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Tytuł :
Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae.
Autorzy :
Grace PM; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA. Electronic address: .
Ramos KM; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Rodgers KM; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Wang X; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA; Department of Chemistry and Biochemistry, and the BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
Hutchinson MR; Discipline of Physiology, School of Medical Sciences, University of Adelaide, South Australia, Australia.
Lewis MT; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Morgan KN; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Kroll JL; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Taylor FR; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Strand KA; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Zhang Y; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Berkelhammer D; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Huey MG; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Greene LI; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Cochran TA; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Yin H; Department of Chemistry and Biochemistry, and the BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
Barth DS; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Johnson KW; MediciNova, Inc., San Diego, CA, USA.
Rice KC; Chemical Biology Research Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.
Maier SF; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Watkins LR; Department of Psychology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
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Źródło :
Neuroscience [Neuroscience] 2014 Nov 07; Vol. 280, pp. 299-317. Date of Electronic Publication: 2014 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Central Nervous System/*drug effects
Endothelial Cells/*drug effects
Morphine/*pharmacology
Morphine Derivatives/*pharmacology
Narcotics/*pharmacology
Toll-Like Receptor 4/*metabolism
Animals ; Central Nervous System/physiology ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; Endothelial Cells/physiology ; Hyperalgesia/drug therapy ; Hyperalgesia/physiopathology ; Male ; NF-kappa B/metabolism ; Neuroglia/drug effects ; Neuroglia/physiology ; Neuroimmunomodulation/drug effects ; Neuroimmunomodulation/physiology ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Receptors, Opioid, mu/antagonists & inhibitors ; Receptors, Opioid, mu/metabolism ; Toll-Like Receptor 4/agonists ; Tumor Necrosis Factor-alpha/metabolism ; Vasodilation/drug effects ; Vasodilation/physiology
Czasopismo naukowe
Tytuł :
Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
Autorzy :
Hutchinson MR; Department of Psychology and The Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
Loram LC
Zhang Y
Shridhar M
Rezvani N
Berkelhammer D
Phipps S
Foster PS
Landgraf K
Falke JJ
Rice KC
Maier SF
Yin H
Watkins LR
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Źródło :
Neuroscience [Neuroscience] 2010 Jun 30; Vol. 168 (2), pp. 551-63. Date of Electronic Publication: 2010 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Heterocyclic Compounds, 3-Ring/*pharmacology
Lymphocyte Antigen 96/*physiology
Toll-Like Receptors/*physiology
Analgesics, Opioid/pharmacology ; Animals ; Cells, Cultured ; Humans ; Interleukin-1/metabolism ; Ligands ; Lymphocyte Antigen 96/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Microglia/drug effects ; Microglia/metabolism ; Models, Molecular ; Morphine/pharmacology ; Myeloid Differentiation Factor 88/genetics ; Pain Measurement ; Protein Binding ; Rats ; Signal Transduction ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 2/antagonists & inhibitors ; Toll-Like Receptor 2/physiology ; Toll-Like Receptor 4/agonists ; Toll-Like Receptor 4/antagonists & inhibitors ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/physiology ; Toll-Like Receptors/agonists ; Toll-Like Receptors/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/biosynthesis
Czasopismo naukowe
Tytuł :
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Autorzy :
Hutchinson MR; Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309-0345, USA. />Lewis SS
Coats BD
Rezvani N
Zhang Y
Wieseler JL
Somogyi AA
Yin H
Maier SF
Rice KC
Watkins LR
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Źródło :
Neuroscience [Neuroscience] 2010 May 19; Vol. 167 (3), pp. 880-93. Date of Electronic Publication: 2010 Feb 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Analgesics, Opioid/*toxicity
Inflammation/*chemically induced
Inflammation Mediators/*toxicity
Lymphocyte Antigen 96/*drug effects
Spinal Cord/*drug effects
Toll-Like Receptor 4/*drug effects
Animals ; Gliosis/chemically induced ; Gliosis/metabolism ; Gliosis/physiopathology ; Hyperalgesia/chemically induced ; Hyperalgesia/metabolism ; Hyperalgesia/physiopathology ; Immunity, Innate/drug effects ; Immunity, Innate/physiology ; Inflammation/metabolism ; Inflammation/physiopathology ; Injections, Spinal ; Interleukin-1/metabolism ; Isomerism ; Lymphocyte Antigen 96/metabolism ; Male ; Methadone/toxicity ; Microglia/drug effects ; Microglia/metabolism ; Morphine/toxicity ; Organ Culture Techniques ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/metabolism ; Spinal Cord/physiopathology ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Autorzy :
Lewis SS; Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA. />Hutchinson MR
Rezvani N
Loram LC
Zhang Y
Maier SF
Rice KC
Watkins LR
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Źródło :
Neuroscience [Neuroscience] 2010 Jan 20; Vol. 165 (2), pp. 569-83.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Central Nervous System Stimulants/*adverse effects
Interleukin-1beta/*metabolism
Lymphocyte Antigen 96/*metabolism
Morphine Derivatives/*adverse effects
Pain/*chemically induced
Toll-Like Receptor 4/*metabolism
Animals ; CD11b Antigen/metabolism ; Central Nervous System Stimulants/administration & dosage ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Injections, Spinal ; Interleukin-1beta/cerebrospinal fluid ; Male ; Microglia/drug effects ; Microglia/metabolism ; Morphine Derivatives/administration & dosage ; Pain/drug therapy ; Pain/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Interleukin-1/antagonists & inhibitors ; Receptors, Interleukin-1/metabolism ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Toll-Like Receptor 4/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Autorzy :
Hutchinson MR; Department of Psychology and The Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
Ramos KM
Loram LC
Wieseler J
Sholar PW
Kearney JJ
Lewis MT
Crysdale NY
Zhang Y
Harrison JA
Maier SF
Rice KC
Watkins LR
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Źródło :
Neuroscience [Neuroscience] 2009 Dec 29; Vol. 164 (4), pp. 1821-32. Date of Electronic Publication: 2009 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HSP90 Heat-Shock Proteins/*physiology
Pain/*physiopathology
Toll-Like Receptor 4/*physiology
Analgesics, Opioid/pharmacology ; Animals ; Benzoquinones/pharmacology ; Constriction, Pathologic/complications ; Dimethyl Sulfoxide/pharmacology ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/biosynthesis ; Injections, Spinal ; Interleukin-1/antagonists & inhibitors ; Lactams, Macrocyclic/pharmacology ; Lipopolysaccharides/pharmacology ; Male ; Microglia/physiology ; Morphine/pharmacology ; Pain/etiology ; Peripheral Nervous System Diseases/etiology ; Peripheral Nervous System Diseases/physiopathology ; Physical Stimulation ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/physiopathology ; Signal Transduction ; Toll-Like Receptor 4/agonists
Czasopismo naukowe
Tytuł :
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Autorzy :
Xu H; Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
Lu YF
Rice KC
Ananthan S
Rothman RB
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Źródło :
Brain research bulletin [Brain Res Bull] 2001 Jul 01; Vol. 55 (4), pp. 507-11.
Typ publikacji :
Journal Article
MeSH Terms :
Benzeneacetamides*
Guanosine 5'-O-(3-Thiotriphosphate)/*metabolism
Morphine/*pharmacology
Naltrexone/*analogs & derivatives
Receptors, Opioid/*metabolism
Analgesics/pharmacology ; Analgesics, Opioid/pharmacology ; Animals ; Benzamides/pharmacology ; Binding, Competitive ; CHO Cells ; Cloning, Molecular ; Cricetinae ; Dose-Response Relationship, Drug ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology ; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology ; Humans ; Iodine Radioisotopes ; Morphine/chemistry ; Morphine Derivatives ; Naltrexone/chemistry ; Naltrexone/pharmacology ; Narcotic Antagonists/chemistry ; Narcotic Antagonists/pharmacology ; Piperazines/pharmacology ; Pyrrolidines/pharmacology ; Receptors, Opioid/genetics ; Receptors, Opioid, delta/antagonists & inhibitors ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, delta/metabolism ; Receptors, Opioid, kappa/genetics ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/agonists ; Receptors, Opioid, mu/genetics ; Receptors, Opioid, mu/metabolism ; Sulfur Radioisotopes ; Tritium
Czasopismo naukowe
Tytuł :
Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters.
Autorzy :
Yu H; Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0815, USA.
Rothman RB
Dersch CM
Partilla JS
Rice KC
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2000 Dec; Vol. 8 (12), pp. 2689-92.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Biogenic Amines/*metabolism
Carrier Proteins/*metabolism
Diethylpropion/*pharmacology
Animals ; Appetite Depressants/chemistry ; Appetite Depressants/metabolism ; Appetite Depressants/pharmacology ; Biological Transport, Active ; Brain/drug effects ; Brain/metabolism ; Diethylpropion/chemistry ; Diethylpropion/metabolism ; Dopamine/metabolism ; In Vitro Techniques ; Ligands ; Norepinephrine/metabolism ; Rats ; Serotonin/metabolism ; Synaptosomes/drug effects ; Synaptosomes/metabolism
Czasopismo naukowe
Tytuł :
Neurochemical neutralization of amphetamine-type stimulants in rat brain by the indatraline analog (-)-HY038.
Autorzy :
Partilla JS; Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
Dersch CM
Yu H
Rice KC
Rothman RB
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Źródło :
Brain research bulletin [Brain Res Bull] 2000 Dec; Vol. 53 (6), pp. 821-6.
Typ publikacji :
Journal Article
MeSH Terms :
Amphetamine-Related Disorders/*drug therapy
Amphetamines/*agonists
Brain/*drug effects
Central Nervous System Stimulants/*pharmacology
Indans/*agonists
Indans/*pharmacology
Methylamines/*agonists
Neurotransmitter Uptake Inhibitors/*agonists
Amphetamine-Related Disorders/metabolism ; Amphetamine-Related Disorders/physiopathology ; Animals ; Biogenic Monoamines/metabolism ; Brain/metabolism ; Brain/physiopathology ; Carrier Proteins/drug effects ; Carrier Proteins/metabolism ; Dopamine/pharmacokinetics ; Indans/metabolism ; Male ; Methylamines/metabolism ; Neurotransmitter Uptake Inhibitors/metabolism ; Radioligand Assay ; Rats ; Rats, Sprague-Dawley ; Synaptosomes/drug effects ; Synaptosomes/metabolism ; Tritium
Czasopismo naukowe
Tytuł :
A practical synthesis of the serotonin 5-HT2A receptor antagonist MDL 100907, its enantiomer and their 3-phenolic derivatives as precursors for [11C]labeled PET ligands.
Autorzy :
Ullrich T; Laboratory of Medicinal Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0815, USA.
Rice KC
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2000 Oct; Vol. 8 (10), pp. 2427-32.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorobenzenes/*chemical synthesis
Fluorobenzenes/*metabolism
Piperidines/*chemical synthesis
Piperidines/*metabolism
Receptors, Serotonin/*drug effects
Serotonin Antagonists/*chemical synthesis
Carbon Radioisotopes ; Fluorobenzenes/pharmacokinetics ; Fluorobenzenes/pharmacology ; Isotope Labeling/methods ; Ligands ; Phenols ; Piperidines/pharmacokinetics ; Piperidines/pharmacology ; Receptor, Serotonin, 5-HT2A ; Serotonin Antagonists/pharmacology ; Stereoisomerism ; Tomography, Emission-Computed
Czasopismo naukowe
Tytuł :
delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice.
Autorzy :
Hosohata Y; Department of Pharmacology, University of Arizona Heatth Sciences Center, Tucson, AZ, USA.
Vanderah TW
Burkey TH
Ossipov MH
Kovelowski CJ
Sora I
Uhl GR
Zhang X
Rice KC
Roeske WR
Hruby VJ
Yamamura HI
Lai J
Porreca F
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2000 Feb 04; Vol. 388 (3), pp. 241-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Analgesics, Opioid/*pharmacology
Guanosine 5'-O-(3-Thiotriphosphate)/*metabolism
Receptors, Opioid, delta/*agonists
Receptors, Opioid, mu/*genetics
Animals ; Benzamides/pharmacology ; Brain/metabolism ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology ; Enkephalin, D-Penicillamine (2,5)-/pharmacology ; Enkephalins/pharmacology ; In Vitro Techniques ; Membranes ; Mice ; Mice, Knockout ; Oligopeptides/pharmacology ; Pain Measurement ; Piperazines/pharmacology ; Protein Binding ; Radioligand Assay ; Receptors, Opioid, delta/metabolism ; Spinal Cord/metabolism
Czasopismo naukowe
Tytuł :
Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.
Autorzy :
Aceto MD; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth Univeristy, Richmond 23298-0613, USA. />Harris LS
Abood ME
Rice KC
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 1999 Jan 22; Vol. 365 (2-3), pp. 143-7.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Analgesics/*pharmacology
Epilepsy/*physiopathology
Pain Measurement/*methods
Receptors, Opioid/*physiology
Thebaine/*metabolism
Animals ; Binding, Competitive ; Cells, Cultured ; Male ; Mice ; Mice, Inbred ICR ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Narcotic Antagonists/pharmacology ; Receptors, Opioid, delta/physiology ; Receptors, Opioid, mu/physiology ; Stereoisomerism ; Thebaine/pharmacology
Czasopismo naukowe
Tytuł :
Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.
Autorzy :
Quock RM; Department of Pharmacology, University of Arizona, Tucson 85724, USA.
Hosohata Y
Knapp RJ
Burkey TH
Hosohata K
Zhang X
Rice KC
Nagase H
Hruby VJ
Porreca F
Roeske WR
Yamamura HI
Pokaż więcej
Źródło :
European journal of pharmacology [Eur J Pharmacol] 1997 May 12; Vol. 326 (1), pp. 101-4.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Opioid, delta/*agonists
Animals ; Benzamides/pharmacology ; CHO Cells ; Cloning, Molecular ; Cricetinae ; Enkephalin, D-Penicillamine (2,5)- ; Enkephalins/pharmacology ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Humans ; Naltrexone/analogs & derivatives ; Naltrexone/metabolism ; Narcotic Antagonists/metabolism ; Piperazines/pharmacology ; Quinolines/pharmacology ; Sulfur Radioisotopes
Czasopismo naukowe
Tytuł :
Dissociation of the motor effects of (+)-pentazocine from binding to sigma 1 sites.
Autorzy :
Matsumoto RR; Department of Neurology, University of California Irvine 92717, USA.
Bowen WD
Walker JM
Patrick SL
Zambon AC
Vo VN
Truong DD
De Costa BR
Rice KC
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 1996 Apr 22; Vol. 301 (1-3), pp. 31-40.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Movement/*drug effects
Narcotics/*pharmacokinetics
Narcotics/*pharmacology
Pentazocine/*pharmacokinetics
Pentazocine/*pharmacology
Receptors, sigma/*physiology
Aging/metabolism ; Animals ; Central Nervous System Depressants/pharmacology ; Dystonia/chemically induced ; Dystonia/psychology ; Haloperidol/pharmacology ; Head Movements/drug effects ; In Vitro Techniques ; Male ; Membranes/drug effects ; Membranes/metabolism ; Narcotic Antagonists/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, sigma/antagonists & inhibitors ; Red Nucleus/drug effects ; Red Nucleus/metabolism ; Substantia Nigra/drug effects ; Substantia Nigra/metabolism
Czasopismo naukowe
Tytuł :
CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity.
Autorzy :
Bowen WD; Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Bertha CM
Vilner BJ
Rice KC
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 1995 May 24; Vol. 278 (3), pp. 257-60.
Typ publikacji :
Journal Article
MeSH Terms :
Benzylidene Compounds/*metabolism
Morphinans/*metabolism
Receptors, sigma/*metabolism
Animals ; Guinea Pigs ; Ligands ; Rats ; Receptors, Opioid, mu/metabolism ; Receptors, sigma/classification ; Sensitivity and Specificity ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Kappa opioid effects on fetal behavior: central administration of U50,488.
Autorzy :
Petrov ES; Pavlovian Physiological Department, Institute for Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Varlinskaya EI
Robinson SR
Smotherman WP
de Costa BR
Rice KC
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Źródło :
Physiology & behavior [Physiol Behav] 1994 Jul; Vol. 56 (1), pp. 175-82.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Analgesics/*pharmacology
Brain/*drug effects
Fetal Movement/*drug effects
Pyrrolidines/*pharmacology
Receptors, Opioid, kappa/*drug effects
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ; Animals ; Brain/embryology ; Dose-Response Relationship, Drug ; Female ; Fetal Movement/physiology ; Gestational Age ; Injections, Intraventricular ; Male ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa/physiology
Czasopismo naukowe
Tytuł :
Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter.
Autorzy :
Reith ME; Department of Basic Sciences, University of Illinois College of Medicine, Peoria 61605.
de Costa B
Rice KC
Jacobson AE
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 1992 Dec 01; Vol. 227 (4), pp. 417-25.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Cocaine/*metabolism
Dopamine/*metabolism
Phencyclidine/*analogs & derivatives
Piperazines/*metabolism
Animals ; Binding Sites/drug effects ; Binding, Competitive ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Dopamine Antagonists ; Female ; Phencyclidine/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Examination of the possible mediation of antineoplastic effects of opiates through the inhibition of tyrosine-specific protein kinases.
Autorzy :
Burke TR Jr; Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Li ZH
Bolen JB
Chapekar M
Gang Y
Glazer RI
Rice KC
Marquez VE
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 1991 May 15; Vol. 41 (10), pp. R17-20.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Narcotics/*pharmacology
Protein-Tyrosine Kinases/*antagonists & inhibitors
Cell Line ; ErbB Receptors/drug effects ; ErbB Receptors/metabolism ; Humans ; Hydroquinones/pharmacology ; Morphine/pharmacology ; Phenazocine/pharmacology ; Phosphorylation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Site-specific acylation of GABA-gated Cl- channels: effects on 36Cl- uptake.
Autorzy :
Moody EJ; Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD 20892.
Lewin AH
de Costa BR
Rice KC
Skolnick P
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 1991 Feb 25; Vol. 206 (2), pp. 113-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bridged Bicyclo Compounds, Heterocyclic*
Membrane Proteins/*metabolism
gamma-Aminobutyric Acid/*metabolism
Acylation ; Animals ; Biological Transport, Active ; Bridged Bicyclo Compounds/pharmacology ; Chloride Channels ; Chlorides/metabolism ; In Vitro Techniques ; Ion Channels/drug effects ; Ion Channels/metabolism ; Ligands ; Male ; Muscimol/metabolism ; Radioligand Assay ; Rats ; Rats, Inbred Strains ; Receptors, GABA-A/drug effects ; Receptors, GABA-A/metabolism ; Synaptosomes/drug effects ; Synaptosomes/metabolism
Czasopismo naukowe
Tytuł :
Interactions between phencyclidine and nifedipine at 45Ca2(+)-uptake sites on mouse brain neurons.
Autorzy :
Rice KC; Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892.
Bolger GT
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 1990 Jun 01; Vol. 39 (11), pp. 1825-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*metabolism
Calcium/*metabolism
Calcium Channels/*drug effects
Neurons/*metabolism
Nifedipine/*pharmacology
Phencyclidine/*pharmacology
Animals ; Brain/drug effects ; Calcium Channels/metabolism ; Kinetics ; Male ; Mice ; Neurons/drug effects ; Phencyclidine/analogs & derivatives ; Potassium/pharmacology
Czasopismo naukowe
Tytuł :
Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice.
Autorzy :
Debler EA; Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, New York, NY 10035.
Lipovac MN
Lajtha A
Zlokovic BV
Jacobson AE
Rice KC
Reith ME
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 1989 Jun 08; Vol. 165 (1), pp. 155-9.
Typ publikacji :
Journal Article
MeSH Terms :
Phencyclidine/*analogs & derivatives
Seizures/*chemically induced
Acoustic Stimulation ; Animals ; Injections ; Injections, Intravenous ; Mice ; Mice, Inbred BALB C ; Orbit ; Phencyclidine/toxicity ; Receptors, N-Methyl-D-Aspartate ; Receptors, Neurotransmitter/drug effects ; Time Factors
Czasopismo naukowe

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