/genetics
Bacterial Proteins/*metabolism
RNA, Messenger/*metabolism
Ribonuclease III/*metabolism
Zebrafish/*metabolism
Animals ; Bacterial Proteins/genetics ; Microscopy, Fluorescence ; RNA, Messenger/genetics ; Ribonuclease III/genetics ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Autorzy :
Wang Y; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, Wenzhou, China.; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, 325003, Zhejiang, People's Republic of China.
Lian M; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, Wenzhou, China.; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, 325003, Zhejiang, People's Republic of China.
Zhou J; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, Wenzhou, China.; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, 325003, Zhejiang, People's Republic of China.
Wu S; School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University, Wenzhou, China. .; State Key Laboratory of Optometry, Ophthalmology, and Visual Science, 270 Xueyuan Road, Wenzhou, 325003, Zhejiang, People's Republic of China. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2020 Nov; Vol. 57 (11), pp. 4417-4437. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*metabolism
Brain/*metabolism
DEAD-box RNA Helicases/*genetics
Down-Regulation/*genetics
NF-E2-Related Factor 2/*metabolism
Peptide Fragments/*metabolism
Ribonuclease III/*genetics
Acetylcysteine/pharmacology ; Animals ; Antioxidant Response Elements/genetics ; Apoptosis/drug effects ; Caspase 3/metabolism ; DEAD-box RNA Helicases/metabolism ; Disease Models, Animal ; Female ; Gene Knockdown Techniques ; Hippocampus/metabolism ; Humans ; Male ; Membrane Potential, Mitochondrial ; Mice, Transgenic ; Neurons/metabolism ; Neurotoxicity Syndromes/pathology ; Presenilin-1/metabolism ; Reactive Oxygen Species/metabolism ; Ribonuclease III/metabolism ; Spatial Learning/drug effects
Czasopismo naukowe
Tytuł :
Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
Autorzy :
Brandão BB; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
Madsen S; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Rabiee A; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Oliverio M; Laboratory of Non-Coding Principles of Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.; Research Area 1, Cologne Cluster of Excellence in Cellular Stress Responses in Ageing-Associated Diseases, 50931 Cologne, Germany.; Internal Medicin I, Apoptosis-Signaling and Therapy Resistance Group, University Hospital of Cologne, 50937 Cologne, Germany.
Ruiz GP; Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
Ferrucci DL; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
Branquinho JL; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.
Razolli D; Obesity and Comorbidities Research Center, University of Campinas, 13083-862 Campinas, Brazil.; Laboratory of Cell and Molecular Biology, São Francisco University, 12916-900 Bragança Paulista, Brazil.
Pinto S; Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
Nielsen TS; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Festuccia WT; Department of Physiology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil.
Martins AS; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.; Orthopedics Department, Maimonides Medical Center, Brooklyn, NY 11219.
Guerra BA; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil.; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
Knittel TL; Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.
Søgaard D; Department of Biomedical Sciences, Center of Healthy Aging, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Larsen S; Department of Biomedical Sciences, Center of Healthy Aging, University of Copenhagen, DK-2200 Copenhagen, Denmark.; Clinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland.
Helge JW; Department of Biomedical Sciences, Center of Healthy Aging, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Brandauer J; Department of Health Sciences, Gettysburg College, Gettysburg, PA 17325.
Velloso LA; Obesity and Comorbidities Research Center, University of Campinas, 13083-862 Campinas, Brazil.
Emanuelli B; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Kornfeld JW; Department for Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense, Denmark.
Kahn CR; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215; .
Vienberg SG; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Zierath JR; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.; Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 77 Stockholm, Sweden.
Treebak JT; Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; .
Mori MA; Program in Molecular Biology, Federal University of São Paulo, 04044-020 São Paulo, Brazil; .; Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862 São Paulo, Brazil.; Obesity and Comorbidities Research Center, University of Campinas, 13083-862 Campinas, Brazil.; Experimental Medicine Research Cluster, University of Campinas, 13083-862 Campinas, Brazil.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 22; Vol. 117 (38), pp. 23932-23941. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue/*metabolism
DEAD-box RNA Helicases/*metabolism
Exercise/*physiology
Ribonuclease III/*metabolism
AMP-Activated Protein Kinases/metabolism ; Adaptation, Physiological/physiology ; Adipocytes/metabolism ; Animals ; Cells, Cultured ; DEAD-box RNA Helicases/deficiency ; DEAD-box RNA Helicases/genetics ; Female ; Glycolysis ; Humans ; Male ; Mice ; Mice, Knockout ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Physical Conditioning, Animal ; Ribonuclease III/deficiency ; Ribonuclease III/genetics
Czasopismo naukowe

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