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Wyświetlanie 1-14 z 14
Tytuł :
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Autorzy :
Huang M; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Tailor J; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Institute of Cancer Research, Sutton, London SM2 5NG, UK; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
Zhen Q; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Gillmor AH; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada; Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, Calgary, AB, Canada.
Miller ML; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Weishaupt H; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
Chen J; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zheng T; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Nash EK; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
McHenry LK; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
An Z; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Ye F; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Takashima Y; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Clarke J; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Ayetey H; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Cavalli FMG; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Luu B; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Moriarity BS; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Ilkhanizadeh S; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Chavez L; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Yu C; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Kurian KM; Institute of Clinical Neurosciences, Level 1, Learning and Research Building, Southmead Hospital, University of Bristol, Bristol BS10 5NB, UK.
Magnaldo T; Institute for Research on Cancer and Aging, Nice UMR CNRS 7284 INSERM U1081 UNS/UCA, Nice, France.
Sevenet N; Institut Bergonie & INSERM U1218, Universite de Bordeaux, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France.
Koch P; Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim and Hector Institut for Translational Brain Research (HITBR gGmbH), Mannheim, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pollard SM; MRC Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, UK.
Dirks P; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Largaespada DA; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Cho YJ; Division of Pediatric Neurology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA; Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Phillips JJ; Departments of Neurological Surgery and Pathology, University of California, San Francisco, CA 94158, USA.
Swartling FJ; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
Morrissy AS; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada; Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, Calgary, AB, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Kool M; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Pfister SM; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Taylor MD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Smith A; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Weiss WA; Department of Neurology and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Departments of Pediatrics, Neurosurgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2019 Sep 05; Vol. 25 (3), pp. 433-446.e7. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basal Cell Nevus Syndrome/*genetics
Brain Neoplasms/*genetics
Medulloblastoma/*genetics
N-Myc Proto-Oncogene Protein/*metabolism
Neural Stem Cells/*physiology
Neuroepithelial Cells/*physiology
Pluripotent Stem Cells/*physiology
Animals ; Basal Cell Nevus Syndrome/metabolism ; Basal Cell Nevus Syndrome/pathology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Carcinogenesis/genetics ; DEAD-box RNA Helicases/genetics ; Disease Models, Animal ; Genetic Engineering ; Genetic Predisposition to Disease ; Humans ; Medulloblastoma/metabolism ; Medulloblastoma/pathology ; Mice ; Mice, SCID ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Proteins/genetics ; Patched-1 Receptor/genetics ; Stem Cell Transplantation ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Germline SUFU mutation carriers and medulloblastoma: clinical characteristics, cancer risk, and prognosis.
Autorzy :
Guerrini-Rousseau L; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Dufour C; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Varlet P; Service de neuropathologie, Hôpital Sainte-Anne, Université Paris Descartes, Paris, France.
Masliah-Planchon J; PSL Research University, INSERM U830 Génétique et Biologie des Cancers Institut Curie, Paris, France.; Unité de génétique somatique, SIREDO pediatric oncology center, Institut Curie, Paris, France.
Bourdeaut F; PSL Research University, INSERM U830 Génétique et Biologie des Cancers Institut Curie, Paris, France.; Département d'oncologie Pédiatrique adolescents Jeunes Adultes, Institut Curie, Paris, France, SIREDO pediatric oncology center, Institut Curie, Paris, France.; Institut Curie SIRIC - Laboratoire de Recherche Translationnelle en Oncologie Pédiatrique, Institut Curie, Paris, France.
Guillaud-Bataille M; Département de Biologie et Pathologie Médicales, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Abbas R; INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.; Service de Biostatistique et d'Epidémiologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Bertozzi AI; Unité d' Hémato-Immuno-Oncologie pédiatrique, CHU Toulouse, Toulouse, France.
Fouyssac F; Onco-hématologie pédiatrique, Hôpital d'Enfants, CHU Nancy, Nancy, France.
Huybrechts S; Hematology-Oncology Unit, Hôpital Universitaire des Enfants Reine Fabiola, ULB Université libre de Bruxelles, Brussels, Belgium.
Puget S; Service de neurochirurgie pédiatrique, Hôpital Necker-Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Bressac-De Paillerets B; Département de Biologie et Pathologie Médicales, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Caron O; PSL Research University, INSERM U830 Génétique et Biologie des Cancers Institut Curie, Paris, France.; Unité de génétique somatique, SIREDO pediatric oncology center, Institut Curie, Paris, France.; Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Sevenet N; Laboratoire de génétique moléculaire, Département de bio-pathologie, Institut Bergonié, Bordeaux, France.; INSERM U1218, Université de Bordeaux, Bordeaux, France.; UFR des Sciences Pharmaceutiques, Université de Bordeaux, Bordeaux, France.
Dimaria M; Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Villebasse S; Département de Médecine Oncologique, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Delattre O; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Valteau-Couanet D; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Grill J; Unité Mixte de Recherche 8203 du Centre National de la Recherche Scientifique, Université Paris-Saclay, Villejuif, France.
Brugières L; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Pokaż więcej
Źródło :
Neuro-oncology [Neuro Oncol] 2018 Jul 05; Vol. 20 (8), pp. 1122-1132.
Typ publikacji :
Journal Article
MeSH Terms :
Germ-Line Mutation*
Heterozygote*
Biomarkers, Tumor/*genetics
Cerebellar Neoplasms/*pathology
Medulloblastoma/*pathology
Neoplasm Recurrence, Local/*pathology
Repressor Proteins/*genetics
Adolescent ; Adult ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/therapy ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Male ; Medulloblastoma/genetics ; Medulloblastoma/therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/therapy ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Clinical, pathological, and molecular data on desmoplastic/nodular medulloblastoma: case studies and a review of the literature.
Autorzy :
Siegfried A
Bertozzi AI
Bourdeaut F
Sevely A
Loukh N
Grison C
Miquel C
Lafon D
Sevenet N
Pietsch T
Dufour C
Delisle MB
Pokaż więcej
Źródło :
Clinical neuropathology [Clin Neuropathol] 2016 May-Jun; Vol. 35 (3), pp. 106-13.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebellar Neoplasms/*pathology
Medulloblastoma/*genetics
Medulloblastoma/*pathology
Biomarkers, Tumor/analysis ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/mortality ; Child, Preschool ; Female ; Humans ; Immunohistochemistry ; Infant ; Kaplan-Meier Estimate ; Male ; Medulloblastoma/mortality ; Mutation ; Retrospective Studies
Czasopismo naukowe
Tytuł :
In vivo antitumor activity of S16020, a topoisomerase II inhibitor, and doxorubicin against human brain tumor xenografts.
Autorzy :
Vassal G; UPRES EA 3535 Pharmacology and New Treatments of Cancers, Institut Gustave-Roussy, Villejuif, France. />Merlin JL
Terrier-Lacombe MJ
Grill J
Parker F
Sainte-Rose C
Aubert G
Morizet J
Sévenet N
Poullain MG
Lucas C
Kalifa C
Pokaż więcej
Źródło :
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2003 May; Vol. 51 (5), pp. 385-94. Date of Electronic Publication: 2003 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Topoisomerase II Inhibitors*
Carbazoles/*pharmacology
Cerebellar Neoplasms/*drug therapy
Doxorubicin/*pharmacology
Glioblastoma/*drug therapy
Medulloblastoma/*drug therapy
Multidrug Resistance-Associated Proteins/*biosynthesis
Pyridines/*pharmacology
Animals ; Cerebellar Neoplasms/pathology ; Cerebellar Neoplasms/veterinary ; Drug Therapy, Combination ; Female ; Gene Expression Regulation ; Glioblastoma/pathology ; Glioblastoma/veterinary ; Medulloblastoma/pathology ; Medulloblastoma/veterinary ; Mice ; Mice, Nude ; Multidrug Resistance-Associated Proteins/pharmacology ; Reverse Transcriptase Polymerase Chain Reaction ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Congenital disseminated malignant rhabdoid tumor and cerebellar tumor mimicking medulloblastoma in monozygotic twins: pathologic and molecular diagnosis.
Autorzy :
Fernandez C; Service d'Anatomie Pathologique et de Neuropathologie, CHU Timone, 264 rue Saint-Pierre, 13385 Marseille cédex 05, France.
Bouvier C
Sévenet N
Liprandi A
Coze C
Lena G
Figarella-Branger D
Pokaż więcej
Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2002 Feb; Vol. 26 (2), pp. 266-70.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Diseases in Twins*
Twins, Monozygotic*
Cerebellar Neoplasms/*pathology
Medulloblastoma/*pathology
Rhabdoid Tumor/*pathology
Spinal Neoplasms/*pathology
Biomarkers, Tumor/analysis ; Cerebellar Neoplasms/congenital ; Cerebellar Neoplasms/genetics ; DNA, Neoplasm/analysis ; Diagnosis, Differential ; Fatal Outcome ; Female ; Gene Deletion ; Germ-Line Mutation ; Humans ; Immunoenzyme Techniques ; Infant ; Magnetic Resonance Imaging ; Rhabdoid Tumor/congenital ; Rhabdoid Tumor/genetics ; Spinal Neoplasms/congenital ; Spinal Neoplasms/genetics
Czasopismo naukowe
    Wyświetlanie 1-14 z 14

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