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Tytuł :
Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections.
Autorzy :
Santos-Ferreira N; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Van Dycke J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
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Źródło :
Microorganisms [Microorganisms] 2021 Jul 27; Vol. 9 (8). Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens".
Autorzy :
Liesenborghs L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium; The Outbreak Research Team, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. Electronic address: .
Spriet I; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jochmans D; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Belmans A; KU Leuven University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
Gyselinck I; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Teuwen LA; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ter Horst S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Dreesen E; Clinical Pharmacology and Pharmacotherapy Unit, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Geukens T; Department of Oncology, Laboratory for Translational Breast Cancer Research, KU Leuven, Belgium.
Engelen MM; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Landeloos E; Department of Oncology, Laboratory for molecular Cancer biology, VIB-KU Leuven, Belgium.
Geldhof V; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ceunen H; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Debaveye B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Vandenberk B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Van der Linden L; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jacobs S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Langendries L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Boudewijns R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Dan Do TN; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Chiu W; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Zhang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Weynand B; Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Belgium.
Vanassche T; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Devos T; Department of Hematology, UZ Leuven and Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Belgium.
Meyfroidt G; Department and Laboratory of Intensive Care Medicine, UZ and KU Leuven, Belgium.
Janssens W; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vos R; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vermeersch P; Department of Cardiovascular Sciences and Clinical Department of Laboratory Medicine, KU Leuven, Belgium.
Wauters J; Medical Intensive Care Unit, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Verbeke G; KU Leuven University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
De Munter P; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Kaptein SJF; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Van Wijngaerden E; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Verhamme P; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
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Źródło :
EBioMedicine [EBioMedicine] 2021 Jul; Vol. 69, pp. 103454. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji :
Published Erratum
Tytuł :
Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors.
Autorzy :
Van Dycke J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Cuvry A; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Knickmann J; University of Lübeck-Institute of Virology and Cell Biology, Lübeck, Germany.
Ny A; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Rakers S; Fraunhofer Research Institution for Marine Biotechnology and Cell Technology EMB, WG Aquatic Cell Technology and Aquaculture, Lübeck, Germany.
Taube S; University of Lübeck-Institute of Virology and Cell Biology, Lübeck, Germany.
de Witte P; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Neyts J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.; Global Virus Network (GVN), Centers of Excellence, Baltimore, MD, USA.
Rocha-Pereira J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium. .
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Źródło :
Nature protocols [Nat Protoc] 2021 Apr; Vol. 16 (4), pp. 1830-1849. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caliciviridae Infections/*virology
Norovirus/*physiology
Small Molecule Libraries/*pharmacology
Zebrafish/*virology
Animals ; Embryo, Nonmammalian/virology ; Humans ; Immunity, Innate ; Larva/drug effects ; Larva/immunology ; Norovirus/genetics ; Reproducibility of Results ; Virus Replication ; Zebrafish/embryology
Czasopismo naukowe
Tytuł :
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial.
Autorzy :
Liesenborghs L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium; The Outbreak Research Team, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. Electronic address: .
Spriet I; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jochmans D; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Belmans A; KU Leuven - University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
Gyselinck I; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Teuwen LA; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ter Horst S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Dreesen E; Clinical Pharmacology and Pharmacotherapy Unit, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Geukens T; Department of Oncology, Laboratory for Translational Breast Cancer Research, KU Leuven, Belgium.
Engelen MM; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Landeloos E; Department of Oncology, Laboratory for molecular Cancer biology, VIB-KU Leuven, Belgium.
Geldhof V; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ceunen H; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Debaveye B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Vandenberk B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Van der Linden L; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jacobs S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Langendries L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Boudewijns R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Do TND; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Chiu W; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Zhang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Weynand B; Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Belgium.
Vanassche T; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Devos T; Department of Hematology, UZ Leuven and Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Belgium.
Meyfroidt G; Department and Laboratory of Intensive Care Medicine, UZ and KU Leuven, Belgium.
Janssens W; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vos R; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vermeersch P; Department of Cardiovascular Sciences and Clinical Department of Laboratory Medicine, KU Leuven, Belgium.
Wauters J; Medical Intensive Care Unit, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Verbeke G; KU Leuven - University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
De Munter P; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Kaptein SJF; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Van Wijngaerden E; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Verhamme P; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
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Źródło :
EBioMedicine [EBioMedicine] 2021 Apr; Vol. 66, pp. 103288. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Itraconazole/*pharmacology
Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; COVID-19/etiology ; COVID-19/transmission ; Chlorocebus aethiops ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Female ; Humans ; Itraconazole/administration & dosage ; Itraconazole/pharmacokinetics ; Itraconazole/therapeutic use ; Male ; Mesocricetus ; Middle Aged ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Proof of Concept Study ; SARS-CoV-2/drug effects ; Treatment Outcome ; Vero Cells
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Screening and in vitro antiviral assessment of small molecules against fluorescent protein-expressing Bunyamwera virus in a cell-based assay using high-content imaging.
Autorzy :
Ter Horst S; Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven - University of Leuven, Leuven, Belgium.
Chiu W; Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven - University of Leuven, Leuven, Belgium.
Neyts J; Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven - University of Leuven, Leuven, Belgium.
Rocha-Pereira J; Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven - University of Leuven, Leuven, Belgium.
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Źródło :
Antiviral chemistry & chemotherapy [Antivir Chem Chemother] 2021 Jan-Dec; Vol. 29, pp. 20402066211033478.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Identification of active compounds.
Autorzy :
Van Dycke J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rymenants J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Neyts J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rocha-Pereira J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
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Źródło :
Antiviral chemistry & chemotherapy [Antivir Chem Chemother] 2021 Jan-Dec; Vol. 29, pp. 20402066211026852.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Autorzy :
Boudewijns R; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Thibaut HJ; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .; Translational Platform Virology and Chemotherapy, Leuven, Belgium. .
Kaptein SJF; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Li R; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Vergote V; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Seldeslachts L; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Van Weyenbergh J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
De Keyzer C; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Bervoets L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Sharma S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liesenborghs L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Ma J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jansen S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Van Looveren D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Vercruysse T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jochmans D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Martens E; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Roose K; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
De Vlieger D; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Schepens B; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Van Buyten T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jacobs S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liu Y; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Martí-Carreras J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Vanmechelen B; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Wawina-Bokalanga T; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Coelmont L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Chiu W; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Leyssen P; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Heylen E; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Schols D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Wang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Close L; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Matthijnssens J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Van Ranst M; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; KU Leuven Department of Laboratory Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.; National Reference Center for Respiratory Pathogens and Enteroviruses, 3000, Leuven, Belgium.; Leuven University Vaccinology Center (LUVAC), 3000, Leuven, Belgium.
Compernolle V; Blood Service, Belgian Red Cross Flanders, Mechelen, Belgium.; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Schramm G; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Van Laere K; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Saelens X; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Callewaert N; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Opdenakker G; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Maes P; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Weynand B; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, 3000, Leuven, Belgium.; Division of Translational Cell and Tissue Research, Leuven, Belgium.
Cawthorne C; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.
Vande Velde G; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Wang Z; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Neyts J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
Dallmeier K; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5838. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Betacoronavirus/*physiology
Coronavirus Infections/*pathology
Coronavirus Infections/*virology
Pneumonia, Viral/*pathology
Pneumonia, Viral/*virology
STAT2 Transcription Factor/*metabolism
Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cricetinae ; Immunity, Innate ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Lung/pathology ; Lung/virology ; Mice ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; STAT2 Transcription Factor/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales.
Autorzy :
Fernández-García Y; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany. Electronic address: .
Horst ST; KU Leuven, Rega Institute for Medical Research, Belgium.
Bassetto M; Department of Chemistry, College of Science, Swansea University, United Kingdom.
Brancale A; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, United Kingdom.
Neyts J; KU Leuven, Rega Institute for Medical Research, Belgium.
Rogolino D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area Delle Scienze, Parma, Italy.
Sechi M; Department of Chemistry and Pharmacy, Laboratory of Drug Design and Nanomedicine, University of Sassari, Italy.
Carcelli M; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area Delle Scienze, Parma, Italy.
Günther S; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Rocha-Pereira J; KU Leuven, Rega Institute for Medical Research, Belgium. Electronic address: .
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Źródło :
Antiviral research [Antiviral Res] 2020 Nov; Vol. 183, pp. 104947. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Bunyaviridae/*drug effects
Bunyaviridae/*enzymology
Endonucleases/*antagonists & inhibitors
Hydroxybutyrates/*pharmacology
Piperidines/*pharmacology
Viral Proteins/*antagonists & inhibitors
Catalytic Domain ; Crystallography, X-Ray ; Endonucleases/metabolism ; Molecular Docking Simulation ; RNA Caps/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin.
Autorzy :
Ter Horst S; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Fernandez-Garcia Y; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Bassetto M; Department of Chemistry, College of Science, Swansea University, Swansea, UK.
Günther S; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Brancale A; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
Neyts J; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rocha-Pereira J; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
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Źródło :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Nov 01; Vol. 75 (11), pp. 3189-3193.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Orthobunyavirus*
Ribavirin*/pharmacology
Antiviral Agents/pharmacology ; Dibenzothiepins ; Endonucleases ; Humans ; Morpholines ; Pyridones ; Triazines
Czasopismo naukowe
Tytuł :
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Autorzy :
Kaptein SJF; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .
Jacobs S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Langendries L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Seldeslachts L; Biomedical MRI and Molecular Small Animal Imaging Centre, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Ter Horst S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Liesenborghs L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Hens B; Drug Delivery & Disposition, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Vergote V; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Heylen E; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Barthelemy K; Unité des Virus Emergents, Aix Marseille University, Institut de Recherche pour le Développement (IRD) 190, Institut National de la Santé et de la Recherche Médicale (INSERM) 1207, 13005 Marseille, France.
Maas E; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
De Keyzer C; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Bervoets L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Rymenants J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Van Buyten T; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Zhang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Abdelnabi R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Pang J; UCL Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, United Kingdom.
Williams R; UCL Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, United Kingdom.
Thibaut HJ; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Dallmeier K; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Boudewijns R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Wouters J; Molecular Small Animal Imaging Centre, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Augustijns P; Drug Delivery & Disposition, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Verougstraete N; Department of Laboratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium.
Cawthorne C; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Breuer J; UCL Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, United Kingdom.
Solas C; Assistance Publique-Hôpitaux de Marseille, Aix-Marseille University, Unité des Virus Emergents, Institut de Recherche pour le Développement (IRD) 190, Institut National de la Santé et de la Recherche Médicale (INSERM) 1207, Laboratoire de Pharmacocinétique et Toxicologie, 13005 Marseille, France.
Weynand B; Translational Cell and Tissue Research, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Annaert P; Drug Delivery & Disposition, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Spriet I; Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.; Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven-University of Leuven, 3000 Leuven, Belgium.
Vande Velde G; Biomedical MRI and Molecular Small Animal Imaging Centre, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .; Global Virus Network, Baltimore, MD 21201.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .
Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 27; Vol. 117 (43), pp. 26955-26965. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides/*therapeutic use
Antiviral Agents/*therapeutic use
Betacoronavirus/*drug effects
Hydroxychloroquine/*therapeutic use
Pyrazines/*therapeutic use
Amides/pharmacokinetics ; Animals ; COVID-19/drug therapy ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cricetinae ; Disease Models, Animal ; Disease Transmission, Infectious/prevention & control ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Hydroxychloroquine/pharmacokinetics ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Pyrazines/pharmacokinetics ; SARS-CoV-2 ; Treatment Outcome ; Vero Cells ; Viral Load/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Animal models for COVID-19.
Autorzy :
Muñoz-Fontela C; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Dowling WE; Centre for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA.
Funnell SGP; National Infection Service, Public Health England, Salisbury, UK.
Gsell PS; World Health Organization, Geneva, Switzerland.
Riveros-Balta AX; World Health Organization, Geneva, Switzerland.
Albrecht RA; Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andersen H; Bioqual Inc, Rockville, MD, USA.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carroll MW; National Infection Service, Public Health England, Salisbury, UK.
Cavaleri M; European Medicines Agency, Amsterdam, The Netherlands.
Qin C; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking, China.
Crozier I; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Dallmeier K; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
de Waal L; Viroclinics Xplore, Schaijk, The Netherlands.
de Wit E; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Delang L; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Dohm E; Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, USA.
Duprex WP; Department of Microbiology and Molecular Genetics, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Falzarano D; VIDO-Intervac, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Finch CL; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Gralinski LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Guilfoyle K; Viroclinics Xplore, Schaijk, The Netherlands.
Haagmans BL; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hamilton GA; Emulate Inc, Boston, MA, USA.
Hartman AL; Department of Microbiology and Molecular Genetics, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Herfst S; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Kaptein SJF; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Klimstra WB; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Knezevic I; World Health Organization, Geneva, Switzerland.
Krause PR; Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, USA.
Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.
Le Grand R; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Inserm, CEA, Université Paris-Saclay, Paris, France.
Lewis MG; Bioqual Inc, Rockville, MD, USA.
Liu WC; Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maisonnasse P; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Inserm, CEA, Université Paris-Saclay, Paris, France.
McElroy AK; Division of Pediatric Infectious Diseases, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Munster V; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Oreshkova N; Wageningen Bioveterinary Research (WBVR), Wageningen University and Research, Lelystad, The Netherlands.
Rasmussen AL; Center for Infection and Immunity, Columbia Mailman |School of Public Health, New York, NY, USA.
Rocha-Pereira J; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rockx B; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Rodríguez E; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Rogers TF; Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA.
Salguero FJ; National Infection Service, Public Health England, Salisbury, UK.
Schotsaert M; Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stittelaar KJ; Viroclinics Xplore, Schaijk, The Netherlands.
Thibaut HJ; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Tseng CT; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Vergara-Alert J; Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat Autònoma de Barcelona, Bellaterra, Spain.
Beer M; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Brasel T; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Chan JFW; Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
García-Sastre A; Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neyts J; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Perlman S; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Reed DS; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Richt JA; College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Roy CJ; Tulane National Primate Research Center, Covington, LA, USA.
Segalés J; Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat Autònoma de Barcelona, Bellaterra, Spain.; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, Bellaterra, Spain.
Vasan SS; Australian Centre for Disease Preparedness, CSIRO, Geelong, Victoria, Australia.; Department of Health Sciences, University of York, York, UK.
Henao-Restrepo AM; World Health Organization, Geneva, Switzerland. .
Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature [Nature] 2020 Oct; Vol. 586 (7830), pp. 509-515. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Models, Animal*
Coronavirus Infections/*drug therapy
Coronavirus Infections/*prevention & control
Pandemics/*prevention & control
Pneumonia, Viral/*drug therapy
Pneumonia, Viral/*prevention & control
Animals ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/immunology ; Ferrets/virology ; Humans ; Mesocricetus/virology ; Mice ; Pneumonia, Viral/immunology ; Primates/virology ; SARS-CoV-2 ; Viral Vaccines/immunology
Czasopismo naukowe
Tytuł :
Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides.
Autorzy :
Li Q; KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 - Box 1041, Leuven, 3000, Belgium.
Groaz E; KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 - Box 1041, Leuven, 3000, Belgium. Electronic address: .
Rocha-Pereira J; KU Leuven, Rega Institute for Medical Research, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Herestraat 49 - Box 1041, Leuven, 3000, Leuven, Belgium.
Neyts J; KU Leuven, Rega Institute for Medical Research, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Herestraat 49 - Box 1041, Leuven, 3000, Leuven, Belgium.
Herdewijn P; KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49 - Box 1041, Leuven, 3000, Belgium. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Jun 01; Vol. 195, pp. 112198. Date of Electronic Publication: 2020 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Norovirus/*drug effects
Nucleosides/*chemistry
Nucleosides/*pharmacology
Pyrroles/*chemistry
Triazines/*chemistry
Animals ; Antiviral Agents/toxicity ; Cell Line ; Drug Design ; Mice ; Norovirus/physiology ; Nucleosides/toxicity ; Structure-Activity Relationship ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase.
Autorzy :
Giancotti G; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Rigo I; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Pasqualetto G; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Young MT; Cardiff School of Biosciences, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Neyts J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rocha-Pereira J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Brancale A; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Ferla S; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK. .
Bassetto M; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.; Department of Chemistry, Swansea University, Swansea, UK.
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 05; Vol. 9 (1), pp. 18413. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*chemical synthesis
Norovirus/*drug effects
Oxazoles/*chemical synthesis
Pyrimidines/*chemical synthesis
RNA-Dependent RNA Polymerase/*antagonists & inhibitors
Sulfonamides/*chemical synthesis
Thiophenes/*chemical synthesis
Viral Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/pharmacology ; Binding Sites ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacology ; Gene Expression ; Humans ; Mice ; Molecular Docking Simulation ; Norovirus/enzymology ; Norovirus/genetics ; Norovirus/growth & development ; Oxazoles/pharmacology ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Pyrimidines/pharmacology ; RAW 264.7 Cells ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/metabolism ; Structure-Activity Relationship ; Substrate Specificity ; Sulfonamides/pharmacology ; Thiophenes/pharmacology ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
A robust human norovirus replication model in zebrafish larvae.
Autorzy :
Van Dycke J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Ny A; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Conceição-Neto N; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, Leuven, Belgium.
Maes J; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Hosmillo M; University of Cambridge-Department of Pathology, Division of Virology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Cuvry A; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Goodfellow I; University of Cambridge-Department of Pathology, Division of Virology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Nogueira TC; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Verbeken E; KU Leuven-Department of Imaging & Pathology, Translational Cell & Tissue Research, Leuven, Belgium.
Matthijnssens J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, Leuven, Belgium.
de Witte P; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Neyts J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.; Global Virus Network (GVN), Centers of Excellence.
Rocha-Pereira J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
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Źródło :
PLoS pathogens [PLoS Pathog] 2019 Sep 19; Vol. 15 (9), pp. e1008009. Date of Electronic Publication: 2019 Sep 19 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Norovirus/*pathogenicity
Norovirus/*physiology
Virus Replication/*physiology
Zebrafish/*virology
Animals ; Antiviral Agents/administration & dosage ; Caliciviridae Infections/virology ; Foodborne Diseases/virology ; Gastroenteritis/virology ; Host Microbial Interactions ; Humans ; Larva/virology ; Metagenomics ; Models, Animal ; Norovirus/genetics ; Virus Cultivation/methods ; Virus Replication/drug effects
Czasopismo naukowe

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