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Tytuł :
Antitumor Effects of a Sesquiterpene Derivative from Marine Sponge in Human Breast Cancer Cells.
Autorzy :
Bai LY; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan.; College of Medicine, China Medical University, Taichung 40402, Taiwan.
Su JH; National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan.
Chiu CF; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan.; Cancer Center, China Medical University Hospital, Taichung 40415, Taiwan.
Lin WY; Department of Pharmacy, Kinmen Hospital, Ministry of Health and Welfare, Kinmen 89142, Taiwan.
Hu JL; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
Feng CH; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Shu CW; Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Weng JR; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
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Źródło :
Marine drugs [Mar Drugs] 2021 Apr 26; Vol. 19 (5). Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Porifera/*metabolism
Quinones/*pharmacology
Sesquiterpenes/*pharmacology
Animals ; Antineoplastic Agents/isolation & purification ; Apoptosis/drug effects ; Autophagy/drug effects ; Breast Neoplasms/enzymology ; Breast Neoplasms/pathology ; Female ; Humans ; MCF-7 Cells ; Membrane Potential, Mitochondrial/drug effects ; Oxidative Stress/drug effects ; Quinones/isolation & purification ; Reactive Oxygen Species/metabolism ; S Phase Cell Cycle Checkpoints/drug effects ; Sesquiterpenes/isolation & purification ; Signal Transduction
Czasopismo naukowe
Tytuł :
The Mechanism of the Synergistic Anticancer Effect of CDDP and EPA in the TE1 Cell Line.
Autorzy :
Ogo A; Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Science, Okayama, Japan; .
Miyake S; Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Science, Okayama, Japan.
Kubota H; Department of Digestive Surgery, Kawasaki Medical School, Okayama, Japan.
Higashida M; Department of Digestive Surgery, Kawasaki Medical School, Okayama, Japan.
Matsumoto H; Mitsugi General Hospital, Hiroshima, Japan.
Teramoto F; Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Science, Okayama, Japan.
Hirai T; Mitsugi General Hospital, Hiroshima, Japan.
Ueno T; Department of Digestive Surgery, Kawasaki Medical School, Okayama, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Apr; Vol. 41 (4), pp. 1771-1778.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Cisplatin/*pharmacology
Eicosapentaenoic Acid/*pharmacology
Esophageal Neoplasms/*drug therapy
Apoptosis/drug effects ; Cell Line, Tumor ; Drug Synergism ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Interleukin-6/metabolism ; NF-kappa B/metabolism ; S Phase Cell Cycle Checkpoints/drug effects ; Signal Transduction
Czasopismo naukowe
Tytuł :
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
Autorzy :
Mao Y; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Li W; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Hua B; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Gu X; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Pan W; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Chen Q; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Xu B; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Wang Z; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Lu C; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Feb 13; Vol. 2020, pp. 2406159. Date of Electronic Publication: 2020 Feb 13 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Gene Expression Regulation, Neoplastic*
Gene Silencing*
M Phase Cell Cycle Checkpoints*
Plasminogen Activator Inhibitor 1*/biosynthesis
Plasminogen Activator Inhibitor 1*/genetics
Prostatic Neoplasms*/genetics
Prostatic Neoplasms*/metabolism
Prostatic Neoplasms*/pathology
Proto-Oncogene Proteins c-ets*/biosynthesis
Proto-Oncogene Proteins c-ets*/genetics
S Phase Cell Cycle Checkpoints*
Up-Regulation*
Animals ; Cell Line, Tumor ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude
Czasopismo naukowe
Tytuł :
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
Autorzy :
Araki R; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan. .
Hoki Y; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Suga T; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Obara C; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Sunayama M; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Imadome K; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Fujita M; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Kamimura S; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Nakamura M; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Wakayama S; Advanced Biotechnology Center, University of Yamanashi, Kofu, 400-8510, Japan.
Nagy A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, 3800, Australia.
Wakayama T; Advanced Biotechnology Center, University of Yamanashi, Kofu, 400-8510, Japan.
Abe M; Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 10; Vol. 11 (1), pp. 197. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G1 Phase Cell Cycle Checkpoints/*genetics
Induced Pluripotent Stem Cells/*metabolism
S Phase Cell Cycle Checkpoints/*genetics
Animals ; Cell Division ; Cellular Reprogramming ; Erythroblasts ; G1 Phase Cell Cycle Checkpoints/radiation effects ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/radiation effects ; Neoplasms/genetics ; Open Reading Frames ; Point Mutation ; S Phase Cell Cycle Checkpoints/radiation effects ; X-Rays
Czasopismo naukowe
Tytuł :
Checkpoint Regulation of Nuclear Tos4 Defines S Phase Arrest in Fission Yeast.
Autorzy :
Kim SM; Program in Molecular and Computational Biology, University of Southern California, Los Angeles CA 90089.
Tripathi VP; Program in Molecular and Computational Biology, University of Southern California, Los Angeles CA 90089.
Shen KF; Program in Molecular and Computational Biology, University of Southern California, Los Angeles CA 90089.
Forsburg SL; Program in Molecular and Computational Biology, University of Southern California, Los Angeles CA 90089 .
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2020 Jan 07; Vol. 10 (1), pp. 255-266. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
S Phase Cell Cycle Checkpoints*
Schizosaccharomyces pombe Proteins/*metabolism
Transcription Factors/*metabolism
Active Transport, Cell Nucleus ; Cell Nucleus/metabolism ; Checkpoint Kinase 1/genetics ; Checkpoint Kinase 1/metabolism ; DNA Replication ; Mutation ; Schizosaccharomyces ; Schizosaccharomyces pombe Proteins/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation.
Autorzy :
Ge S; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: .
Zhang Q; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: .
Chen Y; Department of Pathology, First Hospital, Lanzhou University, Lanzhou 730000, People's Republic of China.
Tian Y; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: .
Yang R; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: .
Chen X; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: .
Li F; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: .
Zhang B; Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Mar 15; Vol. 415, pp. 115450. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cell Proliferation/*drug effects
Colorectal Neoplasms/*drug therapy
DNA Methylation/*drug effects
Eukaryotic Initiation Factor-4E/*metabolism
Histones/*metabolism
Protein-Arginine N-Methyltransferases/*metabolism
Ribavirin/*pharmacology
Animals ; Colitis-Associated Neoplasms/drug therapy ; Colitis-Associated Neoplasms/enzymology ; Colitis-Associated Neoplasms/genetics ; Colitis-Associated Neoplasms/pathology ; Colorectal Neoplasms/enzymology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Down-Regulation ; Eukaryotic Initiation Factor-4E/genetics ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Mice, Inbred ICR ; Promoter Regions, Genetic ; Protein-Arginine N-Methyltransferases/genetics ; S Phase Cell Cycle Checkpoints/drug effects ; Signal Transduction ; Tumor Burden/drug effects
Czasopismo naukowe
Tytuł :
Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication.
Autorzy :
Jones MJK; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia. Electronic address: .
Gelot C; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Munk S; University of Copenhagen and Novo Nordisk Foundation Center for Protein Research, Copenhagen 2200, Denmark.
Koren A; Cornell University, Department of Molecular Biology and Genetics, Ithaca, NY 14853, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kawasoe Y; Graduate School of Science, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan.
George KA; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Santos RE; Division of Hematology/Oncology, Columbia University Medical Center, New York, NY 10032, USA.
Olsen JV; University of Copenhagen and Novo Nordisk Foundation Center for Protein Research, Copenhagen 2200, Denmark.
McCarroll SA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Frattini MG; Division of Hematology/Oncology, Columbia University Medical Center, New York, NY 10032, USA.
Takahashi TS; Graduate School of Science, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan.
Jallepalli PV; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 426-441.e8.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Replication*/drug effects
Replication Origin*
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Checkpoint Kinase 1/genetics ; Checkpoint Kinase 1/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; HCT116 Cells ; HEK293 Cells ; HeLa Cells ; Humans ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; S Phase Cell Cycle Checkpoints ; Substrate Specificity ; Time Factors ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Adipose-Derived Stem Cells Inhibited the Proliferation of Bladder Tumor Cells by S Phase Arrest and Wnt/β-Catenin Pathway.
Autorzy :
Wang T; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Yu X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Lin J; Department of Urology, Peking University First Hospital, Beijing, China.
Qin C; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Bai T; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Xu T; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Wang L; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Liu X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Li S; Department of Radiography, Renmin Hospital of Wuhan University, Wuhan, China.
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Źródło :
Cellular reprogramming [Cell Reprogram] 2019 Dec; Vol. 21 (6), pp. 331-338.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
S Phase Cell Cycle Checkpoints*
Wnt Signaling Pathway*
Adipose Tissue/*metabolism
Stem Cells/*metabolism
Urinary Bladder Neoplasms/*metabolism
Adipose Tissue/pathology ; Cell Line, Tumor ; Coculture Techniques ; Humans ; Neoplasm Proteins/metabolism ; Stem Cells/pathology ; Urinary Bladder Neoplasms/pathology ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions.
Autorzy :
Michelena J; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Gatti M; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Teloni F; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Molecular Life Sciences Program, Life Science Zurich Graduate School, Zurich, Switzerland.
Imhof R; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Altmeyer M; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland .
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Źródło :
The Journal of cell biology [J Cell Biol] 2019 Sep 02; Vol. 218 (9), pp. 2865-2875. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genomic Instability*
Proteolysis*
S Phase Cell Cycle Checkpoints*
Ubiquitination*
Checkpoint Kinase 1/*metabolism
Antigens, Surface/genetics ; Antigens, Surface/metabolism ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Survival ; Checkpoint Kinase 1/genetics ; Enzyme Stability/genetics ; HeLa Cells ; Humans
Czasopismo naukowe
Tytuł :
Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats.
Autorzy :
Li X; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Jin X; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Lin'an, Hangzhou, China.; Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan, Gothenburg, Sweden.
Sharma S; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
Liu X; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Zhang J; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Niu Y; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Li J; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Li Z; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Zhang J; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Cao Q; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Hou W; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
Du LL; National Institute of Biological Sciences, Beijing, China.
Liu B; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Lin'an, Hangzhou, China.; Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan, Gothenburg, Sweden.
Lou H; State Key Laboratory of Agro-Biotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, P.R. China.
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Źródło :
PLoS genetics [PLoS Genet] 2019 Aug 05; Vol. 15 (8), pp. e1008136. Date of Electronic Publication: 2019 Aug 05 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Gene Expression Regulation, Fungal/*physiology
Glycogen Synthase Kinase 3/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
S Phase Cell Cycle Checkpoints/*genetics
Saccharomyces cerevisiae/*physiology
Saccharomyces cerevisiae Proteins/*metabolism
Cell Cycle Proteins/genetics ; DNA Damage ; DNA Replication/drug effects ; Gene Expression Regulation, Fungal/drug effects ; Gene Knockout Techniques ; Glycogen Synthase Kinase 3/genetics ; Hydroxyurea/toxicity ; Nucleotides/metabolism ; Phosphorylation ; Promoter Regions, Genetic/genetics ; Protein-Serine-Threonine Kinases/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Ribonucleotide Reductases/genetics ; Ribonucleotide Reductases/metabolism ; S Phase Cell Cycle Checkpoints/drug effects ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
High temperature suppressed SSC self-renewal through S phase cell cycle arrest but not apoptosis.
Autorzy :
Wang J; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, and Key Laboratory of Reproduction and Genetics of Ningxia Hui Autonomous Region, Department of Anatomy, Histology and Embryology, School of Basic Medical Science, Ningxia Medical University, Yinchuan, 750004, China.
Gao WJ; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, and Key Laboratory of Reproduction and Genetics of Ningxia Hui Autonomous Region, Department of Anatomy, Histology and Embryology, School of Basic Medical Science, Ningxia Medical University, Yinchuan, 750004, China.
Deng SL; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
Liu X; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, and Key Laboratory of Reproduction and Genetics of Ningxia Hui Autonomous Region, Department of Anatomy, Histology and Embryology, School of Basic Medical Science, Ningxia Medical University, Yinchuan, 750004, China.
Jia H; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, and Key Laboratory of Reproduction and Genetics of Ningxia Hui Autonomous Region, Department of Anatomy, Histology and Embryology, School of Basic Medical Science, Ningxia Medical University, Yinchuan, 750004, China. .; Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. .
Ma WZ; Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, and Key Laboratory of Reproduction and Genetics of Ningxia Hui Autonomous Region, Department of Anatomy, Histology and Embryology, School of Basic Medical Science, Ningxia Medical University, Yinchuan, 750004, China. .; Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2019 Jul 29; Vol. 10 (1), pp. 227. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
S Phase Cell Cycle Checkpoints*
Stem Cells/*cytology
Animals ; Cell Proliferation ; Cell Self Renewal ; Janus Kinases/metabolism ; Male ; Mice ; STAT Transcription Factors/metabolism ; Signal Transduction ; Spermatogonia/cytology ; Stem Cells/metabolism ; Temperature
Czasopismo naukowe
Tytuł :
Knockdown of MSI1 inhibits the proliferation of human oral squamous cell carcinoma by inactivating STAT3 signaling.
Autorzy :
Wang CF; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Zhang HC; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Feng XM; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 216000, P.R. China.
Song XM; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Wu YN; Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2019 Jul; Vol. 44 (1), pp. 115-124. Date of Electronic Publication: 2019 May 06.
Typ publikacji :
Journal Article
MeSH Terms :
S Phase Cell Cycle Checkpoints*
Signal Transduction*
Carcinoma, Squamous Cell/*metabolism
Mouth Neoplasms/*metabolism
Neoplasm Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
RNA-Binding Proteins/*metabolism
STAT3 Transcription Factor/*metabolism
Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Female ; Gene Knockdown Techniques ; Humans ; Male ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Neoplasm Proteins/genetics ; Nerve Tissue Proteins/genetics ; RNA-Binding Proteins/genetics ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Palmitoylation of Membrane-Penetrating Magainin Derivatives Reinforces Necroptosis in A549 Cells Dependent on Peptide Conformational Propensities.
Autorzy :
Behzadi M; Peptide Chemistry Laboratory, Institute of Biochemistry and Biophysics, University of Tehran, 16 Azar Street, 14176-14335 Tehran, Iran.
Arasteh S; Peptide Chemistry Laboratory, Institute of Biochemistry and Biophysics, University of Tehran, 16 Azar Street, 14176-14335 Tehran, Iran.
Bagheri M; Peptide Chemistry Laboratory, Institute of Biochemistry and Biophysics, University of Tehran, 16 Azar Street, 14176-14335 Tehran, Iran.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Dec 23; Vol. 12 (51), pp. 56815-56829. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cell-Penetrating Peptides/*pharmacology
Magainins/*pharmacology
Necroptosis/*drug effects
A549 Cells ; Amino Acid Sequence ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/toxicity ; CHO Cells ; Cell-Penetrating Peptides/chemistry ; Cell-Penetrating Peptides/toxicity ; Cricetulus ; Drug Screening Assays, Antitumor ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; Lipoylation ; Magainins/chemistry ; Magainins/toxicity ; Protein Structure, Secondary ; S Phase Cell Cycle Checkpoints/drug effects
Czasopismo naukowe
Tytuł :
Temozolomide treatment combined with AZD3463 shows synergistic effect in glioblastoma cells.
Autorzy :
Goker Bagca B; Ege University, Medical Faculty, Department of Medical Biology, Bornova, 35100, Izmir, Turkey.
Ozates NP; Ege University, Medical Faculty, Department of Medical Biology, Bornova, 35100, Izmir, Turkey.
Asik A; Ege University, Medical Faculty, Department of Medical Biology, Bornova, 35100, Izmir, Turkey.
Caglar HO; Ege University, Health Science Institute, Department of Stem Cell, Bornova, 35100, Izmir, Turkey.
Gunduz C; Ege University, Medical Faculty, Department of Medical Biology, Bornova, 35100, Izmir, Turkey.
Biray Avci C; Ege University, Medical Faculty, Department of Medical Biology, Bornova, 35100, Izmir, Turkey. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 17; Vol. 533 (4), pp. 1497-1504. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
Anaplastic Lymphoma Kinase/*antagonists & inhibitors
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Protein Kinase Inhibitors/*administration & dosage
Temozolomide/*administration & dosage
Apoptosis/drug effects ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Down-Regulation/drug effects ; Drug Resistance, Neoplasm ; Drug Synergism ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; S Phase Cell Cycle Checkpoints/drug effects ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.
Autorzy :
Chen L; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wang X; The State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Cheng H; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhang W; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Liu Y; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zeng W; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yu L; The State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China.
Huang C; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: .
Liu G; Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 17; Vol. 533 (4), pp. 1162-1169. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Cyclin-Dependent Kinase 4/*metabolism
Cyclins/*metabolism
G1 Phase Cell Cycle Checkpoints/*genetics
Liver Neoplasms/*metabolism
Retinoblastoma Protein/*metabolism
S Phase Cell Cycle Checkpoints/*genetics
Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/mortality ; Cell Cycle Checkpoints/genetics ; Cyclin A/genetics ; Cyclin A/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; Humans ; Immunohistochemistry ; Liver Neoplasms/genetics ; Liver Neoplasms/mortality ; Phosphorylation ; Prognosis ; Retinoblastoma Protein/antagonists & inhibitors ; Signal Transduction ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer.
Autorzy :
Veena MS; Department of Surgery, VAGLAHS West Los Angeles and David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Raychaudhuri S; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Basak SK; Department of Surgery, VAGLAHS West Los Angeles and David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Venkatesan N; Department of Surgery, VAGLAHS West Los Angeles and David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Kumar P; Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Biswas R; Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Chakrabarti R; Department of Surgery, VAGLAHS West Los Angeles and David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Lu J; Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California, USA.
Su T; Institute for Quantitative and Computational Biology and Department of Biological Chemistry, UCLA, Los Angeles, California, USA.
Gallagher-Jones M; Department of Chemistry and Biochemistry, UCLA, Los Angeles, California, USA.
Morselli M; Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California, USA.
Fu H; Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA.
Pellegrini M; Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California, USA.
Goldstein T; Institute of Computational Sciences, University of California San Francisco, San Francisco, California, USA.
Aladjem MI; Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA.
Rettig MB; Department of Medicine, VAGLAHS/David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Wilczynski SP; Department of Pathology, City of Hope Medical Center, Duarte, California, USA.
Shin DS; Department of Medicine, VAGLAHS/David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Srivatsan ES; Department of Surgery, VAGLAHS West Los Angeles and David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 11; Vol. 295 (50), pp. 17169-17186. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Damage*
Drug Resistance, Neoplasm*
MicroRNAs/*metabolism
RNA, Neoplasm/*metabolism
Uterine Cervical Neoplasms/*metabolism
Vesicular Transport Proteins/*metabolism
Female ; G1 Phase ; HeLa Cells ; Humans ; MicroRNAs/genetics ; RNA, Neoplasm/genetics ; S Phase Cell Cycle Checkpoints ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology ; Vesicular Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Single-cell sequencing reveals novel mechanisms of Aflatoxin B1-induced hepatotoxicity in S phase-arrested L02 cells.
Autorzy :
Zhang B; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.
Dai Y; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.
Zhu L; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.
He X; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.; Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture and Rural Affairs, Beijing, 100083, China.
Huang K; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.; Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture and Rural Affairs, Beijing, 100083, China.
Xu W; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China. .; Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture and Rural Affairs, Beijing, 100083, China. .
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Źródło :
Cell biology and toxicology [Cell Biol Toxicol] 2020 Dec; Vol. 36 (6), pp. 603-608. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Profiling*
RNA-Seq*
Single-Cell Analysis*
Aflatoxin B1/*toxicity
DNA Methylation/*drug effects
Hepatocytes/*drug effects
S Phase Cell Cycle Checkpoints/*drug effects
Transcriptome/*drug effects
Apoptosis/drug effects ; Cell Line ; Gene Regulatory Networks/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/genetics ; Mitochondria, Liver/metabolism ; Mitochondria, Liver/pathology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Autorzy :
Wei M; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Xie M; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Zhang Z; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Wei Y; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Zhang J; Department of Hematology and Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Xueyuan AVE 1098, Nanshan District, Shenzhen, Guangdong, 518000, PR China.
Pan H; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, PR China.
Li B; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Wang J; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Song Y; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Chong C; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Zhao R; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China.
Wang J; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, PR China. Electronic address: .
Yu L; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, PR China. Electronic address: .
Yang G; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China. Electronic address: .
Yang C; The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin, 300071, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Nov 15; Vol. 206, pp. 112677. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Breast Neoplasms/*pathology
Flavones/*chemistry
Histone Deacetylase Inhibitors/*chemistry
Histone Deacetylase Inhibitors/*pharmacology
STAT3 Transcription Factor/*metabolism
Acetylation/drug effects ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Chemistry Techniques, Synthetic ; Dose-Response Relationship, Drug ; G1 Phase Cell Cycle Checkpoints/drug effects ; Histone Deacetylase Inhibitors/chemical synthesis ; Histones/metabolism ; Humans ; S Phase Cell Cycle Checkpoints/drug effects ; Signal Transduction/drug effects ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Molecular mechanism of the MORC4 ATPase activation.
Autorzy :
Tencer AH; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Cox KL; Department of Physics, Ohio State University, Columbus, OH, 43210, USA.
Wright GM; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Zhang Y; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Petell CJ; Department of Biochemistry & Biophysics, the University of North Carolina School of Medicine, and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 27599, USA.
Klein BJ; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Strahl BD; Department of Biochemistry & Biophysics, the University of North Carolina School of Medicine, and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 27599, USA.
Black JC; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Poirier MG; Department of Physics, Ohio State University, Columbus, OH, 43210, USA.
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 29; Vol. 11 (1), pp. 5466. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Proteins*/chemistry
Nuclear Proteins*/metabolism
Adenosine Triphosphatases/*metabolism
Binding Sites ; Cell Cycle ; Crystallography, X-Ray ; DNA/metabolism ; HEK293 Cells ; Histones/metabolism ; Humans ; Intranuclear Inclusion Bodies/metabolism ; Nucleosomes/metabolism ; Protein Binding ; Protein Domains/physiology ; S Phase Cell Cycle Checkpoints ; Spectrometry, Fluorescence ; Transcription Factors/metabolism ; Zinc Finger Nucleases/chemistry ; Zinc Finger Nucleases/metabolism
Czasopismo naukowe
Tytuł :
Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells.
Autorzy :
Lee SH; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA.
Lee J; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA.
Herald T; Agricultural Research Service, U.S. Department of Agriculture, Center for Grain and Animal Health Research, Manhattan, KS 66502, USA.
Cox S; Agricultural Research Service, U.S. Department of Agriculture, Center for Grain and Animal Health Research, Manhattan, KS 66502, USA.
Noronha L; Agricultural Research Service, U.S. Department of Agriculture, Center for Grain and Animal Health Research, Manhattan, KS 66502, USA.
Perumal R; Kansas State University, Agricultural Research Center, Hays, KS, USA.
Lee HS; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA.
Smolensky D; Agricultural Research Service, U.S. Department of Agriculture, Center for Grain and Animal Health Research, Manhattan, KS 66502, USA.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Oct 02; Vol. 2020, pp. 2890536. Date of Electronic Publication: 2020 Oct 02 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Cell Proliferation/*drug effects
Phenols/*pharmacology
Sorghum/*chemistry
Activating Transcription Factor 3/genetics ; Activating Transcription Factor 3/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; DNA Damage/drug effects ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases/genetics ; JNK Mitogen-Activated Protein Kinases/metabolism ; Phenols/isolation & purification ; Plant Extracts/chemistry ; S Phase Cell Cycle Checkpoints/drug effects ; Sorghum/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe

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