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Tytuł:
Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals.
Autorzy:
Leung JM; Verily Life Sciences, South San Francisco, CA, United States.
Wu MJ; Verily Life Sciences, South San Francisco, CA, United States.
Kheradpour P; Verily Life Sciences, South San Francisco, CA, United States.
Chen C; Verily Life Sciences, South San Francisco, CA, United States.
Drake KA; Verily Life Sciences, South San Francisco, CA, United States.
Tong G; Verily Life Sciences, South San Francisco, CA, United States.
Ridaura VK; Verily Life Sciences, South San Francisco, CA, United States.
Zisser HC; Verily Life Sciences, South San Francisco, CA, United States.
Conrad WA; Providence Little Company of Mary Medical Center Torrance, Torrance, CA, United States.
Hudson N; Oncimmune Limited, Nottingham, United Kingdom.
Allen J; Oncimmune Limited, Nottingham, United Kingdom.
Welberry C; Oncimmune Limited, Nottingham, United Kingdom.
Parsy-Kowalska C; Oncimmune Limited, Nottingham, United Kingdom.
Macdonald I; Oncimmune Limited, Nottingham, United Kingdom.
Tapson VF; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Moy JN; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.
deFilippi CR; Inova Schar Heart and Vascular, Falls Church, VA, United States.
Rosas IO; Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
Basit M; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Krishnan JA; Breathe Chicago Center, University of Illinois Chicago, Chicago, IL, United States.
Parthasarathy S; Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, University of Arizona, Tucson, AZ, United States.
Prabhakar BS; Department of Microbiology and Immunology, University of Illinois - College of Medicine, Chicago, IL, United States.
Salvatore M; Department of Medicine and Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Kim CC; Verily Life Sciences, South San Francisco, CA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2024 Jan 22; Vol. 15, pp. 1348041. Date of Electronic Publication: 2024 Jan 22 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
Humans ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Immunologic Factors ; Autoantibodies ; Disease Progression
Czasopismo naukowe
Tytuł:
Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA.
Autorzy:
Geary B; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Sun B; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States.
Tilvawala RR; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, United States.
Barasa L; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, United States.
Tsoyi K; Pulmonary, Critical Care and Sleep Medicine Section, Baylor College of Medicine, Houston, TX, United States.
Rosas IO; Pulmonary, Critical Care and Sleep Medicine Section, Baylor College of Medicine, Houston, TX, United States.
Thompson PR; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, United States.
Ho IC; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2023 Nov 29; Vol. 14, pp. 1290585. Date of Electronic Publication: 2023 Nov 29 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Arthritis, Rheumatoid*
Idiopathic Pulmonary Fibrosis*
Lung Diseases, Interstitial*
Humans ; Mice ; Animals ; Protein-Arginine Deiminases/genetics ; Proteins/metabolism ; Immunoglobulin A ; Immunoglobulin M
Czasopismo naukowe
Tytuł:
Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers.
Autorzy:
Choi B; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA. .; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA. .
San José Estépar R; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Godbole S; Anschutz Medical Campus, Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA.
Curtis JL; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Wang JM; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
San José Estépar R; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Rosas IO; Baylor College of Medicine, Houston, TX, USA.
Mayers JR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.
Hobbs BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Hersh CP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ash SY; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Department of Critical Care, South Shore Hospital, South Weymouth, MA, USA.
Han MK; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Bowler RP; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Stringer KA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Washko GR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Labaki WW; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
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Źródło:
Respiratory research [Respir Res] 2023 Nov 04; Vol. 24 (1), pp. 265. Date of Electronic Publication: 2023 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Niacin*
Pulmonary Emphysema*/diagnostic imaging
Pulmonary Emphysema*/epidemiology
Emphysema*
Pulmonary Disease, Chronic Obstructive*/diagnostic imaging
Pulmonary Disease, Chronic Obstructive*/epidemiology
Humans ; Smokers ; Lung ; Niacinamide
Czasopismo naukowe
Tytuł:
Distinct temporal trajectories and risk factors for Post-acute sequelae of SARS-CoV-2 infection.
Autorzy:
Chen C; Verily Life Sciences, South San Francisco, CA, United States.
Parthasarathy S; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, AZ, United States.
Leung JM; Verily Life Sciences, South San Francisco, CA, United States.
Wu MJ; Verily Life Sciences, South San Francisco, CA, United States.
Drake KA; Verily Life Sciences, South San Francisco, CA, United States.
Ridaura VK; Verily Life Sciences, South San Francisco, CA, United States.
Zisser HC; Verily Life Sciences, South San Francisco, CA, United States.
Conrad WA; Providence Little Company of Mary Medical Center Torrance, Torrance, CA, United States.
Tapson VF; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Moy JN; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.
deFilippi CR; Inova Heart and Vascular Institute, Falls Church, VA, United States.
Rosas IO; Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
Prabhakar BS; Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, United States.
Basit M; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Salvatore M; Department of Medicine, Weill Cornell Medicine, New York, NY, United States.; Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Krishnan JA; Breathe Chicago Center, University of Illinois Chicago, Chicago, IL, United States.
Kim CC; Verily Life Sciences, South San Francisco, CA, United States.
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Źródło:
Frontiers in medicine [Front Med (Lausanne)] 2023 Oct 16; Vol. 10, pp. 1227883. Date of Electronic Publication: 2023 Oct 16 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
Autorzy:
Hackney JA; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Shivram H; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Vander Heiden J; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Overall C; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Orozco L; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Gao X; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Kim E; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
West N; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Qamra A; Hoffman-La Roche Limited, 7070 Mississauga Road, Mississauga, ON L5N 5M8, Canada.
Chang D; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Chakrabarti A; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Choy DF; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Combes AJ; University of California San Francisco, San Francisco, CA, USA.
Courau T; University of California San Francisco, San Francisco, CA, USA.
Fragiadakis GK; University of California San Francisco, San Francisco, CA, USA.
Rao AA; University of California San Francisco, San Francisco, CA, USA.
Ray A; University of California San Francisco, San Francisco, CA, USA.
Tsui J; University of California San Francisco, San Francisco, CA, USA.
Hu K; University of California San Francisco, San Francisco, CA, USA.
Kuhn NF; University of California San Francisco, San Francisco, CA, USA.
Krummel MF; University of California San Francisco, San Francisco, CA, USA.
Erle DJ; University of California San Francisco, San Francisco, CA, USA.
Kangelaris K; University of California San Francisco, San Francisco, CA, USA.
Sarma A; University of California San Francisco, San Francisco, CA, USA.
Lyon Z; University of California San Francisco, San Francisco, CA, USA.
Calfee CS; University of California San Francisco, San Francisco, CA, USA.
Woodruff PG; University of California San Francisco, San Francisco, CA, USA.
Ghale R; University of California San Francisco, San Francisco, CA, USA.
Mick E; University of California San Francisco, San Francisco, CA, USA.
Byrne A; University of California San Francisco, San Francisco, CA, USA.
Zha BS; University of California San Francisco, San Francisco, CA, USA.
Langelier C; University of California San Francisco, San Francisco, CA, USA.
Hendrickson CM; University of California San Francisco, San Francisco, CA, USA.
van der Wijst MGP; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Hartoularos GC; University of California San Francisco, San Francisco, CA, USA.
Grant T; University of California San Francisco, San Francisco, CA, USA.
Bueno R; University of California San Francisco, San Francisco, CA, USA.
Lee DS; University of California San Francisco, San Francisco, CA, USA.
Greenland JR; University of California San Francisco, San Francisco, CA, USA.
Sun Y; University of California San Francisco, San Francisco, CA, USA.
Perez R; University of California San Francisco, San Francisco, CA, USA.
Ogorodnikov A; University of California San Francisco, San Francisco, CA, USA.
Ward A; University of California San Francisco, San Francisco, CA, USA.
Ye CJ; University of California San Francisco, San Francisco, CA, USA.
Ramalingam T; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
McBride JM; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Cai F; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Teterina A; Hoffman-La Roche Limited, 7070 Mississauga Road, Mississauga, ON L5N 5M8, Canada.
Bao M; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Tsai L; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Rosas IO; Baylor College of Medicine, 7200 Cambridge St, Houston, TX 77030, USA.
Regev A; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Kapadia SB; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Bauer RN; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Rosenberger CM; Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
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Corporate Authors:
UCSF COMET Consortium
Źródło:
IScience [iScience] 2023 Sep 01; Vol. 26 (10), pp. 107813. Date of Electronic Publication: 2023 Sep 01 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Transcriptomic and proteomic assessment of tocilizumab response in a randomized controlled trial of patients hospitalized with COVID-19.
Autorzy:
Shivram H; Genentech, South San Francisco, CA 94080, USA.
Hackney JA; Genentech, South San Francisco, CA 94080, USA.
Rosenberger CM; Genentech, South San Francisco, CA 94080, USA.
Teterina A; Hoffmann-La Roche Ltd, Mississauga, ON L5N 5M8, Canada.
Qamra A; Hoffmann-La Roche Ltd, Mississauga, ON L5N 5M8, Canada.
Onabajo O; Genentech, South San Francisco, CA 94080, USA.
McBride J; Genentech, South San Francisco, CA 94080, USA.
Cai F; Genentech, South San Francisco, CA 94080, USA.
Bao M; Genentech, South San Francisco, CA 94080, USA.
Tsai L; Genentech, South San Francisco, CA 94080, USA.
Regev A; Genentech, South San Francisco, CA 94080, USA.
Rosas IO; Baylor College of Medicine, Houston, TX 77030, USA.
Bauer RN; Genentech, South San Francisco, CA 94080, USA.
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Źródło:
IScience [iScience] 2023 Aug 11; Vol. 26 (9), pp. 107597. Date of Electronic Publication: 2023 Aug 11 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Prognostic value of severe acute respiratory syndrome coronavirus-2 viral load and antibodies in patients hospitalized with COVID-19.
Autorzy:
Bauer RN; Genentech, South San Francisco, California, USA.
Teterina A; F. Hoffmann-La Roche Ltd, Mississauga, Ontario, Canada.
Shivram H; Genentech, South San Francisco, California, USA.
McBride J; Genentech, South San Francisco, California, USA.
Rosenberger CM; Genentech, South San Francisco, California, USA.
Cai F; Genentech, South San Francisco, California, USA.
Bao M; Genentech, South San Francisco, California, USA.
Tsai L; Genentech, South San Francisco, California, USA.
Gordon O; Roche Products Ltd, Welwyn Garden City, UK.
Lee IT; Genentech, South San Francisco, California, USA.
Wallin JJ; Gilead Sciences, Foster City, California, USA.
Porter D; Gilead Sciences, Foster City, California, USA.
Juneja K; Gilead Sciences, Foster City, California, USA.
Camus G; Gilead Sciences, Foster City, California, USA.
Rosas IO; Baylor College of Medicine, Houston, Texas, USA.
Wildum S; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Jun; Vol. 16 (6), pp. 1049-1062. Date of Electronic Publication: 2023 Mar 29.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Humans ; SARS-CoV-2 ; Prognosis ; Viral Load ; Lung ; Antibodies, Viral
Czasopismo naukowe
Tytuł:
Lymphangioleiomyomatosis: circulating levels of FGF23 and pulmonary diffusion.
Autorzy:
Esposito AJ; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago (IL) USA.
Imani J; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.
Shrestha S; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.
Bagwe S; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.
Lamattina AM; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.
Vivero M; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.
Goldberg HJ; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.
Rosas IO; Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston (TX) USA.
Henske EP; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.
El-Chemaly SY; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (MA) USA.; Sanofi, Cambridge (MA) USA.
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Źródło:
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia [J Bras Pneumol] 2023 May 01; Vol. 49 (2), pp. e20220356. Date of Electronic Publication: 2023 May 01 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Lymphangioleiomyomatosis*/complications
Lymphangioleiomyomatosis*/diagnosis
Lymphangioleiomyomatosis*/pathology
Lung Diseases*/complications
Lung Neoplasms*/complications
Humans ; Retrospective Studies ; Biomarkers ; Lung
Czasopismo naukowe
Tytuł:
Correction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3.
Autorzy:
Lee CM; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
He CH; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Park JW; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Lee JH; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Kamle S; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Ma B; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Akosman B; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Cotez R; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Chen E; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Zhou Y; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Herzog EL; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Ryu C; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Peng X; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Rosas IO; Brigham and Women's Hospital, Boston, MA, USA.
Poli S; Brigham and Women's Hospital, Boston, MA, USA.
Bostwick CF; Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Choi AM; Weill Cornell Medicine Pulmonary and Critical Care Medicine, New York, NY, USA.
Elias JA; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.; Division of Medicine and Biological Sciences, Brown University, Warren Alpert School of Medicine, Providence, RI, USA.
Lee CG; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA chun_.
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Źródło:
Life science alliance [Life Sci Alliance] 2023 Apr 10; Vol. 6 (5). Date of Electronic Publication: 2023 Apr 10 (Print Publication: 2023).
Typ publikacji:
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł:
Expert consensus on the management of systemic sclerosis-associated interstitial lung disease.
Autorzy:
Rahaghi FF; Respiratory Center, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA. .
Hsu VM; Rutgers-RWJ Medical School, New Brunswick, NJ, USA.
Kaner RJ; Weill Cornell Medicine, New York, NY, USA.
Mayes MD; University of Texas, Houston, TX, USA.
Rosas IO; Brigham and Women's Hospital, Boston, MA, USA.
Saggar R; University of California Los Angeles, Los Angeles, CA, USA.
Steen VD; Georgetown University, Washington, D.C, USA.
Strek ME; University of Chicago, Chicago, IL, USA.
Bernstein EJ; Columbia University Irving Medical Center, New York, NY, USA.
Bhatt N; Ohio State University, Columbus, OH, USA.
Castelino FV; Harvard Medical School, Boston, MA, USA.
Chung L; Stanford University School of Medicine and Palo Alto VA Health Care System, Stanford, CA, USA.
Domsic RT; University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Flaherty KR; University of Michigan Scleroderma Clinic, Ann Arbor, MI, 48105, USA.
Gupta N; University of Cincinnati, Cincinnati, OH, USA.
Kahaleh B; University of Toledo Medical Center, Toledo, OH, USA.
Martinez FJ; Weill Cornell Medicine, New York, NY, USA.
Morrow LE; Creighton University, Omaha, NE, USA.
Moua T; Mayo Clinic, Rochester, MN, USA.
Patel N; Columbia University Irving Medical Center, New York, NY, USA.; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA.
Shlobin OA; Inova Fairfax Hospital, Falls Church, VA, USA.
Southern BD; Cleveland Clinic, Cleveland, OH, USA.
Volkmann ER; University of California Los Angeles, Los Angeles, CA, USA.
Khanna D; University of Michigan Scleroderma Clinic, Ann Arbor, MI, 48105, USA. .
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Źródło:
Respiratory research [Respir Res] 2023 Jan 09; Vol. 24 (1), pp. 6. Date of Electronic Publication: 2023 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Diseases, Interstitial*/diagnosis
Lung Diseases, Interstitial*/drug therapy
Lung Diseases, Interstitial*/etiology
Scleroderma, Systemic*/complications
Scleroderma, Systemic*/diagnosis
Scleroderma, Systemic*/therapy
Humans ; Consensus ; Immunosuppressive Agents/therapeutic use ; Lung ; Mycophenolic Acid/therapeutic use
Czasopismo naukowe
Tytuł:
TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF.
Autorzy:
Wang L; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Zhao W; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Xia C; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Li Z; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Zhao W; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Xu K; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Wang N; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Lian H; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Rosas IO; Division of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Yu G; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 11; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
Idiopathic Pulmonary Fibrosis*/metabolism
Humans ; Fibrosis ; Lung/pathology ; Extracellular Matrix/metabolism ; Fibroblasts/metabolism ; Repressor Proteins/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Cell Cycle Proteins/metabolism ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism
Czasopismo naukowe
Tytuł:
Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.
Autorzy:
Jyothula SSK; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA; Center for Advanced Cardiopulmonary Therapies and Transplantation at UTHealth/McGovern Medical School, Houston, TX, USA.
Peters A; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Liang Y; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Bi W; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Shivshankar P; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Yau S; Houston Methodist DeBakey Transplant Center, Houston Methodist Hospital, Houston, TX, USA.
Garcha PS; Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Yuan X; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Akkanti B; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA; Center for Advanced Cardiopulmonary Therapies and Transplantation at UTHealth/McGovern Medical School, Houston, TX, USA.
Collum S; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Wareing N; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Thandavarayan RA; Houston Methodist DeBakey Transplant Center, Houston Methodist Hospital, Houston, TX, USA.
Poli de Frias F; Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Rosas IO; Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Zhao B; Department of Pathology and Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Buja LM; Department of Pathology and Laboratory Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Eltzschig HK; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Huang HJ; Houston Methodist DeBakey Transplant Center, Houston Methodist Hospital, Houston, TX, USA.
Karmouty-Quintana H; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA; Center for Advanced Cardiopulmonary Therapies and Transplantation at UTHealth/McGovern Medical School, Houston, TX, USA; UTHealth Pulmonary Center of Excellence, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: .
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Źródło:
EBioMedicine [EBioMedicine] 2022 Dec; Vol. 86, pp. 104351. Date of Electronic Publication: 2022 Nov 11.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/complications
COVID-19*/pathology
Idiopathic Pulmonary Fibrosis*/genetics
Idiopathic Pulmonary Fibrosis*/metabolism
Lung Injury*/metabolism
Humans ; Collagen/metabolism ; Extracellular Matrix Proteins/metabolism ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis ; Lung/pathology
Czasopismo naukowe
Tytuł:
Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity.
Autorzy:
Mehta P; Centre for Inflammation and Tissue Repair, Division of Medicine, UCL Respiratory, University College London (UCL), Rayne 9 Building, London, WC1E 6JF, UK. .; Department of Rheumatology, University College London Hospital (UCLH), London, UK. .
Rosas IO; Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Singer M; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London (UCL), London, UK.
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Źródło:
Intensive care medicine [Intensive Care Med] 2022 Dec; Vol. 48 (12), pp. 1803-1806. Date of Electronic Publication: 2022 Sep 08.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/complications
Lung Diseases, Interstitial*/complications
Humans ; SARS-CoV-2 ; Lung ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility.
Autorzy:
Imani J; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Bodine SPM; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Lamattina AM; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Ma DD; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Shrestha S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Maynard DM; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Bishop K; Zebrafish Core Facility, NHGRI, NIH, Bethesda, MD, 20892, USA.
Nwokeji A; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Malicdan MCV; NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, NIH, Bethesda, MD, 20892, USA.
Testa LC; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Sood R; Zebrafish Core Facility, NHGRI, NIH, Bethesda, MD, 20892, USA.
Stump B; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Rosas IO; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Perrella MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Handin R; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Young LR; Division of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Gochuico BR; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
El-Chemaly S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. .
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Źródło:
Respiratory research [Respir Res] 2022 Jun 23; Vol. 23 (1), pp. 167. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article
MeSH Terms:
Hermanski-Pudlak Syndrome*/genetics
Albinism ; Animals ; Cell Movement ; Fibroblasts/metabolism ; Hemorrhagic Disorders ; Humans ; Losartan/metabolism ; Lung/metabolism ; Nonmuscle Myosin Type IIB/metabolism ; Receptors, Angiotensin ; Zebrafish
SCR Disease Name:
Albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells
Czasopismo naukowe
Tytuł:
Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection.
Autorzy:
Yang CX; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, BC V6T 1Z4, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Tomchaney M; Asthma and Airway Disease Research Center, College of Medicine, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Landecho MF; Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
Zamacona BR; Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
Marin Oto M; Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
Zulueta J; Mount-Sinai Hospital, New York, NY 10029, USA.
Malo J; Department of Surgery, University of Arizona, Tucson, AZ 85719, USA.
Knoper S; Department of Surgery, University of Arizona, Tucson, AZ 85719, USA.
Contoli M; Pulmonary Division, University of Ferrara, 44121 Ferrara, Italy.
Papi A; Pulmonary Division, University of Ferrara, 44121 Ferrara, Italy.
Vasilescu DM; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, BC V6T 1Z4, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Sauler M; Department of Medicine, Yale University, New Haven, CT 06520, USA.
Straub C; Nanostring Technologies, Seattle, WA 98109, USA.
Tan C; Nanostring Technologies, Seattle, WA 98109, USA.
Martinez FD; Asthma and Airway Disease Research Center, College of Medicine, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Bhattacharya D; Department of Immunobiology, University of Arizona, Tucson, AZ 85719, USA.
Rosas IO; Department of Medicine and Center for Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Kheradmand F; Department of Medicine and Center for Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Hackett TL; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, BC V6T 1Z4, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Polverino F; Department of Medicine and Center for Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
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Źródło:
Cells [Cells] 2022 Jun 07; Vol. 11 (12). Date of Electronic Publication: 2022 Jun 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19*
Pulmonary Disease, Chronic Obstructive*/metabolism
Humans ; Lung/metabolism ; Proteomics ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 infection.
Autorzy:
Alba GA; Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.
Samokhin AO; Division of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Wang RS; Division of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Wertheim BM; Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Haley KJ; Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Padera RF; Department of Pathology Brigham and Women's Hospital Boston Massachusetts USA.
Vargas SO; Department of Pathology Boston Children's Hospital Boston Massachusetts USA.
Rosas IO; Division of Pulmonary and Critical Care Medicine Baylor College of Medicine Houston Texas USA.
Hariri LP; Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.; Department of Pathology Massachusetts General Hospital Boston Massachusetts USA.
Shih A; Department of Pathology Massachusetts General Hospital Boston Massachusetts USA.
Thompson BT; Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.
Mitchell RN; Department of Pathology Brigham and Women's Hospital Boston Massachusetts USA.
Maron BA; Division of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
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Źródło:
Pulmonary circulation [Pulm Circ] 2022 May 11; Vol. 12 (2), pp. e12071. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA).
Autorzy:
Rosas IO; Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX 77030, USA.
Bräu N; James J. Peters Veterans Affairs Medical Center, Bronx, and Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Waters M; eStudy Site, Chula Vista, CA, USA.
Go RC; Hackensack Meridian School of Medicine and Hackensack University Medical Center, Hackensack, NJ, USA.
Malhotra A; University of California San Diego, La Jolla, CA, USA.
Hunter BD; Intermountain Healthcare, Salt Lake City, UT, USA.
Bhagani S; Royal Free Hospital, London, UK.
Skiest D; University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
Savic S; Leeds Teaching Hospitals NHS Trust and National Institute for Health Research-Leeds, Biomedical Research Centre, Leeds, UK.
Douglas IS; Denver Health Medical Center, Denver, and University of Colorado, Anschutz School of Medicine, Aurora, CO, USA.
Garcia-Diaz J; Ochsner Clinic Foundation, New Orleans, LA, USA.
Aziz MS; Rush University Medical Center, Chicago, IL, USA.
Cooper N; Imperial College London, London, UK.
Youngstein T; Imperial College London, London, UK.
Sorbo LD; University Health Network, Toronto, ON, Canada.
Zerda DJ; University of Miami Miller School of Medicine, Miami, FL, USA.
Ustianowski A; North Manchester General Hospital, Manchester, UK.
Gracian AC; Hospital Universitario HM Sanchinarro, Centro Integral, Oncológico Clara Campal, and Departamento de Ciencias Médicas Clínicas, Facultad de Medicina, Universidad CEU San Pablo, Madrid, Spain.
Blyth KG; Institute of Cancer Sciences, University of Glasgow/Department of Respiratory Medicine, Queen Elizabeth University Hospital, Glasgow, UK.
Carratalà J; Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, and CIBERINFEC, Barcelona, Spain.
François B; Intensive Care Unit and Inserm CIC1435 and UMR1092, CHU Limoges, Limoges, France.
Benfield T; Center of Research and Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.
Haslem D; Intermountain Medical Group, St George, UT, USA.
Bonfanti P; University of Milano-Bicocca and Azienda Ospedaliera San Gerardo di Monza, Monza, Italy.
van der Leest CH; Amphia Ziekenhuis, Breda, the Netherlands.
Rohatgi N; Division of Hospital Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Wiese L; Department of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark.
Luyt CE; Hôpital de la Pitié Salpêtrière, Paris, France.
Bauer RN; Genentech, South San Francisco, CA, USA.
Cai F; Genentech, South San Francisco, CA, USA.
Lee IT; Genentech, South San Francisco, CA, USA.
Matharu B; Roche Products Ltd, Welwyn Garden City, UK.
Metcalf L; Roche Products Ltd, Welwyn Garden City, UK.
Wildum S; F Hoffmann-La Roche Ltd, Basel, Switzerland.
Graham E; Roche Products Ltd, Welwyn Garden City, UK.
Tsai L; Genentech, South San Francisco, CA, USA.
Bao M; Genentech, South San Francisco, CA, USA.
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Źródło:
EClinicalMedicine [EClinicalMedicine] 2022 May; Vol. 47, pp. 101409. Date of Electronic Publication: 2022 Apr 21.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Autorzy:
Tsoyi K; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA. .
Esposito AJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sun B; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bowen RG; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Xiong K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Poli F; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Cardenas R; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Chu SG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Liang X; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Ryter SW; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Beeton C; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Doyle TJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Robertson MJ; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Celada LJ; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Romero F; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
El-Chemaly SY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Perrella MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ho IC; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rosas IO; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 18; Vol. 12 (1), pp. 2847. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Arthritis, Rheumatoid/*genetics
Lung Injury/*genetics
Protein-Arginine Deiminase Type 2/*genetics
Pulmonary Fibrosis/*genetics
Syndecan-2/*genetics
Animals ; Anti-Citrullinated Protein Antibodies/genetics ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Bleomycin/toxicity ; Citrullination/genetics ; Fibroblasts/metabolism ; Gene Expression Regulation/genetics ; Humans ; Lung/metabolism ; Lung/pathology ; Lung Injury/chemically induced ; Lung Injury/complications ; Lung Injury/pathology ; Mice ; Mice, Transgenic ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/pathology ; Receptor-Like Protein Tyrosine Phosphatases, Class 3 ; Sp1 Transcription Factor/genetics
Czasopismo naukowe
Tytuł:
Characterization of the COPD alveolar niche using single-cell RNA sequencing.
Autorzy:
Sauler M; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA. .
McDonough JE; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA. .
Adams TS; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Kothapalli N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Barnthaler T; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Werder RB; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.
Schupp JC; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Respiratory Medicine, Hannover Medical School and Biomedical Research in End-stage and Obstructive Lung Disease Hannover, German Lung Research Center (DZL), Hannover, Germany.
Nouws J; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Robertson MJ; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Coarfa C; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Yang T; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chioccioli M; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Omote N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Cosme C Jr; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Poli S; Department of Internal Medicine, Mount Sinai Medical Center, Miami, FL, USA.
Ayaub EA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Chu SG; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jensen KH; Intomics A/S, Lyngby, Denmark.
Gomez JL; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Britto CJ; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Raredon MSB; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, USA.
Niklason LE; Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
Wilson AA; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Timshel PN; Intomics A/S, Lyngby, Denmark.
Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Rosas IO; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
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Źródło:
Nature communications [Nat Commun] 2022 Jan 25; Vol. 13 (1), pp. 494. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Alveolar Epithelial Cells/*metabolism
Lung/*metabolism
Pulmonary Disease, Chronic Obstructive/*genetics
RNA-Seq/*methods
Single-Cell Analysis/*methods
A549 Cells ; Alveolar Epithelial Cells/classification ; Animals ; Cells, Cultured ; Cluster Analysis ; Epithelial Cells/metabolism ; Female ; Gene Expression Profiling/methods ; Gene Regulatory Networks ; Humans ; Lung/cytology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Pulmonary Disease, Chronic Obstructive/pathology ; Signal Transduction/genetics ; Mice
Czasopismo naukowe

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