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Tytuł :
No promising antidote 25 years after the Tokyo subway sarin attack: A review.
Autorzy :
Sakurada K; Department of Forensic Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: .
Ohta H; Toxicology Section, Department of Forensic Chemistry, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
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Źródło :
Legal medicine (Tokyo, Japan) [Leg Med (Tokyo)] 2020 Nov; Vol. 47, pp. 101761. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antidotes*
Chemical Terrorism*/prevention & control
Drug Development*/trends
Railroads*
Chemical Warfare Agents/*poisoning
Cholinesterase Inhibitors/*poisoning
Sarin/*poisoning
Blood-Brain Barrier/metabolism ; Chemical Warfare Agents/metabolism ; Cholinesterase Inhibitors/metabolism ; Humans ; Pralidoxime Compounds ; Sarin/metabolism ; Time Factors ; Tokyo
Czasopismo naukowe
Tytuł :
Comparative physiology and efficacy of atropine and scopolamine in sarin nerve agent poisoning.
Autorzy :
Cornelissen AS; TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288, GJ, Rijswijk, the Netherlands. Electronic address: .
Klaassen SD; TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288, GJ, Rijswijk, the Netherlands.
van Groningen T; TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288, GJ, Rijswijk, the Netherlands.
Bohnert S; Defence Research and Development Canada-Suffield Research Centre, Department of National Defence, Suffield, Alberta, Canada.
Joosen MJA; TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288, GJ, Rijswijk, the Netherlands.
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Jun 01; Vol. 396, pp. 114994. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Comparative Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Atropine/*therapeutic use
Chemical Warfare Agents/*poisoning
Sarin/*poisoning
Scopolamine/*therapeutic use
Animals ; Atropine/blood ; Atropine/pharmacokinetics ; Atropine/pharmacology ; Brain Chemistry/drug effects ; Cholinergic Antagonists ; Electrocardiography/drug effects ; Electroencephalography/drug effects ; Male ; Mice ; Rats, Wistar ; Sarin/antagonists & inhibitors ; Scopolamine/blood ; Scopolamine/pharmacokinetics ; Scopolamine/pharmacology ; Telemetry/methods
Raport
Tytuł :
Asymmetric biodegradation of the nerve agents Sarin and VX by human dUTPase: chemometrics, molecular docking and hybrid QM/MM calculations.
Autorzy :
de Castro AA; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Soares FV; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Pereira AF; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Silva TC; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Silva DR; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Mancini DT; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Caetano MS; b Institute of Exact and Biological Sciences, Federal University of Ouro Preto, University Campus , Ouro Preto , Brazil.
da Cunha EFF; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Ramalho TC; a Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.; c Center for Basic and Applied research, University Hradec Kralove , Hradec Kralove , Czech Republic.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2019 May; Vol. 37 (8), pp. 2154-2164. Date of Electronic Publication: 2019 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Quantum Theory*
Nerve Agents/*metabolism
Organothiophosphorus Compounds/*metabolism
Pyrophosphatases/*metabolism
Sarin/*metabolism
Biodegradation, Environmental ; Catalytic Domain ; Humans ; Hydrogen Bonding ; Nerve Agents/chemistry ; Organophosphorus Compounds/chemistry ; Organophosphorus Compounds/metabolism ; Organothiophosphorus Compounds/chemistry ; Principal Component Analysis ; Sarin/chemistry
Czasopismo naukowe
Tytuł :
Rapid quantification of two chemical nerve agent metabolites in serum.
Autorzy :
Kammer M; Department of Chemistry, Vanderbilt University, Nashville, TN, 37615, USA.
Kussrow A; Department of Chemistry, Vanderbilt University, Nashville, TN, 37615, USA.
Carter MD; Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
Isenberg SL; Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
Johnson RC; Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
Batchelor RH; Base Pair Biotechnologies, Pearland, TX, 77584, USA.
Jackson GW; Base Pair Biotechnologies, Pearland, TX, 77584, USA.
Bornhop DJ; Department of Chemistry, Vanderbilt University, Nashville, TN, 37615, USA. Electronic address: .
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2019 Apr 15; Vol. 131, pp. 119-127. Date of Electronic Publication: 2019 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Chemical Warfare Agents/*isolation & purification
Nerve Agents/*isolation & purification
Organothiophosphorus Compounds/*isolation & purification
Sarin/*isolation & purification
Amines/chemistry ; Chemical Warfare Agents/chemistry ; Chromatography, Liquid ; Environmental Exposure ; Enzyme-Linked Immunosorbent Assay ; Humans ; Limit of Detection ; Nerve Agents/chemistry ; Organophosphorus Compounds ; Organothiophosphorus Compounds/chemistry ; Sarin/blood ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Efficacy of retigabine in ameliorating the brain insult following sarin exposure in the rat.
Autorzy :
Gore A; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel. Electronic address: .
Neufeld-Cohen A; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Egoz I; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Baranes S; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Gez R; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Grauer E; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Chapman S; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel.
Lazar S; Department. of Pharmacology, Israel Institute for Biological Research, Ness Ziona 74100, Israel. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 May 15; Vol. 395, pp. 114963. Date of Electronic Publication: 2020 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*administration & dosage
Brain Diseases/*chemically induced
Brain Diseases/*prevention & control
Carbamates/*administration & dosage
Neuroprotective Agents/*administration & dosage
Phenylenediamines/*administration & dosage
Sarin/*toxicity
Animals ; Atropine/administration & dosage ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/pathology ; Brain Diseases/pathology ; Chemical Warfare Agents/toxicity ; Cholinesterase Inhibitors/toxicity ; Male ; Neuroglia/pathology ; Neurons/pathology ; Potassium Channels, Voltage-Gated/drug effects ; Potassium Channels, Voltage-Gated/physiology ; Rats ; Rats, Sprague-Dawley ; Seizures/chemically induced ; Seizures/prevention & control ; Trimedoxime/administration & dosage
Czasopismo naukowe
Tytuł :
Pharmacokinetics of Three Oximes in a Guinea Pig Model and Efficacy of Combined Oxime Therapy.
Autorzy :
Bohnert S; Defense Research and Development Canada - Suffield Research Centre, Casualty Management Section, PO Box 4000 Station Main, Medicine Hat, Alberta, T1A 8K6, Canada. Electronic address: .
van den Berg RM; TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288 GJ, Rijswijk, the Netherlands.
Mikler J; Defense Research and Development Canada - Suffield Research Centre, Casualty Management Section, PO Box 4000 Station Main, Medicine Hat, Alberta, T1A 8K6, Canada.
Klaassen SD; TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288 GJ, Rijswijk, the Netherlands.
Joosen MJA; TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288 GJ, Rijswijk, the Netherlands.
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Źródło :
Toxicology letters [Toxicol Lett] 2020 May 15; Vol. 324, pp. 86-94. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Agents/*poisoning
Oximes/*pharmacokinetics
Oximes/*therapeutic use
Sarin/*poisoning
Acetylcholinesterase/metabolism ; Animals ; Drug Therapy, Combination ; Electrocardiography/drug effects ; Electroencephalography/drug effects ; Guinea Pigs ; Male ; Oximes/administration & dosage
Czasopismo naukowe
Tytuł :
The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident.
Autorzy :
Sugiyama A; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Matsuoka T; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Sakamune K; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Akita T; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Makita R; Department of Forensic Medicine, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Kimura S; Non-Profit Organization (NPO) Recovery Support Center, Tokyo, Japan.
Kuroiwa Y; Non-Profit Organization (NPO) Recovery Support Center, Tokyo, Japan.
Nagao M; Department of Forensic Medicine, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Tanaka J; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
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Źródło :
PloS one [PLoS One] 2020 Jun 23; Vol. 15 (6), pp. e0234967. Date of Electronic Publication: 2020 Jun 23 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Chemical Terrorism*
Chemical Warfare Agents/*poisoning
Miosis/*epidemiology
Sarin/*poisoning
Stress Disorders, Post-Traumatic/*epidemiology
Survivors/*statistics & numerical data
Adolescent ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Miosis/chemically induced ; Prevalence ; Railroads ; Risk Factors ; Self Report/statistics & numerical data ; Stress Disorders, Post-Traumatic/psychology ; Survivors/psychology ; Tokyo/epidemiology ; Young Adult
Czasopismo naukowe
Tytuł :
Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry.
Autorzy :
Rubin KM; Department of Anthropology, University of Florida, 1112 Turlington Hall, Gainesville, FL 32611.; Defense POW/MIA Accounting Agency, 590 Moffet Street, Joint Base Pearl Harbor-Hickam, HI 96853.
Goldberger BA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, 4800 SW 35th Drive, Gainesville, FL 32608.
Garrett TJ; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, 4800 SW 35th Drive, Gainesville, FL 32608.
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Źródło :
Journal of analytical toxicology [J Anal Toxicol] 2020 May 18; Vol. 44 (4), pp. 391-401.
Typ publikacji :
Journal Article
MeSH Terms :
Bone and Bones/*chemistry
Nerve Agents/*analysis
Animals ; Chemical Warfare Agents/analysis ; Chromatography, Liquid ; Humans ; Limit of Detection ; Organophosphorus Compounds/analysis ; Organothiophosphorus Compounds/analysis ; Sarin/analysis ; Soman/analysis ; Swine
Czasopismo naukowe
Tytuł :
Radiosynthesis of O-(1-[ F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin.
Autorzy :
Hayes TR; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Thompson CM; Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA.
Blecha JE; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Gerdes JM; Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA.
VanBrocklin HF; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
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Źródło :
Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2018 Dec; Vol. 61 (14), pp. 1089-1094. Date of Electronic Publication: 2018 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Positron-Emission Tomography*
Sarin*
Nitro Compounds/*chemical synthesis
Nitro Compounds/*chemistry
Organophosphonates/*chemical synthesis
Organophosphonates/*chemistry
Chemistry Techniques, Synthetic ; Radioactive Tracers ; Radiochemistry
Czasopismo naukowe
Tytuł :
Investigation of dried blood sampling with liquid chromatography tandem mass spectrometry to confirm human exposure to nerve agents.
Autorzy :
Shaner RL; Emergency Response Branch, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
Coleman RM; Emergency Response Branch, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
Schulze N; ORISE Fellow, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
Platanitis K; ORISE Fellow, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
Brown AA; ORISE Fellow, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
Seymour C; Battelle Memorial Institute at the Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
Kaplan P; ORISE Fellow, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
Perez J; Emergency Response Branch, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
Hamelin EI; Emergency Response Branch, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA. Electronic address: .
Johnson RC; Emergency Response Branch, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA.
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2018 Nov 29; Vol. 1033, pp. 100-107. Date of Electronic Publication: 2018 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Dried Blood Spot Testing*
Nerve Agents/*analysis
Organophosphorus Compounds/*blood
Organothiophosphorus Compounds/*blood
Sarin/*blood
Soman/*blood
Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Humans ; Nerve Agents/metabolism ; Organophosphorus Compounds/metabolism ; Organothiophosphorus Compounds/metabolism ; Sarin/metabolism ; Soman/metabolism ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
Autorzy :
Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic. Electronic address: .
Timperley CM; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury SP4 0JQ, United Kingdom.
Bird M; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury SP4 0JQ, United Kingdom.
Williams RL; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury SP4 0JQ, United Kingdom.
Green AC; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury SP4 0JQ, United Kingdom.
Tattersall JEH; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury SP4 0JQ, United Kingdom.
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Źródło :
Toxicology [Toxicology] 2018 Sep 01; Vol. 408, pp. 95-100. Date of Electronic Publication: 2018 Jul 10.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organophosphorus Compounds*
Sarin*
Atropine/*pharmacology
Obidoxime Chloride/*pharmacology
Organophosphate Poisoning/*drug therapy
Oximes/*pharmacology
Pyridinium Compounds/*pharmacology
Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Lethal Dose 50 ; Male ; Mice ; Time Factors
Czasopismo naukowe
Tytuł :
Mechanisms of acetylcholinesterase protection against sarin and soman by adenosine A 1 receptor agonist N -cyclopentyladenosine.
Autorzy :
Beste A; US Army Research Laboratory, Deer Creek Loop, Aberdeen Proving Ground, MD 21005-5069, USA. Electronic address: .
Taylor DE; US Army Research Laboratory, Deer Creek Loop, Aberdeen Proving Ground, MD 21005-5069, USA.
Shih TM; US Army Medical Research Institute of Chemical Defense, 2900 Ricketts Point Road, Aberdeen Proving Ground, MD 21010-5400, USA.
Thomas TP; US Army Research Laboratory, Deer Creek Loop, Aberdeen Proving Ground, MD 21005-5069, USA; US Army Medical Research Institute of Chemical Defense, 2900 Ricketts Point Road, Aberdeen Proving Ground, MD 21010-5400, USA.
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Źródło :
Computational biology and chemistry [Comput Biol Chem] 2018 Aug; Vol. 75, pp. 74-81. Date of Electronic Publication: 2018 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcholinesterase/*metabolism
Adenosine/*analogs & derivatives
Adenosine A1 Receptor Agonists/*metabolism
Nerve Agents/*metabolism
Organophosphorus Compounds/*metabolism
Sarin/*metabolism
Soman/*metabolism
Adenosine/chemistry ; Adenosine/metabolism ; Adenosine/pharmacology ; Adenosine A1 Receptor Agonists/chemistry ; Adenosine A1 Receptor Agonists/pharmacology ; Animals ; Molecular Structure ; Nerve Agents/chemistry ; Nerve Agents/pharmacology ; Organophosphorus Compounds/chemistry ; Organophosphorus Compounds/pharmacology ; Quantum Theory ; Rats ; Sarin/chemistry ; Sarin/pharmacology ; Soman/chemistry ; Soman/pharmacology ; Thermodynamics
Czasopismo naukowe
Tytuł :
Proposal for Reforming Prehospital Response to Chemical Terrorism Disasters in Japan: Going Back to the Basics of Saving the Lives of the Injured by Securing the Safety of the Rescue Team.
Autorzy :
Anan H; Emergency Medical Center, Fujisawa City Hospital, Kanagawa, Japan.
Otomo Y; Department of Acute Critical Care and Disaster Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Homma M; Division of Emergency and Disaster Medicine, Tottori University, Tottori, Japan.
Oshiro K; School of Nursing, Kawasaki City College of Nursing, Kanagawa, Japan.
Kondo H; Japan DMAT Secretariat, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
Shimamura F; Trauma Surgery, Chiba Emergency Medical Center, Chiba, Japan.
Takahashi A; Japan DMAT Secretariat, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
Hamada M; Shigematsu Works Co., Ltd., Tokyo, Japan.
Hirabayashi A; Emergency and Critical Care Medicine, Nippon Medical School Hospital, Tokyo, Japan.
Koido Y; Japan DMAT Secretariat, National Hospital Organization Disaster Medical Center, Tokyo, Japan.
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Źródło :
Prehospital and disaster medicine [Prehosp Disaster Med] 2020 Feb; Vol. 35 (1), pp. 88-91. Date of Electronic Publication: 2019 Dec 06.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical Terrorism*
Disaster Planning*
Rescue Work*
Emergency Medical Services/*standards
Humans ; Japan ; Personal Protective Equipment ; Sarin/poisoning
Czasopismo naukowe
Tytuł :
Instantaneous monitoring of free sarin in whole blood by dry blood spot-thermal desorption-GC-FPD/MS analysis.
Autorzy :
Marder D; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel. Electronic address: .
Dagan S; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel.
Yishai-Aviram L; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel.
Loewenthal D; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel.
Chapman S; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel.
Adani R; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel.
Lazar S; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel.
Weissberg A; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel.
Gura S; Analytical Chemistry Department, Israel Institute for Biological Research (IIBR), Ness Ziona, P.O.B 19, 74100, Israel. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 Jan 01; Vol. 1136, pp. 121911. Date of Electronic Publication: 2019 Nov 30.
Typ publikacji :
Journal Article
MeSH Terms :
Dried Blood Spot Testing/*methods
Gas Chromatography-Mass Spectrometry/*methods
Sarin/*blood
Adsorption ; Animals ; Limit of Detection ; Linear Models ; Male ; Mice ; Mice, Inbred ICR ; Reproducibility of Results ; Styrene/chemistry ; Vinyl Compounds/chemistry
Czasopismo naukowe
Tytuł :
pH-Dependent Piecewise Linear Correlation of P Chemical Shifts: Application in NMR Identification of Nerve Agent Metabolites in Urine Samples.
Autorzy :
Koskela H; VERIFIN, Department of Chemistry , University of Helsinki , P.O. Box 55, FIN-00014 Helsinki , Finland.
Andjelkovic B; University of Belgrade , Faculty of Chemistry , Studentski trg 12-16 , 11158 Belgrade , Serbia.
Pettersson A; VERIFIN, Department of Chemistry , University of Helsinki , P.O. Box 55, FIN-00014 Helsinki , Finland.
Rapinoja ML; VERIFIN, Department of Chemistry , University of Helsinki , P.O. Box 55, FIN-00014 Helsinki , Finland.
Kuitunen ML; VERIFIN, Department of Chemistry , University of Helsinki , P.O. Box 55, FIN-00014 Helsinki , Finland.
Vanninen P; VERIFIN, Department of Chemistry , University of Helsinki , P.O. Box 55, FIN-00014 Helsinki , Finland.
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Źródło :
Analytical chemistry [Anal Chem] 2018 Jul 17; Vol. 90 (14), pp. 8495-8500. Date of Electronic Publication: 2018 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemical Warfare Agents/*pharmacokinetics
Magnetic Resonance Spectroscopy/*methods
Nerve Agents/*pharmacokinetics
Sarin/*urine
Soman/*urine
Chemical Warfare Agents/metabolism ; Humans ; Hydrogen/metabolism ; Hydrogen/urine ; Hydrogen-Ion Concentration ; Nerve Agents/metabolism ; Phosphorus Isotopes/metabolism ; Phosphorus Isotopes/urine ; Sarin/metabolism ; Soman/metabolism
Czasopismo naukowe
Tytuł :
Comparative evaluation of antidotal efficacy of 2-PAM and HNK-102 oximes during inhalation of sarin vapor in Swiss albino mice.
Autorzy :
Swami D; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Yadav R; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Bhaskar ASB; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Soni A; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Nagar DP; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Acharya J; b Process Technology Development Division , Defence Research & Development Establishment , Gwalior , India.
Karade HN; b Process Technology Development Division , Defence Research & Development Establishment , Gwalior , India.
Singh KP; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Kumar P; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
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Źródło :
Inhalation toxicology [Inhal Toxicol] 2018 Jun - Jul; Vol. 30 (7-8), pp. 287-298. Date of Electronic Publication: 2018 Oct 30.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Chemical Warfare Agents/*poisoning
Inhalation Exposure/*adverse effects
Oximes/*pharmacology
Pralidoxime Compounds/*pharmacology
Sarin/*poisoning
Acetylcholinesterase/blood ; Animals ; Dose-Response Relationship, Drug ; Gas Poisoning/prevention & control ; Lethal Dose 50 ; Lung/drug effects ; Lung/pathology ; Male ; Mice ; Oximes/chemistry ; Pralidoxime Compounds/chemistry ; Sarin/toxicity
Czasopismo naukowe
Tytuł :
A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds.
Autorzy :
Job L; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
Köhler A; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany; Bundeswehr Institut für Pharmakologie und Toxikologie, Neuherbergstr. 11, 80937 München, Germany. Electronic address: .
Escher B; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
Worek F; Bundeswehr Institut für Pharmakologie und Toxikologie, Neuherbergstr. 11, 80937 München, Germany. Electronic address: .
Skerra A; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Mar 15; Vol. 321, pp. 138-145. Date of Electronic Publication: 2019 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antidotes/*pharmacology
Bacterial Proteins/*pharmacology
Caulobacteraceae/*enzymology
Nerve Agents/*poisoning
Organophosphate Poisoning/*drug therapy
Organophosphorus Compounds/*toxicity
Phosphoric Triester Hydrolases/*pharmacology
Antidotes/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Caulobacteraceae/genetics ; Drug Stability ; Enzyme Stability ; Hot Temperature ; Mutation ; Organophosphate Poisoning/enzymology ; Organothiophosphorus Compounds/poisoning ; Oxidation-Reduction ; Phosphoric Triester Hydrolases/genetics ; Phosphoric Triester Hydrolases/metabolism ; Protein Denaturation ; Recombinant Proteins/pharmacology ; Sarin/poisoning ; Soman/poisoning
SCR Organism :
Brevundimonas diminuta
Czasopismo naukowe
Tytuł :
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.
Autorzy :
Maček Hrvat N; Institute for Medical Research and Occupational Health, HR-10000 Zagreb, Croatia.
Kalisiak J; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Šinko G; Institute for Medical Research and Occupational Health, HR-10000 Zagreb, Croatia.
Radić Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093-0650, United States.
Sharpless KB; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Taylor P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093-0650, United States.
Kovarik Z; Institute for Medical Research and Occupational Health, HR-10000 Zagreb, Croatia. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Mar 15; Vol. 321, pp. 83-89. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Butyrylcholinesterase/*metabolism
Cholinesterase Reactivators/*pharmacology
Nerve Agents/*toxicity
Organophosphate Poisoning/*drug therapy
Oximes/*pharmacology
Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Butyrylcholinesterase/chemistry ; Cholinesterase Inhibitors/toxicity ; Cholinesterase Reactivators/chemical synthesis ; Enzyme Activation ; GPI-Linked Proteins/agonists ; GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/chemistry ; GPI-Linked Proteins/metabolism ; Humans ; Kinetics ; Organophosphate Poisoning/enzymology ; Organophosphates/toxicity ; Organophosphorus Compounds/toxicity ; Organothiophosphorus Compounds/toxicity ; Oximes/chemical synthesis ; Protein Conformation ; Sarin/toxicity ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Sampling and analyses of surfaces contaminated with chemical warfare agents by using a newly developed triple layered composite wipe.
Autorzy :
Imran M; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Kumar N; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Thakare VB; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Gupta AK; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Acharya J; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Garg P; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India. .
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Źródło :
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2020 Feb; Vol. 412 (5), pp. 1097-1110. Date of Electronic Publication: 2020 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Textiles*
Chemical Warfare Agents/*analysis
Mustard Gas/*analysis
Sarin/*analysis
Specimen Handling/*instrumentation
Adsorption ; Environmental Monitoring/methods ; Gas Chromatography-Mass Spectrometry/methods ; Limit of Detection ; Microscopy, Electron, Scanning ; Reference Standards ; Solvents/chemistry ; Surface Properties
Czasopismo naukowe

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