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Wyszukujesz frazę ""Ribosomes"" wg kryterium: Temat


Tytuł :
Nucleolar RNA polymerase II drives ribosome biogenesis.
Autorzy :
Abraham KJ; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Khosraviani N; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Chan JNY; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Gorthi A; Greehey Children's Cancer Research Institute, Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.
Samman A; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Zhao DY; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Wang M; Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Bokros M; Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Vidya E; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ostrowski LA; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Oshidari R; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Pietrobon V; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Patel PS; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Algouneh A; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Singhania R; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Liu Y; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Yerlici VT; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
De Carvalho DD; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ohh M; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Dickson BC; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Hakem R; Princess Margaret Cancer Research Centre, University Health Network, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Greenblatt JF; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Lee S; Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Bishop AJR; Greehey Children's Cancer Research Institute, Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health at San Antonio, San Antonio, TX, USA.
Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. .; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7824), pp. 298-302. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Nucleolus/*enzymology
Cell Nucleolus/*genetics
DNA, Ribosomal/*genetics
RNA Polymerase II/*metabolism
RNA, Untranslated/*biosynthesis
RNA, Untranslated/*genetics
Ribosomes/*metabolism
CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Cell Line, Tumor ; Cell Nucleolus/physiology ; DNA Helicases/metabolism ; DNA, Intergenic/genetics ; Humans ; Multifunctional Enzymes/metabolism ; Protein Biosynthesis ; R-Loop Structures ; RNA Helicases/metabolism ; RNA Polymerase I/antagonists & inhibitors ; RNA Polymerase I/metabolism ; Ribonuclease H/metabolism ; Ribosomes/chemistry ; Ribosomes/genetics ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/pathology
Czasopismo naukowe
Tytuł :
Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
Autorzy :
Itoh Y; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden.; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165, Solna, Sweden.
Naschberger A; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden.
Mortezaei N; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden.
Herrmann JM; Cell Biology, University of Kaiserslautern, Erwin-Schrödinger-Straße 13, 67663, Kaiserslautern, Germany.
Amunts A; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden. .; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17165, Solna, Sweden. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 14; Vol. 11 (1), pp. 5187. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Mitochondria/*metabolism
Mitochondrial Ribosomes/*metabolism
Neurospora crassa/*physiology
Cell Fractionation ; Cryoelectron Microscopy ; Fungal Proteins/metabolism ; Mitochondria/ultrastructure ; Mitochondrial Proteins/metabolism ; Mitochondrial Ribosomes/ultrastructure ; Models, Molecular ; NAD/metabolism ; Proteins/metabolism ; RNA, Messenger/metabolism ; RNA, Ribosomal/metabolism ; RNA, Transfer/metabolism ; Ribosomal Proteins/metabolism
Czasopismo naukowe
Tytuł :
Network theory of the bacterial ribosome.
Autorzy :
Calvet LE; CNRS, Centre de Nanosciences et Nanotechnologies, Université Paris-Saclay, Palaiseau, France.
Matviienko S; CNRS, Centre de Nanosciences et Nanotechnologies, Université Paris-Saclay, Palaiseau, France.
Ducluzaux P; CNRS, Centre de Nanosciences et Nanotechnologies, Université Paris-Saclay, Palaiseau, France.
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Źródło :
PloS one [PLoS One] 2020 Oct 05; Vol. 15 (10), pp. e0239700. Date of Electronic Publication: 2020 Oct 05 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacteria/*genetics
Gene Regulatory Networks/*genetics
Ribosomes/*genetics
Bacteria/metabolism ; Computational Biology/methods ; Protein Biosynthesis/genetics ; Protein Biosynthesis/physiology ; RNA, Ribosomal, 23S/metabolism ; Ribosomal Proteins/metabolism ; Ribosomes/metabolism ; Transcription Elongation, Genetic/physiology
Czasopismo naukowe
Tytuł :
Inferring efficiency of translation initiation and elongation from ribosome profiling.
Autorzy :
Szavits-Nossan J; SUPA, School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UK.
Ciandrini L; Centre de Biologie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier 34090, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9478-9490.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Elongation, Translational*
Peptide Chain Initiation, Translational*
Computational Biology/*methods
Ribosomes/*genetics
Saccharomyces cerevisiae/*genetics
Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Codon, Initiator ; Models, Genetic ; RNA, Messenger ; Ribosomes/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis.
Autorzy :
Huang YH; Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraβe 6, 14195 Berlin, Germany.
Hilal T; Research Center of Electron Microscopy and Core Facility BioSupraMol, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Fabeckstr. 36a, 14195 Berlin, Germany.
Loll B; Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraβe 6, 14195 Berlin, Germany.
Bürger J; Microscopy and Cryo-Electron Microscopy Service Group, Max-Planck-Institut für Molekulare Genetik, Ihnestraße 63-73, 14195 Berlin, Germany; Institute of Medical Physics and Biophysics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, CCO-Virchowweg 6, 10117 Berlin, Germany.
Mielke T; Microscopy and Cryo-Electron Microscopy Service Group, Max-Planck-Institut für Molekulare Genetik, Ihnestraße 63-73, 14195 Berlin, Germany.
Böttcher C; Research Center of Electron Microscopy and Core Facility BioSupraMol, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Fabeckstr. 36a, 14195 Berlin, Germany.
Said N; Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraβe 6, 14195 Berlin, Germany.
Wahl MC; Laboratory of Structural Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraβe 6, 14195 Berlin, Germany; Macromolecular Crystallography, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Straße 15, 12489 Berlin, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Sep 17; Vol. 79 (6), pp. 1024-1036.e5. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Directed RNA Polymerases/*genetics
Molecular Chaperones/*genetics
Ribosomal Proteins/*genetics
Ribosomes/*genetics
Binding Sites/genetics ; Cryoelectron Microscopy ; Escherichia coli/genetics ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/ultrastructure ; Phosphoric Monoester Hydrolases/genetics ; Phosphoric Monoester Hydrolases/ultrastructure ; Protein Biosynthesis/genetics ; RNA Folding/genetics ; RNA, Ribosomal/genetics ; RNA, Ribosomal/ultrastructure ; Ribosomal Proteins/ultrastructure ; Ribosomes/ultrastructure ; Transcriptional Elongation Factors/chemistry ; Transcriptional Elongation Factors/genetics ; Transcriptional Elongation Factors/ultrastructure
Czasopismo naukowe
Tytuł :
DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4.
Autorzy :
Bohlen J; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; CellNetworks-Cluster of Excellence, Heidelberg University, Heidelberg, Germany.; Heidelberg University, 69120, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site, Heidelberg, Germany.
Harbrecht L; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Heidelberg University, 69120, Heidelberg, Germany.
Blanco S; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Heidelberg University, 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site, Heidelberg, Germany.
Clemm von Hohenberg K; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; CellNetworks-Cluster of Excellence, Heidelberg University, Heidelberg, Germany.; Heidelberg University, 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site, Heidelberg, Germany.
Fenzl K; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Heidelberg University, 69120, Heidelberg, Germany.; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, Heidelberg, D-69120, Germany.
Kramer G; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site, Heidelberg, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, Heidelberg, D-69120, Germany.
Bukau B; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), partner site, Heidelberg, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, Heidelberg, D-69120, Germany.
Teleman AA; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. .; CellNetworks-Cluster of Excellence, Heidelberg University, Heidelberg, Germany. .; Heidelberg University, 69120, Heidelberg, Germany. .; Heidelberg Biosciences International Graduate School (HBIGS), Heidelberg, Germany. .; National Center for Tumor Diseases (NCT), partner site, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 16; Vol. 11 (1), pp. 4676. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Activating Transcription Factor 4/*genetics
Eukaryotic Initiation Factors/*metabolism
Ribosomes/*metabolism
5' Untranslated Regions ; Activating Transcription Factor 4/metabolism ; Cell Cycle Proteins/genetics ; Codon ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factors/genetics ; Gene Expression Regulation ; HeLa Cells ; Humans ; Neoplasms/genetics ; Oncogene Proteins/genetics ; Oncogenes ; Open Reading Frames ; RNA, Messenger ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Ribosome Subunits, Small, Eukaryotic/genetics ; Ribosome Subunits, Small, Eukaryotic/metabolism ; Ribosomes/genetics
Czasopismo naukowe
Tytuł :
NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.
Autorzy :
Martin PB; The Jackson Laboratory, Bar Harbor, ME, USA.; The University of Maine, Graduate School of Biomedical Science and Engineering, Orono, ME, USA.
Kigoshi-Tansho Y; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Sher RB; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, USA.; Center for Nervous System Disorders, Stony Brook University, Stony Brook, NY, USA.
Ravenscroft G; Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, WA, Australia.
Stauffer JE; The Jackson Laboratory, Bar Harbor, ME, USA.
Kumar R; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Yonashiro R; Department of Molecular Medicine, Scripps Research, Jupiter, FL, USA.
Müller T; Department of Molecular Medicine, Scripps Research, Jupiter, FL, USA.
Griffith C; College of Medicine Pediatrics, University of South Florida, Tampa, FL, USA.
Allen W; Mission Fullerton Genetics Center, Mission Health, Asheville, NC, USA.
Pehlivan D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Harel T; Department of Genetic and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Zenker M; Institute of Human Genetics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Howting D; Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, WA, Australia.
Schanze D; Institute of Human Genetics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Faqeih EA; Department of Genetics, King Fahad Medical City, Riyadh, Saudi Arabia.
Almontashiri NAM; The Center for Genetics and Inherited Diseases, Taibah University, Almadinah Almunwarah, Saudi Arabia.; Faculty of Applied Medical Sciences, Taibah University, Almadinah Almunwarah, Saudi Arabia.
Maroofian R; Neurogenetics Laboratory, UCL Queen Square Institute of Neurology, London, UK.; The National Hospital for Neurology and Neurosurgery, London, UK.
Houlden H; Neurogenetics Laboratory, UCL Queen Square Institute of Neurology, London, UK.; The National Hospital for Neurology and Neurosurgery, London, UK.
Mazaheri N; Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Galehdari H; Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Douglas G; GeneDx, Inc, Gaithsberg, MD, USA.
Posey JE; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ryan M; Department of Neurology, The Royal Children's Hospital, Melbourne, VIC, Australia.; Murdoch Children's Research Institute and University of Melbourne, Melbourne, VIC, Australia.
Lupski JR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.
Laing NG; Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, WA, Australia.
Joazeiro CAP; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany. .; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA. .
Cox GA; The Jackson Laboratory, Bar Harbor, ME, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 15; Vol. 11 (1), pp. 4625. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuromuscular Diseases/*metabolism
Ribosomes/*metabolism
Amino Acid Sequence ; Animals ; Female ; Humans ; Male ; Mice ; Mice, Knockout ; Mutation ; Neuromuscular Diseases/genetics ; Neuromuscular Diseases/pathology ; Proteolysis ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribosomes/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage.
Autorzy :
Guth-Metzler R; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; NASA Center for the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Bray MS; NASA Center for the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332, USA.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Frenkel-Pinter M; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; NASA Center for the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Suttapitugsakul S; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Montllor-Albalate C; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Bowman JC; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; NASA Center for the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Wu R; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Reddi AR; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Okafor CD; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Glass JB; NASA Center for the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.; School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Williams LD; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.; NASA Center for the Origin of Life, Georgia Institute of Technology, Atlanta, GA 30332, USA.; Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8663-8674.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cations, Divalent/*metabolism
Iron/*metabolism
RNA Cleavage/*genetics
Ribosomes/*genetics
Binding Sites ; Cations, Divalent/chemistry ; Iron/chemistry ; Magnesium/chemistry ; Magnesium/metabolism ; Metals/chemistry ; Metals/metabolism ; Oxidation-Reduction/drug effects ; Ribosomes/chemistry
Czasopismo naukowe
Tytuł :
Ribosomes clear the way for siRNA targeting.
Autorzy :
Małecka EM; T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA.
Woodson SA; T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Sep; Vol. 27 (9), pp. 775-777.
Typ publikacji :
Wiadomości
MeSH Terms :
RNA, Messenger/*genetics
RNA, Small Interfering/*genetics
Ribosomes/*genetics
Animals ; Binding Sites ; Humans ; Protein Biosynthesis ; RNA Folding ; RNA Interference ; RNA, Messenger/metabolism ; RNA, Small Interfering/metabolism ; Ribosomes/metabolism
Periodyk
Tytuł :
Local Sourcing of Secretory Proteins in Faraway Places.
Autorzy :
Farrell RJ; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA; David Rockefeller Graduate Program, The Rockefeller University, New York, NY 10065, USA.
Ryan TA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: .
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Źródło :
Trends in neurosciences [Trends Neurosci] 2020 Sep; Vol. 43 (9), pp. 649-650. Date of Electronic Publication: 2020 Jun 13.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Endoplasmic Reticulum*
Ribosomes*
Proteins
Czasopismo naukowe
Tytuł :
RNA sectors and allosteric function within the ribosome.
Autorzy :
Walker AS; Department of Chemistry, Yale University, New Haven, CT 06520; .
Russ WP; Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ranganathan R; Center for Physics of Evolving Systems, The University of Chicago, Chicago, IL 60637; .; Biochemistry & Molecular Biology, The University of Chicago, Chicago, IL 60637.; The Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL 60637.
Schepartz A; Department of Chemistry, Yale University, New Haven, CT 06520; .; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520.; Department of Chemistry, University of California, Berkeley, CA 94720.; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 18; Vol. 117 (33), pp. 19879-19887. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Escherichia coli/*genetics
RNA, Bacterial/*chemistry
RNA, Ribosomal, 23S/*chemistry
Ribosomes/*genetics
Escherichia coli/chemistry ; Escherichia coli/metabolism ; Evolution, Molecular ; Nucleic Acid Conformation ; Phylogeny ; RNA, Bacterial/genetics ; RNA, Bacterial/metabolism ; RNA, Ribosomal, 23S/genetics ; RNA, Ribosomal, 23S/metabolism ; Ribosomes/chemistry ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Autorzy :
Loveland AB; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.
Demo G; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Korostelev AA; RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA. .
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Źródło :
Nature [Nature] 2020 Aug; Vol. 584 (7822), pp. 640-645. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy*
Guanosine Triphosphate/*metabolism
Peptide Elongation Factor Tu/*metabolism
RNA, Transfer/*genetics
RNA, Transfer/*metabolism
Ribosomes/*metabolism
Ribosomes/*ultrastructure
Escherichia coli ; GTP Phosphohydrolases/metabolism ; Guanosine Diphosphate/chemistry ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/chemistry ; Hydrolysis ; Models, Molecular ; Peptide Elongation Factor Tu/chemistry ; Peptide Elongation Factor Tu/ultrastructure ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/ultrastructure ; Ribosomes/chemistry ; Rotation
Czasopismo naukowe
Tytuł :
[ Cis -regulatory mechanisms and biological effects of translation elongation].
Autorzy :
Zhao TL; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China.
Zhang S; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Qian WF; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
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Źródło :
Yi chuan = Hereditas [Yi Chuan] 2020 Jul 20; Vol. 42 (7), pp. 613-631.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Peptide Chain Elongation, Translational*
Ribosomes*/genetics
Ribosomes*/metabolism
Humans ; Protein Folding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/metabolism
Czasopismo naukowe
Tytuł :
Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro.
Autorzy :
Lee J; Department of Chemical and Biological Engineering and Center for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Schwarz KJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Kim DS; Department of Chemical and Biological Engineering and Center for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA.
Moore JS; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .; The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .
Jewett MC; Department of Chemical and Biological Engineering and Center for Synthetic Biology, Northwestern University, Evanston, IL, 60208, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 27; Vol. 11 (1), pp. 4304. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Peptide Biosynthesis*
Transfer RNA Aminoacylation*
Amino Acids, Cyclic/*metabolism
Ribosomes/*metabolism
Genetic Engineering ; Mutation ; Polymerization ; RNA, Transfer/metabolism ; Ribosomes/genetics
Czasopismo naukowe
Tytuł :
Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer.
Autorzy :
Rosselló-Tortella M; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.; Germans Trias i Pujol Health Science Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Llinàs-Arias P; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Sakaguchi Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 113-8656 Tokyo, Japan.
Miyauchi K; Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 113-8656 Tokyo, Japan.
Davalos V; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Setien F; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Calleja-Cervantes ME; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Piñeyro D; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.; Centro de Investigacion Biomedica en Red Cancer, 28029 Madrid, Spain.
Martínez-Gómez J; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Guil S; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.; Germans Trias i Pujol Health Science Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Joshi R; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain.
Villanueva A; Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, 08908, L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.
Suzuki T; Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, 113-8656 Tokyo, Japan.
Esteller M; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, 08916, Badalona, Barcelona, Catalonia, Spain; .; Centro de Investigacion Biomedica en Red Cancer, 28029 Madrid, Spain.; Institucio Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Catalonia, Spain.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona, 08907 Barcelona, Catalonia, Spain.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 25; Vol. 117 (34), pp. 20785-20793. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Frameshifting, Ribosomal*
Colonic Neoplasms/*genetics
RNA, Transfer/*genetics
Ribosomes/*genetics
tRNA Methyltransferases/*deficiency
Adult ; Aged ; Anticodon/genetics ; Anticodon/metabolism ; Cell Line, Tumor ; Colonic Neoplasms/enzymology ; Colonic Neoplasms/metabolism ; CpG Islands ; Epigenesis, Genetic ; Female ; Humans ; Male ; Middle Aged ; Nucleic Acid Conformation ; Phenylalanine/genetics ; Phenylalanine/metabolism ; Promoter Regions, Genetic ; Protein Biosynthesis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Transfer/metabolism ; Ribosomes/metabolism ; tRNA Methyltransferases/genetics ; tRNA Methyltransferases/metabolism
Czasopismo naukowe
Tytuł :
Human GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation.
Autorzy :
Maiti P; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Antonicka H; Montreal Neurological Institute and Department of Human Genetics, McGill University, Montreal, QC, Canada.
Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Shoubridge EA; Montreal Neurological Institute and Department of Human Genetics, McGill University, Montreal, QC, Canada.
Barrientos A; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Aug 20; Vol. 48 (14), pp. 7924-7943.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Proteins/*metabolism
Mitochondrial Ribosomes/*enzymology
Monomeric GTP-Binding Proteins/*metabolism
RNA, Ribosomal, 16S/*metabolism
Ribosome Subunits, Large, Eukaryotic/*enzymology
Cell Line ; GTP Phosphohydrolases/metabolism ; HEK293 Cells ; Humans ; Methylation ; Methyltransferases/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Proteins/physiology ; Mitochondrial Ribosomes/metabolism ; Monomeric GTP-Binding Proteins/physiology ; Oxidative Phosphorylation ; Protein Biosynthesis ; RNA, Ribosomal, 16S/chemistry ; Ribosome Subunits, Large, Eukaryotic/chemistry ; Ribosome Subunits, Large, Eukaryotic/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes.
Autorzy :
Wagner S; EMBL-Australia Collaborating Group, Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia; Laboratory of Regulation of Gene Expression, Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic. Electronic address: .
Herrmannová A; Laboratory of Regulation of Gene Expression, Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
Hronová V; Laboratory of Regulation of Gene Expression, Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
Gunišová S; Laboratory of Regulation of Gene Expression, Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
Sen ND; Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Hannan RD; Australian Cancer Research Foundation Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Hinnebusch AG; Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Shirokikh NE; EMBL-Australia Collaborating Group, Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Preiss T; EMBL-Australia Collaborating Group, Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia. Electronic address: .
Valášek LS; Laboratory of Regulation of Gene Expression, Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 20; Vol. 79 (4), pp. 546-560.e7. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Multiprotein Complexes/*metabolism
Peptide Initiation Factors/*metabolism
Ribosomes/*metabolism
5' Untranslated Regions ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Codon, Initiator ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factor-3/genetics ; Eukaryotic Initiation Factor-3/metabolism ; HEK293 Cells ; Humans ; Multiprotein Complexes/genetics ; Peptide Initiation Factors/genetics ; Ribosome Subunits, Small, Eukaryotic/genetics ; Ribosome Subunits, Small, Eukaryotic/metabolism ; Ribosomes/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Two Ribosomes Are Better Than One... Sometimes.
Autorzy :
Olson AN; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.
Dinman JD; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 20; Vol. 79 (4), pp. 541-543.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Ribosomes*
Quality Control
Czasopismo naukowe
Tytuł :
Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control.
Autorzy :
Meydan S; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Guydosh NR; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 20; Vol. 79 (4), pp. 588-602.e6. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Genome, Fungal*
DNA Footprinting/*methods
Ribosomes/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
3' Untranslated Regions ; Anisomycin/pharmacology ; Codon, Terminator ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Mutation ; Phosphorylation ; RNA Stability ; Ribosome Subunits, Large, Eukaryotic/genetics ; Ribosome Subunits, Large, Eukaryotic/metabolism ; Ribosomes/metabolism ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae Proteins/genetics ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
Autorzy :
Jaskolowski M; Department of Biology, ETH Zurich, Zurich 8093, Switzerland.
Ramrath DJF; Department of Biology, ETH Zurich, Zurich 8093, Switzerland.
Bieri P; Department of Biology, ETH Zurich, Zurich 8093, Switzerland.
Niemann M; Department of Chemistry and Biochemistry, University of Bern, Bern 3012, Switzerland.
Mattei S; Department of Biology, ETH Zurich, Zurich 8093, Switzerland.
Calderaro S; Department of Chemistry and Biochemistry, University of Bern, Bern 3012, Switzerland.
Leibundgut M; Department of Biology, ETH Zurich, Zurich 8093, Switzerland.
Horn EK; Department of Chemistry and Biochemistry, University of Bern, Bern 3012, Switzerland.
Boehringer D; Department of Biology, ETH Zurich, Zurich 8093, Switzerland.
Schneider A; Department of Chemistry and Biochemistry, University of Bern, Bern 3012, Switzerland. Electronic address: .
Ban N; Department of Biology, ETH Zurich, Zurich 8093, Switzerland. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 20; Vol. 79 (4), pp. 629-644.e4. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondrial Ribosomes/*chemistry
RNA, Ribosomal/*metabolism
Ribosome Subunits, Large/*chemistry
Trypanosoma brucei brucei/*metabolism
Cryoelectron Microscopy ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/metabolism ; GTP Phosphohydrolases/chemistry ; GTP Phosphohydrolases/genetics ; GTP Phosphohydrolases/metabolism ; Mitochondrial Ribosomes/metabolism ; Models, Molecular ; Nucleic Acid Conformation ; RNA, Ribosomal/chemistry ; Ribosomal Proteins/chemistry ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosome Subunits, Large/metabolism ; Trypanosoma brucei brucei/genetics
Czasopismo naukowe

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