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Tytuł :
Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis.
Autorzy :
Fei J; Department of Chemistry, Columbia University, New York, New York, USA.
Richard AC
Bronson JE
Gonzalez RL Jr
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2011 Aug 21; Vol. 18 (9), pp. 1043-51. Date of Electronic Publication: 2011 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protein Biosynthesis*
RNA, Transfer/*physiology
Ribosomes/*metabolism
Fluorescence Resonance Energy Transfer ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; Ribosomes/physiology
Czasopismo naukowe
Tytuł :
TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation.
Autorzy :
Meylan F; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Richard AC
Siegel RM
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Źródło :
Immunological reviews [Immunol Rev] 2011 Nov; Vol. 244 (1), pp. 188-96.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunity, Innate*
Receptors, Tumor Necrosis Factor, Member 25/*immunology
Signal Transduction/*immunology
T-Lymphocytes/*immunology
TNF Receptor-Associated Death Domain Protein/*immunology
Tumor Necrosis Factor Ligand Superfamily Member 15/*immunology
Animals ; Asthma/immunology ; Asthma/metabolism ; Autoimmunity ; Cell Proliferation ; Cytokines/biosynthesis ; Cytokines/immunology ; Gene Expression/immunology ; Humans ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/metabolism ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Lymphocyte Activation ; Mice ; Mice, Knockout ; Receptors, Tumor Necrosis Factor, Member 25/genetics ; Receptors, Tumor Necrosis Factor, Member 25/metabolism ; T-Lymphocytes/metabolism ; TNF Receptor-Associated Death Domain Protein/genetics ; TNF Receptor-Associated Death Domain Protein/metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 15/genetics ; Tumor Necrosis Factor Ligand Superfamily Member 15/metabolism
Czasopismo naukowe
Tytuł :
Enhancing the understanding of asthma.
Autorzy :
Vahedi G; Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Richard AC; Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
O'Shea JJ; Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło :
Nature immunology [Nat Immunol] 2014 Aug; Vol. 15 (8), pp. 701-3.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Genetic Predisposition to Disease*
Asthma/*genetics
Asthma/*immunology
Th1 Cells/*immunology
Th2 Cells/*immunology
Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation.
Autorzy :
Richard AC
Lyons PA
Peters JE
Biasci D
Flint SM
Lee JC
McKinney EF
Siegel RM
Smith KG; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, UK. .
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Źródło :
BMC genomics [BMC Genomics] 2014 Aug 04; Vol. 15, pp. 649. Date of Electronic Publication: 2014 Aug 04.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Profiling/*methods
Oligonucleotide Array Sequence Analysis/*methods
RNA/*genetics
Statistics as Topic/*methods
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/genetics ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Case-Control Studies ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/immunology ; Leukocytes/metabolism ; Organ Specificity
Czasopismo naukowe
Tytuł :
The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.
Autorzy :
Richard AC; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Tan C; Experimental Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892;
Hawley ET; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Gomez-Rodriguez J; Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;
Goswami R; Department of Pediatrics and Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202;
Yang XP; Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Cruz AC; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Penumetcha P; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Hayes ET; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Pelletier M; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Gabay O; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Walsh M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19102;
Ferdinand JR; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, United Kingdom; and.
Keane-Myers A; Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, MD 21702.
Choi Y; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19102;
O'Shea JJ; Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
Al-Shamkhani A; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, United Kingdom; and.
Kaplan MH; Department of Pediatrics and Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202;
Gery I; Experimental Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892;
Siegel RM; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; .
Meylan F; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Apr 15; Vol. 194 (8), pp. 3567-82. Date of Electronic Publication: 2015 Mar 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*immunology
Cell Differentiation/*immunology
Interleukin-9/*immunology
Receptors, Tumor Necrosis Factor, Member 25/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
Tumor Necrosis Factor Ligand Superfamily Member 15/*immunology
Animals ; Asthma/genetics ; Asthma/pathology ; Cell Differentiation/genetics ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Interleukin-13/genetics ; Interleukin-13/immunology ; Interleukin-4/genetics ; Interleukin-4/immunology ; Interleukin-9/genetics ; Mice ; Mice, Knockout ; Receptors, Tumor Necrosis Factor, Member 25/genetics ; Signal Transduction/genetics ; Signal Transduction/immunology ; T-Lymphocytes, Helper-Inducer/pathology ; Tumor Necrosis Factor Ligand Superfamily Member 15/genetics
Czasopismo naukowe
Tytuł :
The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator.
Autorzy :
Richard AC; Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Ferdinand JR; Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Meylan F; Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Hayes ET; Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Gabay O; Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Siegel RM; Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA; Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom .
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2015 Sep; Vol. 98 (3), pp. 333-45. Date of Electronic Publication: 2015 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Review
MeSH Terms :
Autoimmune Diseases/*immunology
Receptors, Death Domain/*metabolism
Tumor Necrosis Factor Ligand Superfamily Member 15/*metabolism
Animals ; Autoimmune Diseases/pathology ; Disease Models, Animal ; Humans ; Lymphocyte Activation/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9-Producing T Cells.
Autorzy :
Richard AC
Tan C
Hawley ET
Gomez-Rodriguez J
Goswami R
Yang XP
Cruz AC
Penumetcha P
Hayes ET
Pelletier M
Gabay O
Walsh M
Ferdinand JR
Keane-Myers A
Choi Y
O'Shea JJ
Al-Shamkhani A
Kaplan MH
Gery I
Siegel RM
Meylan F
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2015 Dec 15; Vol. 195 (12), pp. 5839-40.
Typ publikacji :
Published Erratum
Tytuł :
Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.
Autorzy :
Peters JE; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; Cambridge Institute For Medical Research, University of Cambridge, Cambridge, United Kingdom.; MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, United Kingdom.
Lyons PA; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; Cambridge Institute For Medical Research, University of Cambridge, Cambridge, United Kingdom.
Lee JC; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; Cambridge Institute For Medical Research, University of Cambridge, Cambridge, United Kingdom.
Richard AC; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; Cambridge Institute For Medical Research, University of Cambridge, Cambridge, United Kingdom.; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, United States of America.
Fortune MD; Cambridge Institute For Medical Research, University of Cambridge, Cambridge, United Kingdom.; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom.
Newcombe PJ; MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, United Kingdom.
Richardson S; MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, United Kingdom.
Smith KG; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; Cambridge Institute For Medical Research, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
PLoS genetics [PLoS Genet] 2016 Mar 25; Vol. 12 (3), pp. e1005908. Date of Electronic Publication: 2016 Mar 25 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Association Studies*
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*genetics
Inflammatory Bowel Diseases/*genetics
Quantitative Trait Loci/*genetics
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/pathology ; Female ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/pathology ; Male ; Monocytes/immunology ; Monocytes/metabolism ; Neutrophils/immunology ; Neutrophils/metabolism ; Phenotype ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.
Autorzy :
Richard AC; Department of Medicine and Cambridge Institute for Medical Research, The University of Cambridge, Box 139, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.; Autoimmunity Branch, National Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Peters JE; Department of Medicine and Cambridge Institute for Medical Research, The University of Cambridge, Box 139, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.
Lee JC; Department of Medicine and Cambridge Institute for Medical Research, The University of Cambridge, Box 139, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.
Vahedi G; Department of Genetics, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Schäffer AA; Computational Biology Branch, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, 20894, USA.
Siegel RM; Autoimmunity Branch, National Institute for Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Lyons PA; Department of Medicine and Cambridge Institute for Medical Research, The University of Cambridge, Box 139, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.
Smith KG; Department of Medicine and Cambridge Institute for Medical Research, The University of Cambridge, Box 139, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK. .
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Źródło :
Genome medicine [Genome Med] 2016 Jul 19; Vol. 8 (1), pp. 76. Date of Electronic Publication: 2016 Jul 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Quantitative Trait Loci*
Autoimmune Diseases/*genetics
Hereditary Autoinflammatory Diseases/*genetics
Receptors, Tumor Necrosis Factor/*genetics
Tumor Necrosis Factor-alpha/*genetics
Alleles ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Chromatin/chemistry ; Chromatin/immunology ; Gene Expression Regulation ; Gene Regulatory Networks ; Genome, Human ; Genome-Wide Association Study ; Hereditary Autoinflammatory Diseases/diagnosis ; Hereditary Autoinflammatory Diseases/immunology ; Hereditary Autoinflammatory Diseases/pathology ; Humans ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/pathology ; Protein Isoforms/genetics ; Protein Isoforms/immunology ; Receptors, Tumor Necrosis Factor/immunology ; Risk ; Signal Transduction ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Testing for differential abundance in mass cytometry data.
Autorzy :
Lun ATL; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Richard AC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; EMBL European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
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Źródło :
Nature methods [Nat Methods] 2017 Jul; Vol. 14 (7), pp. 707-709. Date of Electronic Publication: 2017 May 15.
Typ publikacji :
Journal Article
MeSH Terms :
Software*
Flow Cytometry/*methods
Image Processing, Computer-Assisted/*methods
Computer Simulation
Czasopismo naukowe
Tytuł :
Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.
Autorzy :
Ferdinand JR; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom.
Richard AC; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; and.; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Meylan F; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Al-Shamkhani A; Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom.
Siegel RM; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Feb 15; Vol. 200 (4), pp. 1360-1369. Date of Electronic Publication: 2018 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptive Immunity/*immunology
Immunity, Innate/*immunology
Lymphocyte Activation/*immunology
Tumor Necrosis Factor Ligand Superfamily Member 15/*immunology
Tumor Necrosis Factor Ligand Superfamily Member 15/*metabolism
Animals ; Mice ; Mice, Transgenic ; T-Lymphocytes/immunology
Czasopismo naukowe
Tytuł :
Detection and removal of barcode swapping in single-cell RNA-seq data.
Autorzy :
Griffiths JA; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, United Kingdom.
Richard AC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, United Kingdom.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, United Kingdom.
Bach K; Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, United Kingdom.
Lun ATL; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, United Kingdom. .
Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, United Kingdom. .; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, United Kingdom. .; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, United Kingdom. .
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Źródło :
Nature communications [Nat Commun] 2018 Jul 10; Vol. 9 (1), pp. 2667. Date of Electronic Publication: 2018 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA/*genetics
Genomics/*methods
Sequence Analysis, RNA/*methods
Single-Cell Analysis/*methods
Animals ; DNA Probes/genetics ; Humans ; Mice ; Models, Genetic ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
T cell cytolytic capacity is independent of initial stimulation strength.
Autorzy :
Richard AC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Lun ATL; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Lau WWY; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Department of Haematology, Wellcome - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Göttgens B; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Department of Haematology, Wellcome - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. .; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Cambridge, UK. .; Wellcome Sanger Institute, Cambridge, UK. .
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. .
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Źródło :
Nature immunology [Nat Immunol] 2018 Aug; Vol. 19 (8), pp. 849-858. Date of Electronic Publication: 2018 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytotoxicity, Immunologic*
CD8-Positive T-Lymphocytes/*physiology
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Animals ; Cell Line ; Genome ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; RNA/genetics ; Signal Transduction ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.
Autorzy :
Richard AC; Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States of America.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Peters JE; Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Savinykh N; NIHR Cambridge BRC Cell Phenotyping Hub, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Lee JC; Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Hawley ET; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Meylan F; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Siegel RM; Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Lyons PA; Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Smith KGC; Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
PLoS genetics [PLoS Genet] 2018 Sep 10; Vol. 14 (9), pp. e1007458. Date of Electronic Publication: 2018 Sep 10 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Colitis, Ulcerative/*genetics
Crohn Disease/*genetics
Tumor Necrosis Factor Ligand Superfamily Member 15/*metabolism
Adult ; Alleles ; Cells, Cultured ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/immunology ; Crohn Disease/blood ; Crohn Disease/immunology ; Female ; Haplotypes/genetics ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Polymorphism, Single Nucleotide/genetics ; Primary Cell Culture ; Quantitative Trait Loci/immunology ; Tumor Necrosis Factor Ligand Superfamily Member 15/blood ; Tumor Necrosis Factor Ligand Superfamily Member 15/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.
Autorzy :
Gawden-Bone CM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Frazer GL; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Richard AC; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Cancer Research UK Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0RE, UK.
Ma CY; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Strege K; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.
Griffiths GM; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address: .
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Źródło :
Immunity [Immunity] 2018 Sep 18; Vol. 49 (3), pp. 427-437.e4. Date of Electronic Publication: 2018 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*metabolism
Cell Membrane/*metabolism
Cytoplasmic Granules/*metabolism
Immunological Synapses/*metabolism
Phosphatidylinositols/*metabolism
Phosphotransferases (Alcohol Group Acceptor)/*metabolism
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Cell Degranulation ; Cell Line ; Cytotoxicity, Immunologic ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Correcting the Mean-Variance Dependency for Differential Variability Testing Using Single-Cell RNA Sequencing Data.
Autorzy :
Eling N; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
Richard AC; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK; Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Richardson S; MRC Biostatistics Unit, University of Cambridge, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK.
Marioni JC; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK. Electronic address: .
Vallejos CA; The Alan Turing Institute, British Library, 96 Euston Road, London NW1 2DB, UK; Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 7HB, UK; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XY, UK. Electronic address: .
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Źródło :
Cell systems [Cell Syst] 2018 Sep 26; Vol. 7 (3), pp. 284-294.e12. Date of Electronic Publication: 2018 Aug 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Variation, Population*
Models, Theoretical*
Single-Cell Analysis*
CD4-Positive T-Lymphocytes/*physiology
Sequence Analysis, RNA/*methods
Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Computer Simulation ; Gene Expression Regulation ; Immunity/genetics ; Lymphocyte Activation/genetics ; Mice ; Mice, Inbred C57BL ; Transcriptome
Czasopismo naukowe
Tytuł :
Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF.
Autorzy :
Song YJ; Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD, USA.
Choi IA; Division of Rheumatology, Department of Internal Medicine, MMBS, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Meylan F; Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD, USA.
Demoruelle MK; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 80207, USA.
Farley T; Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD, USA.
Richard AC; Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD, USA.
Hawley E; Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD, USA.
Botson J; Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD, USA.
Hong YJ; Division of Rheumatology, Department of Internal Medicine, MMBS, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Lee EY; Division of Rheumatology, Department of Internal Medicine, MMBS, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Mian SR; Division of Rheumatology, Department of Medicine, Los Angeles County University of Southern California Medical Center and University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Hamilton BC; Rheumatology Division, Department of Medicine, University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Thiele GM; Rheumatology Division, Department of Medicine, University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Mikuls TR; Rheumatology Division, Department of Medicine, University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Gara N; Liver Diseases Branch, NIDDK, NIH, Bethesda, MD, USA.
Ward CD; Human Genome Sciences, Rockville, MD, USA.
Lamberth S; Immunology Biomarkers group, Pharmaceutical Companies of J&J, LLC, Spring House, PA, USA.
Deane KD; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 80207, USA.
Heller T; Liver Diseases Branch, NIDDK, NIH, Bethesda, MD, USA.
Ward MM; Clinical Trials and Outcomes Branch, NIAMS, NIH, Bethesda, MD, USA.
Lee DM; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Present address: Janssen Research and Development, Spring House, PA, USA.
Migone TS; Human Genome Sciences, Rockville, MD, USA.
Stohl W; Division of Rheumatology, Department of Medicine, Los Angeles County University of Southern California Medical Center and University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
O'Dell JR; Rheumatology Division, Department of Medicine, University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Norris JM; Colorado School of Public Health, Aurora, CO, USA.
Holers VM; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 80207, USA.
Gregersen P; Center for Genomics & Human Genetics, The Feinstein Institute for Medical Research, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY, USA.
Song YW; Division of Rheumatology, Department of Internal Medicine, MMBS, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Siegel RM; Immunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Bethesda, MD, USA. .
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Źródło :
Arthritis research & therapy [Arthritis Res Ther] 2020 May 07; Vol. 22 (1), pp. 106. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Experimental*/drug therapy
Arthritis, Experimental*/genetics
Arthritis, Rheumatoid*/drug therapy
Arthritis, Rheumatoid*/genetics
Tumor Necrosis Factor Ligand Superfamily Member 15/*blood
Animals ; Humans ; Methotrexate/therapeutic use ; Mice ; Synovial Fluid ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Tumor Necrosis Factor Ligand Superfamily Member 15/antagonists & inhibitors ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling.
Autorzy :
Ma CY; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.; EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.
Griffiths GM; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Richard AC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
ELife [Elife] 2020 May 15; Vol. 9. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*drug effects
Lymphocyte Activation/*drug effects
Ovalbumin/*pharmacology
Receptors, Antigen, T-Cell/*agonists
Signal Transduction/*drug effects
Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; Female ; Flow Cytometry ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Kinetics ; Ligands ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism ; Peptide Fragments/pharmacology ; Phosphorylation ; Receptors, Antigen, T-Cell/metabolism ; Ribosomal Protein S6/metabolism ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death.
Autorzy :
Gisby J; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Clarke CL; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Medjeral-Thomas N; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Malik TH; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Papadaki A; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Mortimer PM; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Buang NB; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Lewis S; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Pereira M; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Toulza F; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Fagnano E; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Mawhin MA; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Dutton EE; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Tapeng L; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Richard AC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Kirk PD; MRC Biostatistics Unit, Forvie Way, University of Cambridge, Cambridge, United Kingdom.; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge, United Kingdom.
Behmoaras J; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Sandhu E; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
McAdoo SP; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Prendecki MF; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Pickering MC; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Botto M; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Willicombe M; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Thomas DC; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Peters JE; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.; Health Data Research UK, London, United Kingdom.
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Źródło :
ELife [Elife] 2021 Mar 11; Vol. 10. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*blood
Kidney Failure, Chronic/*blood
Kidney Failure, Chronic/*virology
Renal Dialysis/*methods
Aged ; Biomarkers/blood ; COVID-19/mortality ; COVID-19/virology ; Female ; Forecasting ; Hospitalization ; Humans ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Longitudinal Studies ; Male ; Middle Aged ; Prognosis ; Proteomics/methods ; Renal Dialysis/mortality ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Czasopismo naukowe

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