Autor: "Roses A." - OpacWWW

Skocz do pozycji: 1.

Tytuł:: A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.
Autorzy:: Davies G; Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Harris SE; 1] Medical Genetics Section, The University of Edinburgh Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Reynolds CA; Department of Psychology, University of California, Riverside, Riverside, CA, USA.
Payton A; Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
Knight HM; CGAT, MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Liewald DC; 1] Department of Psychology, The University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Lopez LM; 1] Department of Psychology, The University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Luciano M; 1] Department of Psychology, The University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Gow AJ; 1] Department of Psychology, The University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Corley J; Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Henderson R; Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Murray C; Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Pattie A; Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Fox HC; Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Redmond P; Department of Psychology, The University of Edinburgh, Edinburgh, UK.
Lutz MW; 1] Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC, USA [2] Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
Chiba-Falek O; 1] Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC, USA [2] Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
Linnertz C; Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Saith S; Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Haggarty P; Nutrition and Epigenetics Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
McNeill G; Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Ke X; Institute of Child Health, University College London, London, UK.
Ollier W; Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
Horan M; School of Community-Based Medicine, Neurodegeneration Research Group, University of Manchester, Clinical sciences Building, Salford Royal NHS Foundation Trust, Salford, UK.
Roses AD; 1] Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC, USA [2] Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA [3] Zinfandel Pharmaceuticals, Chapel Hill, NC, USA.
Ponting CP; CGAT, MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Porteous DJ; 1] Medical Genetics Section, The University of Edinburgh Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.
Tenesa A; 1] MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK [2] The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK.
Pickles A; Clinical Trials Unit, Institute of Psychiatry, London, UK.
Starr JM; 1] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK [2] Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, UK.
Whalley LJ; Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Pedersen NL; 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [2] Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Pendleton N; School of Community-Based Medicine, Neurodegeneration Research Group, University of Manchester, Clinical sciences Building, Salford Royal NHS Foundation Trust, Salford, UK.
Visscher PM; 1] Queensland Institute of Medical Research, Brisbane, Queensland, Australia [2] University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia [3] The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Deary IJ; 1] Department of Psychology, The University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.; Pokaż więcej
Źródło:: Molecular psychiatry [Mol Psychiatry] 2014 Jan; Vol. 19 (1), pp. 76-87. Date of Electronic Publication: 2012 Dec 04.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Aging/*genetics
Apolipoproteins E/*genetics
Cognition/*physiology
Polymorphism, Single Nucleotide/*genetics
Cohort Studies ; England ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Linkage Disequilibrium ; Male ; Membrane Transport Proteins/genetics ; Mitochondrial Precursor Protein Import Complex Proteins ; Scotland

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Skocz do pozycji: 2.

Tytuł:: A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.
Autorzy:: Roses AD; Department of Medicine, Duke University, Durham, NC 27708-0120, USA. allen.roses@duke.edu
Lutz MW
Amrine-Madsen H
Saunders AM
Crenshaw DG
Sundseth SS
Huentelman MJ
Welsh-Bohmer KA
Reiman EM; Pokaż więcej
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2010 Oct; Vol. 10 (5), pp. 375-84. Date of Electronic Publication: 2009 Dec 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Alzheimer Disease/*epidemiology
Alzheimer Disease/*genetics
Membrane Transport Proteins/*genetics
Age of Onset ; Aged ; Aged, 80 and over ; Apolipoprotein E3/genetics ; Apolipoprotein E4/genetics ; Case-Control Studies ; Cohort Studies ; DNA/genetics ; Female ; Genetic Testing ; Humans ; Linkage Disequilibrium ; Male ; Mitochondrial Precursor Protein Import Complex Proteins ; Phylogeny ; Predictive Value of Tests ; Risk

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Skocz do pozycji: 3.

Tytuł:: Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts.
Autorzy:: Muglia P; Genetics Division, Drug Discovery, GlaxoSmithKline R&D, Verona, Italy. />Tozzi F
Galwey NW
Francks C
Upmanyu R
Kong XQ
Antoniades A
Domenici E
Perry J
Rothen S
Vandeleur CL
Mooser V
Waeber G
Vollenweider P
Preisig M
Lucae S
Müller-Myhsok B
Holsboer F
Middleton LT
Roses AD; Pokaż więcej
Źródło:: Molecular psychiatry [Mol Psychiatry] 2010 Jun; Vol. 15 (6), pp. 589-601. Date of Electronic Publication: 2008 Dec 23.
Typ publikacji:: Journal Article
MeSH Terms:: Genome-Wide Association Study*
Depressive Disorder, Major/*genetics
White People/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Europe ; Female ; Genotype ; Humans ; Male ; Meta-Analysis as Topic ; Middle Aged ; Polymorphism, Single Nucleotide ; Recurrence

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Skocz do pozycji: 4.

Tytuł:: A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.
Autorzy:: Pillai SG; Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA. />Ge D
Zhu G
Kong X
Shianna KV
Need AC
Feng S
Hersh CP
Bakke P
Gulsvik A
Ruppert A
Lødrup Carlsen KC
Roses A
Anderson W
Rennard SI
Lomas DA
Silverman EK
Goldstein DB; Pokaż więcej
Corporate Authors:: ICGN Investigators
Źródło:: PLoS genetics [PLoS Genet] 2009 Mar; Vol. 5 (3), pp. e1000421. Date of Electronic Publication: 2009 Mar 20.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Genome-Wide Association Study*
Carrier Proteins/*genetics
Membrane Glycoproteins/*genetics
Pulmonary Disease, Chronic Obstructive/*genetics
Case-Control Studies ; Chromosomes, Human, Pair 4 ; Genetic Predisposition to Disease/genetics ; Humans ; Norway ; Pedigree ; Polymorphism, Single Nucleotide ; Pulmonary Disease, Chronic Obstructive/etiology ; Regression Analysis ; Risk Factors ; Smoking/adverse effects ; White People

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Skocz do pozycji: 5.

Tytuł:: Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions.
Autorzy:: Nelson MR; Pharmacogenetics, GlaxoSmithKline, Research Triangle Park, NC 27709-3398, USA. />Bacanu SA
Mosteller M
Li L
Bowman CE
Roses AD
Lai EH
Ehm MG; Pokaż więcej
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2009 Feb; Vol. 9 (1), pp. 23-33. Date of Electronic Publication: 2008 Feb 26.
Typ publikacji:: Journal Article
MeSH Terms:: Genome, Human*
Polymorphism, Single Nucleotide*
Drug-Related Side Effects and Adverse Reactions/*genetics
Pharmacogenetics/*methods
Clinical Trials as Topic ; DNA/genetics ; Dideoxynucleosides/adverse effects ; Drug Hypersensitivity/genetics ; HLA-B Antigens/genetics ; Humans

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Skocz do pozycji: 6.

Tytuł:: Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility.
Autorzy:: Hughes AR; GlaxoSmithKline Pharmacogenetics, Research Triangle Park, NC 27709, USA. />Spreen WR
Mosteller M
Warren LL
Lai EH
Brothers CH
Cox C
Nelsen AJ
Hughes S
Thorborn DE
Stancil B
Hetherington SV
Burns DK
Roses AD; Pokaż więcej
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2008 Dec; Vol. 8 (6), pp. 365-74. Date of Electronic Publication: 2008 Mar 11.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Pharmacogenetics*
Dideoxynucleosides/*adverse effects
Drug Hypersensitivity/*genetics
Reverse Transcriptase Inhibitors/*adverse effects
HLA-B Antigens/genetics ; Humans ; Patch Tests

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Skocz do pozycji: 7.

Tytuł:: Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations.
Autorzy:: Zhu G; Medical Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, USA.
Carlsen K
Carlsen KH
Lenney W
Silverman M
Whyte MK
Hosking L
Helms P
Roses AD
Hay DW
Barnes MR
Anderson WH
Pillai SG; Pokaż więcej
Źródło:: Genes and immunity [Genes Immun] 2008 Jan; Vol. 9 (1), pp. 23-9. Date of Electronic Publication: 2007 Oct 25.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetics, Population*
Asthma/*genetics
Endothelin-1/*genetics
Polymorphism, Single Nucleotide/*genetics
Adolescent ; Adult ; Alleles ; Case-Control Studies ; Child ; Data Interpretation, Statistical ; Family ; Female ; Gene Frequency ; Genetic Markers ; Haplotypes ; Humans ; Linkage Disequilibrium ; Male ; Norway ; Statistics as Topic ; United Kingdom

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Skocz do pozycji: 8.

Tytuł:: Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan.
Autorzy:: Warren LL; GlaxoSmithKline, RTP, NC 27709, USA.
Hughes AR
Lai EH
Zaykin DV
Haneline SA
Bansal AT
Wooster AW
Spreen WR
Hernandez JE
Scott TR
Roses AD
Mosteller M; Pokaż więcej
Corporate Authors:: CNA30027 and CNA30032 study teams
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2007 Jun; Vol. 7 (3), pp. 180-9. Date of Electronic Publication: 2006 Sep 12.
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:: Genetic Markers*
Pharmacogenetics*
Adult ; Case-Control Studies ; Female ; Genome, Human ; HLA-B Antigens/genetics ; Humans ; Male ; Retrospective Studies ; Sensitivity and Specificity

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Skocz do pozycji: 9.

Tytuł:: Rosiglitazone induces mitochondrial biogenesis in mouse brain.
Autorzy:: Strum JC; Department of Quantitative Expression, Division of Genetics Research, GlaxoSmithKline, Research Triangle Park, NC 27278, USA. />Shehee R
Virley D
Richardson J
Mattie M
Selley P
Ghosh S
Nock C
Saunders A
Roses A; Pokaż więcej
Źródło:: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2007 Mar; Vol. 11 (1), pp. 45-51.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Organelle Biogenesis*
Brain/*drug effects
DNA, Mitochondrial/*genetics
Hypoglycemic Agents/*pharmacology
Mitochondria/*drug effects
RNA, Messenger/*genetics
Receptors, Estrogen/*genetics
Thiazolidinediones/*pharmacology
Alzheimer Disease/drug therapy ; Animals ; Apolipoprotein E3/metabolism ; Apolipoprotein E4/metabolism ; Apolipoproteins E/genetics ; Cognition/drug effects ; Frontal Lobe/drug effects ; Gene Expression Regulation/drug effects ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; PPAR gamma/agonists ; Reverse Transcriptase Polymerase Chain Reaction ; Rosiglitazone ; Thiazolidinediones/therapeutic use ; ERRalpha Estrogen-Related Receptor

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Skocz do pozycji: 10.

Tytuł:: Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).
Autorzy:: Roses AD; Genetics Research, GlaxoSmithKline Research and Development, NC 27709, USA. allen.d.roses@gsk.com
Saunders AM
Huang Y
Strum J
Weisgraber KH
Mahley RW; Pokaż więcej
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2007 Feb; Vol. 7 (1), pp. 10-28. Date of Electronic Publication: 2006 Jun 13.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Pharmacogenetics*
Alzheimer Disease/*drug therapy
Alzheimer Disease/*genetics
Alzheimer Disease/pathology ; Apolipoproteins E/genetics ; Biomarkers ; Drug Industry ; Drug-Related Side Effects and Adverse Reactions ; Genome, Human ; Genotype ; Humans ; Rosiglitazone ; Thiazolidinediones/adverse effects ; Thiazolidinediones/therapeutic use

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Skocz do pozycji: 11.

Tytuł:: Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease.
Autorzy:: Risner ME; World Wide Development, Research and Development, GlaxoSmithKline, Research Triangle Park, NC 27709-3398, USA. />Saunders AM
Altman JF
Ormandy GC
Craft S
Foley IM
Zvartau-Hind ME
Hosford DA
Roses AD; Pokaż więcej
Corporate Authors:: Rosiglitazone in Alzheimer's Disease Study Group
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2006 Jul-Aug; Vol. 6 (4), pp. 246-54. Date of Electronic Publication: 2006 Jan 31.
Typ publikacji:: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms:: Alzheimer Disease/*drug therapy
Apolipoproteins E/*genetics
Hypoglycemic Agents/*therapeutic use
Thiazolidinediones/*therapeutic use
Aged ; Alleles ; Alzheimer Disease/genetics ; Apolipoprotein E4 ; Apolipoproteins E/deficiency ; Cognition/drug effects ; Dose-Response Relationship, Drug ; Female ; Genotype ; Humans ; Hypoglycemic Agents/adverse effects ; Male ; Pharmacogenetics ; Rosiglitazone ; Thiazolidinediones/adverse effects

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Skocz do pozycji: 12.

Tytuł:: Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility loci.
Autorzy:: North BV; Academic Department of Psychiatry, Queen Mary's School of Medicine and Dentistry, London E1 1BB, UK.
Curtis D
Martin ER
Lai EH
Roses AD
Sham PC; Pokaż więcej
Źródło:: Annals of human genetics [Ann Hum Genet] 2004 May; Vol. 68 (Pt 3), pp. 240-8.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Genetics, Population*
Linkage Disequilibrium*
Alzheimer Disease/*genetics
Genetic Predisposition to Disease/*genetics
Polymorphism, Single Nucleotide/*genetics
Case-Control Studies ; Gene Frequency ; Genetic Markers ; Haplotypes/genetics ; Humans ; Likelihood Functions ; Models, Genetic ; Phenotype

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Skocz do pozycji: 13.

Tytuł:: Identification of a pharmacogenetic effect by linkage disequilibrium mapping.
Autorzy:: Xu CF; Discovery and Pipeline Genetics, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, UK. />Lewis KF
Yeo AJ
McCarthy LC
Maguire MF
Anwar Z
Danoff TM
Roses AD
Purvis IJ; Pokaż więcej
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2004; Vol. 4 (6), pp. 374-8.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Linkage Disequilibrium/*genetics
Pharmacogenetics/*methods
Polymorphism, Single Nucleotide/*genetics
Clinical Trials, Phase III as Topic/statistics & numerical data ; Glucuronosyltransferase/genetics ; Humans ; ortho-Aminobenzoates/therapeutic use

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Skocz do pozycji: 14.

Tytuł:: A Gilbert's syndrome UGT1A1 variant confers susceptibility to tranilast-induced hyperbilirubinemia.
Autorzy:: Danoff TM; Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Philadelphia, PA, USA.
Campbell DA
McCarthy LC
Lewis KF
Repasch MH
Saunders AM
Spurr NK
Purvis IJ
Roses AD
Xu CF; Pokaż więcej
Źródło:: The pharmacogenomics journal [Pharmacogenomics J] 2004; Vol. 4 (1), pp. 49-53.
Typ publikacji:: Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genetic Predisposition to Disease*
Gilbert Disease/*enzymology
Gilbert Disease/*genetics
Glucuronosyltransferase/*genetics
Hyperbilirubinemia/*genetics
ortho-Aminobenzoates/*adverse effects
Dinucleotide Repeats/genetics ; Double-Blind Method ; Genetic Variation ; Humans ; Hyperbilirubinemia/chemically induced ; Isoenzymes/genetics ; Polymorphism, Genetic ; Prospective Studies

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Skocz do pozycji: 15.

Tytuł:: Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia.
Autorzy:: Horsburgh K; Department of Neuropathology, University of Glasgow, Glasgow, UK. />McCulloch J
Nilsen M
Roses AD
Nicoll JA; Pokaż więcej
Źródło:: The European journal of neuroscience [Eur J Neurosci] 2000 Dec; Vol. 12 (12), pp. 4309-17.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apolipoproteins E/*physiology
Brain/*pathology
Ischemic Attack, Transient/*pathology
Neurons/*pathology
Alleles ; Animals ; Apolipoprotein E3 ; Apolipoprotein E4 ; Apolipoproteins E/analysis ; Apolipoproteins E/genetics ; Brain/metabolism ; Caudate Nucleus/metabolism ; Caudate Nucleus/pathology ; Humans ; Ischemic Attack, Transient/genetics ; Ischemic Attack, Transient/physiopathology ; Mice ; Mice, Transgenic ; Neuroglia/metabolism ; Neuroglia/pathology ; Neurons/metabolism ; Promoter Regions, Genetic ; Pyramidal Cells/metabolism ; Pyramidal Cells/pathology ; Time Factors

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Skocz do pozycji: 16.

Tytuł:: Pharmacogenetics and the practice of medicine.
Autorzy:: Roses AD; Genetics Directorate, Glaxo Wellcome plc, Greenford, Middlesex, UK.; Pokaż więcej
Źródło:: Nature [Nature] 2000 Jun 15; Vol. 405 (6788), pp. 857-65.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Pharmacogenetics*
Delivery of Health Care/trends ; Drug Evaluation, Preclinical ; Drug Industry ; Drug Therapy/trends ; Genetic Testing ; Genome ; Humans ; Polymorphism, Single Nucleotide

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Skocz do pozycji: 17.

Tytuł:: Pharmacogenetics and future drug development and delivery.
Autorzy:: Roses AD; Genetics Directorate, Glaxo Wellcome plc, Greenford, UK.; Pokaż więcej
Źródło:: Lancet (London, England) [Lancet] 2000 Apr 15; Vol. 355 (9212), pp. 1358-61.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Chemistry, Pharmaceutical/*trends
Drug Delivery Systems/*trends
Pharmacogenetics/*trends
Clinical Trials as Topic/trends ; Forecasting ; Humans