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Tytuł:
The Ability of the Nitric Oxide Synthases Inhibitor T1023 to Selectively Protect the Non-Malignant Tissues.
Autorzy:
Filimonova M; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Saburova A; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Makarchuk V; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Shevchenko L; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Surinova V; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Yuzhakov V; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Yakovleva N; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Sevankaeva L; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Saburov V; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Koryakin S; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Shegay P; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Kaprin A; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Ivanov S; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Filimonov A; A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 28; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 28.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Ehrlich Tumor/*radiotherapy
Gamma Rays/*adverse effects
Nitric Oxide Synthase/*antagonists & inhibitors
Radiation-Protective Agents/*pharmacology
Radiodermatitis/*drug therapy
Sarcoma, Experimental/*radiotherapy
Thiourea/*analogs & derivatives
Animals ; Carcinoma, Ehrlich Tumor/pathology ; Female ; Male ; Mice ; Mice, Inbred ICR ; Radiation Protection/methods ; Radiodermatitis/etiology ; Radiodermatitis/pathology ; Rats ; Rats, Sprague-Dawley ; Sarcoma, Experimental/pathology ; Thiourea/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
Autorzy:
Davis JL; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, United States of America.
Thaler R; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States of America.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America.
Cox L; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, United States of America.
Ricci B; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, United States of America.
Zannit HM; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, United States of America.
Wan F; Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, United States of America.
Faccio R; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, United States of America.; Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States of America.
Dudakovic A; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States of America.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America.
van Wijnen AJ; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States of America.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America.
Veis DJ; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, United States of America.; Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Jul 22; Vol. 16 (7), pp. e0254426. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Integrases*/genetics
Integrases*/metabolism
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Protein Serine-Threonine Kinases*/biosynthesis
Protein Serine-Threonine Kinases*/genetics
S100 Calcium-Binding Protein A4*/genetics
S100 Calcium-Binding Protein A4*/metabolism
Sarcoma, Experimental*/genetics
Sarcoma, Experimental*/metabolism
Sarcoma, Experimental*/pathology
Sp7 Transcription Factor*/genetics
Sp7 Transcription Factor*/metabolism
Animals ; Enzyme Induction ; Mice ; Mice, Transgenic ; NF-kappaB-Inducing Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras .
Autorzy:
Huang J; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, 27708, USA.
Chen M; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, 27708, USA.; Medical Scientist Training Program, Duke University Medical Center, Durham, North Carolina, 27708, USA.
Xu ES; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, 27708, USA.
Luo L; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, 27708, USA.
Ma Y; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, 27708, USA.
Huang W; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, 27708, USA.
Floyd W; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, 27708, USA.; Medical Scientist Training Program, Duke University Medical Center, Durham, North Carolina, 27708, USA.
Klann TS; Department of Biomedical Engineering, Duke University, Durham, North Carolina, 27708, USA.; Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, 27708, USA.
Kim SY; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, 27708, USA.
Gersbach CA; Department of Biomedical Engineering, Duke University, Durham, North Carolina, 27708, USA.; Duke Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, 27708, USA.
Cardona DM; Department of Pathology, Duke University, Durham, North Carolina, 27708, USA.
Kirsch DG; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, 27708, USA. .; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, 27708, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Nov 20; Vol. 9 (1), pp. 17220. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Proliferation*
Mutation*
Cell Transformation, Neoplastic/*pathology
Neoplasm Proteins/*antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)/*genetics
Sarcoma, Experimental/*prevention & control
Animals ; CRISPR-Cas Systems ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cells, Cultured ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression Regulation, Neoplastic ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Neoplasm Proteins/genetics ; Sarcoma, Experimental/genetics ; Sarcoma, Experimental/pathology ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.
Autorzy:
Oppel F; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.
Tao T; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.
Shi H; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.
Ross KN; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.
Zimmerman MW; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.
He S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.
Tong G; Heilongjiang River Fisheries Research Institute of Chinese Academy of Fishery Sciences, Harbin, China.
Aster JC; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America.
Look AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2019 Apr 10; Vol. 15 (4), pp. e1008039. Date of Electronic Publication: 2019 Apr 10 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sarcoma, Experimental/*etiology
Tumor Suppressor Protein p53/*deficiency
Tumor Suppressor Protein p53/*genetics
X-linked Nuclear Protein/*deficiency
X-linked Nuclear Protein/*genetics
Zebrafish Proteins/*deficiency
Zebrafish Proteins/*genetics
Animals ; Animals, Genetically Modified ; CRISPR-Cas Systems ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Disease Models, Animal ; Erythropoiesis ; Female ; Gene Knockout Techniques ; Globins/genetics ; Humans ; Loss of Function Mutation ; Male ; Neurofibromin 1/deficiency ; Neurofibromin 1/genetics ; Sarcoma, Experimental/genetics ; Sarcoma, Experimental/metabolism ; Telomere Homeostasis/genetics ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Establishment and characterization of a canine soft tissue sarcoma patient-derived xenograft model.
Autorzy:
Frazier JP; Presage Biosciences, Seattle, WA, USA.
Beirne E; Presage Biosciences, Seattle, WA, USA.
Ditzler SH; Presage Biosciences, Seattle, WA, USA.
Tretyak I; Presage Biosciences, Seattle, WA, USA.
Casalini JR; Presage Biosciences, Seattle, WA, USA.
Thirstrup DJ; Presage Biosciences, Seattle, WA, USA.
Knoblaugh S; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA.
Ward JG; Specialty VetPath, Shoreline, WA, USA.
Tripp CD; Veterinary Cancer Specialty Care, Lynnwood, WA, USA.
Klinghoffer RA; Presage Biosciences, Seattle, WA, USA.
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Źródło:
Veterinary and comparative oncology [Vet Comp Oncol] 2017 Sep; Vol. 15 (3), pp. 754-763. Date of Electronic Publication: 2016 Mar 18.
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasm Transplantation/*veterinary
Sarcoma/*veterinary
Sarcoma, Experimental/*drug therapy
Animals ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; Disease Models, Animal ; Dogs ; Heterografts ; Male ; Mice ; Mice, Nude ; Neoplasm Transplantation/methods ; Sarcoma/drug therapy ; Sarcoma/pathology ; Sarcoma, Experimental/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Litopenaeus vannamei hemocyanin exhibits antitumor activity in S180 mouse model in vivo.
Autorzy:
Liu S; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.; Reproductive Medicine Department, Affiliated Jingzhou Central Hospital of Tongji Medical College, Jingzhou, China.
Zheng L; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
Aweya JJ; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
Zheng Z; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
Zhong M; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
Chen J; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
Wang F; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
Zhang Y; Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China.
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Źródło:
PloS one [PLoS One] 2017 Aug 30; Vol. 12 (8), pp. e0183783. Date of Electronic Publication: 2017 Aug 30 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Arthropod Proteins/*pharmacology
Hemocyanins/*pharmacology
Penaeidae/*metabolism
Sarcoma, Experimental/*drug therapy
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; HeLa Cells ; Humans ; Immunoblotting ; Liver/drug effects ; Liver/metabolism ; Lymphocytes/cytology ; Lymphocytes/drug effects ; Male ; Malondialdehyde/blood ; Malondialdehyde/metabolism ; Mice ; Sarcoma, Experimental/metabolism ; Superoxide Dismutase/blood ; Superoxide Dismutase/metabolism ; Tumor Burden/drug effects ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Prenyl Ammonium Salts--New Carriers for Gene Delivery: A B16-F10 Mouse Melanoma Model.
Autorzy:
Grecka E; Department of Molecular and Translational Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.; Department of Pharmacology, National Research Institute of Mother and Child, Warsaw, Poland.
Statkiewicz M; Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Gorska A; Department of Applied Pharmacy and Bioengineering, Medical University of Warsaw, Warsaw, Poland.
Biernacka M; Department of Immunology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Grygorowicz MA; Department of Immunology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Masnyk M; Institute of Organic Chemistry PAS, Warsaw, Poland.
Chmielewski M; Institute of Organic Chemistry PAS, Warsaw, Poland.
Gawarecka K; Institute of Biochemistry and Biophysics PAS, Warsaw, Poland.
Chojnacki T; Institute of Biochemistry and Biophysics PAS, Warsaw, Poland.
Swiezewska E; Institute of Biochemistry and Biophysics PAS, Warsaw, Poland.
Malecki M; Department of Applied Pharmacy and Bioengineering, Medical University of Warsaw, Warsaw, Poland.
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Źródło:
PloS one [PLoS One] 2016 Apr 18; Vol. 11 (4), pp. e0153633. Date of Electronic Publication: 2016 Apr 18 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Delivery Systems*
Genetic Therapy*
Ammonium Compounds/*pharmacology
DNA/*administration & dosage
Melanoma, Experimental/*therapy
Neoprene/*chemistry
Sarcoma, Experimental/*therapy
Animals ; Blotting, Western ; Cell Survival ; Drug Carriers ; Female ; Gene Transfer Techniques ; Immunoenzyme Techniques ; Liposomes ; Lung Neoplasms/genetics ; Lung Neoplasms/secondary ; Lung Neoplasms/therapy ; Melanoma, Experimental/genetics ; Melanoma, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Sarcoma, Experimental/genetics ; Sarcoma, Experimental/pathology ; Transfection ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Multistage delivery of CDs-DOX/ICG-loaded liposome for highly penetration and effective chemo-photothermal combination therapy.
Autorzy:
Xue X; a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Fang T; a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Yin L; a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Jiang J; a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.
He Y; a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Dai Y; b Department of Traditional Chinese Medicine, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Wang D; a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.
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Źródło:
Drug delivery [Drug Deliv] 2018 Nov; Vol. 25 (1), pp. 1826-1839.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*administration & dosage
Carbon/*administration & dosage
Doxorubicin/*administration & dosage
Indocyanine Green/*administration & dosage
Photosensitizing Agents/*administration & dosage
Quantum Dots/*administration & dosage
Sarcoma, Experimental/*therapy
Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Carbon/therapeutic use ; Cell Survival/drug effects ; Combined Modality Therapy ; Doxorubicin/therapeutic use ; Drug Delivery Systems/methods ; Drug Design ; Drug Liberation ; Drug Therapy, Combination ; Hep G2 Cells ; Humans ; Hyperthermia, Induced/methods ; Indocyanine Green/therapeutic use ; Liposomes ; Male ; Mice ; Nanoparticles ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Phototherapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of time of initial exposure to MSV sarcoma on bone induction by dentine matrix implants and on orthotopic femora.
Autorzy:
Włodarski K; Chair of Histology and Embryology, Institute of Biostructural Research, Medical University of Warsaw, Chalubinskiego 5 Str., 02-004 Warszawa, Poland; E-Mails: (P.W); (R.G).
Włodarski P
Galus R
Brodzikowska A
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2010 Sep 15; Vol. 11 (9), pp. 3277-87. Date of Electronic Publication: 2010 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Osteogenesis*
Femoral Neoplasms/*pathology
Periodontal Ligament/*transplantation
Sarcoma, Experimental/*pathology
Animals ; Female ; Femur/pathology ; Femur/surgery ; Incisor/cytology ; Incisor/transplantation ; Mice ; Mice, Inbred BALB C ; Moloney murine sarcoma virus/pathogenicity ; Osteoclasts/cytology ; Periodontal Ligament/cytology ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dose painting based on tumor uptake of Cu-ATSM and FDG: a comparative study.
Autorzy:
Clausen MM; Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .; Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, Denmark. .
Hansen AE; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .; Technical University of Denmark, DTU Nanotech, Center of Nanomedicine and theranostics, Lyngby, Denmark. .
Lundemann M; Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .
Hollensen C; Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .
Pommer T; Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .; Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark. .
Munck Af Rosenschöld P; Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .; Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark. .
Kristensen AT; Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, Denmark. .
Kjær A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .
McEvoy FJ; Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, Denmark. .
Engelholm SA; Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. .
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Źródło:
Radiation oncology (London, England) [Radiat Oncol] 2014 Oct 16; Vol. 9, pp. 228. Date of Electronic Publication: 2014 Oct 16.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Squamous Cell/*veterinary
Copper Radioisotopes/*pharmacokinetics
Dog Diseases/*diagnostic imaging
Dog Diseases/*pathology
Fluorodeoxyglucose F18/*pharmacokinetics
Organometallic Compounds/*pharmacokinetics
Positron-Emission Tomography/*methods
Sarcoma, Experimental/*metabolism
Thiosemicarbazones/*pharmacokinetics
Animals ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Hypoxia ; Coordination Complexes ; Dog Diseases/metabolism ; Dogs ; Glycolysis ; Radiopharmaceuticals/pharmacokinetics ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated ; Sarcoma, Experimental/diagnostic imaging ; Sarcoma, Experimental/pathology ; Tissue Distribution ; Tomography, X-Ray Computed/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats.
Autorzy:
Buijs N; a Department of Surgery , VU University Medical Center , Amsterdam , The Netherlands and Department of Surgery , Medical Center Alkmaar, Trial Center Holland Health , Alkmaar , The Netherlands.
Vermeulen MA
Weeda VB
Bading JR
Houdijk AP
van Leeuwen PA
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Źródło:
Nutrition and cancer [Nutr Cancer] 2015; Vol. 67 (5), pp. 713-20. Date of Electronic Publication: 2015 Apr 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet*
Arginine/*metabolism
Cachexia/*metabolism
Glutamine/*administration & dosage
Intestinal Mucosa/*metabolism
Kidney/*metabolism
Sarcoma, Experimental/*metabolism
Animals ; Arginine/biosynthesis ; Cachexia/chemically induced ; Immune System/drug effects ; Immune System/physiopathology ; Male ; Methylcholanthrene ; Parenteral Nutrition ; Rats ; Rats, Inbred F344 ; Renal Circulation/physiology ; Sarcoma, Experimental/chemically induced
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia.
Autorzy:
Ihnatko R; Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, Linköping, S-581 85, Sweden.
Post C
Blomqvist A
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Źródło:
British journal of cancer [Br J Cancer] 2013 Oct 01; Vol. 109 (7), pp. 1867-75. Date of Electronic Publication: 2013 Sep 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Anorexia/*metabolism
Cachexia/*metabolism
Hypothalamus/*metabolism
Sarcoma, Experimental/*metabolism
Animals ; Disease Models, Animal ; Dynamin I/biosynthesis ; GTP-Binding Protein alpha Subunits, Gi-Go/biosynthesis ; HSP70 Heat-Shock Proteins/biosynthesis ; Hexokinase/biosynthesis ; Ketoglutarate Dehydrogenase Complex/biosynthesis ; Methylcholanthrene ; Mice ; Mice, Inbred C57BL ; N-Ethylmaleimide-Sensitive Proteins/biosynthesis ; Protein Biosynthesis ; Proteins/metabolism ; Pyruvate Carboxylase/biosynthesis ; Sarcoma, Experimental/chemically induced ; Selenium-Binding Proteins/biosynthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells.
Autorzy:
D'Andrea FP; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark. />Safwat A
Burns JS
Kassem M
Horsman MR
Overgaard J
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Źródło:
International journal of radiation biology [Int J Radiat Biol] 2012 Jun; Vol. 88 (6), pp. 457-65. Date of Electronic Publication: 2012 May 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Radiation Tolerance*
Mesenchymal Stem Cells/*pathology
Neoplastic Stem Cells/*pathology
Sarcoma, Experimental/*etiology
Sarcoma, Experimental/*radiotherapy
Tumor Microenvironment/*radiation effects
Animals ; Cell Line, Tumor ; Cell Survival/radiation effects ; Female ; Humans ; Hypoxia/metabolism ; Hypoxia/radiotherapy ; Mesenchymal Stem Cells/radiation effects ; Mice ; Mice, Nude ; Neoplastic Stem Cells/radiation effects ; Oxygen/metabolism ; Sarcoma, Experimental/blood supply ; Sarcoma, Experimental/pathology ; Tumor Microenvironment/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neem leaf glycoprotein activates CD8(+) T cells to promote therapeutic anti-tumor immunity inhibiting the growth of mouse sarcoma.
Autorzy:
Mallick A; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), Kolkata, India.
Barik S
Goswami KK
Banerjee S
Ghosh S
Sarkar K
Bose A
Baral R
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Źródło:
PloS one [PLoS One] 2013; Vol. 8 (1), pp. e47434. Date of Electronic Publication: 2013 Jan 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*immunology
CD8-Positive T-Lymphocytes/*immunology
Glycoproteins/*immunology
Plant Proteins/*immunology
Sarcoma, Experimental/*immunology
Animals ; Antineoplastic Agents/pharmacology ; Azadirachta/chemistry ; Azadirachta/immunology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cytotoxicity, Immunologic/drug effects ; Cytotoxicity, Immunologic/immunology ; Female ; Glycoproteins/pharmacology ; Immunohistochemistry ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Mice ; Plant Leaves/chemistry ; Plant Leaves/immunology ; Plant Proteins/pharmacology ; Receptors, CCR5/genetics ; Receptors, CCR5/immunology ; Receptors, CCR5/metabolism ; Receptors, CXCR3/genetics ; Receptors, CXCR3/immunology ; Receptors, CXCR3/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sarcoma, Experimental/drug therapy ; Sarcoma, Experimental/pathology ; Spleen/drug effects ; Spleen/immunology ; Spleen/pathology ; Survival Analysis ; Time Factors ; Tumor Burden/drug effects ; Tumor Burden/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression.
Autorzy:
Redmond WL; Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, Oregon, United States of America. />Triplett T
Floyd K
Weinberg AD
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (4), pp. e34467. Date of Electronic Publication: 2012 Apr 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunotherapy*
Interleukin-2/*therapeutic use
Interleukin-2 Receptor alpha Subunit/*metabolism
Receptors, OX40/*physiology
Sarcoma, Experimental/*immunology
Sarcoma, Experimental/*therapy
Animals ; Blotting, Western ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation ; Cytokines/metabolism ; Drug Therapy, Combination ; Female ; Flow Cytometry ; Janus Kinase 3/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; STAT3 Transcription Factor/physiology ; STAT5 Transcription Factor/physiology ; Sarcoma, Experimental/metabolism ; Signal Transduction ; T-Lymphocytes, Cytotoxic ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of IL-1 molecules on growth patterns of 3-MCA-induced cell lines: an interplay between immunogenicity and invasive potential.
Autorzy:
Voronov E; The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. />Reich E
Dotan S
Dransh P
Cohen I
Huszar M
Fogel M
Kleinman HK
White RM
Apte RN
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Źródło:
Journal of immunotoxicology [J Immunotoxicol] 2010 Mar; Vol. 7 (1), pp. 27-38.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fibrosarcoma/*immunology
Interleukin-1/*immunology
Neoplasm Invasiveness/*immunology
Neoplasm Transplantation/*immunology
Sarcoma, Experimental/*immunology
Animals ; Aorta, Thoracic/drug effects ; Cell Line, Tumor ; Chick Embryo ; Culture Media, Conditioned/pharmacology ; Cytokines/metabolism ; Endothelial Cells/drug effects ; Female ; Fibrosarcoma/chemically induced ; Fibrosarcoma/pathology ; Interleukin-1/deficiency ; Methylcholanthrene/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neovascularization, Pathologic/immunology ; Sarcoma, Experimental/chemically induced ; Sarcoma, Experimental/pathology ; Spleen/drug effects ; Spleen/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice.
Autorzy:
Ren X; School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.
Zheng N
Gao Y
Chen T
Lu W
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Źródło:
Drug delivery [Drug Deliv] 2012 Jan; Vol. 19 (1), pp. 36-44.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Absorbable Implants*
Drug Delivery Systems/*methods
Fluorouracil/*administration & dosage
Fluorouracil/*metabolism
Sarcoma, Experimental/*metabolism
Animals ; Drug Delivery Systems/instrumentation ; Lactic Acid/administration & dosage ; Lactic Acid/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Polyglycolic Acid/administration & dosage ; Polyglycolic Acid/metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer ; Random Allocation ; Sarcoma, Experimental/drug therapy ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Solid tumours arising from differently pre-oxygenated cells: comparable growth rates despite dissimilar tissue oxygenation.
Autorzy:
Mayer A; Department of Radiooncology and Radiotherapy, University Medical Center, Mainz, Germany.
Steimel M
Wree A
Kelleher D
Vaupel P
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Źródło:
International journal of radiation biology [Int J Radiat Biol] 2009 Nov; Vol. 85 (11), pp. 981-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sarcoma, Experimental/*metabolism
Sarcoma, Experimental/*pathology
Animals ; Cell Line, Tumor ; Glucose Transporter Type 1/metabolism ; Hypoxia/metabolism ; Hypoxia/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunohistochemistry ; Ki-67 Antigen/metabolism ; Male ; Neovascularization, Pathologic ; Oxygen/metabolism ; Rats ; Rats, Sprague-Dawley ; Sarcoma, Experimental/blood supply
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tempol reduces the therapeutic effect of cyclophosphamide on an experimental tumour model.
Autorzy:
Kaledin VI; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Popova NA
Nikolin VP
Vasilieva ED
Kirilyuk IA
Grigor'ev IA
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Źródło:
Free radical research [Free Radic Res] 2009 Jul; Vol. 43 (7), pp. 685-90.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Alkylating/*therapeutic use
Antioxidants/*pharmacology
Cyclic N-Oxides/*pharmacology
Cyclophosphamide/*therapeutic use
Lymphoma, Non-Hodgkin/*drug therapy
Sarcoma, Experimental/*drug therapy
Aldehyde Dehydrogenase/metabolism ; Animals ; Drug Therapy, Combination ; Female ; Lymphoma, Non-Hodgkin/enzymology ; Lymphoma, Non-Hodgkin/pathology ; Male ; Mice ; Mice, Inbred CBA ; Sarcoma, Experimental/enzymology ; Sarcoma, Experimental/pathology ; Spin Labels ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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