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Tytuł:
The gut microbiota in multiple sclerosis varies with disease activity.
Autorzy:
Thirion F; Université Paris-Saclay, INRAE, MGP, 78350, Jouy-en-Josas, France.
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, 2600, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, 2200, Copenhagen, Denmark.
Fan Y; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark.
Lyu L; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark.
Hansen TH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark.
Pons N; Université Paris-Saclay, INRAE, MGP, 78350, Jouy-en-Josas, France.
Levenez F; Université Paris-Saclay, INRAE, MGP, 78350, Jouy-en-Josas, France.
Quinquis B; Université Paris-Saclay, INRAE, MGP, 78350, Jouy-en-Josas, France.
Stankevic E; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark.
Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, 2600, Glostrup, Denmark.
Dantoft TM; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg University Hospital, 2400, Frederiksberg, Denmark.
Poulsen CS; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark.
Forslund SK; Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin and the Max-Delbrück Center, 10117, Berlin, Germany.; Max Delbrück Center for Molecular Medicine (MDC), 13125, Berlin, Germany.; Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785, Berlin, Germany.; Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117, Heidelberg, Germany.
Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark.; Department of Medicine, Rønne Hospital, 3700, Bornholm, Denmark.
Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark.
Brix S; Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Oturai A; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, 2600, Glostrup, Denmark.
Sørensen PS; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, 2600, Glostrup, Denmark.
Ehrlich SD; Université Paris-Saclay, INRAE, MGP, 78350, Jouy-en-Josas, France.; Department of Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3RX, UK.
Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, 2200, Copenhagen, Denmark. .; Center for Clinical Metabolic Research, Herlev-Gentofte University Hospital, Hellerup, 2900, Copenhagen, Denmark. .
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Źródło:
Genome medicine [Genome Med] 2023 Jan 05; Vol. 15 (1), pp. 1. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple Sclerosis*
Gastrointestinal Microbiome*
Microbiota*
Young Adult ; Humans ; Inflammation ; Feces/microbiology ; Bacteria ; Cytokines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey.
Autorzy:
Gustavsen S; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark. .
Olsson A; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.
Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.
Andresen SR; Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.
Sørensen PS; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Oturai A; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.
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Źródło:
BMC neurology [BMC Neurol] 2021 Aug 16; Vol. 21 (1), pp. 317. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji:
Journal Article
MeSH Terms:
Multiple Sclerosis*/complications
Multiple Sclerosis*/epidemiology
Quality of Life*
Cross-Sectional Studies ; Denmark/epidemiology ; Fatigue/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Self Report ; Surveys and Questionnaires
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration.
Autorzy:
Subhi Y; 1Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, DK-4000 Roskilde, Denmark.
Nielsen MK; 1Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, DK-4000 Roskilde, Denmark.
Molbech CR; 1Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, DK-4000 Roskilde, Denmark.; 2Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Liisborg C; 1Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, DK-4000 Roskilde, Denmark.; 2Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Søndergaard HB; 3Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Sellebjerg F; 1Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, DK-4000 Roskilde, Denmark.; 3Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Sørensen TL; 1Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, DK-4000 Roskilde, Denmark.; 2Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
Immunity & ageing : I & A [Immun Ageing] 2019 Aug 15; Vol. 16, pp. 20. Date of Electronic Publication: 2019 Aug 15 (Print Publication: 2019).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms.
Autorzy:
Mehta D; School of Psychology and Counselling, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
Rex-Haffner M; Max Planck Institute of Psychiatry, Munich, Germany.
Søndergaard HB; Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Pinborg A; Fertility Clinic, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Gynecology and Obstetrics, Copenhagen University Hospital, Hvidovre, Denmark.
Binder EB; Max Planck Institute of Psychiatry, Munich, Germany.; Emory University, Atlanta, GA, USA.
Frokjaer VG; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Mental Health Services Copenhagen, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
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Źródło:
Acta psychiatrica Scandinavica [Acta Psychiatr Scand] 2019 Jul; Vol. 140 (1), pp. 77-84. Date of Electronic Publication: 2019 May 24.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
Gene Expression*
Genome, Human*
Depression/*metabolism
Estradiol/*metabolism
Gonadotropin-Releasing Hormone/*pharmacology
Adult ; Biomarkers/metabolism ; Double-Blind Method ; Female ; Gonadotropin-Releasing Hormone/administration & dosage ; Gonadotropin-Releasing Hormone/agonists ; Goserelin/pharmacology ; Humans ; Longitudinal Studies ; Models, Biological
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls.
Autorzy:
Buhelt S; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark. .
Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark. .
Oturai A; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark. .
Ullum H; Department of Clinical Immunology, Center of Clinical Investigation, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. .
von Essen MR; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark. .
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, 2600 Glostrup, Denmark. .
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Źródło:
Cells [Cells] 2019 Jun 25; Vol. 8 (6). Date of Electronic Publication: 2019 Jun 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alleles*
Genetic Predisposition to Disease*
Genetic Variation*
Interleukin-2 Receptor alpha Subunit/*genetics
Multiple Sclerosis/*genetics
Multiple Sclerosis/*immunology
T-Lymphocytes/*immunology
Adult ; Aged ; Antigens, CD/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Case-Control Studies ; Female ; Genotype ; Humans ; Immunologic Memory ; Male ; Middle Aged ; Phenotype ; Risk Factors ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis.
Autorzy:
von Essen MR; The Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. .
Søndergaard HB; The Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. .
Petersen ERS; The Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. .
Sellebjerg F; The Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark. .
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Źródło:
Cells [Cells] 2019 Mar 26; Vol. 8 (3). Date of Electronic Publication: 2019 Mar 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Signal Transduction*
Interleukins/*metabolism
Lymphocytes/*immunology
Multiple Sclerosis/*genetics
Multiple Sclerosis/*immunology
STAT Transcription Factors/*metabolism
Adult ; Alleles ; Case-Control Studies ; Cross-Priming/immunology ; Female ; Humans ; Interleukin-12/metabolism ; Interleukin-23/metabolism ; Interleukin-6/metabolism ; Male ; Middle Aged ; Receptors, Interleukin/metabolism ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Short-chain fatty acids and gut microbiota in multiple sclerosis.
Autorzy:
Melbye P; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Olsson A; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hansen TH; Faculty of Health Sciences, Section for Metabolic Genetics, Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Søndergaard HB; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Bang Oturai A; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
Acta neurologica Scandinavica [Acta Neurol Scand] 2019 Mar; Vol. 139 (3), pp. 208-219. Date of Electronic Publication: 2018 Dec 03.
Typ publikacji:
Journal Article; Systematic Review
MeSH Terms:
Fatty Acids, Volatile*
Gastrointestinal Microbiome/*physiology
Multiple Sclerosis/*immunology
Multiple Sclerosis/*microbiology
Animals ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/microbiology ; Humans ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bone microarchitecture and bone mineral density in multiple sclerosis.
Autorzy:
Olsson A; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Oturai AB; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Søndergaard HB; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Sellebjerg F; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Oturai PS; Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark.
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Źródło:
Acta neurologica Scandinavica [Acta Neurol Scand] 2018 Mar; Vol. 137 (3), pp. 363-369. Date of Electronic Publication: 2017 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Density*
Bone and Bones/*pathology
Image Interpretation, Computer-Assisted/*methods
Multiple Sclerosis/*pathology
Absorptiometry, Photon ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Regression Analysis ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of Suitable Reference Genes for Peripheral Blood Mononuclear Cell Subset Studies in Multiple Sclerosis.
Autorzy:
Oturai DB; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Søndergaard HB; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Börnsen L; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Sellebjerg F; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Christensen JR; Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
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Źródło:
Scandinavian journal of immunology [Scand J Immunol] 2016 Jan; Vol. 83 (1), pp. 72-80.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukocytes, Mononuclear*
Gene Expression Profiling/*standards
Multiple Sclerosis, Relapsing-Remitting/*genetics
Real-Time Polymerase Chain Reaction/*standards
Flow Cytometry ; Humans ; Immunologic Factors/therapeutic use ; Interferon-beta/therapeutic use ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Reference Standards ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Class II HLA interactions modulate genetic risk for multiple sclerosis.
Autorzy:
Moutsianas L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Jostins L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Beecham AH; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Dilthey AT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Xifara DK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Ban M; Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Shah TS; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Patsopoulos NA; Program in Translational NeuroPsychiatric Genomics, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard University and MIT, Cambridge, Massachusetts, USA.
Alfredsson L; Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden.
Anderson CA; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Attfield KE; Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Baranzini SE; Department of Neurology, University of California, San Francisco, Sandler Neurosciences Center, San Francisco, California, USA.
Barrett J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Binder TMC; HLA Laboratory, Department of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Booth D; Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.
Buck D; Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Celius EG; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway.
Cotsapas C; Program in Medical and Population Genetics, Broad Institute of Harvard University and MIT, Cambridge, Massachusetts, USA.; Department of Neurology and Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
D'Alfonso S; Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Dendrou CA; Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Donnelly P; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Dubois B; Department of Neurosciences, Laboratory for Neuroimmunology, KU Leuven, Leuven, Belgium.
Fontaine B; INSERM, Université Pierre et Marie Curie, CNRS, Assistance Publique-Hôpitaux de Paris (AP-HP), Département des Maladies du Système Nerveux and UMRS 1127-7225, Institut Cerveau Moelle Spinal Cord and Brain Institute, Pitié-Salpêtrière, Paris, France.
Fugger L; Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Goris A; Department of Neurosciences, Laboratory for Neuroimmunology, KU Leuven, Leuven, Belgium.
Gourraud PA; Department of Neurology, University of California, San Francisco, Sandler Neurosciences Center, San Francisco, California, USA.
Graetz C; Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University-Medical Center, Mainz, Germany.
Hemmer B; Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.
Hillert J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Kockum I; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Leslie S; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne, Victoria, Australia.; Department of Mathematics and Statistics, University of Melbourne, Parkville, Melbourne, Victoria, Australia.
Lill CM; Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University-Medical Center, Mainz, Germany.; Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.
Martinelli-Boneschi F; Laboratory of Genetics of Neurological Complex Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.; Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
Oksenberg JR; Department of Neurology, University of California, San Francisco, Sandler Neurosciences Center, San Francisco, California, USA.
Olsson T; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Oturai A; Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital, Copenhagen, Denmark.
Saarela J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Søndergaard HB; Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital, Copenhagen, Denmark.
Spurkland A; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Taylor B; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
Winkelmann J; Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institut für Humangenetik, Technische Universität München, Munich, Germany.; Institut für Humangenetik, Helmholtz Zentrum München, Munich, Germany.; Department of Neurology and Neurological Sciences, Center for Sleep Sciences and Medicine, Stanford University, Stanford, California, USA.
Zipp F; Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University-Medical Center, Mainz, Germany.
Haines JL; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Spencer CCA; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Stewart G; Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.
Hafler DA; Program in Medical and Population Genetics, Broad Institute of Harvard University and MIT, Cambridge, Massachusetts, USA.; Department of Neurology and Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.; Broad Institute of Harvard University and MIT, Cambridge, Massachusetts, USA.
Ivinson AJ; Harvard NeuroDiscovery Center, Harvard Medical School, Boston, Massachusetts, USA.
Harbo HF; Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway.; University of Oslo, Oslo, Norway.
Hauser SL; Department of Neurology, University of California, San Francisco, Sandler Neurosciences Center, San Francisco, California, USA.
De Jager PL; Program in Translational NeuroPsychiatric Genomics, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard University and MIT, Cambridge, Massachusetts, USA.
Compston A; Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
McCauley JL; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA.
Sawcer S; Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
McVean G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
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Corporate Authors:
International IBD Genetics Consortium (IIBDGC)
Źródło:
Nature genetics [Nat Genet] 2015 Oct; Vol. 47 (10), pp. 1107-1113. Date of Electronic Publication: 2015 Sep 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Histocompatibility Antigens Class II/*immunology
Multiple Sclerosis/*genetics
Alleles ; Epistasis, Genetic ; Histocompatibility Antigens Class II/genetics ; Humans ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosis.
Autorzy:
Börnsen L; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Romme Christensen J; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ratzer R; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hedegaard C; Institute for Inflammation Research, Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Krakauer M; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hesse D; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Nielsen CH; Institute for Inflammation Research, Department of Rheumatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Sorensen PS; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
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Źródło:
PloS one [PLoS One] 2015 Mar 04; Vol. 10 (3), pp. e0118830. Date of Electronic Publication: 2015 Mar 04 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes/*drug effects
Interferon-beta/*metabolism
Interferon-beta/*pharmacology
Multiple Sclerosis/*immunology
Myelin Basic Protein/*metabolism
Adult ; Biomarkers/metabolism ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Proliferation/drug effects ; Female ; Gene Expression Regulation/drug effects ; Humans ; Interferon Type I/pharmacology ; Interleukin-10/pharmacology ; Intracellular Space/drug effects ; Intracellular Space/metabolism ; Male ; Monocytes/cytology ; Monocytes/drug effects ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/drug effects ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Prediction of response to interferon therapy in multiple sclerosis.
Autorzy:
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Søndergaard HB
Koch-Henriksen N
Sørensen PS
Oturai AB
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Źródło:
Acta neurologica Scandinavica [Acta Neurol Scand] 2014 Oct; Vol. 130 (4), pp. 268-75. Date of Electronic Publication: 2014 Jun 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease/*genetics
Glypicans/*genetics
Interferon Regulatory Factors/*genetics
Multiple Sclerosis, Relapsing-Remitting/*genetics
Adult ; Disease Progression ; Female ; Humans ; Interferon-beta/therapeutic use ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Polymorphism, Single Nucleotide ; Recurrence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.
Autorzy:
Sundqvist E; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Buck D; Department of Neurology, Technische Universität München, Munich, Germany.
Warnke C; The Multiple Sclerosis Research Group, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Khademi M; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Lima Bomfim I; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Fogdell-Hahn A; The Multiple Sclerosis Research Group, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Link J; The Multiple Sclerosis Research Group, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Alfredsson L; Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Hillert J; The Multiple Sclerosis Research Group, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Oturai AB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Hemmer B
Kockum I; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Olsson T; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Pokaż więcej
Corporate Authors:
International Multiple Sclerosis Genetics Consortium
Źródło:
PLoS pathogens [PLoS Pathog] 2014 Apr 24; Vol. 10 (4), pp. e1004084. Date of Electronic Publication: 2014 Apr 24 (Print Publication: 2014).
Typ publikacji:
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Alleles*
Haplotypes*
JC Virus*
HLA-DQ beta-Chains/*genetics
HLA-DRB1 Chains/*genetics
Polyomavirus Infections/*genetics
CD4-Positive T-Lymphocytes/immunology ; Female ; HLA-DQ beta-Chains/immunology ; HLA-DRB1 Chains/immunology ; Humans ; Male ; Polyomavirus Infections/immunology ; Scandinavian and Nordic Countries
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The chemokine receptor CCR5 Δ32 allele in natalizumab-treated multiple sclerosis.
Autorzy:
Møller M; Department of Neurology, The Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Søndergaard HB
Koch-Henriksen N
Sorensen PS
Sellebjerg F
Oturai AB
Pokaż więcej
Źródło:
Acta neurologica Scandinavica [Acta Neurol Scand] 2014 Jan; Vol. 129 (1), pp. 27-31. Date of Electronic Publication: 2013 May 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal, Humanized/*therapeutic use
Multiple Sclerosis, Relapsing-Remitting/*drug therapy
Receptors, CCR5/*genetics
Adult ; Alleles ; Disease Progression ; Female ; Follow-Up Studies ; Genotype ; Humans ; Integrin alpha4beta1/antagonists & inhibitors ; Male ; Multiple Sclerosis, Relapsing-Remitting/genetics ; Natalizumab ; Prospective Studies ; Receptors, CCR5/physiology ; Sequence Deletion ; Severity of Illness Index ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
Autorzy:
Beecham AH
Patsopoulos NA
Xifara DK
Davis MF
Kemppinen A
Cotsapas C
Shah TS
Spencer C
Booth D
Goris A
Oturai A
Saarela J
Fontaine B
Hemmer B
Martin C
Zipp F
D'Alfonso S
Martinelli-Boneschi F
Taylor B
Harbo HF
Kockum I
Hillert J
Olsson T
Ban M
Oksenberg JR
Hintzen R
Barcellos LF
Agliardi C
Alfredsson L
Alizadeh M
Anderson C
Andrews R
Søndergaard HB
Baker A
Band G
Baranzini SE
Barizzone N
Barrett J
Bellenguez C
Bergamaschi L
Bernardinelli L
Berthele A
Biberacher V
Binder TM
Blackburn H
Bomfim IL
Brambilla P
Broadley S
Brochet B
Brundin L
Buck D
Butzkueven H
Caillier SJ
Camu W
Carpentier W
Cavalla P
Celius EG
Coman I
Comi G
Corrado L
Cosemans L
Cournu-Rebeix I
Cree BA
Cusi D
Damotte V
Defer G
Delgado SR
Deloukas P
di Sapio A
Dilthey AT
Donnelly P
Dubois B
Duddy M
Edkins S
Elovaara I
Esposito F
Evangelou N
Fiddes B
Field J
Franke A
Freeman C
Frohlich IY
Galimberti D
Gieger C
Gourraud PA
Graetz C
Graham A
Grummel V
Guaschino C
Hadjixenofontos A
Hakonarson H
Halfpenny C
Hall G
Hall P
Hamsten A
Harley J
Harrower T
Hawkins C
Hellenthal G
Hillier C
Hobart J
Hoshi M
Hunt SE
Jagodic M
Jelčić I
Jochim A
Kendall B
Kermode A
Kilpatrick T
Koivisto K
Konidari I
Korn T
Kronsbein H
Langford C
Larsson M
Lathrop M
Lebrun-Frenay C
Lechner-Scott J
Lee MH
Leone MA
Leppä V
Liberatore G
Lie BA
Lill CM
Lindén M
Link J
Luessi F
Lycke J
Macciardi F
Männistö S
Manrique CP
Martin R
Martinelli V
Mason D
Mazibrada G
McCabe C
Mero IL
Mescheriakova J
Moutsianas L
Myhr KM
Nagels G
Nicholas R
Nilsson P
Piehl F
Pirinen M
Price SE
Quach H
Reunanen M
Robberecht W
Robertson NP
Rodegher M
Rog D
Salvetti M
Schnetz-Boutaud NC
Sellebjerg F
Selter RC
Schaefer C
Shaunak S
Shen L
Shields S
Siffrin V
Slee M
Sorensen PS
Sorosina M
Sospedra M
Spurkland A
Strange A
Sundqvist E
Thijs V
Thorpe J
Ticca A
Tienari P
van Duijn C
Visser EM
Vucic S
Westerlind H
Wiley JS
Wilkins A
Wilson JF
Winkelmann J
Zajicek J
Zindler E
Haines JL
Pericak-Vance MA
Ivinson AJ
Stewart G
Hafler D
Hauser SL
Compston A
McVean G
De Jager P
Sawcer SJ
McCauley JL
Pokaż więcej
Corporate Authors:
International Multiple Sclerosis Genetics Consortium (IMSGC); 1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].
Wellcome Trust Case Control Consortium 2 (WTCCC2)
International IBD Genetics Consortium (IIBDGC)
Źródło:
Nature genetics [Nat Genet] 2013 Nov; Vol. 45 (11), pp. 1353-60. Date of Electronic Publication: 2013 Sep 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple Sclerosis/*genetics
Multiple Sclerosis/*immunology
Chromosome Mapping ; Gene Frequency ; Genetic Loci ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; White People/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients.
Autorzy:
Leone MA; MS Centre, SCDU Neurology, AOU Maggiore della Carità, Novara, Italy. />Barizzone N
Esposito F
Lucenti A
Harbo HF
Goris A
Kockum I
Oturai AB
Celius EG
Mero IL
Dubois B
Olsson T
Søndergaard HB
Cusi D
Lupoli S
Andreassen BK
Myhr KM
Guerini FR
Comi G
Martinelli-Boneschi F
D'Alfonso S
Pokaż więcej
Corporate Authors:
International Multiple Sclerosis Genetics Consortium
Wellcome Trust Case Control Consortium 2
PROGEMUS Group
PROGRESSO Group
Źródło:
PloS one [PLoS One] 2013 Jun 13; Vol. 8 (6), pp. e64408. Date of Electronic Publication: 2013 Jun 13 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome-Wide Association Study*
Multiple Sclerosis/*cerebrospinal fluid
Multiple Sclerosis/*genetics
Oligoclonal Bands/*cerebrospinal fluid
Adult ; Female ; Genetic Markers ; HLA-DRB1 Chains/genetics ; Humans ; Male ; Meta-Analysis as Topic ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.
Autorzy:
Mero IL; Department of Neurology, Oslo University Hospital, Ullevål, and Department of Medical Genetics, University of Oslo, Oslo, Norway.
Gustavsen MW
Sæther HS
Flåm ST
Berg-Hansen P
Søndergaard HB
Jensen PE
Berge T
Bjølgerud A
Muggerud A
Aarseth JH
Myhr KM
Celius EG
Sellebjerg F
Hillert J
Alfredsson L
Olsson T
Oturai AB
Kockum I
Lie BA
Andreassen BK
Harbo HF
Pokaż więcej
Corporate Authors:
International Multiple Sclerosis Genetics Consortium
Źródło:
PloS one [PLoS One] 2013; Vol. 8 (3), pp. e58352. Date of Electronic Publication: 2013 Mar 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome-Wide Association Study*
Multiple Sclerosis/*epidemiology
Multiple Sclerosis/*genetics
Oligoclonal Bands/*genetics
Adult ; Alleles ; Case-Control Studies ; Denmark ; Female ; Gene Frequency ; Genotype ; HLA-DRB1 Chains/genetics ; Humans ; Male ; Multiple Sclerosis/cerebrospinal fluid ; Norway ; Oligoclonal Bands/cerebrospinal fluid ; Polymorphism, Single Nucleotide ; Sweden
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis.
Autorzy:
Romme Christensen J; Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark. />Börnsen L
Hesse D
Krakauer M
Sørensen PS
Søndergaard HB
Sellebjerg F
Pokaż więcej
Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2012 Sep 14; Vol. 9, pp. 215. Date of Electronic Publication: 2012 Sep 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Cells/*metabolism
Cytokines/*metabolism
Gene Expression Regulation/*physiology
Multiple Sclerosis, Relapsing-Remitting/*metabolism
Multiple Sclerosis, Relapsing-Remitting/*pathology
Adult ; Blood Cells/classification ; Cytokines/genetics ; Female ; Humans ; Male ; Middle Aged ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Endogenous and recombinant type I interferons and disease activity in multiple sclerosis.
Autorzy:
Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. />Krakauer M
Limborg S
Hesse D
Lund H
Langkilde A
Søndergaard HB
Sørensen PS
Pokaż więcej
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (6), pp. e35927. Date of Electronic Publication: 2012 Jun 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes/*immunology
Immunotherapy/*methods
Interferon Type I/*immunology
Interferon-beta/*immunology
Multiple Sclerosis/*drug therapy
Recombinant Proteins/*immunology
Adult ; Antigens, CD/immunology ; Dendritic Cells ; Denmark ; Female ; Flow Cytometry ; HLA-DR Antigens/immunology ; Humans ; Integrin alpha4/immunology ; Interferon-beta/therapeutic use ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Monocytes ; Multiple Sclerosis/immunology ; Receptors, Transferrin/immunology ; Statistics, Nonparametric ; T-Lymphocyte Subsets/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 29

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