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Wyświetlanie 1-36 z 36
Tytuł :
Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens".
Autorzy :
Liesenborghs L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium; The Outbreak Research Team, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. Electronic address: .
Spriet I; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jochmans D; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Belmans A; KU Leuven University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
Gyselinck I; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Teuwen LA; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ter Horst S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Dreesen E; Clinical Pharmacology and Pharmacotherapy Unit, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Geukens T; Department of Oncology, Laboratory for Translational Breast Cancer Research, KU Leuven, Belgium.
Engelen MM; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Landeloos E; Department of Oncology, Laboratory for molecular Cancer biology, VIB-KU Leuven, Belgium.
Geldhof V; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ceunen H; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Debaveye B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Vandenberk B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Van der Linden L; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jacobs S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Langendries L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Boudewijns R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Dan Do TN; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Chiu W; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Zhang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Weynand B; Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Belgium.
Vanassche T; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Devos T; Department of Hematology, UZ Leuven and Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Belgium.
Meyfroidt G; Department and Laboratory of Intensive Care Medicine, UZ and KU Leuven, Belgium.
Janssens W; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vos R; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vermeersch P; Department of Cardiovascular Sciences and Clinical Department of Laboratory Medicine, KU Leuven, Belgium.
Wauters J; Medical Intensive Care Unit, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Verbeke G; KU Leuven University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
De Munter P; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Kaptein SJF; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Van Wijngaerden E; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Verhamme P; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
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Źródło :
EBioMedicine [EBioMedicine] 2021 Jul; Vol. 69, pp. 103454. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji :
Published Erratum
Tytuł :
Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors.
Autorzy :
Van Dycke J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Cuvry A; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Knickmann J; University of Lübeck-Institute of Virology and Cell Biology, Lübeck, Germany.
Ny A; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Rakers S; Fraunhofer Research Institution for Marine Biotechnology and Cell Technology EMB, WG Aquatic Cell Technology and Aquaculture, Lübeck, Germany.
Taube S; University of Lübeck-Institute of Virology and Cell Biology, Lübeck, Germany.
de Witte P; KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Molecular Biodiscovery, Leuven, Belgium.
Neyts J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.; Global Virus Network (GVN), Centers of Excellence, Baltimore, MD, USA.
Rocha-Pereira J; KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium. .
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Źródło :
Nature protocols [Nat Protoc] 2021 Apr; Vol. 16 (4), pp. 1830-1849. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caliciviridae Infections/*virology
Norovirus/*physiology
Small Molecule Libraries/*pharmacology
Zebrafish/*virology
Animals ; Embryo, Nonmammalian/virology ; Humans ; Immunity, Innate ; Larva/drug effects ; Larva/immunology ; Norovirus/genetics ; Reproducibility of Results ; Virus Replication ; Zebrafish/embryology
Czasopismo naukowe
Tytuł :
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial.
Autorzy :
Liesenborghs L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium; The Outbreak Research Team, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. Electronic address: .
Spriet I; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jochmans D; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Belmans A; KU Leuven - University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
Gyselinck I; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Teuwen LA; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ter Horst S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Dreesen E; Clinical Pharmacology and Pharmacotherapy Unit, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Geukens T; Department of Oncology, Laboratory for Translational Breast Cancer Research, KU Leuven, Belgium.
Engelen MM; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Landeloos E; Department of Oncology, Laboratory for molecular Cancer biology, VIB-KU Leuven, Belgium.
Geldhof V; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Ceunen H; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Debaveye B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Vandenberk B; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Van der Linden L; Pharmacy Department University Hospitals Leuven and Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.
Jacobs S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Langendries L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Boudewijns R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Do TND; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Chiu W; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Zhang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Weynand B; Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Belgium.
Vanassche T; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
Devos T; Department of Hematology, UZ Leuven and Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology (Rega Institute), KU Leuven, Belgium.
Meyfroidt G; Department and Laboratory of Intensive Care Medicine, UZ and KU Leuven, Belgium.
Janssens W; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vos R; Department of Respiratory Diseases, UZ Leuven and CHROMETA, Research group BREATHE, KU Leuven, Leuven, Belgium.
Vermeersch P; Department of Cardiovascular Sciences and Clinical Department of Laboratory Medicine, KU Leuven, Belgium.
Wauters J; Medical Intensive Care Unit, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Verbeke G; KU Leuven - University of Leuven & Universiteit Hasselt, I-BioStat, Leuven, Belgium.
De Munter P; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Kaptein SJF; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Van Wijngaerden E; Department of General Internal Medicine, UZ Leuven and Department of Microbiology, Immunology and Transplantation, KU Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Verhamme P; Department of Cardiovascular Sciences, UZ and KU Leuven, Belgium.
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Źródło :
EBioMedicine [EBioMedicine] 2021 Apr; Vol. 66, pp. 103288. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Itraconazole/*pharmacology
Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; COVID-19/etiology ; COVID-19/transmission ; Chlorocebus aethiops ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Female ; Humans ; Itraconazole/administration & dosage ; Itraconazole/pharmacokinetics ; Itraconazole/therapeutic use ; Male ; Mesocricetus ; Middle Aged ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Proof of Concept Study ; SARS-CoV-2/drug effects ; Treatment Outcome ; Vero Cells
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Identification of active compounds.
Autorzy :
Van Dycke J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rymenants J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Neyts J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rocha-Pereira J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
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Źródło :
Antiviral chemistry & chemotherapy [Antivir Chem Chemother] 2021 Jan-Dec; Vol. 29, pp. 20402066211026852.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Autorzy :
Boudewijns R; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Thibaut HJ; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .; Translational Platform Virology and Chemotherapy, Leuven, Belgium. .
Kaptein SJF; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Li R; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Vergote V; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Seldeslachts L; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Van Weyenbergh J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
De Keyzer C; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Bervoets L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Sharma S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liesenborghs L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Ma J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jansen S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Van Looveren D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Vercruysse T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; Translational Platform Virology and Chemotherapy, Leuven, Belgium.
Wang X; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jochmans D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Martens E; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Roose K; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
De Vlieger D; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Schepens B; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Van Buyten T; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Jacobs S; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Liu Y; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Martí-Carreras J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Vanmechelen B; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Wawina-Bokalanga T; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Delang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Coelmont L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Chiu W; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Leyssen P; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Heylen E; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Schols D; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Wang L; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.
Close L; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Matthijnssens J; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Laboratory of Viral Metagenomics, Leuven, Belgium.
Van Ranst M; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; KU Leuven Department of Laboratory Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.; National Reference Center for Respiratory Pathogens and Enteroviruses, 3000, Leuven, Belgium.; Leuven University Vaccinology Center (LUVAC), 3000, Leuven, Belgium.
Compernolle V; Blood Service, Belgian Red Cross Flanders, Mechelen, Belgium.; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Schramm G; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Van Laere K; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.; Division of Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium.
Saelens X; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Callewaert N; VIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9052, Ghent, Belgium.
Opdenakker G; Immunity and Inflammation Research Group, Immunobiology Unit, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.
Maes P; Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium.; Zoonotic Infectious Diseases Unit, Leuven, Belgium.
Weynand B; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, 3000, Leuven, Belgium.; Division of Translational Cell and Tissue Research, Leuven, Belgium.
Cawthorne C; KU Leuven Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging and MoSAIC, 3000, Leuven, Belgium.
Vande Velde G; KU Leuven Department of Imaging and Pathology, Biomedical MRI and MoSAIC, 3000, Leuven, Belgium.
Wang Z; Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.
Neyts J; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
Dallmeier K; Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven Department of Microbiology, Immunology and Transplantation, 3000, Leuven, Belgium. .; Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium. .; GVN, Global Virus Network, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5838. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Signal Transduction*
Betacoronavirus/*physiology
Coronavirus Infections/*pathology
Coronavirus Infections/*virology
Pneumonia, Viral/*pathology
Pneumonia, Viral/*virology
STAT2 Transcription Factor/*metabolism
Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Cricetinae ; Immunity, Innate ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Lung/pathology ; Lung/virology ; Mice ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; STAT2 Transcription Factor/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales.
Autorzy :
Fernández-García Y; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany. Electronic address: .
Horst ST; KU Leuven, Rega Institute for Medical Research, Belgium.
Bassetto M; Department of Chemistry, College of Science, Swansea University, United Kingdom.
Brancale A; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, United Kingdom.
Neyts J; KU Leuven, Rega Institute for Medical Research, Belgium.
Rogolino D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area Delle Scienze, Parma, Italy.
Sechi M; Department of Chemistry and Pharmacy, Laboratory of Drug Design and Nanomedicine, University of Sassari, Italy.
Carcelli M; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area Delle Scienze, Parma, Italy.
Günther S; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Rocha-Pereira J; KU Leuven, Rega Institute for Medical Research, Belgium. Electronic address: .
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Źródło :
Antiviral research [Antiviral Res] 2020 Nov; Vol. 183, pp. 104947. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Bunyaviridae/*drug effects
Bunyaviridae/*enzymology
Endonucleases/*antagonists & inhibitors
Hydroxybutyrates/*pharmacology
Piperidines/*pharmacology
Viral Proteins/*antagonists & inhibitors
Catalytic Domain ; Crystallography, X-Ray ; Endonucleases/metabolism ; Molecular Docking Simulation ; RNA Caps/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin.
Autorzy :
Ter Horst S; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Fernandez-Garcia Y; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Bassetto M; Department of Chemistry, College of Science, Swansea University, Swansea, UK.
Günther S; Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Brancale A; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
Neyts J; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rocha-Pereira J; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
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Źródło :
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Nov 01; Vol. 75 (11), pp. 3189-3193.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Orthobunyavirus*
Ribavirin*/pharmacology
Antiviral Agents/pharmacology ; Dibenzothiepins ; Endonucleases ; Humans ; Morpholines ; Pyridones ; Triazines
Czasopismo naukowe
Tytuł :
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Autorzy :
Kaptein SJF; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .
Jacobs S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Langendries L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Seldeslachts L; Biomedical MRI and Molecular Small Animal Imaging Centre, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Ter Horst S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Liesenborghs L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Hens B; Drug Delivery & Disposition, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Vergote V; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Heylen E; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Barthelemy K; Unité des Virus Emergents, Aix Marseille University, Institut de Recherche pour le Développement (IRD) 190, Institut National de la Santé et de la Recherche Médicale (INSERM) 1207, 13005 Marseille, France.
Maas E; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
De Keyzer C; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Bervoets L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Rymenants J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Van Buyten T; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Zhang X; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Abdelnabi R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Pang J; UCL Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, United Kingdom.
Williams R; UCL Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, United Kingdom.
Thibaut HJ; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Dallmeier K; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Boudewijns R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Wouters J; Molecular Small Animal Imaging Centre, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Augustijns P; Drug Delivery & Disposition, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Verougstraete N; Department of Laboratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium.
Cawthorne C; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Breuer J; UCL Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, United Kingdom.
Solas C; Assistance Publique-Hôpitaux de Marseille, Aix-Marseille University, Unité des Virus Emergents, Institut de Recherche pour le Développement (IRD) 190, Institut National de la Santé et de la Recherche Médicale (INSERM) 1207, Laboratoire de Pharmacocinétique et Toxicologie, 13005 Marseille, France.
Weynand B; Translational Cell and Tissue Research, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Annaert P; Drug Delivery & Disposition, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Spriet I; Pharmacy Department, University Hospitals Leuven, 3000 Leuven, Belgium.; Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven-University of Leuven, 3000 Leuven, Belgium.
Vande Velde G; Biomedical MRI and Molecular Small Animal Imaging Centre, Department of Imaging and Pathology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Neyts J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .; Global Virus Network, Baltimore, MD 21201.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .
Delang L; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 27; Vol. 117 (43), pp. 26955-26965. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides/*therapeutic use
Antiviral Agents/*therapeutic use
Betacoronavirus/*drug effects
Hydroxychloroquine/*therapeutic use
Pyrazines/*therapeutic use
Amides/pharmacokinetics ; Animals ; COVID-19/drug therapy ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cricetinae ; Disease Models, Animal ; Disease Transmission, Infectious/prevention & control ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Hydroxychloroquine/pharmacokinetics ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Pyrazines/pharmacokinetics ; SARS-CoV-2 ; Treatment Outcome ; Vero Cells ; Viral Load/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Assessing the Efficacy of Small Molecule Inhibitors in aMouse Model of Persistent Norovirus Infection.
Autorzy :
Van Dycke J; Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven - University of Leuven, Leuven, Belgium.
Neyts J; Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven - University of Leuven, Leuven, Belgium.
Rocha-Pereira J; Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven - University of Leuven, Leuven, Belgium.
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Źródło :
Bio-protocol [Bio Protoc] 2018 May 05; Vol. 8 (9), pp. e2831. Date of Electronic Publication: 2018 May 05 (Print Publication: 2018).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants.
Autorzy :
Rocha-Pereira J; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Van Dycke J; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Neyts J; KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec 28; Vol. 60 (3), pp. 1907-11. Date of Electronic Publication: 2015 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caliciviridae Infections/*drug therapy
Cytidine/*analogs & derivatives
Gastroenteritis/*drug therapy
Norovirus/*drug effects
Virus Shedding/*drug effects
Amides/therapeutic use ; Animals ; Caliciviridae Infections/virology ; Cytidine/therapeutic use ; Disease Models, Animal ; Feces/virology ; Gastroenteritis/virology ; Mice ; Mice, Knockout ; Norovirus/growth & development ; Pyrazines/therapeutic use ; Receptors, Interferon/genetics ; Transplant Recipients
Czasopismo naukowe
Tytuł :
(E)-2-styrylchromones as potential anti-norovirus agents.
Autorzy :
Rocha-Pereira J; Serviço de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, Porto, Portugal.
Cunha R
Pinto DC
Silva AM
Nascimento MS
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Jun 15; Vol. 18 (12), pp. 4195-201. Date of Electronic Publication: 2010 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*chemistry
Chromones/*chemistry
Norovirus/*drug effects
Styrenes/*chemistry
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/therapeutic use ; Caliciviridae Infections/drug therapy ; Cell Line, Tumor ; Chromones/chemical synthesis ; Chromones/therapeutic use ; Disease Models, Animal ; Gastroenteritis/drug therapy ; Humans ; Mice ; Stereoisomerism ; Styrenes/chemical synthesis ; Styrenes/therapeutic use
Czasopismo naukowe
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