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Tytuł:
Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome.
Autorzy:
Su L; Sino-American Cancer Foundation, Covina, CA, 91722, USA.
Wang X; Sino-American Cancer Foundation, Covina, CA, 91722, USA.
Wang J; Sino-American Cancer Foundation, Covina, CA, 91722, USA.
Luh F; Sino-American Cancer Foundation, Covina, CA, 91722, USA.
Yen Y; Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110301, Taiwan. .; Center for Cancer Translational Research, Tzu Chi University, Hualien, 970374, Taiwan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 14; Vol. 13 (1), pp. 19899. Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation, Missense*
Ribonucleotide Reductases*/metabolism
Humans ; Mutation ; Phenylalanine/genetics ; DNA, Mitochondrial/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure of a ribonucleotide reductase R2 protein radical.
Autorzy:
Lebrette H; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.; Laboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative, CNRS, Université Toulouse III, Toulouse, France.
Srinivas V; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
John J; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Aurelius O; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.; MAX IV Laboratory, Lund University, Lund, Sweden.
Kumar R; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Lundin D; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Brewster AS; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Bhowmick A; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Sirohiwal A; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Kim IS; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Gul S; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Pham C; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Sutherlin KD; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Simon P; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Butryn A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Aller P; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Orville AM; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.
Fuller FD; LCLS, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Alonso-Mori R; LCLS, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Batyuk A; LCLS, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Sauter NK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yachandra VK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Yano J; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Kaila VRI; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Sjöberg BM; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
Kern J; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Roos K; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Högbom M; Department of Biochemistry and Biophysics, Stockholm University, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 06; Vol. 382 (6666), pp. 109-113. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article
MeSH Terms:
Ribonucleotide Reductases*/chemistry
Entomoplasmataceae*/enzymology
Bacterial Proteins*/chemistry
Electron Transport ; Protons ; Crystallography, X-Ray/methods ; Catalytic Domain
SCR Organism:
Mesoplasma florum
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ribonucleotide reductase regulatory subunit M2 (RRM2) as a potential sero-diagnostic biomarker in non-small cell lung cancer.
Autorzy:
Zhou D; Department of Clinical Laboratory, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China.; Chongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing, 400021, China.
Zhai X; Department of Clinical Laboratory, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China.
Zhang R; School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
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Źródło:
PloS one [PLoS One] 2023 Sep 12; Vol. 18 (9), pp. e0291461. Date of Electronic Publication: 2023 Sep 12 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/diagnosis
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/diagnosis
Lung Neoplasms*/genetics
Ribonucleotide Reductases*/genetics
Humans ; Biomarkers, Tumor/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Diagnosing mitochondrial, neurogastrointestinal leukoencephalopathy requires mutations in TYMP1, POLG1, LIG1, or RRM2B.
Autorzy:
Finsterer J; Neurology and Neurophysiology Center, Postfach 20, 1180, Vienna, Austria. .
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Źródło:
Journal of medical case reports [J Med Case Rep] 2023 Apr 14; Vol. 17 (1), pp. 162. Date of Electronic Publication: 2023 Apr 14.
Typ publikacji:
Letter; Comment
MeSH Terms:
Mitochondrial Encephalomyopathies*/diagnosis
Mitochondrial Encephalomyopathies*/genetics
Leukoencephalopathies*/genetics
Ribonucleotide Reductases*/genetics
Humans ; Female ; Pakistan ; Mutation ; Cell Cycle Proteins/genetics ; DNA Ligase ATP/genetics
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Requirement and functional redundancy of two large ribonucleotide reductase subunit genes for cell cycle, chloroplast biogenesis and photosynthesis in tomato.
Autorzy:
Gu M; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China.
Lu Q; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Liu Y; Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang, Jiangxi, China.
Cui M; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China.
Si Y; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China.
Wu H; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.
Chai T; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Ling HQ; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China.; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China.
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Źródło:
Annals of botany [Ann Bot] 2022 Sep 06; Vol. 130 (2), pp. 173-187.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Solanum lycopersicum*/genetics
Solanum lycopersicum*/metabolism
Ribonucleotide Reductases*/genetics
Ribonucleotide Reductases*/metabolism
Cell Cycle/genetics ; Chloroplasts ; Gene Expression Regulation, Plant ; Photosynthesis/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of Novel Ribonucleotide Reductase Inhibitors for Therapeutic Application in Bile Tract Cancer: An Advanced Pharmacoinformatics Study.
Autorzy:
Islam MA; 3BIGS Omicscore Private Limited, 909 Lavelle Building, Richmond Circle, Bangalore 560025, India.
Barshetty MM; 3BIGS Omicscore Private Limited, 909 Lavelle Building, Richmond Circle, Bangalore 560025, India.
Srinivasan S; 3BIGS Omicscore Private Limited, 909 Lavelle Building, Richmond Circle, Bangalore 560025, India.
Dudekula DB; 3BIGS Omicscore Private Limited, 909 Lavelle Building, Richmond Circle, Bangalore 560025, India.
Rallabandi VPS; 3BIGS Omicscore Private Limited, 909 Lavelle Building, Richmond Circle, Bangalore 560025, India.
Mohammed S; 3BIGS Omicscore Private Limited, 909 Lavelle Building, Richmond Circle, Bangalore 560025, India.
Natarajan S; 3BIGS Co., Ltd., B-831, Geumgang Penterium IX Tower, Hwaseong 18469, Korea.
Park J; 3BIGS Co., Ltd., B-831, Geumgang Penterium IX Tower, Hwaseong 18469, Korea.
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Źródło:
Biomolecules [Biomolecules] 2022 Sep 10; Vol. 12 (9). Date of Electronic Publication: 2022 Sep 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biliary Tract Neoplasms*/drug therapy
Ribonucleotide Reductases*
Amino Acids ; Bile ; Humans ; Hydrazones/therapeutic use ; Molecular Docking Simulation ; Molecular Dynamics Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present.
Autorzy:
Huff SE; Department of Pediatrics, University of California, San Diego, CA 92093, USA.
Winter JM; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, Akron, OH 44106, USA.
Dealwis CG; Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Jun 10; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 10.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Neoplasms*/drug therapy
Ribonucleotide Reductases*/metabolism
Catalytic Domain ; Diphosphates ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma.
Autorzy:
Xie Y; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Wang Y; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Xu Z; CAS Key Laboratory of Receptor Research; State Key Laboratory of Drug Research; Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.
Lu Y; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Song D; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Gao L; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Yu D; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Li B; CAS Key Laboratory of Receptor Research; State Key Laboratory of Drug Research; Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.
Chen G; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Zhang H; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Feng Q; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Zhang Y; CAS Key Laboratory of Receptor Research; State Key Laboratory of Drug Research; Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.
Hu K; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Huang C; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Peng Y; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Wu X; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China.
Mao Z; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Shao J; Department of Pathology and Pathophysiology, Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University Cancer Center, 866 Yuhangtang Road, Hangzhou, 310058, Zhejiang, China. .
Zhu W; CAS Key Laboratory of Receptor Research; State Key Laboratory of Drug Research; Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. .
Shi J; Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 YanChang Road, Shanghai, 200072, China. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2022 May 12; Vol. 29 (1), pp. 32. Date of Electronic Publication: 2022 May 12.
Typ publikacji:
Clinical Trial, Phase I; Journal Article
MeSH Terms:
Multiple Myeloma*/drug therapy
Multiple Myeloma*/genetics
Ribonucleotide Reductases*/genetics
Ribonucleotide Reductases*/metabolism
DNA Breaks, Double-Stranded ; DNA Damage ; DNA Repair ; DNA Replication ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations.
Autorzy:
Saeed A; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Ejaz SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Khalid A; Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Channar PA; Department of Basic Sciences and Humanities, Faculty of of Information Science and Humanities, Dawood University of Engineering and Technology, Karachi 74800, Pakistan.
Aziz M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Abbas Q; Department of Biology, College of Science, University of Bahrain, Sakhir Campus, Zallaq 32038, Bahrain.; Department of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju 314-701, Chungnam, Korea.
Wani TA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Alsaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Al-Hossaini AM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Altwaijry N; Department of Biochemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11451, Saudi Arabia.
Zargar S; Department of Biochemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11451, Saudi Arabia.
Elhadi M; Department of Physics, Faculty of Science and Humanities, Ed Dawadmi, Shaqra University, Shaqra 11961, Saudi Arabia.
Hökelek T; Department of Physics, Faculty of Engineering, Hacettepe University, Beytepe, Ankara 06800, Turkey.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 29; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Monophenol Monooxygenase*
Ribonucleotide Reductases*
Thiones/pharmacology ; Molecular Docking Simulation ; Acetophenones/pharmacology ; DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress.
Autorzy:
Ueno H; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan. .
Hoshino T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Yano W; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Tsukioka S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Suzuki T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Hara S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Ogino Y; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Chong KT; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Suzuki T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Tsuji S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Itadani H; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Yamamiya I; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Otsu Y; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Ito S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Yonekura T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Terasaka M; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Tanaka N; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Miyahara S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan. .
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Źródło:
Communications biology [Commun Biol] 2022 Jun 09; Vol. 5 (1), pp. 571. Date of Electronic Publication: 2022 Jun 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
Enzyme Inhibitors*/pharmacology
Ribonucleotide Reductases*/antagonists & inhibitors
Animals ; DNA Replication ; Humans ; Nuclear Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates.
Autorzy:
Levitz TS; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Andree GA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Jonnalagadda R; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Dawson CD; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Bjork RE; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
Drennan CL; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, United States of America.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, United States of America.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, United States of America.; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Jun 08; Vol. 17 (6), pp. e0269572. Date of Electronic Publication: 2022 Jun 08 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Escherichia coli*/metabolism
Ribonucleotide Reductases*/genetics
Anaerobiosis ; Chromatography, Liquid ; Ribonucleotides ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase.
Autorzy:
Knighton LE; Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America.
Nitika; Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America.
Omkar S; Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America.
Truman AW; Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2022 Apr 13; Vol. 18 (4), pp. e1010079. Date of Electronic Publication: 2022 Apr 13 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Ribonucleotide Reductases*/genetics
Ribonucleotide Reductases*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
DNA Replication/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Response ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bone marrow ribonucleotide reductase mRNA levels and methylation status as prognostic factors in patients with myelodysplastic syndrome treated with 5-Azacytidine.
Autorzy:
Kontandreopoulou CN; Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Diamantopoulos PT; Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Giannopoulos A; Haematology Research Lab, Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Athens, Greece.
Symeonidis A; Department of Internal Medicine, University Hospital of Patras, Rio, Greece.
Kotsianidis I; Department of Hematology, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Pappa V; Haematology Division, Second Department of Internal Medicine, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Galanopoulos A; Department of Clinical Hematology, 'G. Gennimatas' District General Hospital, Athens, Greece.
Panayiotidis P; First Department of Propedeutic Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Dimou M; First Department of Propedeutic Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Solomou E; Department of Internal Medicine, University Hospital of Patras, Rio, Greece.
Loupis T; Haematology Research Lab, Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Athens, Greece.
Zoi K; Haematology Research Lab, Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Athens, Greece.
Giannakopoulou N; Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Dryllis G; Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Hatzidavid S; Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Viniou NA; Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
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Corporate Authors:
Hellenic MDS study Group
Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2022 Mar; Vol. 63 (3), pp. 729-737. Date of Electronic Publication: 2021 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Myelodysplastic Syndromes*/diagnosis
Myelodysplastic Syndromes*/drug therapy
Myelodysplastic Syndromes*/genetics
Ribonucleotide Reductases*/genetics
Azacitidine/pharmacology ; Azacitidine/therapeutic use ; Bone Marrow/metabolism ; Humans ; Methylation ; Prognosis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribonucleoside Diphosphate Reductase/genetics ; Ribonucleoside Diphosphate Reductase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in Saccharomyces cerevisiae.
Autorzy:
Lamb NA; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY 14203, USA.
Bard JE; University at Buffalo Genomics and Bioinformatics Core, Buffalo, NY 14203, USA.; Genetics, Genomics and Bioinformatics Graduate Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY 14203, USA.
Buck MJ; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY 14203, USA.; Genetics, Genomics and Bioinformatics Graduate Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY 14203, USA.
Surtees JA; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY 14203, USA.; Genetics, Genomics and Bioinformatics Graduate Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY 14203, USA.
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Jun 17; Vol. 11 (6).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Ribonucleotide Reductases*/genetics
Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; High-Throughput Nucleotide Sequencing ; DNA Replication ; Mutation ; Nucleotides/metabolism ; Genotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Biotechnological and Biomedical Applications of Enzymes Involved in the Synthesis of Nucleosides and Nucleotides.
Autorzy:
Fernández-Lucas J; Applied Biotechnology Group, Biomedical Science School, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain.; Research Group in Natural and Exact Sciences, GICNEX, Universidad de la Costa, CUC, Barranquilla 080002, Colombia.
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Źródło:
Biomolecules [Biomolecules] 2021 Aug 03; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 03.
Typ publikacji:
Editorial
MeSH Terms:
Glycosyltransferases/*metabolism
Nucleosides/*biosynthesis
Nucleotides/*biosynthesis
Pentosyltransferases/*metabolism
Phosphotransferases/*metabolism
Phosphotransferases (Phosphate Group Acceptor)/*metabolism
Ribonucleotide Reductases/*metabolism
Animals ; Bacteria/enzymology ; Bacteria/genetics ; Biocatalysis ; Biotechnology/methods ; DNA/biosynthesis ; DNA/genetics ; Fungi/enzymology ; Fungi/genetics ; Gene Expression ; Glycosyltransferases/genetics ; Humans ; Pentosyltransferases/genetics ; Phosphotransferases/genetics ; Phosphotransferases (Phosphate Group Acceptor)/genetics ; RNA/biosynthesis ; RNA/genetics ; Ribonucleotide Reductases/genetics
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The single nucleotide variant at c.662A>G in human RRM2B is a loss-of-function mutation.
Autorzy:
Tseng YT; Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.
Li SW; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
HuangFu WC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Yen Y; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.; Cancer Center, Taipei Municipal WanFang Hospital, Taipei, Taiwan.
Liu IH; Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Nov; Vol. 8 (11), pp. e1497. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Loss of Function Mutation*
Cell Cycle Proteins/*genetics
Mitochondrial Diseases/*genetics
Muscular Dystrophies/*genetics
Ribonucleotide Reductases/*genetics
Animals ; Cell Cycle Proteins/metabolism ; Humans ; Point Mutation ; Ribonucleotide Reductases/metabolism ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study.
Autorzy:
Ait El Cadi C; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.; Laboratory of Biosciences, Functional Integrated and Molecular Exploration-LBEFIM-, Biology Department, Faculty of Sciences and Technics of Mohammedia, University of Hassan II, Mohammedia 28806, Morocco.
Krami AM; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.
Charoute H; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.
Elkarhat Z; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.
Sifeddine N; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.
Lakhiari H; Laboratory of Biosciences, Functional Integrated and Molecular Exploration-LBEFIM-, Biology Department, Faculty of Sciences and Technics of Mohammedia, University of Hassan II, Mohammedia 28806, Morocco.
Rouba H; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.
Barakat A; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.
Nahili H; Laboratory of Genomics and Human Genetics, Institut Pasteur du Maroc, 20360 Casablanca, Morocco.
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Źródło:
BioMed research international [Biomed Res Int] 2020 Jul 25; Vol. 2020, pp. 7614634. Date of Electronic Publication: 2020 Jul 25 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Cell Cycle Proteins*/chemistry
Cell Cycle Proteins*/genetics
Models, Molecular*
Mutation*
Polymorphism, Single Nucleotide*
Ribonucleotide Reductases*/chemistry
Ribonucleotide Reductases*/genetics
Humans ; Protein Domains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron.
Autorzy:
Grāve K; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.
Griese JJ; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.; Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, 75124, Uppsala, Sweden.
Berggren G; Department of Chemistry, Ångström Laboratory, Uppsala University, Lägerhyddsvägen 1, 75120, Uppsala, Sweden.
Bennett MD; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.
Högbom M; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden. .
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Źródło:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2020 Jun; Vol. 25 (4), pp. 571-582. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacillus anthracis/*enzymology
Bacterial Proteins/*metabolism
Iron/*metabolism
Manganese/*metabolism
Ribonucleotide Reductases/*metabolism
Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Crystallography, X-Ray ; Iron/chemistry ; Manganese/chemistry ; Models, Molecular ; Protein Conformation ; Ribonucleotide Reductases/chemistry ; Ribonucleotide Reductases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Class Id ribonucleotide reductase utilizes a Mn 2 (IV,III) cofactor and undergoes large conformational changes on metal loading.
Autorzy:
Rozman Grinberg I; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Berglund S; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Hasan M; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
Lundin D; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Ho FM; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Magnuson A; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Logan DT; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden. .
Sjöberg BM; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. .
Berggren G; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden. .
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Źródło:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2019 Sep; Vol. 24 (6), pp. 863-877. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Manganese/*metabolism
Ribonucleotide Reductases/*metabolism
Aerococcaceae/metabolism ; Crystallography, X-Ray ; Electron Spin Resonance Spectroscopy ; Flavobacteriaceae/metabolism ; Free Radicals/metabolism ; Hydrogen Peroxide/metabolism ; Oxidation-Reduction ; Ribonucleotide Reductases/chemistry ; Ribonucleotide Reductases/genetics ; Superoxides/metabolism
SCR Organism:
Facklamia ignava; Leeuwenhoekiella blandensis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-guided design of anti-cancer ribonucleotide reductase inhibitors.
Autorzy:
Misko TA; a Department of Pharmacology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.
Liu YT; b School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.
Harris ME; c Department of Chemistry , University of Florida , Gainesville , FL , United States.
Oleinick NL; d Department of Radiation Oncology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.
Pink J; e Case Comprehensive Cancer Center, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.
Lee HY; b School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.; f Ph.D Program in Biotechnology Research and Development, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.
Dealwis CG; a Department of Pharmacology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.; g Department of Chemistry, Center for Proteomics , Case Western Reserve University , Cleveland , OH , USA.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 438-450.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Ribonucleotide Reductases/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Ribonucleotide Reductases/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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