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Tytuł:
Monitoring Exposure to Five Chemical Warfare Agents Using the Dried Urine Spot Technique and Liquid Chromatography-Mass Spectrometry/Mass Spectrometry-In Vivo Determination of Sarin Metabolite in Mice.
Autorzy:
Yishai Aviram L; Department of Analytical Chemistry, Israel Institute for Biological Research (IIBR), Ness Ziona 7410001, Israel.
Dagan S; Department of Analytical Chemistry, Israel Institute for Biological Research (IIBR), Ness Ziona 7410001, Israel.
Hindi A; Department of Analytical Chemistry, Israel Institute for Biological Research (IIBR), Ness Ziona 7410001, Israel.
Chapman S; Department of Analytical Chemistry, Israel Institute for Biological Research (IIBR), Ness Ziona 7410001, Israel.
Gez R; Department of Analytical Chemistry, Israel Institute for Biological Research (IIBR), Ness Ziona 7410001, Israel.
Drug E; Department of Analytical Chemistry, Israel Institute for Biological Research (IIBR), Ness Ziona 7410001, Israel.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Nov 21; Vol. 28 (23). Date of Electronic Publication: 2023 Nov 21.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents*/analysis
Mice ; Humans ; Animals ; Sarin/analysis ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Organophosphorus Compounds/analysis
Czasopismo naukowe
Tytuł:
Multiple Hospital In-Situ Mass Casualty Incident Training Simulation for Emergency Medicine Residents: A Sarin Bomb Scenario.
Autorzy:
Musisca NJ; Assistant Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI.
Rybasack-Smith H; Assistant Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI.
Musits A; Assistant Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI.
Petrone G; Assistant Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI.
Wightman RS; Assistant Professor, Department of Emergency Medicine, and Assistant Professor, Department of Epidemiology, Alpert Medical School of Brown University, Providence, RI.
Smith JL; Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI.
Brown LL; Professor, Department of Emergency Medicine; Alpert Medical School of Brown University, Providence, RI.
Foggle JL; Associate Professor, Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI.
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Źródło:
Rhode Island medical journal (2013) [R I Med J (2013)] 2023 Oct 02; Vol. 106 (9), pp. 36-40. Date of Electronic Publication: 2023 Oct 02.
Typ publikacji:
Journal Article
MeSH Terms:
Mass Casualty Incidents*
Emergency Medicine*
Humans ; Sarin ; Curriculum ; Hospitals
Czasopismo naukowe
Tytuł:
Untargeted and targeted analysis of sarin poisoning biomarkers in rat urine by liquid chromatography and tandem mass spectrometry.
Autorzy:
Vokuev MF; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia. .
Baygildiev ТМ; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Plyushchenko IV; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Ikhalaynen YA; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Ogorodnikov RL; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Solontsov IK; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.
Braun АV; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.; Laboratory for the Chemical and Analytical Control of the Military Research Centre, 105005, Moscow, Russia.
Savelieva EI; Research Institute of Hygiene, Occupational Pathology and Human Ecology Federal State Unitary Enterprise, Federal Medical Biological Agency of Russia, Kuz'molovsky g/p, 188663, Leningrad Region, Russia.
Rуbalchenko IV; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.; Laboratory for the Chemical and Analytical Control of the Military Research Centre, 105005, Moscow, Russia.
Rodin IA; Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia.; Department of Epidemiology and Evidence Based Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2021 Nov; Vol. 413 (28), pp. 6973-6985. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents/*analysis
Chemical Warfare Agents/*poisoning
Chromatography, Liquid/*methods
Sarin/*poisoning
Sarin/*urine
Tandem Mass Spectrometry/*methods
Animals ; Biomarkers/urine ; Chemical Warfare Agents/standards ; Limit of Detection ; Male ; Metabolomics/methods ; Rats ; Reference Standards ; Reproducibility of Results ; Sarin/standards
Czasopismo naukowe
Tytuł:
Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist's Toolbox.
Autorzy:
Valdez CA; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.; Nuclear and Chemical Sciences Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.; Forensic Science Center, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Leif RN; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.; Nuclear and Chemical Sciences Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.; Forensic Science Center, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 30; Vol. 26 (15). Date of Electronic Publication: 2021 Jul 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Nerve Agents/*analysis
Organophosphates/*analysis
Organophosphorus Compounds/*analysis
Organothiophosphorus Compounds/*analysis
Sarin/*analysis
Soman/*analysis
Alkylation ; Fluorobenzenes/chemistry ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; Hydrolysis ; Methylation ; Nerve Agents/chemistry ; Organophosphates/chemistry ; Organophosphorus Compounds/chemistry ; Organothiophosphorus Compounds/chemistry ; Sarin/chemistry ; Soman/chemistry
Czasopismo naukowe
Tytuł:
A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent.
Autorzy:
Jett DA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Sibrizzi CA; ICF, Fairfax, VA, USA.
Blain RB; ICF, Fairfax, VA, USA.
Hartman PA; ICF, Fairfax, VA, USA.
Lein PJ; School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Taylor KW; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, NC, USA.
Rooney AA; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, NC, USA.
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Źródło:
Critical reviews in toxicology [Crit Rev Toxicol] 2020 Jul; Vol. 50 (6), pp. 474-490. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms:
Nerve Agents*
Sarin*
Environmental Exposure/*statistics & numerical data
Chemical Warfare Agents ; Humans ; Time
Czasopismo naukowe
Tytuł:
Zinc Phthalocyanine Sensing Mechanism Quantification for Potential Application in Chemical Warfare Agent Detectors.
Autorzy:
Powroźnik P; Institute of Physics-Center for Science and Education, Silesian University of Technology, S. Konarskiego Str. 22B, 44-100 Gliwice, Poland.
Solecka B; Institute of Physics-Center for Science and Education, Silesian University of Technology, S. Konarskiego Str. 22B, 44-100 Gliwice, Poland.
Pander P; Faculty of Chemistry, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland.; Department of Physics, Durham University, South Road, Durham DH1 3LE, UK.
Jakubik W; Institute of Physics-Center for Science and Education, Silesian University of Technology, S. Konarskiego Str. 22B, 44-100 Gliwice, Poland.
Dias FB; Department of Physics, Durham University, South Road, Durham DH1 3LE, UK.
Krzywiecki M; Institute of Physics-Center for Science and Education, Silesian University of Technology, S. Konarskiego Str. 22B, 44-100 Gliwice, Poland.
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Źródło:
Sensors (Basel, Switzerland) [Sensors (Basel)] 2022 Dec 16; Vol. 22 (24). Date of Electronic Publication: 2022 Dec 16.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents*/analysis
Organometallic Compounds*/chemistry
Sarin ; Zinc Compounds
Czasopismo naukowe
Tytuł:
Chemical forensic profiling and attribution signature determination of sarin nerve agent using GC-MS, LC-MS and NMR.
Autorzy:
Webster RL; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia. .
Ovenden SPB; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia.
McDowall LJ; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia.
Dennison GH; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia.
Laws MJ; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia.
McGill NW; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia.
Williams J; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia.
Zanatta SD; Defence Science and Technology Group, 506 Lorimer St, Fishermans Bend, VIC, 3207, Australia.
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2022 May; Vol. 414 (13), pp. 3863-3873. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Warfare Agents*/analysis
Nerve Agents*/analysis
Chromatography, Liquid/methods ; Gas Chromatography-Mass Spectrometry ; Sarin/analysis ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
Comparative evaluation of antidotal efficacy of 2-PAM and HNK-102 oximes during inhalation of sarin vapor in Swiss albino mice.
Autorzy:
Swami D; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Yadav R; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Bhaskar ASB; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Soni A; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Nagar DP; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Acharya J; b Process Technology Development Division , Defence Research & Development Establishment , Gwalior , India.
Karade HN; b Process Technology Development Division , Defence Research & Development Establishment , Gwalior , India.
Singh KP; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
Kumar P; a Pharmacology and Toxicology Division , Defence Research & Development Establishment , Gwalior , India.
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2018 Jun - Jul; Vol. 30 (7-8), pp. 287-298. Date of Electronic Publication: 2018 Oct 30.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Chemical Warfare Agents/*poisoning
Inhalation Exposure/*adverse effects
Oximes/*pharmacology
Pralidoxime Compounds/*pharmacology
Sarin/*poisoning
Acetylcholinesterase/blood ; Animals ; Dose-Response Relationship, Drug ; Gas Poisoning/prevention & control ; Lethal Dose 50 ; Lung/drug effects ; Lung/pathology ; Male ; Mice ; Oximes/chemistry ; Pralidoxime Compounds/chemistry ; Sarin/toxicity
Czasopismo naukowe
Tytuł:
Radiosynthesis of O-(1-[ F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin.
Autorzy:
Hayes TR; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Thompson CM; Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA.
Blecha JE; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Gerdes JM; Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA.
VanBrocklin HF; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
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Źródło:
Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2018 Dec; Vol. 61 (14), pp. 1089-1094. Date of Electronic Publication: 2018 Nov 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Positron-Emission Tomography*
Sarin*
Nitro Compounds/*chemical synthesis
Nitro Compounds/*chemistry
Organophosphonates/*chemical synthesis
Organophosphonates/*chemistry
Chemistry Techniques, Synthetic ; Radioactive Tracers ; Radiochemistry
Czasopismo naukowe
Tytuł:
The preservation of sarin and O,O′-diisopropyl fluorophosphate inside coordination cage hosts.
Autorzy:
Dorrat, Jack C. (AUTHOR)
Young, Rosemary J. (AUTHOR)
Taylor, Christopher G. P. (AUTHOR)
Tipping, Max B. (AUTHOR)
Blok, Andrew J. (AUTHOR)
Turner, David R. (AUTHOR)
McKay, Alasdair I. (AUTHOR)
Ovenden, Simon (AUTHOR)
Ward, Michael D. (AUTHOR)
Dennison, Genevieve H. (AUTHOR)
Tuck, Kellie L. (AUTHOR)
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Źródło:
Dalton Transactions: An International Journal of Inorganic Chemistry. 9/14/2023, Vol. 52 Issue 34, p11802-11814. 13p.
Czasopismo naukowe
Tytuł:
Online coupling of immunoextraction, digestion, and microliquid chromatography-tandem mass spectrometry for the analysis of sarin and soman-butyrylcholinesterase adducts in human plasma.
Autorzy:
Bonichon M; Department of Analytical, Bioanalytical Sciences and Miniaturization (LSABM), UMR CNRS-ESPCI Paris, CBI 8231, PSL Research University, ESPCI Paris, 10 rue Vauquelin, Paris, France.
Valbi V; Department of Analytical, Bioanalytical Sciences and Miniaturization (LSABM), UMR CNRS-ESPCI Paris, CBI 8231, PSL Research University, ESPCI Paris, 10 rue Vauquelin, Paris, France.
Combès A; Department of Analytical, Bioanalytical Sciences and Miniaturization (LSABM), UMR CNRS-ESPCI Paris, CBI 8231, PSL Research University, ESPCI Paris, 10 rue Vauquelin, Paris, France.
Desoubries C; DGA, CBRN Defence, 5 rue Lavoisier, Vert-le-Petit, France.
Bossée A; DGA, CBRN Defence, 5 rue Lavoisier, Vert-le-Petit, France.
Pichon V; Department of Analytical, Bioanalytical Sciences and Miniaturization (LSABM), UMR CNRS-ESPCI Paris, CBI 8231, PSL Research University, ESPCI Paris, 10 rue Vauquelin, Paris, France. .; UPMC, Sorbonne University, 4 Place Jussieu, Paris, France. .
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2018 Jan; Vol. 410 (3), pp. 1039-1051. Date of Electronic Publication: 2017 Oct 02.
Typ publikacji:
Journal Article
MeSH Terms:
Butyrylcholinesterase/*metabolism
Chemical Warfare Agents/*pharmacokinetics
Cholinesterase Inhibitors/*blood
Sarin/*blood
Soman/*blood
Butyrylcholinesterase/blood ; Chemical Warfare Agents/metabolism ; Cholinesterase Inhibitors/metabolism ; Chromatography, Affinity/methods ; Chromatography, Liquid/methods ; Humans ; Sarin/analogs & derivatives ; Sarin/metabolism ; Soman/analogs & derivatives ; Soman/metabolism ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł:
A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness.
Autorzy:
Cruz-Hernandez A; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Roney A; Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
Goswami DG; Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
Tewari-Singh N; Department of Pharmacology and Toxicology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.
Brown JM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2022; Vol. 34 (13-14), pp. 412-432. Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Review; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
Chemical Warfare Agents*/toxicity
Persian Gulf Syndrome*/chemically induced
Veterans*
Humans ; Gulf War ; Sarin
Czasopismo naukowe
Tytuł:
Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice.
Autorzy:
Wei Z; Department of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.
Zhang X; Department of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.
Nie H; Department of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.
Yao L; Department of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.
Liu Y; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
Zheng Z; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
Ouyang Q; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 400038, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Feb 07; Vol. 27 (3). Date of Electronic Publication: 2022 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylcholinesterase/*metabolism
Antidotes/*pharmacology
Cholinesterase Reactivators/*pharmacology
Neurotoxicity Syndromes/*drug therapy
Pyridinium Compounds/*pharmacology
Sarin/*toxicity
Animals ; Chemical Warfare Agents/toxicity ; Humans ; Mice ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/pathology ; Oximes
Czasopismo naukowe
Tytuł:
UiO-66-NH 2 and Zeolite-Templated Carbon Composites for the Degradation and Adsorption of Nerve Agents.
Autorzy:
Lee J; Agency for Defense Development, P.O. Box 35, Yuseong-gu, Daejeon 34186, Korea.
Ka D; Agency for Defense Development, P.O. Box 35, Yuseong-gu, Daejeon 34186, Korea.
Jung H; Agency for Defense Development, P.O. Box 35, Yuseong-gu, Daejeon 34186, Korea.
Cho K; Agency for Defense Development, P.O. Box 35, Yuseong-gu, Daejeon 34186, Korea.
Jin Y; Agency for Defense Development, P.O. Box 35, Yuseong-gu, Daejeon 34186, Korea.
Kim M; Agency for Defense Development, P.O. Box 35, Yuseong-gu, Daejeon 34186, Korea.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 23; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 23.
Typ publikacji:
Journal Article
MeSH Terms:
Carbon/*chemistry
Metal-Organic Frameworks/*chemistry
Nerve Agents/*chemistry
Organometallic Compounds/*chemistry
Phthalic Acids/*chemistry
Zeolites/*chemistry
Adsorption ; Metal-Organic Frameworks/chemical synthesis ; Metal-Organic Frameworks/ultrastructure ; Microscopy, Electron, Scanning ; Porosity ; Sarin/chemistry ; Soman/chemistry ; Spectroscopy, Fourier Transform Infrared ; Water/chemistry ; X-Ray Diffraction
Czasopismo naukowe
Tytuł:
A Rapid and Sensitive Strip-Based Quick Test for Nerve Agents Tabun, Sarin, and Soman Using BODIPY-Modified Silica Materials.
Autorzy:
Climent E; Chemical and Optical Sensing Division (1.9), Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Strasse 11, 12489, Berlin, Germany.
Biyikal M; Chemical and Optical Sensing Division (1.9), Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Strasse 11, 12489, Berlin, Germany.
Gawlitza K; Chemical and Optical Sensing Division (1.9), Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Strasse 11, 12489, Berlin, Germany.
Dropa T; Laboratory of Toxic Compounds, National Institute for Nuclear, Chemical and Biological Protection, Kamenná 71, 262 31, Milín, Czech Republic.
Urban M; Laboratory of Toxic Compounds, National Institute for Nuclear, Chemical and Biological Protection, Kamenná 71, 262 31, Milín, Czech Republic.
Costero AM; Organic Chemistry Department, Universitat de Valencia, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain.; Research Institute for Molecular Recognition and Technological, Development (IDM), Unidad Mixta Universidad Politécnica de Valencia-, Universidad de Valencia, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain.
Martínez-Máñez R; Research Institute for Molecular Recognition and Technological, Development (IDM), Unidad Mixta Universidad Politécnica de Valencia-, Universidad de Valencia, Spain.; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain.; Department of Chemistry, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia, Spain.
Rurack K; Chemical and Optical Sensing Division (1.9), Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Strasse 11, 12489, Berlin, Germany. .
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2016 Aug 01; Vol. 22 (32), pp. 11138-42. Date of Electronic Publication: 2016 May 30.
Typ publikacji:
Journal Article
MeSH Terms:
Boron Compounds/*chemistry
Chemical Warfare Agents/*chemistry
Nerve Agents/*chemistry
Organophosphates/*chemistry
Prothrombin Time/*methods
Sarin/*chemistry
Silicon Dioxide/*chemistry
Soman/*chemistry
Chemical Warfare Agents/analysis ; Nerve Agents/analysis ; Organophosphates/analysis ; Sarin/analysis ; Soman/analysis
Czasopismo naukowe
Tytuł:
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
Autorzy:
Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense , Hradec Kralove , Czech Republic.
Sepsova V
Matouskova L
Horova A
Musilek K
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Źródło:
Toxicology mechanisms and methods [Toxicol Mech Methods] 2015 Mar; Vol. 25 (3), pp. 229-33. Date of Electronic Publication: 2015 Apr 20.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidotes/*therapeutic use
Cholinesterase Inhibitors/*toxicity
Cholinesterase Reactivators/*therapeutic use
Neurotoxicity Syndromes/*drug therapy
Oximes/*therapeutic use
Pyridinium Compounds/*therapeutic use
Sarin/*toxicity
Acetylcholinesterase/blood ; Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Animals ; Animals, Outbred Strains ; Atropine/therapeutic use ; Brain/drug effects ; Brain/enzymology ; Cholinesterase Inhibitors/administration & dosage ; Cholinesterase Inhibitors/chemistry ; Diaphragm/drug effects ; Diaphragm/enzymology ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Male ; Mice ; Muscarinic Antagonists/therapeutic use ; Nerve Tissue Proteins/agonists ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/metabolism ; Neurons/drug effects ; Neurons/enzymology ; Neurotoxicity Syndromes/blood ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/metabolism ; Obidoxime Chloride/therapeutic use ; Rats, Wistar ; Sarin/administration & dosage ; Sarin/antagonists & inhibitors
Czasopismo naukowe
Tytuł:
Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase.
Autorzy:
Jończyk J; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Kukułowicz J; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Łątka K; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Malawska B; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Jung YS; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, Daejeon 34114, Korea.; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, Daejeon 34113, Korea.
Musilek K; Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.; Biomedical Research Center, University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic.
Bajda M; Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
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Źródło:
Biomolecules [Biomolecules] 2021 Jan 27; Vol. 11 (2). Date of Electronic Publication: 2021 Jan 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Docking Simulation*
Acetylcholinesterase/*metabolism
Butyrylcholinesterase/*metabolism
Cholinesterase Inhibitors/*pharmacology
Cholinesterase Reactivators/*pharmacology
Animals ; Catalytic Domain ; Cluster Analysis ; Enzyme Activation ; Humans ; Ligands ; Mice ; Models, Molecular ; Organophosphates/chemistry ; Oximes/chemistry ; Phosphorus/chemistry ; Protein Binding ; Protein Biosynthesis ; Protein Conformation ; Quantum Theory ; Sarin/chemistry
Czasopismo naukowe
Tytuł:
A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study.
Autorzy:
Bzdrenga J; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
Trenet E; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
Chantegreil F; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
Bernal K; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
Nachon F; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
Brazzolotto X; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jan 27; Vol. 26 (3). Date of Electronic Publication: 2021 Jan 27.
Typ publikacji:
Journal Article
MeSH Terms:
Esterases/*chemistry
Nerve Agents/*chemistry
Planctomycetales/*chemistry
Amino Acids/chemistry ; Crystallography, X-Ray/methods ; Kinetics ; Organophosphates/chemistry ; Organophosphorus Compounds/chemistry ; Paraoxon/chemistry ; Planctomycetes ; Sarin/chemistry
SCR Organism:
Thermogutta terrifontis
Czasopismo naukowe
Tytuł:
SAW Chemical Array Device Coated with Polymeric Sensing Materials for the Detection of Nerve Agents.
Autorzy:
Kim J; Laboratory of Intelligent Devices and Thermal Control, Department of Mechanical Engineering, INHA University, inha-ro 100, Incheon 22212, Korea.
Park H; Laboratory of Intelligent Devices and Thermal Control, Department of Mechanical Engineering, INHA University, inha-ro 100, Incheon 22212, Korea.
Kim J; Inha Institute of Space Science and Technology (Inha IST), INHA University, inha-ro 100, Incheon 22212, Korea.
Seo BI; Inha Institute of Space Science and Technology (Inha IST), INHA University, inha-ro 100, Incheon 22212, Korea.
Kim JH; Laboratory of Intelligent Devices and Thermal Control, Department of Mechanical Engineering, INHA University, inha-ro 100, Incheon 22212, Korea.; Inha Institute of Space Science and Technology (Inha IST), INHA University, inha-ro 100, Incheon 22212, Korea.
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Źródło:
Sensors (Basel, Switzerland) [Sensors (Basel)] 2020 Dec 08; Vol. 20 (24). Date of Electronic Publication: 2020 Dec 08.
Typ publikacji:
Letter
MeSH Terms:
Chemical Warfare Agents*/analysis
Nerve Agents*
Smart Materials*
Humans ; Polymers ; Sarin
Opinia redakcyjna
Tytuł:
Chemoselective Hydrogenation of 6-Alkynyl-3-fluoro-2-pyridinaldoximes: Access to First-in-Class 6-Alkyl-3-Fluoro-2-pyridinaldoxime Scaffolds as New Reactivators of Sarin-Inhibited Human Acetylcholinesterase with Increased Blood-Brain Barrier Permeability.
Autorzy:
Yerri J; ICPEES UMR CNRS 7515, Institut de Chimie des Procédés, pour l'Energie, l'Environnement, et la Santé, 25 Rue Becquerel, 67087, Strasbourg, France.
Dias J; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220, Brétigny-sur-Orge, France.
Nimmakayala MR; ICPEES UMR CNRS 7515, Institut de Chimie des Procédés, pour l'Energie, l'Environnement, et la Santé, 25 Rue Becquerel, 67087, Strasbourg, France.
Razafindrainibe F; ICPEES UMR CNRS 7515, Institut de Chimie des Procédés, pour l'Energie, l'Environnement, et la Santé, 25 Rue Becquerel, 67087, Strasbourg, France.
Courageux C; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220, Brétigny-sur-Orge, France.
Gastellier AJ; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220, Brétigny-sur-Orge, France.
Jegoux J; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220, Brétigny-sur-Orge, France.
Coisne C; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UArtois), 62307, Lens, France.
Landry C; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UArtois), 62307, Lens, France.
Gosselet F; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UArtois), 62307, Lens, France.
Hachani J; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UArtois), 62307, Lens, France.
Goossens JF; ULR 7365-GRITA-Groupe de Recherche sur les Formes, Injectables et Technologies Associées, University of Lille, 59000, Lille, France.
Dehouck MP; UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois (UArtois), 62307, Lens, France.
Nachon F; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220, Brétigny-sur-Orge, France.
Baati R; ICPEES UMR CNRS 7515, Institut de Chimie des Procédés, pour l'Energie, l'Environnement, et la Santé, 25 Rue Becquerel, 67087, Strasbourg, France.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Nov 20; Vol. 26 (65), pp. 15035-15044. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Blood-Brain Barrier*/metabolism
Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors ; Cholinesterase Reactivators ; Humans ; Hydrogenation ; Oximes ; Permeability ; Pyridinium Compounds ; Sarin
Czasopismo naukowe
Tytuł:
Diagnostics and treatment of nerve agent poisoning-current status and future developments.
Autorzy:
Amend N; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Niessen KV; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Seeger T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Wille T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Thiermann H; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Nov; Vol. 1479 (1), pp. 13-28. Date of Electronic Publication: 2020 Mar 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Organophosphate Poisoning*/diagnosis
Organophosphate Poisoning*/drug therapy
Antidotes/*therapeutic use
Cholinesterase Reactivators/*therapeutic use
Nerve Agents/*toxicity
Sarin/*toxicity
Humans ; Oximes/therapeutic use ; United Kingdom
Czasopismo naukowe
Tytuł:
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice - a comparison with oxime-based treatment.
Autorzy:
Kassa J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Timperley CM; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (DSTL), Salisbury, United Kingdom.
Bird M; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (DSTL), Salisbury, United Kingdom.
Green AC; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (DSTL), Salisbury, United Kingdom.
Tattersall JEH; Chemical, Biological and Radiological Division, Defence Science and Technology Laboratory (DSTL), Salisbury, United Kingdom.
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Źródło:
Toxicology mechanisms and methods [Toxicol Mech Methods] 2020 Nov; Vol. 30 (9), pp. 703-710. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Antidotes/*pharmacology
Chemical Warfare Agents/*toxicity
Cholinesterase Reactivators/*pharmacology
Nicotinic Antagonists/*pharmacology
Organophosphate Poisoning/*drug therapy
Animals ; Lethal Dose 50 ; Male ; Mice ; Organophosphate Poisoning/etiology ; Organophosphates/toxicity ; Organophosphorus Compounds/toxicity ; Oximes/pharmacology ; Pyridinium Compounds/pharmacology ; Sarin/toxicity ; Soman/toxicity ; Time Factors
Czasopismo naukowe
Tytuł:
Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.
Autorzy:
Chambers JE; Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.
Meek EC; Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Nov; Vol. 1479 (1), pp. 5-12. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
Antidotes/*therapeutic use
Nerve Agents/*toxicity
Neuroprotection/*drug effects
Organothiophosphorus Compounds/*toxicity
Pralidoxime Compounds/*therapeutic use
Sarin/*toxicity
Acetylcholinesterase/metabolism ; Animals ; GPI-Linked Proteins/metabolism ; Male ; Rats ; United States
Czasopismo naukowe
Tytuł:
An enhanced butyrylcholinesterase method to measure organophosphorus nerve agent exposure in humans.
Autorzy:
Pantazides BG; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
Watson CM
Carter MD
Crow BS
Perez JW
Blake TA
Thomas JD
Johnson RC
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2014 Aug; Vol. 406 (21), pp. 5187-94. Date of Electronic Publication: 2014 Mar 07.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Biological Assay*
Butyrylcholinesterase/*chemistry
Chemical Warfare Agents/*analysis
Organothiophosphorus Compounds/*blood
Sarin/*blood
Antibodies, Monoclonal/chemistry ; Chemical Warfare Agents/chemistry ; Chromatography, Liquid ; Humans ; Immunomagnetic Separation ; In Vitro Techniques ; Organothiophosphorus Compounds/chemistry ; Sarin/chemistry ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident.
Autorzy:
Sugiyama A; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Matsuoka T; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Sakamune K; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Akita T; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Makita R; Department of Forensic Medicine, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Kimura S; Non-Profit Organization (NPO) Recovery Support Center, Tokyo, Japan.
Kuroiwa Y; Non-Profit Organization (NPO) Recovery Support Center, Tokyo, Japan.
Nagao M; Department of Forensic Medicine, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Tanaka J; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
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Źródło:
PloS one [PLoS One] 2020 Jun 23; Vol. 15 (6), pp. e0234967. Date of Electronic Publication: 2020 Jun 23 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Chemical Terrorism*
Chemical Warfare Agents/*poisoning
Miosis/*epidemiology
Sarin/*poisoning
Stress Disorders, Post-Traumatic/*epidemiology
Survivors/*statistics & numerical data
Adolescent ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Miosis/chemically induced ; Prevalence ; Railroads ; Risk Factors ; Self Report/statistics & numerical data ; Stress Disorders, Post-Traumatic/psychology ; Survivors/psychology ; Tokyo/epidemiology ; Young Adult
Czasopismo naukowe
Tytuł:
Chemical weapons. U.N. taps special labs to investigate Syrian attack.
Autorzy:
Enserink M
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Źródło:
Science (New York, N.Y.) [Science] 2013 Sep 06; Vol. 341 (6150), pp. 1050-1.
Typ publikacji:
Wiadomości
MeSH Terms:
Cause of Death*
Child Mortality*
Chemical Warfare Agents/*analysis
Sarin/*analysis
Chemical Warfare Agents/metabolism ; Child, Preschool ; Female ; Humans ; Laboratories ; Male ; Sarin/blood ; Sarin/metabolism ; Sarin/urine ; Soil/analysis ; Syria ; Tissue Distribution ; United Nations ; Water/analysis
Periodyk
Tytuł:
Lung damage following whole body, but not intramuscular, exposure to median lethality dose of sarin: findings in rats and guinea pigs.
Autorzy:
Chapman S; a Department of Pharmacology, Israel Institute for Biological Research (IIBR) , Ness-Ziona , Israel.
Lazar S; a Department of Pharmacology, Israel Institute for Biological Research (IIBR) , Ness-Ziona , Israel.
Gez R; a Department of Pharmacology, Israel Institute for Biological Research (IIBR) , Ness-Ziona , Israel.
Rabinovitz I; a Department of Pharmacology, Israel Institute for Biological Research (IIBR) , Ness-Ziona , Israel.
Yaakov G; a Department of Pharmacology, Israel Institute for Biological Research (IIBR) , Ness-Ziona , Israel.
Grauer E; a Department of Pharmacology, Israel Institute for Biological Research (IIBR) , Ness-Ziona , Israel.
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2019 Apr; Vol. 31 (5), pp. 203-211. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical Warfare Agents/*toxicity
Lung/*pathology
Sarin/*administration & dosage
Sarin/*toxicity
Administration, Inhalation ; Animals ; Bronchoalveolar Lavage ; Cholinesterase Inhibitors/administration & dosage ; Cholinesterase Inhibitors/toxicity ; Guinea Pigs ; Inflammation ; Injections, Intramuscular ; Lethal Dose 50 ; Lung/drug effects ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Sampling and analyses of surfaces contaminated with chemical warfare agents by using a newly developed triple layered composite wipe.
Autorzy:
Imran M; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Kumar N; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Thakare VB; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Gupta AK; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Acharya J; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India.
Garg P; Defence Research & Development Establishment, Defence Research & Development Organization, Jhansi Road, Gwalior, 474002, India. .
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2020 Feb; Vol. 412 (5), pp. 1097-1110. Date of Electronic Publication: 2020 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Textiles*
Chemical Warfare Agents/*analysis
Mustard Gas/*analysis
Sarin/*analysis
Specimen Handling/*instrumentation
Adsorption ; Environmental Monitoring/methods ; Gas Chromatography-Mass Spectrometry/methods ; Limit of Detection ; Microscopy, Electron, Scanning ; Reference Standards ; Solvents/chemistry ; Surface Properties
Czasopismo naukowe
Tytuł:
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.
Autorzy:
Kassa J; Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic. />Misik J
Karasova JZ
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2012 Nov; Vol. 111 (5), pp. 333-8. Date of Electronic Publication: 2012 May 24.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidotes/*therapeutic use
Cholinesterase Reactivators/*therapeutic use
Neurotoxicity Syndromes/*drug therapy
Obidoxime Chloride/*therapeutic use
Oximes/*therapeutic use
Pyridinium Compounds/*therapeutic use
Sarin/*antagonists & inhibitors
Animals ; Antidotes/adverse effects ; Atropine/therapeutic use ; Autonomic Nervous System/drug effects ; Autonomic Nervous System/physiopathology ; Chemical Warfare Agents/chemistry ; Chemical Warfare Agents/toxicity ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/toxicity ; Cholinesterase Reactivators/adverse effects ; Czech Republic ; Drug Therapy, Combination ; Lethal Dose 50 ; Male ; Muscarinic Antagonists/therapeutic use ; Neurons/drug effects ; Neurotoxicity Syndromes/physiopathology ; Obidoxime Chloride/adverse effects ; Oximes/adverse effects ; Psychomotor Performance/drug effects ; Pyridinium Compounds/adverse effects ; Rats ; Rats, Wistar ; Sarin/toxicity
Czasopismo naukowe
Tytuł:
The benefit of combination of oximes for the neuroprotective efficacy of antidotal treatment of sarin-poisoned rats.
Autorzy:
Kassa J; Department of Toxicology, Faculty of Military Health Sciences , Hradec Kralove , Czech Republic. />Kunesova G
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Źródło:
Toxicology mechanisms and methods [Toxicol Mech Methods] 2012 May; Vol. 22 (4), pp. 260-7. Date of Electronic Publication: 2011 Dec 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuroprotective Agents/*therapeutic use
Oximes/*therapeutic use
Pyridinium Compounds/*therapeutic use
Sarin/*poisoning
Trimedoxime/*therapeutic use
Animals ; Antidotes/administration & dosage ; Antidotes/therapeutic use ; Atropine/chemistry ; Chemical Warfare Agents/poisoning ; Chemical Warfare Agents/toxicity ; Cholinesterase Inhibitors/poisoning ; Cholinesterase Inhibitors/toxicity ; Cholinesterase Reactivators/administration & dosage ; Cholinesterase Reactivators/therapeutic use ; Drug Therapy, Combination ; Male ; Molecular Structure ; Oximes/administration & dosage ; Oximes/chemistry ; Pyridinium Compounds/administration & dosage ; Pyridinium Compounds/chemistry ; Rats ; Rats, Wistar ; Sarin/toxicity ; Trimedoxime/administration & dosage ; Trimedoxime/chemistry
Czasopismo naukowe
Tytuł:
Kinetics of sarin (GB) following a single sublethal inhalation exposure in the guinea pig.
Autorzy:
Whalley CE; U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010-5424, USA. />McGuire JM
Miller DB
Jakubowski EM
Mioduszewski RJ
Thomson SA
Lumley LA
McDonough JH
Shih TM
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2007 Jun; Vol. 19 (8), pp. 667-81.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Inhalation Exposure/*analysis
Sarin/*administration & dosage
Sarin/*pharmacokinetics
Animals ; Atmosphere Exposure Chambers ; Guinea Pigs ; Lethal Dose 50 ; Male ; Sarin/blood ; Tissue Distribution
Czasopismo naukowe
Tytuł:
Detection of sarin in plasma of rats after inhalation intoxication.
Autorzy:
Bartosova L; Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, Hradec Kralove, Czech Republic. />Bielavska M
Bajgar J
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2006 Oct; Vol. 21 (5), pp. 509-14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Inhalation*
Sarin/*blood
Sarin/*toxicity
Acetates/blood ; Animals ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/blood ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/toxicity ; Chromatography, Gas ; Female ; Fluorides/pharmacology ; Molecular Structure ; Rats ; Rats, Wistar ; Sarin/chemistry
Czasopismo naukowe
Czasopismo naukowe
Tytuł:
The Relationship Between Traumatic Brain Injury and Rates of Chronic Symptomatic Illness in 202 Gulf War Veterans.
Autorzy:
Chao LL; Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, 4150 Clement Street (114 M), San Francisco, CA.; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA.; Department of Psychiatry, University of California, San Francisco, San Francisco, CA.
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Źródło:
Military medicine [Mil Med] 2018 Nov 01; Vol. 183 (11-12), pp. e571-e579.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Brain Injuries, Traumatic/*complications
Chronic Disease/*rehabilitation
Veterans/*statistics & numerical data
Brain Injuries, Traumatic/epidemiology ; Brain Injuries, Traumatic/physiopathology ; Chi-Square Distribution ; Chronic Disease/epidemiology ; Cohort Studies ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/etiology ; Female ; Gulf War ; Humans ; Male ; Middle Aged ; Organophosphorus Compounds/adverse effects ; Psychometrics/instrumentation ; Psychometrics/methods ; Sarin/adverse effects ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/etiology ; Surveys and Questionnaires ; United States ; United States Department of Veterans Affairs/organization & administration ; United States Department of Veterans Affairs/statistics & numerical data ; Veterans/psychology
Czasopismo naukowe
Tytuł:
The application of the fluoride reactivation process to the detection of sarin and soman nerve agent exposures in biological samples.
Autorzy:
Adams TK; US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA.
Capacio BR
Smith JR
Whalley CE
Korte WD
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Źródło:
Drug and chemical toxicology [Drug Chem Toxicol] 2004 Feb; Vol. 27 (1), pp. 77-91.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Chemical Warfare Agents/*pharmacokinetics
Cholinesterase Reactivators/*pharmacology
Fluorides/*pharmacology
Sarin/*pharmacokinetics
Soman/*pharmacokinetics
Animals ; Chemical Warfare Agents/toxicity ; Dose-Response Relationship, Drug ; Guinea Pigs ; Humans ; Kidney/drug effects ; Kidney/metabolism ; Lethal Dose 50 ; Macaca mulatta ; Sarin/blood ; Sarin/toxicity ; Soman/blood ; Soman/toxicity
Czasopismo naukowe
Tytuł:
Chemical exposures and suspected impact on Gulf War Veterans
Autorzy:
Rami Elhaj
Joseph M. Reynolds
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Temat:
Gulf War Illness (GWI)
Sarin
Neuroinflammation
Organophosphate (OP)
Medicine (General)
R5-920
Military Science
Źródło:
Military Medical Research, Vol 10, Iss 1, Pp 1-11 (2023)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2054-9369
Dostęp URL:
https://doaj.org/article/806d0e6ea283465fbe34ec82b27bc0cf  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
The alteration of immune reactions in inbred BALB/c mice following low-level sarin inhalation exposure.
Autorzy:
Kassa J; Department of Toxicology, Purkyne Military Medical Academy, Hradec Králové, Czech Republic. />Krocová Z
Sevelová L
Sheshko V
Kasalová I
Neubauerová V
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2004 Jul; Vol. 16 (8), pp. 509-15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
B-Lymphocytes/*drug effects
Chemical Warfare Agents/*toxicity
Immune System/*drug effects
Killer Cells, Natural/*drug effects
Sarin/*toxicity
T-Lymphocytes/*drug effects
Administration, Inhalation ; Animals ; B-Lymphocytes/metabolism ; Dose-Response Relationship, Drug ; Female ; Immune System/metabolism ; Immunity, Cellular/drug effects ; Immunophenotyping ; Inhalation Exposure ; Killer Cells, Natural/metabolism ; Lymphocyte Count ; Mice ; Mice, Inbred BALB C ; Mitogens/pharmacology ; Nitric Oxide/metabolism ; Sarin/administration & dosage ; Spleen/cytology ; Spleen/drug effects ; Spleen/metabolism ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł:
Protective effect of equine butyrylcholinesterase in inhalation intoxication of rats with sarin: determination of blood and brain cholinesterase activities.
Autorzy:
Sevelová L; Department of Toxicology, Purkyne Military Medical Academy, Hradec Králové, Czech Republic. />Bajgar J
Saxena A
Doctor BP
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2004 Jul; Vol. 16 (8), pp. 531-6.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Butyrylcholinesterase*/blood
Butyrylcholinesterase*/pharmacokinetics
Butyrylcholinesterase*/therapeutic use
Cholinesterase Inhibitors*/blood
Cholinesterase Inhibitors*/pharmacokinetics
Cholinesterase Inhibitors*/therapeutic use
Brain/*drug effects
Brain/*enzymology
Chemical Warfare Agents/*poisoning
Poisoning/*prevention & control
Sarin/*poisoning
Administration, Inhalation ; Animals ; Dose-Response Relationship, Drug ; Drug Antagonism ; Female ; Horses ; Inhalation Exposure ; Rats ; Rats, Wistar ; Sarin/administration & dosage
Czasopismo naukowe
Tytuł:
The influence of sarin on various physiological functions in rats following single or repeated low-level inhalation exposure.
Autorzy:
Kassa J; Department of Toxicology, Purkyne Military Medical Academy, Hradec Králové, Czech Republic. />Krejcová G
Skopec F
Herink J
Bajgar J
Sevelová L
Tichý M
Pecka M
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Źródło:
Inhalation toxicology [Inhal Toxicol] 2004 Jul; Vol. 16 (8), pp. 517-30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Behavior, Animal/*drug effects
Chemical Warfare Agents/*toxicity
Cholinesterase Inhibitors/*toxicity
Nervous System Physiological Phenomena/*drug effects
Sarin/*toxicity
Administration, Inhalation ; Animals ; Cholinesterase Inhibitors/administration & dosage ; Clinical Chemistry Tests ; DNA Replication/drug effects ; Dose-Response Relationship, Drug ; Erythrocytes/drug effects ; Erythrocytes/enzymology ; Hematologic Tests ; Inhalation Exposure ; Liver/drug effects ; Liver/metabolism ; Male ; Rats ; Sarin/administration & dosage ; Specific Pathogen-Free Organisms ; Time Factors
Czasopismo naukowe

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