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    Wyświetlanie 1-4 z 4
    Tytuł:
    Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase.
    Autorzy:
    Giancotti G; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
    Nannetti G; Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, UK.
    Padalino G; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
    Landini M; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
    Santos-Ferreira N; KU Leuven-Rega Institute, Department of Microbiology, Immunology and Transplantation, 3000 Leuven, Belgium.
    Van Dycke J; KU Leuven-Rega Institute, Department of Microbiology, Immunology and Transplantation, 3000 Leuven, Belgium.
    Naccarato V; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
    Patel U; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
    Silvestri R; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
    Neyts J; KU Leuven-Rega Institute, Department of Microbiology, Immunology and Transplantation, 3000 Leuven, Belgium.
    Gozalbo-Rovira R; Department of Microbiology, School of Medicine, University of Valencia, 46010 Valencia, Spain.
    Rodríguez-Díaz J; Department of Microbiology, School of Medicine, University of Valencia, 46010 Valencia, Spain.
    Rocha-Pereira J; KU Leuven-Rega Institute, Department of Microbiology, Immunology and Transplantation, 3000 Leuven, Belgium.
    Brancale A; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.; Vysoká Škola Chemiko-Technologiká v Praze, 165 00 Prague, Czech Republic.
    Ferla S; Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, UK.
    Bassetto M; Department of Chemistry, College of Science and Engineering, Swansea University, Swansea SA2 8PP, UK.
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    Źródło:
    Viruses [Viruses] 2022 Dec 27; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiviral Agents*/pharmacology
    Antiviral Agents*/chemistry
    Enzyme Inhibitors*/chemistry
    Enzyme Inhibitors*/pharmacology
    Norovirus*/drug effects
    Norovirus*/enzymology
    Humans ; RNA-Dependent RNA Polymerase/antagonists & inhibitors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase.
    Autorzy:
    Giancotti G; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
    Rigo I; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
    Pasqualetto G; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
    Young MT; Cardiff School of Biosciences, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
    Neyts J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
    Rocha-Pereira J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
    Brancale A; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
    Ferla S; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK. .
    Bassetto M; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.; Department of Chemistry, Swansea University, Swansea, UK.
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    Źródło:
    Scientific reports [Sci Rep] 2019 Dec 05; Vol. 9 (1), pp. 18413. Date of Electronic Publication: 2019 Dec 05.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiviral Agents/*chemical synthesis
    Norovirus/*drug effects
    Oxazoles/*chemical synthesis
    Pyrimidines/*chemical synthesis
    RNA-Dependent RNA Polymerase/*antagonists & inhibitors
    Sulfonamides/*chemical synthesis
    Thiophenes/*chemical synthesis
    Viral Proteins/*antagonists & inhibitors
    Animals ; Antiviral Agents/pharmacology ; Binding Sites ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacology ; Gene Expression ; Humans ; Mice ; Molecular Docking Simulation ; Norovirus/enzymology ; Norovirus/genetics ; Norovirus/growth & development ; Oxazoles/pharmacology ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Pyrimidines/pharmacology ; RAW 264.7 Cells ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/metabolism ; Structure-Activity Relationship ; Substrate Specificity ; Sulfonamides/pharmacology ; Thiophenes/pharmacology ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; Virus Replication/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy.
    Autorzy:
    Bassetto M; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB Cardiff, UK. .
    Van Dycke J; KU Leuven-Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven 3000, Belgium. .
    Neyts J; KU Leuven-Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven 3000, Belgium. .
    Brancale A; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB Cardiff, UK. .
    Rocha-Pereira J; KU Leuven-Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven 3000, Belgium. .
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    Źródło:
    Viruses [Viruses] 2019 Feb 20; Vol. 11 (2). Date of Electronic Publication: 2019 Feb 20.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Antiviral Agents/*isolation & purification
    Diarrhea/*drug therapy
    Diarrhea/*virology
    Gastroenteritis/*drug therapy
    Gastroenteritis/*virology
    RNA-Dependent RNA Polymerase/*metabolism
    Adenovirus Infections, Human/drug therapy ; Animals ; Antiviral Agents/therapeutic use ; DNA Viruses/drug effects ; DNA Viruses/enzymology ; Humans ; Norovirus/drug effects ; Norovirus/enzymology ; Nucleic Acid Synthesis Inhibitors/isolation & purification ; Nucleic Acid Synthesis Inhibitors/therapeutic use ; RNA Viruses/drug effects ; RNA Viruses/enzymology ; Rotavirus/drug effects ; Rotavirus/enzymology ; Rotavirus Infections/drug therapy
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-4 z 4

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