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Wyświetlanie 1-3 z 3
Tytuł :
Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors.
Autorzy :
Van Dycke J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Cuvry A; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Knickmann J; University of Lübeck-Institute of Virology and Cell Biology, Lübeck, Germany.
Ny A; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Rakers S; Fraunhofer Research Institution for Marine Biotechnology and Cell Technology EMB, WG Aquatic Cell Technology and Aquaculture, Lübeck, Germany.
Taube S; University of Lübeck-Institute of Virology and Cell Biology, Lübeck, Germany.
de Witte P; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Neyts J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.; Global Virus Network (GVN), Centers of Excellence, Baltimore, MD, USA.
Rocha-Pereira J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium. .
Pokaż więcej
Źródło :
Nature protocols [Nat Protoc] 2021 Apr; Vol. 16 (4), pp. 1830-1849. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caliciviridae Infections/*virology
Norovirus/*physiology
Small Molecule Libraries/*pharmacology
Zebrafish/*virology
Animals ; Embryo, Nonmammalian/virology ; Humans ; Immunity, Innate ; Larva/drug effects ; Larva/immunology ; Norovirus/genetics ; Reproducibility of Results ; Virus Replication ; Zebrafish/embryology
Czasopismo naukowe
Tytuł :
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Autorzy :
Boudewijns R; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Thibaut HJ; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .; Translational Platform Virology and Chemotherapy, Leuven, Belgium. .
Kaptein SJF; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Li R; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Vergote V; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Seldeslachts L; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Van Weyenbergh J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
De Keyzer C; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Bervoets L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Sharma S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liesenborghs L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Ma J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jansen S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Van Looveren D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Vercruysse T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jochmans D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Martens E; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Roose K; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
De Vlieger D; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Schepens B; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Van Buyten T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jacobs S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liu Y; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Martí-Carreras J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Vanmechelen B; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Wawina-Bokalanga T; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Coelmont L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Chiu W; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Leyssen P; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Heylen E; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Schols D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Wang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Close L; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Matthijnssens J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Van Ranst M; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; KU Leuven Department of Laboratory Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.; National Reference Center for Respiratory Pathogens and Enteroviruses, 3000, Leuven, Belgium.; Leuven University Vaccinology Center (LUVAC), 3000, Leuven, Belgium.
Compernolle V; Blood Service, Belgian Red Cross Flanders, Mechelen, Belgium.; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Schramm G; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Van Laere K; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Saelens X; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Callewaert N; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Opdenakker G; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Maes P; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Weynand B; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, 3000, Leuven, Belgium.; Division of Translational Cell and Tissue Research, Leuven, Belgium.
Cawthorne C; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.
Vande Velde G; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Wang Z; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Neyts J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
Dallmeier K; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5838. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Betacoronavirus/*physiology
Coronavirus Infections/*pathology
Coronavirus Infections/*virology
Pneumonia, Viral/*pathology
Pneumonia, Viral/*virology
STAT2 Transcription Factor/*metabolism
Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cricetinae ; Immunity, Innate ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Lung/pathology ; Lung/virology ; Mice ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; STAT2 Transcription Factor/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients.
Autorzy :
Funnell SGP; National Infection Service, Public Health England, Porton Down, Manor Farm Road, Salisbury, Wiltshire, SP40JG, UK. .
Dowling WE; Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Avenue, NW, Suite 1003, Washington, DC, 20006, USA.
Muñoz-Fontela C; Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse. 74, 20359, Hamburg, Germany.
Gsell PS; World Health Organisation, Avenue Appia, 1211, Geneva, Switzerland.
Ingber DE; Wyss Institute for Biologically Inspired Engineering, Harvard University, CLSB5, 3 Blackfan Circle, Boston, MA, 02115, USA.
Hamilton GA; Emulate Inc., 27 Drydock Avenue, 5th Floor, Boston, MA, 02210, USA.
Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
Kaptein S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
Dallmeier KH; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Global Virus Network, KU Leuven, 3000, Leuven, Belgium.
Rosenke K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, 59840, MT, USA.
de Wit E; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, 59840, MT, USA.
Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Hamilton, 59840, MT, USA.
Maisonnasse P; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases » (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, 92265, France.
Le Grand R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases » (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, 92265, France.
Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Coleman CM; School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Aug 26; Vol. 11 (1), pp. 4253. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Betacoronavirus*/drug effects
Betacoronavirus*/pathogenicity
Models, Biological*
Antiviral Agents/*therapeutic use
Coronavirus Infections/*drug therapy
Hydroxychloroquine/*therapeutic use
Pneumonia, Viral/*drug therapy
Animals ; COVID-19 ; Cricetinae ; Humans ; Mice ; Pandemics ; Primates ; SARS-CoV-2 ; Treatment Failure
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
    Wyświetlanie 1-3 z 3

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