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Wyszukujesz frazę ""Ribosomes"" wg kryterium: Temat


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Tytuł :
Loading messenger RNAs onto ribosomes in human mitochondria: lessons learned from a bacterial toxin.
Autorzy :
Borowski LS; Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland.; Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Poland.
Szczesny RJ; Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland.
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Źródło :
The FEBS journal [FEBS J] 2021 Jan; Vol. 288 (2), pp. 434-436. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Bacterial Toxins*/metabolism
Mitochondrial Ribosomes*
Humans ; Mitochondria/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Structural basis of translation termination, rescue, and recycling in mammalian mitochondria.
Autorzy :
Kummer E; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland. Electronic address: .
Schubert KN; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland.
Schoenhut T; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland.
Scaiola A; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland.
Ban N; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jun 17; Vol. 81 (12), pp. 2566-2582.e6. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria/*physiology
Mitochondrial Ribosomes/*metabolism
Peptide Chain Termination, Translational/*physiology
Animals ; Carboxylic Ester Hydrolases ; Codon, Terminator ; Cryoelectron Microscopy/methods ; Humans ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism ; Peptide Chain Termination, Translational/genetics ; Peptide Elongation Factor G/metabolism ; Peptide Termination Factors/metabolism ; Protein Biosynthesis ; Ribosomal Proteins/metabolism ; Ribosomal Proteins/physiology ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Hydrophobic and electrostatic interactions modulate protein escape at the ribosomal exit tunnel.
Autorzy :
Bui PT; Institute of Theoretical and Applied Research, Duy Tan University, Hanoi, Vietnam; Faculty of Pharmacy, Duy Tan University, Da Nang, Vietnam.
Hoang TX; Institute of Physics, Vietnam Academy of Science and Technology, Ba Dinh, Hanoi, Vietnam; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Nov 02; Vol. 120 (21), pp. 4798-4808. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteins*
Ribosomes*
Diffusion ; Molecular Dynamics Simulation ; Static Electricity
Czasopismo naukowe
Tytuł :
Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs.
Autorzy :
Sun YH; Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Wang RH; Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Du K; Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Zhu J; Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Zheng J; School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Xie LH; Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Pereira AA; Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Zhang C; School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Ricci EP; Université de Lyon, ENSL, UCBL, INSERM, CNRS, LBMC, 46 Allée d'Italie, Lyon, 69007, France.
Li XZ; Center for RNA Biology: From Genome to Therapeutics, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 13; Vol. 12 (1), pp. 5970. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
3' Untranslated Regions*
Protein Biosynthesis*
Fertility/*genetics
RNA, Small Interfering/*genetics
Ribosomes/*genetics
Spermatogenesis/*genetics
Animals ; Base Sequence ; Chickens ; DNA Transposable Elements ; Gene Expression Regulation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pachytene Stage ; RNA, Small Interfering/metabolism ; Ribosomes/metabolism ; Testis/cytology ; Testis/growth & development ; Testis/metabolism
Czasopismo naukowe
Tytuł :
Structural mechanism of GTPase-powered ribosome-tRNA movement.
Autorzy :
Petrychenko V; Department of Structural Dynamics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Peng BZ; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
de A P Schwarzer AC; Department of Structural Dynamics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.; Department of Molecular Biology, University Medical Center Göttingen, Göttingen, Germany.
Peske F; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Rodnina MV; Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. .
Fischer N; Department of Structural Dynamics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 11; Vol. 12 (1), pp. 5933. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Escherichia coli/*genetics
Peptide Elongation Factor G/*chemistry
RNA, Messenger/*chemistry
RNA, Ribosomal, 23S/*chemistry
RNA, Transfer/*chemistry
Ribosomes/*metabolism
Binding Sites ; Biomechanical Phenomena ; Cryoelectron Microscopy ; Escherichia coli/metabolism ; Guanosine Triphosphate/chemistry ; Guanosine Triphosphate/metabolism ; Hydrolysis ; Kinetics ; Models, Molecular ; Peptide Elongation Factor G/genetics ; Peptide Elongation Factor G/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Folding ; Protein Interaction Domains and Motifs ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Ribosomal, 23S/genetics ; RNA, Ribosomal, 23S/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Ribosomes/ultrastructure ; Thermodynamics
Czasopismo naukowe
Tytuł :
Simultaneous ribosome profiling of hundreds of microbes from the human microbiome.
Autorzy :
Fremin BJ; Department of Genetics, Stanford University, Stanford, CA, USA.
Nicolaou C; Divisions of Hematology and Blood & Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA, USA.
Bhatt AS; Department of Genetics, Stanford University, Stanford, CA, USA. .; Divisions of Hematology and Blood & Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA, USA. .
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Źródło :
Nature protocols [Nat Protoc] 2021 Oct; Vol. 16 (10), pp. 4676-4691. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Microbiota*
Ribosomes*
Feces ; Humans ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Mechanism of membrane-tethered mitochondrial protein synthesis.
Autorzy :
Itoh Y; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165 Solna, Stockholm, Sweden. .; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Andréll J; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165 Solna, Stockholm, Sweden. .; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Choi A; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. .
Richter U; Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland. .; Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland.; Wellcome Centre for Mitochondrial Research, Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Maiti P; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Best RB; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA.
Barrientos A; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. .
Battersby BJ; Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland. .
Amunts A; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165 Solna, Stockholm, Sweden. .; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 846-849.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Electron Transport Complex IV/*metabolism
Membrane Proteins/*biosynthesis
Mitochondrial Proteins/*metabolism
Mitochondrial Ribosomes/*metabolism
Nuclear Proteins/*metabolism
Cryoelectron Microscopy ; Electron Transport Complex IV/chemistry ; Humans ; Membrane Proteins/chemistry ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/chemistry ; Mitochondrial Ribosomes/ultrastructure ; Models, Molecular ; Nuclear Proteins/chemistry ; Protein Binding ; Protein Conformation ; Protein Folding ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Exploring Ribosome-Positioning on Translating Transcripts with Ribosome Profiling.
Autorzy :
Cope AL; Department of Genetics, Rutgers University, Piscataway, NJ, USA.; Human Genetics Institute of New Jersey, Piscataway, NJ, USA.
Vellappan S; Department of Genetics, Rutgers University, Piscataway, NJ, USA.; Waksman Institute, Rutgers University, Piscataway, NJ, USA.
Favate JS; Department of Genetics, Rutgers University, Piscataway, NJ, USA.; Human Genetics Institute of New Jersey, Piscataway, NJ, USA.
Skalenko KS; Department of Genetics, Rutgers University, Piscataway, NJ, USA.; Waksman Institute, Rutgers University, Piscataway, NJ, USA.
Yadavalli SS; Department of Genetics, Rutgers University, Piscataway, NJ, USA.; Waksman Institute, Rutgers University, Piscataway, NJ, USA.
Shah P; Department of Genetics, Rutgers University, Piscataway, NJ, USA. .; Human Genetics Institute of New Jersey, Piscataway, NJ, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2404, pp. 83-110.
Typ publikacji :
Journal Article
MeSH Terms :
Ribosomes*/genetics
Ribosomes*/metabolism
Gene Expression Profiling ; Gene Expression Regulation ; Protein Biosynthesis ; Quality Control ; RNA, Messenger/metabolism ; Sequence Analysis, RNA ; Transcriptome
Czasopismo naukowe
Tytuł :
Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling.
Autorzy :
van der Stel AX; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France.
Gordon ER; Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, USA.
Sengupta A; Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, USA.
Martínez AK; Department of Biology, Texas A&M University, College Station, TX, USA.
Klepacki D; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Perry TN; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France.
Herrero Del Valle A; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France.
Vázquez-Laslop N; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Sachs MS; Department of Biology, Texas A&M University, College Station, TX, USA. .
Cruz-Vera LR; Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, AL, USA. .
Innis CA; Univ. Bordeaux, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, ARNA, UMR 5320, U1212, Institut Européen de Chimie et Biologie, Pessac, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 09; Vol. 12 (1), pp. 5340. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Bacterial*
Peptide Chain Initiation, Translational*
Escherichia coli/*genetics
Ribosomes/*genetics
Tryptophan/*chemistry
Amino Acid Substitution ; Binding Sites ; Cryoelectron Microscopy ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Models, Molecular ; Mutation ; Operon ; Peptide Chain Termination, Translational ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA, Transfer, Amino Acyl/genetics ; RNA, Transfer, Amino Acyl/metabolism ; Ribosomes/metabolism ; Ribosomes/ultrastructure ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density.
Autorzy :
Schott J; Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. .; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany. .
Reitter S; Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.
Lindner D; Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.
Grosser J; Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.
Bruer M; Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.
Shenoy A; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.
Geiger T; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Mathes A; Department of Anatomy and Developmental Biology, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Center for Cardiovascular Research (DZHK), Heidelberg, Germany.
Dobreva G; Department of Anatomy and Developmental Biology, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Center for Cardiovascular Research (DZHK), Heidelberg, Germany.
Stoecklin G; Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), German Cancer Research Center (DKFZ)-ZMBH Alliance, Heidelberg, Germany.
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Źródło :
Nature methods [Nat Methods] 2021 Sep; Vol. 18 (9), pp. 1068-1074. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Ribosomes/*genetics
Ribosomes/*metabolism
Sequence Analysis, RNA/*methods
Animals ; Cytoplasm/genetics ; Kinetics ; Lipopolysaccharides/pharmacology ; Mice ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/physiology ; RAW 264.7 Cells ; RNA, Messenger/genetics ; Ribosomal Proteins/biosynthesis ; Ribosomal Proteins/genetics ; Ribosomes/drug effects ; Time Factors
Czasopismo naukowe
Tytuł :
Somatic genetic rescue of a germline ribosome assembly defect.
Autorzy :
Tan S; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Kermasson L; Université de Paris, Imagine Institute, Laboratory of Genome Dynamics in the Immune System, Equipe Labellisée Ligue contre le Cancer, INSERM UMR 1163, Paris, France.
Hilcenko C; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Kargas V; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Traynor D; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Boukerrou AZ; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Escudero-Urquijo N; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Faille A; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Bertrand A; Université de Paris, Imagine Institute, Laboratory of Genome Dynamics in the Immune System, Equipe Labellisée Ligue contre le Cancer, INSERM UMR 1163, Paris, France.
Rossmann M; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom.; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.
Goyenechea B; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; PolyProx Therapeutics, Babraham Research Campus, Cambridge, UK.
Jin L; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, UK.
Moreil J; Université de Paris, Imagine Institute, Laboratory of Genome Dynamics in the Immune System, Equipe Labellisée Ligue contre le Cancer, INSERM UMR 1163, Paris, France.
Alibeu O; INSERM Unité Mixte de Recherche 1163, Structure Fédérative de Recherche Necker INSERM US24/CNRS UMS3633, Genomic Core Facility, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Beaupain B; French Neutropenia Registry, Assistance Publique-Hôpitaux de Paris, Trousseau Hospital, Paris, France.
Bôle-Feysot C; INSERM Unité Mixte de Recherche 1163, Structure Fédérative de Recherche Necker INSERM US24/CNRS UMS3633, Genomic Core Facility, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Fumagalli S; Institut Necker Enfants Malades, Paris, France.; INSERM, U1151, Université Paris Descartes Sorbonne Cité, Paris, France.
Kaltenbach S; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France.; Service de cytogénétique, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France.
Martignoles JA; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, AP-HP, Hôpital Saint-Antoine, Hématologie Biologique, Paris, France.
Masson C; INSERM Unité Mixte de Recherche 1163, Bioinformatics Platform, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Nitschké P; INSERM Unité Mixte de Recherche 1163, Bioinformatics Platform, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Parisot M; INSERM Unité Mixte de Recherche 1163, Structure Fédérative de Recherche Necker INSERM US24/CNRS UMS3633, Genomic Core Facility, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Pouliet A; INSERM Unité Mixte de Recherche 1163, Structure Fédérative de Recherche Necker INSERM US24/CNRS UMS3633, Genomic Core Facility, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Radford-Weiss I; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France.; Service de cytogénétique, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France.
Tores F; INSERM Unité Mixte de Recherche 1163, Bioinformatics Platform, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
de Villartay JP; Université de Paris, Imagine Institute, Laboratory of Genome Dynamics in the Immune System, Equipe Labellisée Ligue contre le Cancer, INSERM UMR 1163, Paris, France.
Zarhrate M; INSERM Unité Mixte de Recherche 1163, Structure Fédérative de Recherche Necker INSERM US24/CNRS UMS3633, Genomic Core Facility, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Paris, France.
Koh AL; Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Singapore.
Phua KB; Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Singapore.
Reversade B; Genome Institute of Singapore, A*STAR, Biopolis, Singapore, Singapore.
Bond PJ; Bioinformatics Institute (A*STAR), Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Bellanné-Chantelot C; Department of Genetics, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Callebaut I; Sorbonne Université, Muséum National d'Histoire Naturelle, UMR CNRS 7590, Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie, IMPMC, Paris, France.
Delhommeau F; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, AP-HP, Hôpital Saint-Antoine, Hématologie Biologique, Paris, France.
Donadieu J; Service d'Hémato-Oncologie Pédiatrique, Assistance Publique-Hôpitaux de Paris Hôpital Trousseau, Registre des neutropénies-Centre de référence des neutropénies chroniques, Paris, France.
Warren AJ; Cambridge Institute for Medical Research, Cambridge Biomedical Campus Keith Peters Building, Hills Rd, Cambridge, United Kingdom. .; Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK. .; Department of Haematology, University of Cambridge School of Clinical Medicine, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK. .
Revy P; Université de Paris, Imagine Institute, Laboratory of Genome Dynamics in the Immune System, Equipe Labellisée Ligue contre le Cancer, INSERM UMR 1163, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 19; Vol. 12 (1), pp. 5044. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Ribosome Subunits, Large, Eukaryotic/*metabolism
Ribosomes/*genetics
Ribosomes/*pathology
Shwachman-Diamond Syndrome/*genetics
Shwachman-Diamond Syndrome/*pathology
Adolescent ; Adult ; Animals ; Biological Phenomena ; Cells, Cultured ; Child ; Child, Preschool ; Dictyostelium ; Drosophila ; Eukaryotic Initiation Factors/genetics ; Eukaryotic Initiation Factors/metabolism ; Germ Cells ; Humans ; Infant ; Molecular Dynamics Simulation ; Peptide Elongation Factors/genetics ; Peptide Elongation Factors/metabolism ; Protein Binding ; Protein Biosynthesis ; Proteins/genetics ; Proteins/metabolism ; Ribonucleoprotein, U5 Small Nuclear/genetics ; Ribonucleoprotein, U5 Small Nuclear/metabolism ; Ribosomes/metabolism ; Saccharomyces cerevisiae ; Sequence Homology, Amino Acid ; Shwachman-Diamond Syndrome/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Structures of tmRNA and SmpB as they transit through the ribosome.
Autorzy :
Guyomar C; Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290, Rennes, France.
D'Urso G; Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290, Rennes, France.
Chat S; Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290, Rennes, France.
Giudice E; Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290, Rennes, France. .
Gillet R; Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290, Rennes, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 13; Vol. 12 (1), pp. 4909. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Escherichia coli/*genetics
Escherichia coli Proteins/*genetics
Protein Biosynthesis/*genetics
RNA, Bacterial/*genetics
RNA-Binding Proteins/*genetics
Ribosomes/*genetics
Binding Sites/genetics ; Cryoelectron Microscopy ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Models, Molecular ; Nucleic Acid Conformation ; Protein Binding ; Protein Domains ; RNA, Bacterial/chemistry ; RNA, Bacterial/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism ; Ribosomes/metabolism ; Ribosomes/ultrastructure
Czasopismo naukowe
Tytuł :
RIBO-seq in Bacteria: a Sample Collection and Library Preparation Protocol for NGS Sequencing.
Autorzy :
Kopik N; Laboratory of Gene Expression, ECOTECH-Complex, Maria Curie-Sklodowska University; Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Sklodowska University.
Chrobak O; Laboratory of Gene Expression, ECOTECH-Complex, Maria Curie-Sklodowska University; Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Sklodowska University.
Latoch P; Laboratory of Gene Expression, ECOTECH-Complex, Maria Curie-Sklodowska University; Faculty of Information Technology, Polish-Japanese Academy of Information Technology.
Kovalenko M; Laboratory of Gene Expression, ECOTECH-Complex, Maria Curie-Sklodowska University; Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Sklodowska University.
Starosta AL; Laboratory of Gene Expression, ECOTECH-Complex, Maria Curie-Sklodowska University; Department of Molecular Biology, Institute of Biological Sciences, Maria Curie-Sklodowska University; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Aug 07 (174). Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
High-Throughput Nucleotide Sequencing*
Ribosomes*/genetics
Ribosomes*/metabolism
Bacteria/genetics ; Gene Library ; Protein Biosynthesis ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation.
Autorzy :
de Jesus V; Institute of Organic Chemistry and Chemical Biology - Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany.
Qureshi NS; Institute of Organic Chemistry and Chemical Biology - Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany.
Warhaut S; Institute of Organic Chemistry and Chemical Biology - Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany.
Bains JK; Institute of Organic Chemistry and Chemical Biology - Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany.
Dietz MS; Institute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany.
Heilemann M; Institute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany.
Schwalbe H; Institute of Organic Chemistry and Chemical Biology - Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany.
Fürtig B; Institute of Organic Chemistry and Chemical Biology - Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue Straße 7, Frankfurt am Main, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 05; Vol. 12 (1), pp. 4723. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Ribosomal Proteins/*genetics
Ribosomal Proteins/*metabolism
Ribosomes/*genetics
Ribosomes/*metabolism
Riboswitch/*genetics
Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Models, Molecular ; Nucleic Acid Conformation ; Protein Conformation ; RNA, Bacterial/chemistry ; RNA, Bacterial/genetics ; RNA, Bacterial/metabolism ; Ribosome Subunits, Small, Bacterial/chemistry ; Ribosome Subunits, Small, Bacterial/genetics ; Ribosome Subunits, Small, Bacterial/metabolism ; Ribosomes/chemistry ; Vibrio vulnificus/genetics ; Vibrio vulnificus/metabolism
Czasopismo naukowe
Tytuł :
HRIBO: high-throughput analysis of bacterial ribosome profiling data.
Autorzy :
Gelhausen R; Bioinformatics Group, Department of Computer Science, University of Freiburg, 79110 Freiburg, Germany.
Svensson SL; Chair of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg, 97080 Würzburg, Germany.
Froschauer K; Chair of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg, 97080 Würzburg, Germany.
Heyl F; Bioinformatics Group, Department of Computer Science, University of Freiburg, 79110 Freiburg, Germany.
Hadjeras L; Chair of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg, 97080 Würzburg, Germany.
Sharma CM; Chair of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg, 97080 Würzburg, Germany.
Eggenhofer F; Bioinformatics Group, Department of Computer Science, University of Freiburg, 79110 Freiburg, Germany.
Backofen R; Bioinformatics Group, Department of Computer Science, University of Freiburg, 79110 Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2021 Aug 04; Vol. 37 (14), pp. 2061-2063.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Ribosomes*/genetics
Ribosomes*/metabolism
Animals ; Bacteria/genetics ; High-Throughput Nucleotide Sequencing ; Horses ; Open Reading Frames ; RNA, Ribosomal
Czasopismo naukowe
Tytuł :
Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation.
Autorzy :
Demo G; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, MA, USA.; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Gamper HB; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Loveland AB; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, MA, USA.
Masuda I; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Carbone CE; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, MA, USA.
Svidritskiy E; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, MA, USA.
Hou YM; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. .
Korostelev AA; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 30; Vol. 12 (1), pp. 4644. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Frameshifting, Ribosomal/*genetics
Peptide Chain Elongation, Translational/*genetics
Peptide Elongation Factor G/*genetics
RNA, Messenger/*genetics
RNA, Transfer/*genetics
Ribosomes/*genetics
Biocatalysis ; Cryoelectron Microscopy ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Models, Molecular ; Nucleic Acid Conformation ; Peptide Elongation Factor G/chemistry ; Peptide Elongation Factor G/metabolism ; Protein Conformation ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA, Ribosomal, 16S/chemistry ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; Ribosomes/metabolism ; Ribosomes/ultrastructure ; tRNA Methyltransferases/genetics ; tRNA Methyltransferases/metabolism
Czasopismo naukowe
Tytuł :
Translation stress and collided ribosomes are co-activators of cGAS.
Autorzy :
Wan L; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Juszkiewicz S; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Blears D; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen, Denmark.
Bajpe PK; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Han Z; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen, Denmark.
Faull P; Protein Analysis and Proteomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Mitter R; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Stewart A; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Snijders AP; Protein Analysis and Proteomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Hegde RS; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Svejstrup JQ; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jul 01; Vol. 81 (13), pp. 2808-2822.e10. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleus*/chemistry
Cell Nucleus*/genetics
Cell Nucleus*/metabolism
Nucleotidyltransferases*/chemistry
Nucleotidyltransferases*/genetics
Nucleotidyltransferases*/metabolism
Protein Biosynthesis*
Ribosomes*/chemistry
Ribosomes*/genetics
Ribosomes*/metabolism
Signal Transduction*
Stress, Physiological*
Active Transport, Cell Nucleus ; HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
Directed evolution of rRNA improves translation kinetics and recombinant protein yield.
Autorzy :
Liu F; The Broad Institute of MIT & Harvard University, Cambridge, MA, 02142, USA.
Bratulić S; The Broad Institute of MIT & Harvard University, Cambridge, MA, 02142, USA.; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Göteborg, Sweden.
Costello A; The Broad Institute of MIT & Harvard University, Cambridge, MA, 02142, USA.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Miettinen TP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.
Badran AH; The Broad Institute of MIT & Harvard University, Cambridge, MA, 02142, USA. .; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 24; Vol. 12 (1), pp. 5638. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Biosynthesis*
RNA, Ribosomal/*metabolism
Recombinant Proteins/*metabolism
Ribosomal Proteins/*metabolism
Ribosomes/*metabolism
Base Sequence ; Directed Molecular Evolution/methods ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Kinetics ; Mass Spectrometry/methods ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; Proteome/metabolism ; RNA, Ribosomal/chemistry ; RNA, Ribosomal/genetics ; RNA, Ribosomal, 16S/chemistry ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; Ribosomal Proteins/genetics ; Ribosomes/genetics
Czasopismo naukowe
Tytuł :
Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.
Autorzy :
Su T; Gene Center Munich, Department of Biochemistry, University of Munich, Munich 81377, Germany.
Kudva R; Department of Biochemistry and Biophysics, Stockholm University, Stockholm SE-10691, Sweden.; Science for Life Laboratories, Solna 17165, Sweden.
Becker T; Gene Center Munich, Department of Biochemistry, University of Munich, Munich 81377, Germany.
Buschauer R; Gene Center Munich, Department of Biochemistry, University of Munich, Munich 81377, Germany.
Komar T; Gene Center Munich, Department of Biochemistry, University of Munich, Munich 81377, Germany.
Berninghausen O; Gene Center Munich, Department of Biochemistry, University of Munich, Munich 81377, Germany.
von Heijne G; Department of Biochemistry and Biophysics, Stockholm University, Stockholm SE-10691, Sweden.; Science for Life Laboratories, Solna 17165, Sweden.
Cheng J; Gene Center Munich, Department of Biochemistry, University of Munich, Munich 81377, Germany.
Beckmann R; Gene Center Munich, Department of Biochemistry, University of Munich, Munich 81377, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9539-9547.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Escherichia coli Proteins/*ultrastructure
Peptide Termination Factors/*ultrastructure
Ribosomes/*ultrastructure
Codon, Terminator/genetics ; Cryoelectron Microscopy ; Escherichia coli/genetics ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Peptide Termination Factors/chemistry ; Peptide Termination Factors/genetics ; Protein Conformation ; Protein Conformation, alpha-Helical ; Ribosomes/genetics ; Tryptophan/genetics
Czasopismo naukowe
Tytuł :
In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli.
Autorzy :
Erdmann PS; Max Planck Institute of Biochemistry, Martinsried, Germany. .; Fondazione Human Technopole, Milano, Italy. .
Hou Z; Max Planck Institute of Biochemistry, Martinsried, Germany.
Klumpe S; Max Planck Institute of Biochemistry, Martinsried, Germany.
Khavnekar S; Max Planck Institute of Biochemistry, Martinsried, Germany.
Beck F; Max Planck Institute of Biochemistry, Martinsried, Germany.
Wilfling F; Max Planck Institute of Biochemistry, Martinsried, Germany.; Max Planck Institute of Biophysics, Frankfurt, Germany.
Plitzko JM; Max Planck Institute of Biochemistry, Martinsried, Germany.
Baumeister W; Max Planck Institute of Biochemistry, Martinsried, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 10; Vol. 12 (1), pp. 5364. Date of Electronic Publication: 2021 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleolus/*metabolism
Ribosomes/*metabolism
Cell Nucleolus/ultrastructure ; Chlamydomonas reinhardtii ; Cryoelectron Microscopy ; Electron Microscope Tomography ; Intravital Microscopy/methods ; Organogenesis ; Ribosomes/ultrastructure ; Spatio-Temporal Analysis
Czasopismo naukowe

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