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    Wyświetlanie 1-7 z 7
    Tytuł:
    Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo.
    Autorzy:
    Risner ML; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave S., Nashville, TN, 37232, USA. .; Department of Foundational Medical Studies, Eye Research Center, Oakland University William Beaumont School of Medicine, 369 Dodge Hall, 118 Library Dr., Rochester, MI, 48309, USA. .
    Ribeiro M; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave S., Nashville, TN, 37232, USA.
    McGrady NR; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave S., Nashville, TN, 37232, USA.
    Kagitapalli BS; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave S., Nashville, TN, 37232, USA.
    Chamling X; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
    Zack DJ; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
    Calkins DJ; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave S., Nashville, TN, 37232, USA. .
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    Źródło:
    Cell communication and signaling : CCS [Cell Commun Signal] 2023 Oct 30; Vol. 21 (1), pp. 305. Date of Electronic Publication: 2023 Oct 30.
    Typ publikacji:
    Video-Audio Media; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Sphingomyelins*
    Sphingomyelin Phosphodiesterase*/metabolism
    Mice ; Animals ; Humans ; Annexin A5 ; Reactive Oxygen Species/metabolism ; Phosphatidylserines ; Ceramides/metabolism ; Retinal Ganglion Cells/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina.
    Autorzy:
    Croteau LP; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Risner ML; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Wareham LK; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    McGrady NR; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Chamling X; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
    Zack DJ; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
    Calkins DJ; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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    Źródło:
    Cells [Cells] 2022 Oct 15; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 15.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Retina*/surgery
    Retinal Ganglion Cells*/transplantation
    Neural Stem Cells*/transplantation
    Animals ; Humans ; Mice ; Adenylyl Cyclases ; Brain-Derived Neurotrophic Factor ; Colforsin/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice.
    Autorzy:
    Holden JM; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Al Hussein Al Awamlh S; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Croteau LP; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Boal AM; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Rex TS; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Risner ML; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Calkins DJ; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Wareham LK; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2022 Mar 12; Vol. 23 (6). Date of Electronic Publication: 2022 Mar 12.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Astrocytes*/metabolism
    Nitric Oxide*/metabolism
    Animals ; Cyclic GMP/metabolism ; Mice ; Mice, Knockout ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Neuroprotection by Wld depends on retinal ganglion cell type and age in glaucoma.
    Autorzy:
    Risner ML; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave. S, Nashville, TN, 37232, USA.
    Pasini S; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave. S, Nashville, TN, 37232, USA.
    McGrady NR; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave. S, Nashville, TN, 37232, USA.
    D'Alessandro KB; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave. S, Nashville, TN, 37232, USA.
    Yao V; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave. S, Nashville, TN, 37232, USA.
    Cooper ML; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave. S, Nashville, TN, 37232, USA.
    Calkins DJ; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, AA7103 MCN/VUIIS, 1161 21st Ave. S, Nashville, TN, 37232, USA. .
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    Źródło:
    Molecular neurodegeneration [Mol Neurodegener] 2021 Jun 05; Vol. 16 (1), pp. 36. Date of Electronic Publication: 2021 Jun 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Nerve Tissue Proteins*
    Aging/*pathology
    Glaucoma/*pathology
    Neuroprotection/*physiology
    Retinal Ganglion Cells/*pathology
    Animals ; Male ; Mice ; Mice, Inbred C57BL
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration.
    Autorzy:
    Boal AM; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, 1161 21st Ave S, AA7103D Medical Center North, Nashville, TN 37232-0654, USA.
    Risner ML; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, 1161 21st Ave S, AA7103D Medical Center North, Nashville, TN 37232-0654, USA.
    Cooper ML; Skirball Institute for Biomolecular Medicine, NYU Langone Medical Center, New York, NY 10016, USA.; Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA.
    Wareham LK; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, 1161 21st Ave S, AA7103D Medical Center North, Nashville, TN 37232-0654, USA.
    Calkins DJ; Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, 1161 21st Ave S, AA7103D Medical Center North, Nashville, TN 37232-0654, USA.
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    Źródło:
    Cells [Cells] 2021 Jun 02; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 02.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Astrocytes/*metabolism
    Connexin 43/*metabolism
    Gap Junctions/*metabolism
    Glaucoma/*metabolism
    Neurodegenerative Diseases/*metabolism
    Optic Nerve Diseases/*metabolism
    Astrocytes/pathology ; Gap Junctions/pathology ; Glaucoma/pathology ; Humans ; Neurodegenerative Diseases/pathology ; Optic Nerve Diseases/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration.
    Autorzy:
    Al Hussein Al Awamlh S; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Wareham LK; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Risner ML; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
    Calkins DJ; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Ophthalmology & Visual Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Apr 28; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 28.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Glaucoma/*metabolism
    Insulin/*metabolism
    Neurodegenerative Diseases/*metabolism
    Animals ; Disease Models, Animal ; Glaucoma/pathology ; Glaucoma/therapy ; Humans ; Molecular Targeted Therapy ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/therapy ; Neuroprotection ; Retina/metabolism ; Retina/pathology ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Divergent roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators.
    Autorzy:
    Ruan GX; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
    Gamble KL
    Risner ML
    Young LA
    McMahon DG
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    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (6), pp. e38985. Date of Electronic Publication: 2012 Jun 11.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Circadian Clocks/*genetics
    Circadian Rhythm/*physiology
    Luminescent Proteins/*metabolism
    Retina/*physiology
    Suprachiasmatic Nucleus/*physiology
    Analysis of Variance ; Animals ; CLOCK Proteins/metabolism ; Circadian Rhythm/genetics ; Cryptochromes/genetics ; Cryptochromes/metabolism ; Luciferases/metabolism ; Luminescent Proteins/physiology ; Mice ; Mice, Knockout ; Period Circadian Proteins/metabolism ; Retina/metabolism ; Statistics, Nonparametric ; Suprachiasmatic Nucleus/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-7 z 7

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