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Tytuł :
Preliminary studies on the different roles of T6SSs in pathogenicity of Pseudomonas plecoglossicida NB2011.
Autorzy :
Jin J; Biological and Environmental College, Zhejiang Wanli University, Ningbo, China.
Li Y; Biological and Environmental College, Zhejiang Wanli University, Ningbo, China.
Huang M; Biological and Environmental College, Zhejiang Wanli University, Ningbo, China.
Li S; Biological and Environmental College, Zhejiang Wanli University, Ningbo, China.
Mao Z; Biological and Environmental College, Zhejiang Wanli University, Ningbo, China.
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Źródło :
Journal of fish diseases [J Fish Dis] 2021 Nov; Vol. 44 (11), pp. 1669-1679. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Type VI Secretion Systems*/physiology
Virulence*
Fish Diseases/*microbiology
Perciformes/*microbiology
Pseudomonas/*pathogenicity
Animals ; Pseudomonas/genetics ; Pseudomonas Infections/veterinary ; Virulence Factors
SCR Organism :
Pseudomonas plecoglossicida
Czasopismo naukowe
Tytuł :
Structural Dynamics of the Functional Nonameric Type III Translocase Export Gate.
Autorzy :
Yuan B; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium; Centre for Structural Systems Biology (CSSB), Notkestrasse 85, D-22607 Hamburg, Germany; University Medical Center Hamburg-Eppendorf (UKE), Institute for Structural and Systems Biology, Notkestrasse 85, D-22607 Hamburg, Germany; German Electron Synchrotron Centre (DESY), Notkestrasse 85, D-22607 Hamburg, Germany. Electronic address: .
Portaliou AG; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium. Electronic address: .
Parakra R; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium. Electronic address: .
Smit JH; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium; Molecular Microscopy Research Group, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands. Electronic address: .
Wald J; Centre for Structural Systems Biology (CSSB), Notkestrasse 85, D-22607 Hamburg, Germany; University Medical Center Hamburg-Eppendorf (UKE), Institute for Structural and Systems Biology, Notkestrasse 85, D-22607 Hamburg, Germany; German Electron Synchrotron Centre (DESY), Notkestrasse 85, D-22607 Hamburg, Germany. Electronic address: .
Li Y; Molecular Microscopy Research Group, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands. Electronic address: .
Srinivasu B; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium. Electronic address: .
Loos MS; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium.
Dhupar HS; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
Fahrenkamp D; Centre for Structural Systems Biology (CSSB), Notkestrasse 85, D-22607 Hamburg, Germany; University Medical Center Hamburg-Eppendorf (UKE), Institute for Structural and Systems Biology, Notkestrasse 85, D-22607 Hamburg, Germany; German Electron Synchrotron Centre (DESY), Notkestrasse 85, D-22607 Hamburg, Germany. Electronic address: .
Kalodimos CG; Department of Structural Biology, St. Jude Children's Research Hospital, 263 Danny Thomas Place, Memphis, TN 38105, United States. Electronic address: .
Duong van Hoa F; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, Canada. Electronic address: .
Cordes T; Molecular Microscopy Research Group, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands; Physical and Synthetic Biology, Faculty of Biology, Ludwig Maximilians-Universität München, Großhadernerstr. 2-4, 82152 Planegg-Martinsried, Germany. Electronic address: .
Karamanou S; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium. Electronic address: .
Marlovits TC; Centre for Structural Systems Biology (CSSB), Notkestrasse 85, D-22607 Hamburg, Germany; University Medical Center Hamburg-Eppendorf (UKE), Institute for Structural and Systems Biology, Notkestrasse 85, D-22607 Hamburg, Germany; German Electron Synchrotron Centre (DESY), Notkestrasse 85, D-22607 Hamburg, Germany. Electronic address: .
Economou A; KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, B-3000 Leuven, Belgium. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Oct 15; Vol. 433 (21), pp. 167188. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphatases/*chemistry
Enteropathogenic Escherichia coli/*ultrastructure
Escherichia coli Proteins/*chemistry
Flagella/*ultrastructure
SEC Translocation Channels/*chemistry
Type III Secretion Systems/*ultrastructure
Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Allosteric Regulation ; Binding Sites ; Cloning, Molecular ; Cryoelectron Microscopy ; Deuterium Exchange Measurement ; Enteropathogenic Escherichia coli/genetics ; Enteropathogenic Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Flagella/genetics ; Flagella/metabolism ; Gene Expression ; Gene Expression Regulation, Bacterial ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Kinetics ; Mass Spectrometry ; Models, Molecular ; Molecular Chaperones/chemistry ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; SEC Translocation Channels/genetics ; SEC Translocation Channels/metabolism ; Substrate Specificity ; Type III Secretion Systems/genetics ; Type III Secretion Systems/metabolism
Czasopismo naukowe
Tytuł :
Transmembrane domains of type III-secreted proteins affect bacterial-host interactions in enteropathogenic E. coli .
Autorzy :
Gershberg J; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Braverman D; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Sal-Man N; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
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Źródło :
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 902-917.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host Microbial Interactions*
Bacterial Outer Membrane Proteins/*metabolism
Bacterial Proteins/*metabolism
Enteropathogenic Escherichia coli/*genetics
Enteropathogenic Escherichia coli/*physiology
Type III Secretion Systems/*metabolism
Bacterial Outer Membrane Proteins/genetics ; Bacterial Proteins/genetics ; Escherichia coli Proteins/metabolism ; HeLa Cells ; Humans ; Protein Domains ; Type III Secretion Systems/genetics
Czasopismo naukowe
Tytuł :
Conserved Salt Bridges Facilitate Assembly of the Helical Core Export Apparatus of a Salmonella enterica Type III Secretion System.
Autorzy :
Singh N; Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Tübingen, Germany.
Kronenberger T; University Hospital Tübingen, Department of Internal Medicine VIII, Tübingen, Germany; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Eipper A; Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Tübingen, Germany.
Weichel F; Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Tübingen, Germany; Partner-site Tübingen, German Center for Infection Research (DZIF), Tübingen, Germany.
Franz-Wachtel M; Proteome Center Tübingen, University of Tübingen, Tübingen, Germany.
Macek B; Excellence Cluster 'Controlling Microbes to Fight Infections' (CMFI), Tübingen, Germany; Proteome Center Tübingen, University of Tübingen, Tübingen, Germany.
Wagner S; Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of Tübingen, Tübingen, Germany; Excellence Cluster 'Controlling Microbes to Fight Infections' (CMFI), Tübingen, Germany; Partner-site Tübingen, German Center for Infection Research (DZIF), Tübingen, Germany. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Sep 17; Vol. 433 (19), pp. 167175. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Salmonella enterica/*metabolism
Type III Secretion Systems/*chemistry
Type III Secretion Systems/*metabolism
Models, Molecular ; Multiprotein Complexes/metabolism ; Mutation ; Protein Conformation ; Protein Domains ; Salmonella enterica/genetics ; Salmonella enterica/pathogenicity ; Type III Secretion Systems/genetics ; Virulence
Czasopismo naukowe
Tytuł :
Glucagon Potentiates Insulin Secretion Via β-Cell GCGR at Physiological Concentrations of Glucose.
Autorzy :
Zhang Y; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Han C; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Zhu W; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Yang G; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Peng X; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Mehta S; Department of Pharmacology, University of California San Diego, La Jolla, CA 92093-0702, USA.
Zhang J; Department of Pharmacology, University of California San Diego, La Jolla, CA 92093-0702, USA.
Chen L; State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.; Beijing Academy of Artificial Intelligence, Beijing 100871, China.
Liu Y; Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China.
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Źródło :
Cells [Cells] 2021 Sep 21; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon/*pharmacology
Insulin Secretion/*physiology
Receptors, Glucagon/*physiology
Animals ; Glucagon/metabolism ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors ; Glucagon-Like Peptide-1 Receptor/metabolism ; Glucagon-Like Peptide-1 Receptor/physiology ; Glucose/metabolism ; Glucose Intolerance/metabolism ; Insulin/metabolism ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Glucagon/antagonists & inhibitors ; Signal Transduction
Czasopismo naukowe
Tytuł :
miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells.
Autorzy :
Zhang K; Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing 210009, China.
Zhang Y; Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210009, China.
Chen C; Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing 210009, China.
Yuan Y; Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing 210009, China.
Jiang X; Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210009, China.
Yuan X; Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210009, China.
Wang Y; Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing 210009, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Jul 28; Vol. 53 (8), pp. 1017-1026.
Typ publikacji :
Journal Article
MeSH Terms :
C-Reactive Protein/*metabolism
Insulin Secretion/*drug effects
MicroRNAs/*metabolism
Nerve Tissue Proteins/*metabolism
Palmitates/*pharmacology
Animals ; C-Reactive Protein/genetics ; Insulin Secretion/genetics ; Male ; Mice ; MicroRNAs/genetics ; Nerve Tissue Proteins/genetics ; Rats
Czasopismo naukowe
Tytuł :
Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secretion System.
Autorzy :
Kunttu HMT; Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
Runtuvuori-Salmela A; Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
Sundell K; Laboratory of Aquatic Pathobiology, Åbo Akademi University, Turku, Finland.
Wiklund T; Laboratory of Aquatic Pathobiology, Åbo Akademi University, Turku, Finland.
Middelboe M; Department of Biology, Marine Biological Section, University of Copenhagen, Helsingør, Denmark.
Landor L; Laboratory of Aquatic Pathobiology, Åbo Akademi University, Turku, Finland.
Ashrafi R; Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
Hoikkala V; Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
Sundberg LR; Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
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Źródło :
Applied and environmental microbiology [Appl Environ Microbiol] 2021 Jul 27; Vol. 87 (16), pp. e0081221. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*genetics
Bacterial Secretion Systems/*genetics
Bacteriophages/*physiology
Fish Diseases/*microbiology
Flavobacteriaceae Infections/*veterinary
Flavobacterium/*cytology
Flavobacterium/*pathogenicity
Flavobacterium/*virology
Animals ; Bacterial Proteins/immunology ; Bacterial Secretion Systems/immunology ; Bacteriophages/genetics ; Fishes ; Flavobacteriaceae Infections/microbiology ; Flavobacterium/immunology ; Mutation ; Virulence
SCR Organism :
Flavobacterium columnare
Czasopismo naukowe
Tytuł :
Native flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries.
Autorzy :
Kawamoto A; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.; Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Miyata T; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
Makino F; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.; JEOL Ltd., Akishima, Tokyo, Japan.
Kinoshita M; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
Minamino T; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
Imada K; Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan.
Kato T; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan. .; Institute for Protein Research, Osaka University, Suita, Osaka, Japan. .
Namba K; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan. .; RIKEN Center for Biosystems Dynamics Research and SPring-8 Center, Suita, Osaka, Japan. .; JEOL YOKOGUSHI Research Alliance Laboratories, Osaka University, Suita, Osaka, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 09; Vol. 12 (1), pp. 4223. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*ultrastructure
Flagella/*ultrastructure
Membrane Proteins/*ultrastructure
Type III Secretion Systems/*ultrastructure
Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/metabolism ; Cell Fractionation ; Cryoelectron Microscopy ; Flagella/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/isolation & purification ; Membrane Proteins/metabolism ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutation ; Protein Conformation ; Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism ; Salmonella typhimurium/ultrastructure ; Type III Secretion Systems/genetics ; Type III Secretion Systems/metabolism
Czasopismo naukowe
Tytuł :
Editorial: Bacterial Effectors as Drivers of Human Disease: Models, Methods, Mechanisms.
Autorzy :
Schroeder GN; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Melbourne, VIC, Australia.
Thurston TLM; MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Jul 08; Vol. 11, pp. 708228. Date of Electronic Publication: 2021 Jul 08 (Print Publication: 2021).
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacteria*/genetics
Bacterial Secretion Systems*
Bacterial Proteins ; Host-Pathogen Interactions ; Humans ; Virulence Factors
Raport
Tytuł :
DctR contributes to the virulence of avian pathogenic Escherichia coli through regulation of type III secretion system 2 expression.
Autorzy :
Zhang Y; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Wang Y; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Zhu H; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Yi Z; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Afayibo DJA; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Tao C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Li T; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Tian M; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Qi J; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Ding C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Yu S; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China. .
Wang S; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China. .
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Źródło :
Veterinary research [Vet Res] 2021 Jul 06; Vol. 52 (1), pp. 101. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
Escherichia coli/*pathogenicity
Escherichia coli/*physiology
Escherichia coli Proteins/*genetics
Transcription Factors/*genetics
Type III Secretion Systems/*genetics
Bacterial Adhesion/genetics ; Biofilms/growth & development ; Escherichia coli/genetics ; Escherichia coli Proteins/metabolism ; Transcription Factors/metabolism ; Type III Secretion Systems/metabolism ; Virulence/genetics
Czasopismo naukowe
Tytuł :
A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.
Autorzy :
Asai S; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10, Prague 6, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University, 12840, Prague 2, Czech Republic.
Žáková L; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10, Prague 6, Czech Republic.
Selicharová I; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10, Prague 6, Czech Republic.
Marek A; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10, Prague 6, Czech Republic.
Jiráček J; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 116 10, Prague 6, Czech Republic. .
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Źródło :
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2021 Jul; Vol. 413 (17), pp. 4531-4543. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Secretion*
Insulin/*analysis
Insulin/*metabolism
Animals ; Arginine/metabolism ; Cell Line ; Dopamine/metabolism ; Glucose/metabolism ; Humans ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Mice ; Ornithine/metabolism ; Radioimmunoassay/methods ; Radioligand Assay/methods ; Rats ; Rats, Wistar ; Serotonin/metabolism
Czasopismo naukowe
Tytuł :
Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells.
Autorzy :
Nolan LM; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.
Cain AK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Clamens T; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.
Furniss RCD; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Manoli E; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.
Sainz-Polo MA; Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.
Dougan G; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Albesa-Jové D; Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), Fundación Biofísica Bizkaia/Biofisika Bizkaia Fundazioa (FBB) and Departamento de Bioquímica y Biología Molecular, University of the Basque Country, Leioa, Spain.
Parkhill J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Mavridou DAI; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK. .; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA. .
Filloux A; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK. .
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Źródło :
Nature microbiology [Nat Microbiol] 2021 Sep; Vol. 6 (9), pp. 1199-1210. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Bacterial Proteins/*metabolism
Bacterial Toxins/*metabolism
Multiprotein Complexes/*metabolism
Pseudomonas aeruginosa/*genetics
Pseudomonas aeruginosa/*metabolism
Type VI Secretion Systems/*metabolism
Bacterial Proteins/genetics ; Multiprotein Complexes/genetics ; Protein Binding ; Type VI Secretion Systems/genetics
Czasopismo naukowe
Tytuł :
Beta-cell function is disrupted in patients with systemic lupus erythematosus.
Autorzy :
García-Dorta A; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain.
Quevedo-Abeledo JC; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Rua-Figueroa Í; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain.
de Vera-González AM; Division of Central Laboratory, Hospital Universitario de Canarias, Tenerife, Spain.
González-Delgado A; Division of Central Laboratory, Hospital Universitario de Canarias, Tenerife, Spain.
Medina-Vega L; Division of Central Laboratory, Hospital Universitario de Canarias, Tenerife, Spain.
González-Rivero AF; Division of Central Laboratory, Hospital Universitario de Canarias, Tenerife, Spain.
Francisco-Hernández F; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain.
González-Gay MA; Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain.; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ferraz-Amaro I; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain.
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2021 Aug 02; Vol. 60 (8), pp. 3826-3833.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Secretion*
C-Peptide/*metabolism
Diabetes Mellitus/*metabolism
Insulin/*metabolism
Insulin-Secreting Cells/*metabolism
Lupus Erythematosus, Systemic/*metabolism
Proinsulin/*metabolism
Adult ; Female ; Glucocorticoids/therapeutic use ; Humans ; Insulin Resistance ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Middle Aged
SCR Disease Name :
Hyperproinsulinemia
Czasopismo naukowe
Tytuł :
Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice.
Autorzy :
Peyot ML; Department of Nutrition, Montreal Diabetes Research Center, CRCHUM, Montreal, Canada.
Roubtsova A; Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Montreal, Canada.
Lussier R; Department of Nutrition, Montreal Diabetes Research Center, CRCHUM, Montreal, Canada.
Chamberland A; Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Montreal, Canada.
Essalmani R; Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Montreal, Canada.
Murthy Madiraju SR; Department of Nutrition, Montreal Diabetes Research Center, CRCHUM, Montreal, Canada.
Seidah NG; Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Montreal, Canada.
Prentki M; Department of Nutrition, Montreal Diabetes Research Center, CRCHUM, Montreal, Canada.
Prat A; Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal (IRCM), Montreal, Canada. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Aug; Vol. 1866 (8), pp. 158968. Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeostasis*
Insulin Secretion*
Glucose/*metabolism
Insulin-Secreting Cells/*metabolism
Proprotein Convertase 9/*deficiency
Proprotein Convertase 9/*genetics
Animals ; Enzyme Activation ; Gene Knockout Techniques ; Mice
Czasopismo naukowe
Tytuł :
The transcriptional regulator Zur regulates the expression of ZnuABC and T6SS4 in response to stresses in Yersinia pseudotuberculosis.
Autorzy :
Cai R; Beijing Capital Co., LTD, Beijing, 100044, China.
Gao F; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Pan J; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Hao X; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Yu Z; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Qu Y; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Li J; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Wang D; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Wang Y; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Shen X; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
Liu X; General Research Institute for Nonferrous Metals, Beijing, 100088, China. Electronic address: .
Yang Y; State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, China. Electronic address: .
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Źródło :
Microbiological research [Microbiol Res] 2021 Aug; Vol. 249, pp. 126787. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Bacterial*
Oxidative Stress*
Bacterial Proteins/*genetics
Transcription Factors/*metabolism
Type VI Secretion Systems/*genetics
Yersinia pseudotuberculosis/*genetics
Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Bacterial Proteins/metabolism ; Operon ; Porins/genetics ; Porins/metabolism ; Promoter Regions, Genetic ; Type VI Secretion Systems/metabolism ; Yersinia pseudotuberculosis/physiology ; Zinc/metabolism
Czasopismo naukowe
Tytuł :
Microtubules and Gαo-signaling modulate the preferential secretion of young insulin secretory granules in islet β cells via independent pathways.
Autorzy :
Hu R; Department of Cell and Developmental Biology, The Program of Developmental Biology and the Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, United States of America.
Zhu X; Department of Cell and Developmental Biology, The Program of Developmental Biology and the Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, United States of America.
Yuan M; Department of Cell and Developmental Biology, The Program of Developmental Biology and the Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, United States of America.
Ho KH; Department of Cell and Developmental Biology, The Program of Developmental Biology and the Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, United States of America.
Kaverina I; Department of Cell and Developmental Biology, The Program of Developmental Biology and the Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, United States of America.
Gu G; Department of Cell and Developmental Biology, The Program of Developmental Biology and the Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Jul 22; Vol. 16 (7), pp. e0241939. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Secretion*/drug effects
GTP-Binding Protein alpha Subunits, Gi-Go/*metabolism
Microtubules/*metabolism
Secretory Vesicles/*metabolism
Animals ; Cell Membrane/metabolism ; Cells, Cultured ; Cellular Senescence ; GTP-Binding Protein alpha Subunits, Gi-Go/genetics ; Glucose/pharmacology ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Mice ; Mice, Inbred ICR ; Mice, Knockout ; Nocodazole/pharmacology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.
Autorzy :
Ikushima YM; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Awazawa M; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Kobayashi N; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Osonoi S; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Takemiya S; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Kobayashi H; Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Suwanai H; Department of Diabetes, Metabolism and Endocrinology, Tokyo Medical University, Tokyo, Japan.
Morimoto Y; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan.
Soeda K; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Adachi J; Laboratory of Proteome Research, Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Muratani M; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Charron J; Centre de Recherche sur le Cancer de l'Université Laval, L'Hôtel-Dieu de Québec, Quebec City, Quebec, Canada.
Mizukami H; Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Takahashi N; Department of Physiology, Kitasato University School of Medicine, Sagamihara, Japan.
Ueki K; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan .; Department of Molecular Diabetology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
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Źródło :
Diabetes [Diabetes] 2021 Jul; Vol. 70 (7), pp. 1519-1535. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeostasis*
Insulin Secretion*
Blood Glucose/*metabolism
Extracellular Signal-Regulated MAP Kinases/*physiology
Insulin-Secreting Cells/*metabolism
Mitogen-Activated Protein Kinase Kinases/*physiology
Animals ; Cell Line ; Diet, High-Fat ; Exocytosis ; Humans ; Insulin-Secreting Cells/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; Signal Transduction
Czasopismo naukowe
Tytuł :
Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion.
Autorzy :
Zakaria A; Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris, Paris, France.
Berthault C; Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris, Paris, France.
Cosson B; Epigenetics and Cell Fate Center, CNRS UMR 7216, Université de Paris, Paris, France.
Jung V; Plateforme protéomique Necker, INSERM US24/CNRS UMS3633, Université de Paris, Structure Fédérative de Recherche Necker, Paris, France.
Guerrera IC; Plateforme protéomique Necker, INSERM US24/CNRS UMS3633, Université de Paris, Structure Fédérative de Recherche Necker, Paris, France.
Rachdi L; Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris, Paris, France. Electronic address: .
Scharfmann R; Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris, Paris, France. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100839. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism/*genetics
Glucose/*pharmacology
Insulin Secretion/*genetics
Insulin-Secreting Cells/*metabolism
Protein Biosynthesis/*genetics
Cell Line ; Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit/metabolism ; Energy Metabolism/drug effects ; Humans ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/drug effects ; Mitogen-Activated Protein Kinases/metabolism ; Proprotein Convertase 1/metabolism ; Protein Biosynthesis/drug effects ; Puromycin/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems.
Autorzy :
Wang J; Biozentrum, University of Basel, CH 4056 Basel, Switzerland; email: .
Brodmann M; Biozentrum, University of Basel, CH 4056 Basel, Switzerland; email: .
Basler M; Biozentrum, University of Basel, CH 4056 Basel, Switzerland; email: .
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Źródło :
Annual review of microbiology [Annu Rev Microbiol] 2019 Sep 08; Vol. 73, pp. 621-638. Date of Electronic Publication: 2019 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Type VI Secretion Systems*/biosynthesis
Type VI Secretion Systems*/chemistry
Type VI Secretion Systems*/metabolism
Type VI Secretion Systems*/ultrastructure
Gram-Negative Bacteria/*metabolism
Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Bacterial Secretion Systems ; Cell Membrane/metabolism ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Lipoproteins/chemistry ; Lipoproteins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Bacterial injection machines: Evolutionary diverse but functionally convergent.
Autorzy :
Bleves S; LISM (Laboratoire d'Ingénierie des Systèmes Macromoléculaires-UMR7255), IMM (Institut de Microbiologie de la Méditerranée), Aix-Marseille Univ and CNRS, Marseille, France.
Galán JE; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut.
Llosa M; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-SODERCAN, Santander, Spain.
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Źródło :
Cellular microbiology [Cell Microbiol] 2020 May; Vol. 22 (5), pp. e13157. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacteria/*metabolism
Bacterial Proteins/*metabolism
Bacterial Secretion Systems/*metabolism
Bacteria/genetics ; Bacterial Proteins/genetics ; Bacterial Secretion Systems/chemistry ; Bacterial Secretion Systems/genetics ; Humans ; Protein Transport ; Spain ; Type III Secretion Systems/genetics ; Type III Secretion Systems/metabolism ; Type IV Secretion Systems/genetics ; Type IV Secretion Systems/metabolism ; Type VI Secretion Systems/genetics ; Type VI Secretion Systems/metabolism ; Virulence
Czasopismo naukowe

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