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Tytuł :
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Autorzy :
Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; .; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Kehrer T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Zhang K; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Cohen P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Patel RS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Cupic A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Makio T; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Mei M; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Danziger O; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Rathnasinghe R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Uccellini M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Gao S; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Aydillo T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Mena I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Yin X; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Martin-Sancho L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Krogan NJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Quantitative Biosciences Institute, University of California San Francisco, CA 94158.; Gladstone Institute of Data Science and Biosciences, J. David Gladstone Institutes, San Francisco, CA 94158.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, CA 94143.
Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Wozniak RW; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Ren Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Fontoura BMA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; .; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28344-28354. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
COVID-19/*metabolism
Interferons/*metabolism
Nuclear Pore/*metabolism
Nuclear Pore Complex Proteins/*metabolism
STAT1 Transcription Factor/*metabolism
STAT2 Transcription Factor/*metabolism
Viral Proteins/*metabolism
Active Transport, Cell Nucleus ; Animals ; Binding Sites ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; Nuclear Matrix-Associated Proteins/chemistry ; Nuclear Matrix-Associated Proteins/metabolism ; Nucleocytoplasmic Transport Proteins/chemistry ; Nucleocytoplasmic Transport Proteins/metabolism ; Protein Binding ; Signal Transduction ; Vero Cells
Czasopismo naukowe
Tytuł :
Structural basis for STAT2 suppression by flavivirus NS5.
Autorzy :
Wang B; Department of Biochemistry, University of California, Riverside, CA, USA.
Thurmond S; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA.; Cell, Molecular and Developmental Biology Graduate Program, University of California, Riverside, CA, USA.
Zhou K; California NanoSystems Institute, University of California, Los Angeles, CA, USA.
Sánchez-Aparicio MT; GlobalHealth and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fang J; Department of Biochemistry, University of California, Riverside, CA, USA.
Lu J; Department of Biochemistry, University of California, Riverside, CA, USA.
Gao L; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA.
Ren W; Department of Biochemistry, University of California, Riverside, CA, USA.
Cui Y; California NanoSystems Institute, University of California, Los Angeles, CA, USA.
Veit EC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hong H; Department of Biochemistry, University of California, Riverside, CA, USA.
Evans MJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
O'Leary SE; Department of Biochemistry, University of California, Riverside, CA, USA.
García-Sastre A; GlobalHealth and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhou ZH; California NanoSystems Institute, University of California, Los Angeles, CA, USA. .; Departement of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA. .
Hai R; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA. .; Cell, Molecular and Developmental Biology Graduate Program, University of California, Riverside, CA, USA. .
Song J; Department of Biochemistry, University of California, Riverside, CA, USA. .; Environmental Toxicology Graduate Program, University of California, Riverside, CA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Oct; Vol. 27 (10), pp. 875-885. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media
MeSH Terms :
STAT2 Transcription Factor/*chemistry
STAT2 Transcription Factor/*metabolism
Viral Nonstructural Proteins/*chemistry
Cryoelectron Microscopy ; Crystallography, X-Ray ; Cytoplasm/metabolism ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Models, Molecular ; Protein Conformation ; STAT2 Transcription Factor/genetics ; Viral Nonstructural Proteins/metabolism ; Zika Virus Infection/virology
Czasopismo naukowe
Tytuł :
Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice.
Autorzy :
Uccellini MB; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bardina SV; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hou YJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.
Lim JK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Apr 07; Vol. 31 (1), pp. 107498.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Armadillo Domain Proteins/*genetics
Armadillo Domain Proteins/*metabolism
Cytoskeletal Proteins/*genetics
Cytoskeletal Proteins/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis/genetics ; Apoptosis Regulatory Proteins/metabolism ; Axons/metabolism ; Brain/metabolism ; Encephalitis, California/genetics ; Eye Diseases, Hereditary ; Female ; La Crosse virus ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation/genetics ; Phenotype ; Receptors, Interleukin-1/metabolism ; Retinal Degeneration ; Signal Transduction/genetics ; Toll-Like Receptors/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Vision Disorders ; West Nile Fever/genetics
SCR Disease Name :
Enhanced S-Cone Syndrome
Czasopismo naukowe
Tytuł :
Influenza virus infection causes global RNAPII termination defects.
Autorzy :
Zhao N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sebastiano V; Department of Obstetrics and Gynecology, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University, Stanford, CA, USA.
Moshkina N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mena N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hultquist J; Department of Medicine (Infectious Diseases), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jimenez-Morales D; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Ma Y; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rialdi A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Albrecht R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fenouil R; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ayllon J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ravisankar S; Department of Obstetrics and Gynecology, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University, Stanford, CA, USA.
Haddad B; Department of Obstetrics and Gynecology, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University, Stanford, CA, USA.
Ho JSY; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Low D; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yurchenko V; Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.
Prinjha RK; Epinova Epigenetics Discovery Performance Unit, Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK.
Tarakhovsky A; Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, New York, NY, USA.
Squatrito M; Cancer Cell Biology Programme, Centro Nacional de Investigaciones Oncológicas, CNIO, Madrid, Spain.
Pinto D; Department of Psychiatry, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Allette K; Department of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Byun M; Department of Medicine, Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Smith ML; Department of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sebra R; Department of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Guccione E; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Tumpey T; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Krogan N; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Greenbaum B; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology and Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
van Bakel H; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marazzi I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2018 Sep; Vol. 25 (9), pp. 885-893. Date of Electronic Publication: 2018 Sep 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Influenza, Human/*genetics
RNA Polymerase II/*genetics
Terminator Regions, Genetic/*genetics
Humans ; Influenza A virus/pathogenicity ; Influenza A virus/physiology ; Virulence
Czasopismo naukowe
Tytuł :
Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus.
Autorzy :
Rodríguez Pulido M; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, United States of America.
Martínez-Salas E; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, United States of America.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, United States of America.
Sobrino F; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Sáiz M; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
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Źródło :
PLoS pathogens [PLoS Pathog] 2018 Jun 29; Vol. 14 (6), pp. e1007135. Date of Electronic Publication: 2018 Jun 29 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endopeptidases/*metabolism
Foot-and-Mouth Disease/*virology
Foot-and-Mouth Disease Virus/*immunology
Immune Evasion/*immunology
Immunity, Innate/*immunology
RNA Helicases/*metabolism
Animals ; Cells, Cultured ; Chlorocebus aethiops ; Cricetinae ; Endopeptidases/genetics ; Foot-and-Mouth Disease/immunology ; Foot-and-Mouth Disease/pathology ; Foot-and-Mouth Disease Virus/enzymology ; HEK293 Cells ; Humans ; RNA Helicases/genetics ; RNA Helicases/immunology ; Vero Cells
Czasopismo naukowe
Tytuł :
Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling.
Autorzy :
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Feinman LJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Shaw ML; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA .
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Źródło :
Journal of virology [J Virol] 2018 Feb 26; Vol. 92 (6). Date of Electronic Publication: 2018 Feb 26 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Signal Transduction*
Virus Replication*
DEAD Box Protein 58/*metabolism
Paramyxoviridae/*physiology
Paramyxoviridae Infections/*metabolism
Transcription Factors/*metabolism
Tripartite Motif Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Viral Proteins/*metabolism
A549 Cells ; Animals ; DEAD Box Protein 58/genetics ; Dogs ; HeLa Cells ; Humans ; Madin Darby Canine Kidney Cells ; Multienzyme Complexes/genetics ; Multienzyme Complexes/metabolism ; Paramyxoviridae Infections/genetics ; Transcription Factors/genetics ; Tripartite Motif Proteins/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection.
Autorzy :
Canton J; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Fehr AR; Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Fernandez-Delgado R; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Gutierrez-Alvarez FJ; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.; Global Health and Emerging Pathogens Institute. Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.; Global Health and Emerging Pathogens Institute. Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Perlman S; Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Enjuanes L; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Sola I; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
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Źródło :
PLoS pathogens [PLoS Pathog] 2018 Jan 25; Vol. 14 (1), pp. e1006838. Date of Electronic Publication: 2018 Jan 25 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Evasion*
Immunity, Innate*/physiology
Coronavirus Infections/*immunology
Middle East Respiratory Syndrome Coronavirus/*physiology
NF-kappa B/*physiology
Viral Proteins/*physiology
Animals ; Cells, Cultured ; Coronavirus Infections/virology ; Cricetinae ; Host-Pathogen Interactions/immunology ; Humans ; Middle East Respiratory Syndrome Coronavirus/immunology ; NF-kappa B/metabolism
Czasopismo naukowe
Tytuł :
Loss of Sendai virus C protein leads to accumulation of RIG-I immunostimulatory defective interfering RNA.
Autorzy :
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Garcin D; Department of Genetics and Microbiology, University of Geneva School of Medicine, CMU, CH1211 Geneva, Switzerland.
Rice CM; Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
Kolakofsky D; Department of Genetics and Microbiology, University of Geneva School of Medicine, CMU, CH1211 Geneva, Switzerland.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.; Department of Medicine Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Baum A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.; Present address: Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
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Źródło :
The Journal of general virology [J Gen Virol] 2017 Jun; Vol. 98 (6), pp. 1282-1293. Date of Electronic Publication: 2017 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Deletion*
Gene Expression Regulation, Viral*
DEAD Box Protein 58/*metabolism
RNA, Small Interfering/*metabolism
Sendai virus/*immunology
Viral Proteins/*genetics
Adjuvants, Immunologic/metabolism ; Genetic Complementation Test ; HeLa Cells ; Humans ; RNA, Viral/metabolism ; Sendai virus/genetics
Czasopismo naukowe
Tytuł :
Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.
Autorzy :
Luthra P; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Aguirre S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yen BC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Pietzsch CA; Department of Pathology, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Global Health and Emergent Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Tigabu B; Department of Pathology, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Morlock LK; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Global Health and Emergent Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Leung DW; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Williams NS; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas, USA.
Fernandez-Sesma A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Bukreyev A; Department of Pathology, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.; Department of Microbiology & Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.; Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Basler CF; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA .
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Źródło :
MBio [mBio] 2017 Apr 04; Vol. 8 (2). Date of Electronic Publication: 2017 Apr 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antiviral Agents/*pharmacology
DNA Damage/*immunology
Ebolavirus/*physiology
Immune Evasion/*drug effects
Interferons/*metabolism
Topoisomerase II Inhibitors/*pharmacology
Virus Replication/*drug effects
Cell Line ; Ebolavirus/immunology ; Humans
Czasopismo naukowe
Tytuł :
Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.
Autorzy :
Aguirre S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Luthra P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Maestre AM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Patel J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Lamothe F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Fredericks AC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Tripathi S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Zhu T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Pintado-Silva J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Webb LG; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Bernal-Rubio D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Solovyov A; Tisch Cancer Institute, Division of Hematology and Medical Oncology, Department of Medicine, Department of Pathology and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Greenbaum B; Tisch Cancer Institute, Division of Hematology and Medical Oncology, Department of Medicine, Department of Pathology and Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Mulder LC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
Fernandez-Sesma A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, USA.
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Źródło :
Nature microbiology [Nat Microbiol] 2017 Mar 27; Vol. 2, pp. 17037. Date of Electronic Publication: 2017 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Host-Pathogen Interactions*
DNA, Mitochondrial/*physiology
Dengue Virus/*genetics
Nucleotidyltransferases/*metabolism
Viral Nonstructural Proteins/*metabolism
DNA, Mitochondrial/genetics ; Dendritic Cells/virology ; Dengue/immunology ; Dengue/virology ; Dengue Virus/chemistry ; Dengue Virus/enzymology ; Dengue Virus/immunology ; HEK293 Cells ; Humans ; Immunity, Innate ; Interferon Type I/immunology ; Membrane Proteins/metabolism ; Nucleotidyltransferases/deficiency ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/immunology ; Signal Transduction ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Autorzy :
Soonthornvacharin S; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Rodriguez-Frandsen A; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.
Zhou Y; Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.
Galvez F; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.
Huffmaster NJ; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.
Tripathi S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.; Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.
Balasubramaniam VR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.; Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.
Inoue A; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
de Castro E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.; Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.
Moulton H; Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, 450 SW 30th Street, Oregon 97331, USA.
Stein DA; Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University Corvallis, 450 SW 30th Street, Oregon 97331, USA.
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.; Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.
De Jesus PD; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.
Nguyen Q; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.
König R; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; Host-Pathogen-Interactions, Paul-Ehrlich-Institute, German Center for Infection Research (DZIF), Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany.
Krogan NJ; Department of Cellular and Molecular Pharmacology, University of California San Francisco, 1700 4th Street, Byers Hall 308D, Box 2530, San Francisco, California 94158, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.; Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, New York 10029, USA.
Yoh SM; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.
Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.; The San Diego Center for Systems Biology (SDCSB), La Jolla, California 92093, USA.
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Źródło :
Nature microbiology [Nat Microbiol] 2017 Mar 01; Vol. 2, pp. 17022. Date of Electronic Publication: 2017 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
DEAD Box Protein 58/*antagonists & inhibitors
RNA, Viral/*immunology
RNA-Binding Proteins/*metabolism
Trans-Activators/*metabolism
HEK293 Cells ; Humans ; Immunity, Innate ; Influenza A Virus, H1N1 Subtype/immunology ; Protein Binding ; Protein Interaction Mapping ; Protein Interaction Maps
Czasopismo naukowe
Tytuł :
Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes.
Autorzy :
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ayllón J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Leo-Macias A; The Leon H. Charney Division of Cardiology, New York University School of Medicine (NYU-SoM), New York, New York, USA.
Wolff T; Division of Influenza Viruses and Other Respiratory Viruses, Robert Koch Institute, Berlin, Germany.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA .; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
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Źródło :
Journal of virology [J Virol] 2017 Jan 03; Vol. 91 (2). Date of Electronic Publication: 2017 Jan 03 (Print Publication: 2017).
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
DEAD Box Protein 58/*metabolism
Multiprotein Complexes/*metabolism
Transcription Factors/*metabolism
Tripartite Motif Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Cell Line ; DEAD Box Protein 58/chemistry ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Intracellular Space ; Protein Binding ; Protein Multimerization ; Protein Transport ; Signal Transduction ; Transcription Factors/chemistry ; Tripartite Motif Proteins/chemistry ; Ubiquitin-Protein Ligases/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
The therapeutic effect of death: Newcastle disease virus and its antitumor potential.
Autorzy :
Cuadrado-Castano S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: .
Sanchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Division of Infectious Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Villar E; Department of Biochemistry and Molecular Biology, University of Salamanca, Salamanca, Spain.
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Źródło :
Virus research [Virus Res] 2015 Nov 02; Vol. 209, pp. 56-66. Date of Electronic Publication: 2015 Jul 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Newcastle disease virus/*physiology
Oncolytic Virotherapy/*methods
Oncolytic Viruses/*physiology
Animals ; Apoptosis ; Autophagy ; Disease Models, Animal ; Host-Pathogen Interactions ; Humans ; Newcastle disease virus/growth & development ; Oncolytic Viruses/growth & development
Czasopismo naukowe
Tytuł :
Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
Autorzy :
Ferrer-Orta C; Institut de Biologia Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Barcelona, Spain.
de la Higuera I; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
Caridi F; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Sánchez-Aparicio MT; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Moreno E; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Perales C; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
Singh K; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Sarafianos SG; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, USA Department of Biochemistry, University of Missouri, Columbia, Missouri, USA.
Sobrino F; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Domingo E; Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
Verdaguer N; Institut de Biologia Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Barcelona, Spain .
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Źródło :
Journal of virology [J Virol] 2015 Jul; Vol. 89 (13), pp. 6848-59. Date of Electronic Publication: 2015 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Localization Signals*
Antigens, Viral/*chemistry
Antigens, Viral/*metabolism
Foot-and-Mouth Disease Virus/*enzymology
Nucleotides/*metabolism
Viral Nonstructural Proteins/*chemistry
Viral Nonstructural Proteins/*metabolism
Amino Acid Substitution ; Antigens, Viral/genetics ; Crystallography, X-Ray ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Mutation, Missense ; Protein Binding ; Protein Conformation ; RNA/metabolism ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA.
Autorzy :
Riegger D; Institute of Virology, University Medical Center, Freiburg, Germany.
Hai R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Dornfeld D; Institute of Virology, University Medical Center, Freiburg, Germany.
Mänz B; Institute of Virology, University Medical Center, Freiburg, Germany.
Leyva-Grado V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sánchez-Aparicio MT; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Albrecht RA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Haller O; Institute of Virology, University Medical Center, Freiburg, Germany.
Schwemmle M; Institute of Virology, University Medical Center, Freiburg, Germany.
García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kochs G; Institute of Virology, University Medical Center, Freiburg, Germany .
Schmolke M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA .
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Źródło :
Journal of virology [J Virol] 2015 Feb; Vol. 89 (4), pp. 2241-52. Date of Electronic Publication: 2014 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Evasion*
Influenza A Virus, H7N9 Subtype/*immunology
Influenza in Birds/*virology
Influenza, Human/*immunology
Myxovirus Resistance Proteins/*immunology
RNA-Binding Proteins/*immunology
Viral Core Proteins/*immunology
Animals ; Birds ; Cell Line ; China ; Humans ; Influenza A Virus, H7N9 Subtype/growth & development ; Mice, Inbred C57BL ; Molecular Sequence Data ; Nucleocapsid Proteins ; RNA, Viral/genetics ; RNA-Binding Proteins/genetics ; Sequence Analysis, DNA ; Viral Core Proteins/genetics ; Zoonoses/transmission ; Zoonoses/virology
Czasopismo naukowe
Tytuł :
Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses.
Autorzy :
Santiago FW; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Covaleda LM
Sanchez-Aparicio MT
Silvas JA
Diaz-Vizarreta AC
Patel JR
Popov V
Yu XJ
García-Sastre A
Aguilar PV
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Źródło :
Journal of virology [J Virol] 2014 Apr; Vol. 88 (8), pp. 4572-85. Date of Electronic Publication: 2014 Jan 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bunyaviridae Infections/*enzymology
DEAD-box RNA Helicases/*metabolism
Endosomes/*metabolism
Interferon Type I/*immunology
Phlebovirus/*metabolism
Viral Nonstructural Proteins/*metabolism
Bunyaviridae Infections/genetics ; Bunyaviridae Infections/immunology ; Bunyaviridae Infections/virology ; Cell Line ; Cytoplasmic Structures ; DEAD Box Protein 58 ; DEAD-box RNA Helicases/genetics ; Endosomes/genetics ; Humans ; Interferon Type I/genetics ; Phlebovirus/genetics ; Promoter Regions, Genetic ; Protein Transport ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.
Autorzy :
Schmolke M
Patel JR
de Castro E
Sánchez-Aparicio MT
Uccellini MB
Miller JC
Manicassamy B
Satoh T
Kawai T
Akira S
Merad M
García-Sastre A
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Źródło :
MBio [mBio] 2014 Apr 01; Vol. 5 (2), pp. e01006-14. Date of Electronic Publication: 2014 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Host-Pathogen Interactions*
DEAD-box RNA Helicases/*immunology
RNA, Bacterial/*immunology
RNA, Messenger/*immunology
Receptors, Immunologic/*immunology
Salmonella typhimurium/*immunology
Animals ; Cell Line ; DEAD Box Protein 58 ; DEAD-box RNA Helicases/metabolism ; Humans ; Interferon-beta/immunology ; Interferon-beta/metabolism ; Mice ; Protein Binding ; RNA, Bacterial/metabolism ; RNA, Messenger/metabolism ; Receptors, Immunologic/metabolism
Czasopismo naukowe
Tytuł :
Characterization of a nuclear localization signal in the foot-and-mouth disease virus polymerase.
Autorzy :
Sanchez-Aparicio MT; Centro de Biología Molecular, 'Severo Ochoa' (CSIC-UAM), Cantoblanco 28049, Madrid, Spain.
Rosas MF
Sobrino F
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Źródło :
Virology [Virology] 2013 Sep; Vol. 444 (1-2), pp. 203-10. Date of Electronic Publication: 2013 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Localization Signals*
Antigens, Viral/*genetics
Foot-and-Mouth Disease Virus/*genetics
Viral Nonstructural Proteins/*genetics
Amino Acid Substitution ; Animals ; Antigens, Viral/metabolism ; Cell Line ; Cell Nucleus/chemistry ; Cricetinae ; DNA Mutational Analysis ; Genes, Reporter ; Green Fluorescent Proteins/analysis ; Green Fluorescent Proteins/genetics ; Mutagenesis, Site-Directed ; Protein Transport ; Recombinant Fusion Proteins/analysis ; Recombinant Fusion Proteins/genetics ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activation.
Autorzy :
Ferrage F; Ecole Normale Supérieure, Département de Chimie, UMR 7203 CNRS-UPMC-ENS, 24, rue Lhomond, 75005 Paris, France. />Dutta K
Nistal-Villán E
Patel JR
Sánchez-Aparicio MT
De Ioannes P
Buku A
Aseguinolaza GG
García-Sastre A
Aggarwal AK
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Źródło :
Structure (London, England : 1993) [Structure] 2012 Dec 05; Vol. 20 (12), pp. 2048-61. Date of Electronic Publication: 2012 Oct 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
DEAD-box RNA Helicases/*chemistry
Amino Acid Substitution ; Catalytic Domain ; DEAD Box Protein 58 ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; HEK293 Cells ; Humans ; Interferon-beta/genetics ; Mutagenesis, Site-Directed ; Nuclear Magnetic Resonance, Biomolecular ; Phosphoproteins/chemistry ; Phosphorylation ; Promoter Regions, Genetic ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Surface Properties ; Transcriptional Activation ; Ubiquitination
Czasopismo naukowe

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