Autor: "Rocha-Pereira J" - OpacWWW

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Tytuł:: A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo.
Autorzy:: Van Dycke J; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.
Dai W; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Stylianidou Z; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.
Li J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Qixia District, Nanjing 210023, China.
Cuvry A; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.
Roux E; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.
Li B; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Rymenants J; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.
Bervoets L; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.
de Witte P; Laboratory for Molecular Biodiscovery, KU Leuven-Department of Pharmaceutical and Pharmacological Sciences, 3000 Leuven, Belgium.
Liu H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Neyts J; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.
Rocha-Pereira J; Laboratory of Virology and Chemotherapy, KU Leuven-Department of Microbiology, Immunology and Transplantation, Rega Institute, 3000 Leuven, Belgium.; Pokaż więcej
Źródło:: Viruses [Viruses] 2021 Sep 16; Vol. 13 (9). Date of Electronic Publication: 2021 Sep 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Caliciviridae Infections/*drug therapy
Norovirus/*drug effects
Viral Protease Inhibitors/*pharmacology
Animals ; Caliciviridae Infections/virology ; Cell Line ; Cytopathogenic Effect, Viral/drug effects ; Drug Resistance, Viral ; Isoxazoles/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Mutation ; Norovirus/enzymology ; Norovirus/genetics ; Norovirus/physiology ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Phenylalanine/analogs & derivatives ; Phenylalanine/pharmacology ; Pyrrolidinones/pharmacology ; RNA, Viral/metabolism ; Replicon ; Small Molecule Libraries ; Valine/analogs & derivatives ; Valine/pharmacology ; Viral Protease Inhibitors/chemistry ; Viral Protease Inhibitors/pharmacokinetics ; Virus Replication/drug effects ; Zebrafish/virology

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