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Wyszukujesz frazę ""S-Adenosylmethionine"" wg kryterium: Temat


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Tytuł :
Rapid analysis of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) isotopologues in stable isotope-resolved metabolomics (SIRM) using direct infusion nanoelectrospray ultra-high-resolution Fourier transform mass spectrometry (DI-nESI-UHR-FTMS).
Autorzy :
Yang J; Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, USA.
Fan TWM; Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, USA. Electronic address: .
Brandon JA; Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, USA.
Lane AN; Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, USA.
Higashi RM; Center for Environmental and Systems Biochemistry (CESB), Markey Cancer Center, Department of Toxicology and Cancer Biology, University of Kentucky, USA. Electronic address: .
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2021 Oct 09; Vol. 1181, pp. 338873. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
S-Adenosylhomocysteine*
S-Adenosylmethionine*
Adaptor Proteins, Signal Transducing ; Animals ; Epigenesis, Genetic ; Fourier Analysis ; Isotopes ; Mass Spectrometry ; Metabolomics ; Mice
Czasopismo naukowe
Tytuł :
Identification of methionine adenosyltransferase with high diastereoselectivity for biocatalytic synthesis of (S)-S-adenosyl-l-methionine and exploring its relationship with fluorinated biosynthetic pathway.
Autorzy :
Ren S; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Laboratory of Metabolic Control Fermentation Technology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Cheng X; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Laboratory of Metabolic Control Fermentation Technology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China. Electronic address: .
Ma L; State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Laboratory of Metabolic Control Fermentation Technology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China. Electronic address: .
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Źródło :
Enzyme and microbial technology [Enzyme Microb Technol] 2021 Oct; Vol. 150, pp. 109881. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Methionine Adenosyltransferase*/genetics
Methionine Adenosyltransferase*/metabolism
S-Adenosylmethionine*/metabolism
Biosynthetic Pathways ; Methionine/metabolism ; Molecular Docking Simulation ; Streptomyces
SCR Organism :
Streptomyces xinghaiensis
Czasopismo naukowe
Tytuł :
Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product.
Autorzy :
Caruso A; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Seyedsayamdost MR; Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.; Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Aug 20; Vol. 86 (16), pp. 11284-11289. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Products*
S-Adenosylmethionine*
Amino Acid Sequence ; Peptides ; Ribosomes
Czasopismo naukowe
Tytuł :
Profiling and Validation of Live-Cell Protein Methylation with Engineered Enzymes and Methionine Analogues.
Autorzy :
Weiss N; BCMB Allied Program, Weill Cornell Medical College, Cornell University, New York, New York.
Seneviranthe C; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Jiang M; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, New York.
Wang K; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Luo M; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, New York.
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Źródło :
Current protocols [Curr Protoc] 2021 Aug; Vol. 1 (8), pp. e213.
Typ publikacji :
Journal Article
MeSH Terms :
Methionine*
S-Adenosylmethionine*/metabolism
Humans ; Methylation ; Protein Methyltransferases/metabolism ; Protein-Arginine N-Methyltransferases/genetics ; Proteome/metabolism ; Repressor Proteins
Czasopismo naukowe
Tytuł :
Duodenal-jejunal bypass maintains hepatic S-adenosylmethionine/S-homocysteine ratio in diet-induced obese rats.
Autorzy :
Kim M; Department of Biochemistry, School of Medicine, Keimyung University, Daegu, Republic of Korea.
Rho Y; Department of Biochemistry, School of Medicine, Keimyung University, Daegu, Republic of Korea.
Park R; Department of Biochemistry, Brandeis University, Waltham, Massachusetts.
Jung J; Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Hwang GS; Integrated Metabolomics Research Group, Seoul Western Center, Korea Basic Science Institute, Seoul, Republic Korea.
Seo YK; Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul, Republic Korea.
Seo JH; Department of Biochemistry, School of Medicine, Keimyung University, Daegu, Republic of Korea.
Heo Y; Department of Surgery, Inha University Hospital, Incheon, Republic Korea.
Ha TK; Department of Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Ha E; Department of Biochemistry, School of Medicine, Keimyung University, Daegu, Republic of Korea. Electronic address: .
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Źródło :
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery [Surg Obes Relat Dis] 2021 Jul; Vol. 17 (7), pp. 1359-1368. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Homocysteine*
S-Adenosylmethionine*
Animals ; Diet, High-Fat ; Duodenum ; Jejunum ; Liver ; Mice ; Obesity/etiology ; Obesity/surgery ; Phosphatidylethanolamine N-Methyltransferase ; Rats
Czasopismo naukowe
Tytuł :
Crystal Structure and Regiospecificity of Catechol O -Methyltransferase from Niastella koreensis .
Autorzy :
Lee SH; School of Life Sciences, KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea.; KNU Institute for Microorganisms, Kyungpook National University, Daegu 41566, Republic of Korea.
Kim B; School of Life Sciences, KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea.; KNU Institute for Microorganisms, Kyungpook National University, Daegu 41566, Republic of Korea.
Kim KJ; School of Life Sciences, KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea.; KNU Institute for Microorganisms, Kyungpook National University, Daegu 41566, Republic of Korea.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Mar 03; Vol. 69 (8), pp. 2531-2538. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Catechol O-Methyltransferase*/genetics
Catechol O-Methyltransferase*/metabolism
S-Adenosylmethionine*
Bacteroidetes ; Substrate Specificity
SCR Organism :
Niastella koreensis
Czasopismo naukowe
Tytuł :
Biosynthesis of Oxetanocin-A Includes a B 12 -Dependent Radical SAM Enzyme That Can Catalyze both Oxidative Ring Contraction and the Demethylation of SAM.
Autorzy :
Zhong A
Lee YH
Liu YN
Liu HW
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Źródło :
Biochemistry [Biochemistry] 2021 Feb 23; Vol. 60 (7), pp. 537-546. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenine/*analogs & derivatives
S-Adenosylmethionine/*chemistry
Adenine/biosynthesis ; Adenine/metabolism ; Biocatalysis ; Catalysis ; Demethylation ; Methylation ; Oxidative Stress ; Phosphoric Monoester Hydrolases/metabolism ; S-Adenosylhomocysteine/metabolism ; S-Adenosylmethionine/metabolism
Czasopismo naukowe
Tytuł :
Crystal structure of a S-adenosyl-L-methionine-dependent O-methyltransferase-like enzyme from Aspergillus flavus.
Autorzy :
Liao L; Shandong Provincial Key Laboratory of Microbial Engineering, College of Bioengineering, Qilu University of Technology, Jinan, China.; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Zhou Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Peng T; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Guo Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Zhao Y; Department of Resources Science of Traditional Chinese Medicines and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, P. R. China.
Zeng Z; Shandong Provincial Key Laboratory of Microbial Engineering, College of Bioengineering, Qilu University of Technology, Jinan, China.
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Źródło :
Proteins [Proteins] 2021 Feb; Vol. 89 (2), pp. 185-192. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aspergillus flavus/*enzymology
Fungal Proteins/*chemistry
Methyltransferases/*chemistry
S-Adenosylhomocysteine/*chemistry
S-Adenosylmethionine/*chemistry
Amino Acid Sequence ; Aspergillus flavus/chemistry ; Aspergillus flavus/classification ; Catalytic Domain ; Crystallography, X-Ray ; Evolution, Molecular ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression ; Hydrogen Bonding ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Models, Molecular ; Phylogeny ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; S-Adenosylhomocysteine/metabolism ; S-Adenosylmethionine/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Structure-Activity Relationship ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product.
Autorzy :
Cameron BR; MSI Methylation Sciences Inc, Suite 300, 15300 Croydon Drive, Surrey, BC, V3Z 0Z5, Canada.
Ferreira L; MSI Methylation Sciences Inc, Suite 300, 15300 Croydon Drive, Surrey, BC, V3Z 0Z5, Canada.
MacDonald ID; MSI Methylation Sciences Inc, Suite 300, 15300 Croydon Drive, Surrey, BC, V3Z 0Z5, Canada. .
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Źródło :
BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2020 Dec 14; Vol. 21 (1), pp. 88. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dietary Supplements*
Drug Compounding/*methods
Food-Drug Interactions/*physiology
S-Adenosylmethionine/*administration & dosage
S-Adenosylmethionine/*pharmacokinetics
Administration, Oral ; Adult ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Fasting/metabolism ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; S-Adenosylmethionine/chemistry ; Young Adult
Czasopismo naukowe
Tytuł :
Mg-protoporphyrin IX monomethyl ester cyclase from Rhodobacter capsulatus: radical SAM-dependent synthesis of the isocyclic ring of bacteriochlorophylls.
Autorzy :
Wiesselmann M; Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany.
Hebecker S; Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany.
Borrero-de Acuña JM; Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany.
Nimtz M; Cellular Proteome Research, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany.
Bollivar D; Department of Biology, Illinois Wesleyan University, Bloomington, IL 61702-2900, U.S.A.
Jänsch L; Cellular Proteome Research, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany.
Moser J; Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany.
Jahn D; Braunschweig Centre of Integrated Systems Biology, Technische Universität Braunschweig, Rebenring 56, D-38106 Braunschweig, Germany.
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Źródło :
The Biochemical journal [Biochem J] 2020 Dec 11; Vol. 477 (23), pp. 4635-4654.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Bacteriochlorophylls*/biosynthesis
Bacteriochlorophylls*/chemistry
Bacteriochlorophylls*/genetics
Oxygenases*/chemistry
Oxygenases*/genetics
Oxygenases*/metabolism
Protoporphyrins*/biosynthesis
Protoporphyrins*/chemistry
Protoporphyrins*/genetics
Rhodobacter capsulatus*/chemistry
Rhodobacter capsulatus*/genetics
Rhodobacter capsulatus*/metabolism
S-Adenosylmethionine*/chemistry
S-Adenosylmethionine*/metabolism
Czasopismo naukowe
Tytuł :
An Enzyme Containing the Conserved Domain of Unknown Function DUF62 Acts as a Stereoselective (R s ,S c )-S-Adenosylmethionine Hydrolase.
Autorzy :
Kornfuehrer T; Department of Pharmaceutical Sciences and, Center for Biomolecular Sciences, University of Illinois, Chicago, IL 60607, USA.
Romanowski S; Department of Pharmaceutical Sciences and, Center for Biomolecular Sciences, University of Illinois, Chicago, IL 60607, USA.
de Crécy-Lagard V; Department of Microbiology and Cell Science and, Genetics Institute, University of Florida, Gainesville, FL 32611, USA.
Hanson AD; Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA.
Eustáquio AS; Department of Pharmaceutical Sciences and, Center for Biomolecular Sciences, University of Illinois, Chicago, IL 60607, USA.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2020 Dec 11; Vol. 21 (24), pp. 3495-3499. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Hydrolases/*metabolism
S-Adenosylmethionine/*metabolism
Hydrolases/chemistry ; Micromonosporaceae/enzymology ; Molecular Structure ; S-Adenosylmethionine/chemistry ; Stereoisomerism
SCR Organism :
Salinispora tropica
Czasopismo naukowe
Tytuł :
S-adenosylmethionine induces apoptosis and cycle arrest of gallbladder carcinoma cells by suppression of JAK2/STAT3 pathways.
Autorzy :
Liu Y; Department of Surgery for Vascular Thyroid and Hernia, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China.
Bi T; Department of Gastroenterology, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China.
Yuan F; Department of Surgery for Vascular Thyroid and Hernia, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China.
Gao X; Department of Surgery for Vascular Thyroid and Hernia, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China.
Jia G; Department of Surgery for Vascular Thyroid and Hernia, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China. .
Tian Z; Department of Surgery for Vascular Thyroid and Hernia, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China. .
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Źródło :
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2020 Dec; Vol. 393 (12), pp. 2507-2515. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cell Cycle Checkpoints/*drug effects
Gallbladder Neoplasms/*drug therapy
Janus Kinase 2/*antagonists & inhibitors
S-Adenosylmethionine/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Cell Cycle Checkpoints/physiology ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Gallbladder Neoplasms/metabolism ; Humans ; Janus Kinase 2/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; S-Adenosylmethionine/therapeutic use ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism.
Autorzy :
Bhatia M; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India.
Thakur J; BioX Center, School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.
Suyal S; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India.
Oniel R; Institute for Stem Cell Science and Regenerative Medicine (inStem), NCBS-TIFR Campus, Bangalore, India.
Chakraborty R; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, New Delhi, India.
Pradhan S; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, New Delhi, India.
Sharma M; Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India.
Sengupta S; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, New Delhi, India.
Laxman S; Institute for Stem Cell Science and Regenerative Medicine (inStem), NCBS-TIFR Campus, Bangalore, India.
Masakapalli SK; BioX Center, School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.
Bachhawat AK; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Nov 20; Vol. 295 (47), pp. 16037-16057. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*chemistry
Methylenetetrahydrofolate Reductase (NADPH2)/*chemistry
S-Adenosylmethionine/*chemistry
Saccharomyces cerevisiae/*enzymology
Saccharomyces cerevisiae Proteins/*chemistry
Adenosine Triphosphate/genetics ; Adenosine Triphosphate/metabolism ; Allosteric Regulation ; Humans ; Methylation ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Methylenetetrahydrofolate Reductase (NADPH2)/metabolism ; S-Adenosylmethionine/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Therapeutic Potential of the Natural Compound S-Adenosylmethionine as a Chemoprotective Synergistic Agent in Breast, and Head and Neck Cancer Treatment: Current Status of Research.
Autorzy :
Mosca L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Vitiello F; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Coppola A; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Borzacchiello L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Ilisso CP; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Pagano M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Caraglia M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Cacciapuoti G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
Porcelli M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via L. De Crecchio 7, 80138 Naples, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 13; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/metabolism
Head and Neck Neoplasms*/pathology
Squamous Cell Carcinoma of Head and Neck*/drug therapy
Squamous Cell Carcinoma of Head and Neck*/metabolism
Squamous Cell Carcinoma of Head and Neck*/pathology
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
S-Adenosylmethionine/*therapeutic use
Drug Synergism ; Female ; Humans ; Male ; Neoplasm Metastasis ; S-Adenosylmethionine/agonists
Czasopismo naukowe
Tytuł :
Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of S -Adenosylmethionine in Radical SAM Enzymes.
Autorzy :
Impano S; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Yang H; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Jodts RJ; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Pagnier A; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Swimley R; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
McDaniel EC; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Shepard EM; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Broderick WE; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Broderick JB; Department of Chemistry & Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Hoffman BM; Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2021 Jan 13; Vol. 143 (1), pp. 335-348. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Oxidoreductases Acting on Sulfur Group Donors/*chemistry
S-Adenosylmethionine/*chemistry
Bacterial Proteins/chemistry ; Bacterial Proteins/radiation effects ; Biocatalysis ; Catalytic Domain ; Clostridium acetobutylicum/enzymology ; Density Functional Theory ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/radiation effects ; Light ; Models, Chemical ; Molecular Structure ; Oxidation-Reduction/radiation effects ; Oxidoreductases Acting on Sulfur Group Donors/radiation effects ; Photolysis ; S-Adenosylmethionine/radiation effects ; Thermotoga maritima/enzymology
Czasopismo naukowe
Tytuł :
From Synthetic to Biological Fe 4 S 4 Complexes: Redox Properties Correlated to Function of Radical S-Adenosylmethionine Enzymes.
Autorzy :
Bím D; J. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, Dolejškova 3, Prague, 8 182 23, Czech Republic.
Alonso-Gil S; J. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, Dolejškova 3, Prague, 8 182 23, Czech Republic.
Srnec M; J. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, Dolejškova 3, Prague, 8 182 23, Czech Republic.
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Źródło :
ChemPlusChem [Chempluschem] 2020 Nov; Vol. 85 (11), pp. 2534-2541.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Iron-Sulfur Proteins/*metabolism
S-Adenosylmethionine/*metabolism
Free Radicals/chemistry ; Free Radicals/metabolism ; Iron-Sulfur Proteins/chemistry ; Oxidation-Reduction ; S-Adenosylmethionine/chemistry
Czasopismo naukowe
Tytuł :
S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-κB Activation.
Autorzy :
Mosca L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138 Naples, Italy.
Pagano M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138 Naples, Italy.; Department of Pharmacy, University of Naples 'Federico II', Via Domenico Montesano 49, 80131 Naples, Italy.
Borzacchiello L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138 Naples, Italy.
Mele L; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Via Luciano Armanni 5, 80138 Naples, Italy.
Russo A; Department of Pharmacy, University of Naples 'Federico II', Via Domenico Montesano 49, 80131 Naples, Italy.
Russo G; Department of Pharmacy, University of Naples 'Federico II', Via Domenico Montesano 49, 80131 Naples, Italy.
Cacciapuoti G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138 Naples, Italy.
Porcelli M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138 Naples, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 27; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
Colorectal Neoplasms/*drug therapy
Fluorouracil/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
NF-kappa B/*metabolism
S-Adenosylmethionine/*pharmacology
Antimetabolites, Antineoplastic/pharmacology ; Apoptosis ; Cell Proliferation ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Drug Synergism ; Drug Therapy, Combination ; Humans ; NF-kappa B/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells.
Autorzy :
Vergani L; Department of Earth, Environment and Life Science, University of Genoa, 16132 Genova, Italy.
Baldini F; Department of Experimemtal Medicine, University of Genoa, 16132 Genova, Italy.
Khalil M; School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Voci A; Department of Earth, Environment and Life Science, University of Genoa, 16132 Genova, Italy.
Putignano P; SP Diabetic Outpatient Clinic, ASST Monza, 20900 Monza, Italy.
Miraglia N; Clinical & Pre-clinical Development, Gnosis by Lesaffre S.p.A, 20832 Desio, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 15; Vol. 25 (18). Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress/*drug effects
S-Adenosylmethionine/*pharmacology
Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Malondialdehyde/metabolism ; Nitric Oxide/metabolism ; Non-alcoholic Fatty Liver Disease/chemically induced ; Non-alcoholic Fatty Liver Disease/drug therapy ; Oleanolic Acid/toxicity ; Palmitic Acid/toxicity ; Rats ; Reactive Oxygen Species/metabolism ; S-Adenosylmethionine/therapeutic use
Czasopismo naukowe
Tytuł :
S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis.
Autorzy :
Mahmood N; Department of Medicine, McGill University Health Centre, Montréal, QC, Canada.
Arakelian A; Department of Medicine, McGill University Health Centre, Montréal, QC, Canada.
Cheishvili D; Department of Molecular Biology, Ariel University, Ariel, Israel.; Gerald Bronfman Department of Oncology, McGill University, Montréal, QC, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.; HKG Epitherapeutics, Hong Kong, China.
Szyf M; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.
Rabbani SA; Department of Medicine, McGill University Health Centre, Montréal, QC, Canada.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Sep; Vol. 24 (18), pp. 10322-10337. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Breast Neoplasms/*drug therapy
Breast Neoplasms/*pathology
Decitabine/*therapeutic use
S-Adenosylmethionine/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Methylation/drug effects ; DNA Methylation/genetics ; Decitabine/pharmacology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Metastasis ; Reproducibility of Results ; S-Adenosylmethionine/pharmacology ; Transcription, Genetic/drug effects ; Transcriptome/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression.
Autorzy :
Zsigrai S; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Kalmár A; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.; MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences, 1051 Budapest, Hungary.
Nagy ZB; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Barták BK; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Valcz G; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.; MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences, 1051 Budapest, Hungary.
Szigeti KA; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Galamb O; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.; MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences, 1051 Budapest, Hungary.
Dankó T; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.
Sebestyén A; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.
Barna G; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.
Szabó V; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.
Pipek O; Department of Physics of Complex Systems, ELTE Eötvös Loránd University, 1117 Budapest, Hungary.
Medgyes-Horváth A; Department of Physics of Complex Systems, ELTE Eötvös Loránd University, 1117 Budapest, Hungary.
Csabai I; Department of Physics of Complex Systems, ELTE Eötvös Loránd University, 1117 Budapest, Hungary.
Tulassay Z; MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences, 1051 Budapest, Hungary.; Department of Internal Medicine and Hematology, Semmelweis University, 1088 Budapest, Hungary.
Igaz P; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.; MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences, 1051 Budapest, Hungary.
Takács I; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Molnár B; Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.; MTA-SE Molecular Medicine Research Group, Hungarian Academy of Sciences, 1051 Budapest, Hungary.
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Źródło :
Cells [Cells] 2020 Aug 09; Vol. 9 (8). Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carcinoma/*drug therapy
Colorectal Neoplasms/*drug therapy
DNA Methylation/*drug effects
DNA Repair/*drug effects
S-Adenosylmethionine/*pharmacology
Antineoplastic Agents/administration & dosage ; Gene Expression Regulation, Neoplastic/drug effects ; HT29 Cells ; Humans ; S-Adenosylmethionine/administration & dosage
Czasopismo naukowe

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